Thromboxane b2 is a lipid of Fatty Acyls (FA) class. Thromboxane b2 is associated with abnormalities such as endothelial dysfunction, Diabetes Mellitus, Non-Insulin-Dependent, Diabetes Mellitus, Ischemia and Thrombocytosis. The involved functions are known as Platelet Activation, Excretory function, Anabolism, Inflammation and mRNA Expression. Thromboxane b2 often locates in Endothelium, Hepatic and Microsomes, Liver. The associated genes with Thromboxane b2 are PTGS2 gene, prothrombin fragment 2 and CCL14 wt Allele.
To understand associated biological information of Thromboxane b2, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
Thromboxane b2 is suspected in endothelial dysfunction, Diabetes Mellitus, Non-Insulin-Dependent, Diabetes Mellitus, Ischemia, Thrombocytosis, Acute Coronary Syndrome and other diseases in descending order of the highest number of associated sentences.
Disease | Cross reference | Weighted score | Related literature |
---|
We collected disease MeSH terms mapped to the references associated with Thromboxane b2
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
Location | Cross reference | Weighted score | Related literatures |
---|
Function | Cross reference | Weighted score | Related literatures |
---|
There are no associated biomedical information in the current reference collection.
Gene | Cross reference | Weighted score | Related literatures |
---|
There are no associated biomedical information in the current reference collection.
Authors | Title | Published | Journal | PubMed Link |
---|---|---|---|---|
Mäkilä UM et al. | Regulation of prostacyclin and thromboxane production by human umbilical vessels: the effect of estradiol and progesterone in a superfusion model. | 1982 | Prostaglandins Leukot Med | pmid:7043492 |
Krausz MM et al. | Adverse effects of prostacyclin used to perfuse isolated lung lobes. | 1982 | Am. J. Physiol. | pmid:7044149 |
Siess W et al. | Plasma catecholamines, platelet aggregation and associated thromboxane formation after physical exercise, smoking or norepinephrine infusion. | 1982 | Circulation | pmid:7044612 |
Chierchia S et al. | Failure of thromboxane A2 blockade to prevent attacks of vasospastic angina. | 1982 | Circulation | pmid:7116586 |
Sasagawa S et al. | Effects of thromboxane A2 injection on the rabbit coronary artery. I. Physiologic effects in healthy animals. | 1982 | Exp. Mol. Pathol. | pmid:7117494 |
Socini A et al. | Effects of the coumarin derivative AD6 on platelet aggregation, platelet vessel wall interactions and 6 keto PGF1 alpha production in perfused aortas, in experimentally hypercholesterolaemic rabbits. | 1982 | Pharmacol Res Commun | pmid:7048340 |
Simpson RM et al. | Generation of thromboxane A2 and aorta-contracting activity from platelets stimulated with modified C-reactive protein. | 1982 | Immunology | pmid:7118160 |
Leach CM and Thorburn GD | A comparative study of collagen induced thromboxane release from platelets of different species: implications for human atherosclerosis models. | 1982 | Prostaglandins | pmid:7122912 |
Bottoms GD et al. | Thromboxane, prostaglandin I2 (epoprostenol), and the hemodynamic changes in equine endotoxin shock. | 1982 | Am. J. Vet. Res. | pmid:7049018 |
Poubelle P et al. | [Mononucleated phagocytes from rheumatoid synovial fluid. Synthesis of prostanoids and first pharmacological applications]. | 1982 | Rev Rhum Mal Osteoartic | pmid:7123126 |
Homma T and Malik KU | Effect of prostaglandins on pancreatic circulation in anesthetized dogs. | 1982 | J. Pharmacol. Exp. Ther. | pmid:7050343 |
Bradlow BA and Chetty N | Dosage frequency for suppression of platelet function by low dose aspirin therapy. | 1982 | Thromb. Res. | pmid:7123514 |
Buchanan MR et al. | Aspirin inhibits platelet function independent of the acetylation of cyclo-oxygenase. | 1982 | Thromb. Res. | pmid:7071811 |
Tremoli E et al. | Metformin reduces platelet hypersensitivity in hypercholesterolemic rabbits. | 1982 | Atherosclerosis | pmid:7073794 |
Martin JF et al. | Effect of acetylsalicylic acid on platelet aggregation and thromboxane B2 production in flowing aortic blood in the rat studied with a filter loop technique. | 1982 | Thromb. Res. | pmid:6814004 |
Strano A et al. | Platelet sensitivity to prostacyclin and thromboxane production in hyperlipidemic patients. | 1982 | Thromb. Haemost. | pmid:6753232 |
Flynn JT and Demling RH | Inhibition of endogenous thromboxane synthesis by exogenous prostacyclin during endotoxemia in conscious sheep. | 1982 | Adv Shock Res | pmid:6753534 |
Smith MC et al. | Prostacyclin substitution for heparin in long-term hemodialysis. | 1982 | Am. J. Med. | pmid:6753575 |
Ylikorkala O et al. | Prostacyclin and thromboxane in chronic uremia: effect of hemodialysis. | 1982 | Clin. Nephrol. | pmid:6754193 |
Ylikorkala O et al. | Production of prostacyclin and thromboxane during cesarean section. | 1982 | Obstet Gynecol | pmid:6755324 |
Utsunomiya T et al. | Modification of inflammatory response to aspiration with ibuprofen. | 1982 | Am. J. Physiol. | pmid:6756172 |
Goldsmith JC and Needleman SW | A comparative study of thromboxane and prostacyclin release from ex vivo and cultured bovine vascular endothelium. | 1982 | Prostaglandins | pmid:6815717 |
Numano F et al. | Changes in the plasma levels of thromboxane B2 and cyclic nucleotides in patients with Takayasu disease. | 1982 | Jpn. Circ. J. | pmid:6119373 |
Foegh ML et al. | Aspirin inhibition of thromboxane release in thrombosis and renal transplant rejection. | 1982 | Lancet | pmid:6119441 |
Ody C et al. | 6-Ketoprostaglandin F1 alpha, prostaglandins E2, F2 alpha and thromboxane B2 production by endothelial cells, smooth muscle cells and fibroblasts cultured from piglet aorta. | 1982 | Biochim. Biophys. Acta | pmid:6214281 |
Rock JA et al. | Cul-de-sac fluid in women with endometriosis: fluid volume and prostanoid concentration during the proliferative phase of the cycle--days 8 to 12. | 1982 | Fertil. Steril. | pmid:6953017 |
Whinnery MA et al. | Thromboxane B2 and prostaglandin E2 in the rat kidney with unilateral ureteral obstruction. | 1982 | Am. J. Physiol. | pmid:6950670 |
Hornych A et al. | [Urinary thromboxane B2 in hypertensive patients]. | 1982 | Arch Mal Coeur Vaiss | pmid:6810812 |
Worthington RE and Nakeff A | Aspirin inhibits rat megakaryocyte thromboxane synthesis. | 1982 | Prostaglandins | pmid:6812167 |
Havill AM et al. | alpha-Naphthylthiourea produces dose-dependent lung vascular injury in sheep. | 1982 | Am. J. Physiol. | pmid:6812437 |
Meydani SN and Dupont J | Effect of zinc deficiency on prostaglandin synthesis in different organs of the rat. | 1982 | J. Nutr. | pmid:7045297 |
Landgraf-Leurs MM et al. | Aggregation and thromboxane formation by platelets and vascular prostacyclin production from BB rats. An animal model for type I diabetes. | 1982 | Prostaglandins | pmid:6812171 |
Miller JL et al. | Arachidonic acid metabolism in guinea pig megakaryocytes. | 1982 | Biochem. Biophys. Res. Commun. | pmid:6812584 |
Rothberg KG and Hitchcock M | In vitro biosynthesis of cyclooxygenase metabolites in ovalbumin-sensitized and control lungs of guinea pigs. | 1982 | Biochem. Pharmacol. | pmid:6812589 |
Uyama O et al. | Plasma concentrations of 6-keto-prostaglandin F1 alpha in patients with hypertension, cerebrovascular disease or Takayasu's arteritis. | 1982 Jan 1-15 | Thromb. Res. | pmid:6121391 |
Sakai K et al. | Roles of endogenous prostacyclin and thromboxane A2 in the ischemic canine heart. | 1982 Jan-Feb | J. Cardiovasc. Pharmacol. | pmid:6176788 |
Giannessi D et al. | Methodological assessment and applications of a radioimmunoassay for thromboxane (TxB2) to measurement of TxB2 release by platelets. | 1982 Jan-Mar | J. Nucl. Med. Allied Sci. | pmid:7108634 |
Shohami E et al. | The effect of incomplete cerebral ischemia on prostaglandin levels in rat brain. | 1982 Jul-Aug | Stroke | pmid:6896589 |
Mest HJ et al. | [Effect of stress on blood level of prostaglandins in students during exams]. | 1982 May-Jun | Farmakol Toksikol | pmid:7095121 |
Simmons PM et al. | The release of leukotriene B4 during experimental inflammation. | 1983 | Biochem. Pharmacol. | pmid:6305369 |
Svensson J and Samuelsson K | Inhibition of platelet function by low dose acetylsalicylic acid in patients with cerebrovascular disease. | 1983 | Thromb. Res. | pmid:20218005 |
Johnsen SA et al. | Conversion of arachidonic acid in human maternal and neonatal mononuclear leukocytes. | 1983 | Immunol. Lett. | pmid:6411611 |
Nordøy A et al. | Platelets and coagulation in patients with familial hypercholesterolemia (type IIa). | 1983 | Acta Med Scand | pmid:6188328 |
Roth DM et al. | Protective actions of ibuprofen in arachidonate-induced sudden death. | 1983 | Pharmacology | pmid:6413987 |
Salmon JA et al. | Synthesis of arachidonate cyclo-oxygenase products by rheumatoid and nonrheumatoid synovial lining in nonproliferative organ culture. | 1983 | Ann. Rheum. Dis. | pmid:6402992 |
Harlan J et al. | Selective inhibition of thromboxane synthesis during experimental endotoxemia in the goat: effects on pulmonary haemodynamics and lung lymph flow. | 1983 | Br J Clin Pharmacol | pmid:6337602 |
Ball HA et al. | Effect of dazoxiben, a specific inhibitor of thromboxane synthetase, on acute pulmonary responses to E. coli endotoxin in anaesthetized cats. | 1983 | Br J Clin Pharmacol | pmid:6337603 |
Dodd NJ et al. | Use of a thromboxane synthetase inhibitor, dazoxiben, during haemodialysis. | 1983 | Br J Clin Pharmacol | pmid:6337605 |
Di Minno G et al. | Exposure of platelet fibrinogen-binding sites by collagen, arachidonic acid, and ADP: inhibition by a monoclonal antibody to the glycoprotein IIb-IIIa complex. | 1983 | Blood | pmid:6216929 |
Ylikorkala O et al. | Maternal prostacyclin, thromboxane, and placental blood flow. | 1983 | Am. J. Obstet. Gynecol. | pmid:6338724 |
Williams GA et al. | Prostacyclin and thromboxane A2 derivatives in rhegmatogenous subretinal fluid. | 1983 | Arch. Ophthalmol. | pmid:6338873 |
Ylikorkala O et al. | Effect of vacuum curettage on the concentrations of plasma 6-keto-prostaglandin F1 alpha and serum thromboxane B2. | 1983 | Br J Obstet Gynaecol | pmid:6338904 |
Marcella JJ et al. | Exercise-induced myocardial ischemia in patients with coronary artery disease: lack of evidence for platelet activation or fibrin formation in peripheral venous blood. | 1983 | J. Am. Coll. Cardiol. | pmid:6339591 |
Brox JH et al. | Effects of cod liver oil on platelets and coagulation in familial hypercholesterolemia (type IIa). | 1983 | Acta Med Scand | pmid:6340424 |
Vlasses PH et al. | Urinary excretion of prostacyclin and thromboxane A2 metabolites after angiotensin converting enzyme inhibition in hypertensive patients. | 1983 | Prostaglandins Leukot Med | pmid:6308685 |
Huval WV et al. | Thromboxane mediation of cardiovascular dysfunction following aspiration. | 1983 | Surgery | pmid:6308843 |
Hartung HP | Acetyl glyceryl ether phosphorylcholine (platelet-activating factor) mediates heightened metabolic activity in macrophages. Studies on PGE, TXB2 and O2- production, spreading, and the influence of calmodulin-inhibitor W-7. | 1983 | FEBS Lett. | pmid:6309563 |
Sheng WY et al. | Kinetic comparison and regulation of the cascade of microsomal enzymes involved in renal arachidonate and endoperoxide metabolism. | 1983 | J. Biol. Chem. | pmid:6401732 |
Chetty N and Bradlow BA | The effects of a vegetarian diet on platelet function and fatty acids. | 1983 | Thromb. Res. | pmid:6612688 |
Parry MJ | Effects of thromboxane synthetase inhibition on arachidonate metabolism and platelet behaviour. | 1983 | Br J Clin Pharmacol | pmid:6401997 |
Ujiie A et al. | [Studies on the inhibitory effect of etafenone hydrochloride on platelet aggregation]. | 1983 | Nippon Yakurigaku Zasshi | pmid:6618341 |
Kawaguchi H | Thromboxane synthesis in hypercholesterolemic platelets--on the mechanism of increased thromboxane synthesis. | 1983 | Hokkaido Igaku Zasshi | pmid:6618425 |
Jakubowski JA et al. | Arachidonic acid metabolism by platelets of differing size. | 1983 | Br. J. Haematol. | pmid:6402003 |
Dubin NH et al. | Thromboxane production in the pregnant rat: differential recovery by platelets and uterus following aspirin administration. | 1983 | Biol. Reprod. | pmid:6626652 |
Krishnamurthi S et al. | Paradoxical effects of indomethacin and trifluoperazine on Ca2+ ionophore A23187-induced human platelet aggregation, thromboxane B2 production, and dense granule release. | 1983 | Adv. Prostaglandin Thromboxane Leukot. Res. | pmid:6221559 |
Lecompte T et al. | Interference of transmethylation inhibitors with thromboxane synthesis in rat platelets: evidence for the requirement of a methyl transfer reaction in platelet activation. | 1983 | Adv. Prostaglandin Thromboxane Leukot. Res. | pmid:6221560 |
Patrono C et al. | Evidence for a renal origin of urinary thromboxane B2 in health and disease. | 1983 | Adv. Prostaglandin Thromboxane Leukot. Res. | pmid:6221569 |
Fletcher JR et al. | Thromboxane inhibition in gram-negative sepsis fails to improve survival. | 1983 | Adv. Prostaglandin Thromboxane Leukot. Res. | pmid:6221586 |
Socini A et al. | Fish oil administration lowers prostacyclin production and the antiaggregatory activity of aortic walls more effectively than platelet aggregation and thromboxane in the rat. | 1983 | Adv. Prostaglandin Thromboxane Leukot. Res. | pmid:6221591 |
Hornstra G et al. | Dietary-fat-induced changes in the formation of prostanoids of the 2 and 3 series in relation to arterial thrombosis (rat) and atherosclerosis (rabbit). | 1983 | Adv. Prostaglandin Thromboxane Leukot. Res. | pmid:6221593 |
Tremoli E et al. | North Karelian study: changes in dietary fat reduce thromboxane B2 formation by platelets only in male subjects--preliminary report. | 1983 | Adv. Prostaglandin Thromboxane Leukot. Res. | pmid:6221594 |
Sinzinger H and Firbas W | [Cells of the vascular wall synthesize thromboxane]. | 1983 | Wien. Klin. Wochenschr. | pmid:6369802 |
Mehta P et al. | Inhibitory effects of diltiazem on platelet activation caused by ionophore A23187 plus ADP or epinephrine in subthreshold concentrations. | 1983 | J. Lab. Clin. Med. | pmid:6411841 |
Gordon PR et al. | Platelet arachidonate metabolism and platelet function in zinc-deficient rats. | 1983 | J. Nutr. | pmid:6403678 |
Okegawa T et al. | Endotoxin induces chronic prostaglandin and thromboxane synthesis from ureter-obstructed kidneys: role of inflammatory cells. | 1983 | J. Pharmacol. Exp. Ther. | pmid:6403696 |
Ellsworth ML et al. | Pulmonary prostacyclin production with increased flow and sympathetic stimulation. | 1983 | J Appl Physiol Respir Environ Exerc Physiol | pmid:6415017 |
Dahl ML et al. | Sodium salicylate interferes with the inhibitory effects of aspirin and indomethacin on human platelets. | 1983 | Prostaglandins Leukot Med | pmid:6415666 |
Han P et al. | Verapamil and collagen-induced platelet reactions--evidence for a role for intracellular calcium in platelet activation. | 1983 | Thromb. Haemost. | pmid:6415847 |
Fischer S et al. | In vivo and in vitro effects of nafazatrom (Bay g 6575), an antithrombotic compound, on arachidonic acid metabolism in platelets and vascular tissue. | 1983 | Biochem. Pharmacol. | pmid:6688182 |
Bailey IA et al. | Effects of vascular trauma and transient myocardial ischaemia on coronary venous prostaglandin levels in the dog. | 1983 | Cardiovasc. Res. | pmid:6688202 |
Srivastava KC and Awasthi KK | Separation and quantitative determination of radiolabeled prostaglandins, thromboxanes, 6-keto-prostaglandin F1 alpha and other arachidonic acid metabolites produced in biological material. | 1983 | J. Chromatogr. | pmid:6688256 |
Wilson L and Huang LS | Effects of the fetal-placental unit on uterine prostaglandin levels at term in the pregnant rat. | 1983 | Prostaglandins | pmid:6688474 |
Saldeen P and Saldeen T | 6-keto-prostaglandin F1 alpha/thromboxane B2 ratio in vascular and lung tissue. | 1983 | Thromb. Res. | pmid:6688484 |
Wilson TW | Responses to furosemide in normotensive and hypertensive subjects. | 1983 | Clin. Pharmacol. Ther. | pmid:6688772 |
Gurtner GH et al. | Oxidant- and lipid-induced pulmonary vasoconstriction mediated by arachidonic acid metabolites. | 1983 | J Appl Physiol Respir Environ Exerc Physiol | pmid:6688802 |
Hidaka T et al. | Thromboxane formation from arachidonic acid and prostaglandin H2 in rabbit spleen. | 1983 | J. Biochem. | pmid:6404897 |
Gerozissis K and Dray F | In-vitro prostanoid production by the rat vas deferens. | 1983 | J. Reprod. Fertil. | pmid:6572721 |
Okahara T et al. | Zonal heterogeneity of prostaglandin and thromboxane release in the dog kidney. | 1983 | Prostaglandins | pmid:6575405 |
Hoult JR and Robinson C | Selective inhibition of thromboxane B2 accumulation and metabolism in perfused guinea-pig lung. | 1983 | Br. J. Pharmacol. | pmid:6824820 |
Hirsh PD et al. | Effects of provocation on transcardiac thromboxane in patients with coronary artery disease. | 1983 | Am. J. Cardiol. | pmid:6829431 |
Rojas J et al. | Effects of cyclooxygenase inhibition on the response to group B streptococcal toxin in sheep. | 1983 | Pediatr. Res. | pmid:6402752 |
Förster W and Pönicke K | Influence of sympathomimetic drugs (1-phenyl-2-amino-ethan-1-ol derivatives) on the biosynthesis of prostaglandins and thromboxane B2. | 1983 | Br. J. Pharmacol. | pmid:6403094 |
Nenci GG et al. | Platelet malondialdehyde production kinetics after cyclooxygenase block. A study performed with a modified high sensitivity assay. | 1983 | Haemostasis | pmid:6404715 |
Lewy RI | Role of thromboxanes in vasotonic versus vaso-occlusive angina. | 1983 | Arch Mal Coeur Vaiss | pmid:6407435 |
Hayashi Y et al. | Enzyme immunoassay of thromboxane B2. | 1983 | Biochim. Biophys. Acta | pmid:6407530 |
Poyser NL and Brydon LJ | Prostaglandin release from the guinea-pig uterus superfused in vitro. Effect of stage of estrous cycle, progesterone, estradiol, oxytocin and A23187. | 1983 | Prostaglandins | pmid:6408712 |
Butler RR et al. | Gentamicin and indomethacin in the treatment of septic shock: effects on prostacyclin and thromboxane A2 production. | 1983 | J. Pharmacol. Exp. Ther. | pmid:6339712 |
Laitinen O et al. | Plasma levels and urinary excretion of prostaglandins in patients with rheumatoid arthritis. | 1983 | Clin. Rheumatol. | pmid:6589104 |
Ouwendijk RJ et al. | Raised plasma levels of thromboxane B2 in systemic mastocytosis. | 1983 | Eur. J. Clin. Invest. | pmid:6409646 |
Asbóth G et al. | Conversion of arachidonic acid to prostanoids in the avian uterus. | 1983 | Biochim. Biophys. Acta | pmid:6402032 |