Thromboxane b2 is a lipid of Fatty Acyls (FA) class. Thromboxane b2 is associated with abnormalities such as endothelial dysfunction, Diabetes Mellitus, Non-Insulin-Dependent, Diabetes Mellitus, Ischemia and Thrombocytosis. The involved functions are known as Platelet Activation, Excretory function, Anabolism, Inflammation and mRNA Expression. Thromboxane b2 often locates in Endothelium, Hepatic and Microsomes, Liver. The associated genes with Thromboxane b2 are PTGS2 gene, prothrombin fragment 2 and CCL14 wt Allele.
To understand associated biological information of Thromboxane b2, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
Thromboxane b2 is suspected in endothelial dysfunction, Diabetes Mellitus, Non-Insulin-Dependent, Diabetes Mellitus, Ischemia, Thrombocytosis, Acute Coronary Syndrome and other diseases in descending order of the highest number of associated sentences.
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We collected disease MeSH terms mapped to the references associated with Thromboxane b2
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
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Function | Cross reference | Weighted score | Related literatures |
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There are no associated biomedical information in the current reference collection.
Gene | Cross reference | Weighted score | Related literatures |
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There are no associated biomedical information in the current reference collection.
Authors | Title | Published | Journal | PubMed Link |
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Ziser A et al. | Propofol does not induce pulmonary dysfunction in stressed endotoxic pigs receiving Intralipid. | 2003 | Crit. Care Med. | pmid:12847400 |
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Al-Waili NS and Boni NS | Natural honey lowers plasma prostaglandin concentrations in normal individuals. | 2003 | J Med Food | pmid:12935324 |
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Cerletti C et al. | Pharmacokinetic and pharmacodynamic differences between two low dosages of aspirin may affect therapeutic outcomes. | 2003 | Clin Pharmacokinet | pmid:12959636 |
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Hayashi M et al. | Characterization of five marker levels of the hemostatic system and endothelial status in normotensive pregnancy and pre-eclampsia. | 2002 Nov-Dec | Eur. J. Haematol. | pmid:12460234 |
Wolfram RM et al. | Effect of black tea on (iso-)prostaglandins and platelet aggregation in healthy volunteers. | 2002 May-Jun | Prostaglandins Leukot. Essent. Fatty Acids | pmid:12144875 |
Alarayyed NA et al. | Differential actions of naftopidil, doxazosin and nifedipine on platelet thromboxane generation and platelet-derived growth factor efflux in vitro. | 2002 Aug-Sep | Platelets | pmid:12189011 |
Ersöz G et al. | Effect of submaximal and incremental upper extremity exercise on platelet function and the role of blood shear stress. | 2002 | Thromb. Res. | pmid:12676189 |
Connolly E et al. | Cyclooxygenase isozyme expression and intimal hyperplasia in a rat model of balloon angioplasty. | 2002 | J. Pharmacol. Exp. Ther. | pmid:11805196 |
Pinheiro RM and Calixto JB | Effect of the selective COX-2 inhibitors, celecoxib and rofecoxib in rat acute models of inflammation. | 2002 | Inflamm. Res. | pmid:12558194 |
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Bermejo BP et al. | Sesquiterpenes from Jasonia glutinosa: in vitro anti-inflammatory activity. | 2002 | Biol. Pharm. Bull. | pmid:11824534 |
Küsters S et al. | Effects of antihistamines on leukotriene and cytokine release from dispersed nasal polyp cells. | 2002 | Arzneimittelforschung | pmid:11878205 |
Schelzig H et al. | Role of recombinant hirudin in a pig-to-human lung transplantation model. | 2002 | Transplant. Proc. | pmid:12270449 |
Huang CG et al. | Effect of berberine on arachidonic acid metabolism in rabbit platelets and endothelial cells. | 2002 | Thromb. Res. | pmid:12297129 |
Lees P and Landoni MF | Pharmacodynamics and enantioselective pharmacokinetics of racemic carprofen in the horse. | 2002 | J. Vet. Pharmacol. Ther. | pmid:12485349 |
Tang L et al. | [Relationship between cyclooxygenase-2 protein expression, prostaglandins levels and biologic behavior in ovarian carcinoma tissue]. | 2002 | Zhonghua Fu Chan Ke Za Zhi | pmid:12487927 |
Tuersun K and Huang Y | [Changes of blood vessel active substances in acute pulmonary embolism induced by echinococus granulous cyst in rabbits]. | 2002 | Zhonghua Jie He He Hu Xi Za Zhi | pmid:12490126 |
Zaitsu M et al. | Induction of thromboxane A2 synthesizing enzymes in DMSO-induced granulocytic differentiation of HL-60 cells. | 2002 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:12468261 |
Thomson M et al. | The use of ginger (Zingiber officinale Rosc.) as a potential anti-inflammatory and antithrombotic agent. | 2002 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:12468270 |
Sheu JR et al. | Mechanisms involved in the antiplatelet activity of magnesium in human platelets. | 2002 | Br. J. Haematol. | pmid:12472585 |
Fiorucci S et al. | NCX-4016 (NO-aspirin) inhibits lipopolysaccharide-induced tissue factor expression in vivo: role of nitric oxide. | 2002 | Circulation | pmid:12473561 |
Rouvier J et al. | Aspirin resistance. | 2002 | Circulation | pmid:12473569 |
Celik I et al. | Effects of ibuprofen on the physiology and outcome of rabbit endotoxic shock. | 2002 | BMC Infect. Dis. | pmid:12445332 |
Dai CF et al. | [Clinical and experimental study of treatment of nanmiqing capsule for chronic prostatitis]. | 2002 | Zhonghua Nan Ke Xue | pmid:12479132 |
Khan I et al. | Cyclooxygenase-2 inhibition and experimental colitis: beneficial effects of phosphorothioated antisense oligonucleotide and meloxicam. | 2002 | Scand. J. Gastroenterol. | pmid:12523593 |
Miyataka M et al. | Nitric oxide, anti-inflammatory drugs on renal prostaglandins and cyclooxygenase-2. | 2002 | Hypertension | pmid:11897764 |
Minuz P et al. | Increased oxidative stress and platelet activation in patients with hypertension and renovascular disease. | 2002 | Circulation | pmid:12451006 |
Ozaki N et al. | Differential regulation of prostacyclin and thromboxane by dexamethasone and celecoxib during oxidative stress in newborn rabbits. | 2002 | Prostaglandins Other Lipid Mediat. | pmid:12428679 |
De La Cruz JP et al. | Effects of the selective inhibition of platelet thromboxane synthesis on the platelet-subendothelium interaction. | 2002 | Br. J. Pharmacol. | pmid:12429581 |
Bruno A et al. | Aspirin and urinary 11-dehydrothromboxane B(2) in African American stroke patients. | 2002 | Stroke | pmid:11779889 |
Canbaz M et al. | Effects of tibolone on thromboxane B(2) levels in postmenopausal women. | 2002 | Gynecol. Obstet. Invest. | pmid:11803222 |
Huang F et al. | Anti-platelet and anti-thrombotic effects of triacetylshikimic acid in rats. | 2002 | J. Cardiovasc. Pharmacol. | pmid:11791012 |
Bayorh MA et al. | 1A-779 attenuates angiotensin-(1-7) depressor response in salt-induced hypertensive rats. | 2002 | Peptides | pmid:11814618 |
Jeng JH et al. | Modulation of platelet aggregation by areca nut and betel leaf ingredients: roles of reactive oxygen species and cyclooxygenase. | 2002 | Free Radic. Biol. Med. | pmid:11978487 |
Streppa HK et al. | Cyclooxygenase selectivity of nonsteroidal anti-inflammatory drugs in canine blood. | 2002 | Am. J. Vet. Res. | pmid:16206787 |
Jiang Z et al. | [The changes of thromboxane B2 (TXB2) and 6-keto-prostaglandin F1 alpha(6-keto-PGF1 alpha) in the lungs of rats drowned in hypothermic-sea-water]. | 2002 | Zhonghua Lao Dong Wei Sheng Zhi Ye Bing Za Zhi | pmid:14694611 |
Saareks V et al. | Opposite effects of nicotinic acid and pyridoxine on systemic prostacyclin, thromboxane and leukotriene production in man. | 2002 | Pharmacol. Toxicol. | pmid:12403056 |
Kudolo GB et al. | Effect of the ingestion of Ginkgo biloba extract on platelet aggregation and urinary prostanoid excretion in healthy and Type 2 diabetic subjects. | 2002 | Thromb. Res. | pmid:12590952 |
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Kirchheiner J et al. | Enantiospecific effects of cytochrome P450 2C9 amino acid variants on ibuprofen pharmacokinetics and on the inhibition of cyclooxygenases 1 and 2. | 2002 | Clin. Pharmacol. Ther. | pmid:12152005 |
Wang L et al. | Enhancement of human platelet activation by the combination of low concentrations of collagen and rabbit anticardiolipin antibodies. | 2002 | Br. J. Haematol. | pmid:12199800 |
Park CH et al. | Investigations of new lead structures for the design of novel cyclooxygenase-2 inhibitors. | 2002 | Eur J Med Chem | pmid:12204472 |
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Association between ibuprofen, aspirin therapy found. | 2002 | J Am Dent Assoc | pmid:12136787 | |
Rinder HM et al. | Effects of meloxicam on platelet function in healthy adults: a randomized, double-blind, placebo-controlled trial. | 2002 | J Clin Pharmacol | pmid:12162470 |
Wong DA et al. | Discrete role for cytosolic phospholipase A(2)alpha in platelets: studies using single and double mutant mice of cytosolic and group IIA secretory phospholipase A(2). | 2002 | J. Exp. Med. | pmid:12163563 |
Kiemer AK et al. | Inhibition of cyclooxygenase-2 by natriuretic peptides. | 2002 | Endocrinology | pmid:11861506 |
Huang K et al. | Role of selenium in cytoprotection against cholesterol oxide-induced vascular damage in rats. | 2002 | Atherosclerosis | pmid:11947907 |
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Burleigh ME et al. | Cyclooxygenase-2 promotes early atherosclerotic lesion formation in LDL receptor-deficient mice. | 2002 | Circulation | pmid:11956125 |
Jankov RP et al. | Thromboxane A(2) receptors mediate pulmonary hypertension in 60% oxygen-exposed newborn rats by a cyclooxygenase-independent mechanism. | 2002 | Am. J. Respir. Crit. Care Med. | pmid:12119234 |
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Signorello MG et al. | Effect of homocysteine on arachidonic acid release in human platelets. | 2002 | Eur. J. Clin. Invest. | pmid:11952814 |
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Eikelboom JW et al. | Aspirin-resistant thromboxane biosynthesis and the risk of myocardial infarction, stroke, or cardiovascular death in patients at high risk for cardiovascular events. | 2002 | Circulation | pmid:11940542 |
Knijff-Dutmer EA et al. | Platelet function is inhibited by non-selective non-steroidal anti-inflammatory drugs but not by cyclo-oxygenase-2-selective inhibitors in patients with rheumatoid arthritis. | 2002 | Rheumatology (Oxford) | pmid:11961179 |
Hayashi M et al. | The levels of five markers of hemostasis and endothelial status at different stages of normotensive pregnancy. | 2002 | Acta Obstet Gynecol Scand | pmid:11966476 |
Saldeen P et al. | Structural, functional and circulatory placental changes associated with impaired glucose metabolism. | 2002 | Eur. J. Obstet. Gynecol. Reprod. Biol. | pmid:12381475 |
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Valeri CR et al. | Circulation and hemostatic function of autologous fresh, liquid-preserved, and cryopreserved baboon platelets transfused to correct an aspirin-induced thrombocytopathy. | 2002 | Transfusion | pmid:12430680 |
Wilner KD et al. | Celecoxib does not affect the antiplatelet activity of aspirin in healthy volunteers. | 2002 | J Clin Pharmacol | pmid:12211219 |
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Khan I et al. | Altered expression of Na(+)/H(+) exchanger isoforms 1 and 3 in clipped and unclipped kidneys of a 2-kidney-1-clip Goldblatt model of hypertension. | 2002 | Nephron | pmid:12218313 |
Yokoyama C et al. | Prostacyclin-deficient mice develop ischemic renal disorders, including nephrosclerosis and renal infarction. | 2002 | Circulation | pmid:12403673 |
Evgenov OV et al. | Methylene blue reduces pulmonary oedema and cyclo-oxygenase products in endotoxaemic sheep. | 2002 | Eur. Respir. J. | pmid:12412689 |
Bergh K et al. | Production of prostaglandin e(2) by iridial melanocytes exposed to latanoprost acid, a prostaglandin F(2 alpha) analogue. | 2002 | J Ocul Pharmacol Ther | pmid:12419090 |
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Kim H et al. | Effect of mannitol on Helicobacter pylori-induced cyclooxygenase-2 expression in gastric epithelial AGS cells. | 2002 | Pharmacology | pmid:12393940 |
Shashikant MP et al. | Physicochemical properties of perfluorochemical liquids influence ventilatory requirements, pulmonary mechanics, and microvascular permeability during partial liquid ventilation following intestinal ischemia/reperfusion injury. | 2002 | Crit. Care Med. | pmid:12394959 |
Vaughan JE and Walsh SW | Oxidative stress reproduces placental abnormalities of preeclampsia. | 2002 | Hypertens Pregnancy | pmid:12517328 |
Ferlito M et al. | Implication of Galpha i proteins and Src tyrosine kinases in endotoxin-induced signal transduction events and mediator production. | 2002 | J. Endotoxin Res. | pmid:12701623 |