Thromboxane b2

Thromboxane b2 is a lipid of Fatty Acyls (FA) class. Thromboxane b2 is associated with abnormalities such as endothelial dysfunction, Diabetes Mellitus, Non-Insulin-Dependent, Diabetes Mellitus, Ischemia and Thrombocytosis. The involved functions are known as Platelet Activation, Excretory function, Anabolism, Inflammation and mRNA Expression. Thromboxane b2 often locates in Endothelium, Hepatic and Microsomes, Liver. The associated genes with Thromboxane b2 are PTGS2 gene, prothrombin fragment 2 and CCL14 wt Allele.

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Introduction

To understand associated biological information of Thromboxane b2, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.

What diseases are associated with Thromboxane b2?

Thromboxane b2 is suspected in endothelial dysfunction, Diabetes Mellitus, Non-Insulin-Dependent, Diabetes Mellitus, Ischemia, Thrombocytosis, Acute Coronary Syndrome and other diseases in descending order of the highest number of associated sentences.

Related references are mostly published in these journals:

Disease Cross reference Weighted score Related literature
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Possible diseases from mapped MeSH terms on references

We collected disease MeSH terms mapped to the references associated with Thromboxane b2

MeSH term MeSH ID Detail
Asthma D001249 52 associated lipids
Kidney Diseases D007674 29 associated lipids
Femoral Fractures D005264 7 associated lipids
Weight Gain D015430 101 associated lipids
Hyperemia D006940 25 associated lipids
Cardiovascular Diseases D002318 24 associated lipids
Acidosis D000138 13 associated lipids
Glioma D005910 112 associated lipids
Staphylococcal Infections D013203 15 associated lipids
Cell Transformation, Neoplastic D002471 126 associated lipids
Ulcer D014456 16 associated lipids
Hypercholesterolemia D006937 91 associated lipids
Thrombosis D013927 49 associated lipids
Hypertension, Pulmonary D006976 32 associated lipids
Endometriosis D004715 29 associated lipids
Uterine Neoplasms D014594 18 associated lipids
Myocardial Infarction D009203 21 associated lipids
Proteinuria D011507 30 associated lipids
Arteriosclerosis D001161 86 associated lipids
Magnesium Deficiency D008275 9 associated lipids
Carcinoma, Hepatocellular D006528 140 associated lipids
Liver Cirrhosis D008103 67 associated lipids
Fibrosis D005355 23 associated lipids
Anemia, Sickle Cell D000755 34 associated lipids
Fetal Diseases D005315 8 associated lipids
Glomerulonephritis D005921 35 associated lipids
Cerebral Hemorrhage D002543 13 associated lipids
Sepsis D018805 11 associated lipids
Leukopenia D007970 9 associated lipids
Respiratory Insufficiency D012131 10 associated lipids
Erectile Dysfunction D007172 19 associated lipids
Infarction, Middle Cerebral Artery D020244 35 associated lipids
Stroke D020521 32 associated lipids
Liver Cirrhosis, Biliary D008105 12 associated lipids
Hyperlipoproteinemia Type II D006938 22 associated lipids
Hyperlipoproteinemia Type IV D006953 6 associated lipids
Nephrotic Syndrome D009404 11 associated lipids
Brain Ischemia D002545 89 associated lipids
Leukemia, Myeloid D007951 52 associated lipids
Respiratory Distress Syndrome, Adult D012128 15 associated lipids
Seizures D012640 87 associated lipids
Peptic Ulcer D010437 19 associated lipids
Birth Weight D001724 23 associated lipids
Hypertension D006973 115 associated lipids
Ischemic Attack, Transient D002546 42 associated lipids
Glomerulosclerosis, Focal Segmental D005923 4 associated lipids
Cerebrovascular Disorders D002561 25 associated lipids
Thromboembolism D013923 6 associated lipids
Nasal Polyps D009298 26 associated lipids
Gastrointestinal Diseases D005767 20 associated lipids
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PubChem Associated disorders and diseases

What pathways are associated with Thromboxane b2

There are no associated biomedical information in the current reference collection.

PubChem Biomolecular Interactions and Pathways

Link to PubChem Biomolecular Interactions and Pathways

What cellular locations are associated with Thromboxane b2?

Related references are published most in these journals:

Location Cross reference Weighted score Related literatures
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What functions are associated with Thromboxane b2?


Related references are published most in these journals:

Function Cross reference Weighted score Related literatures

What lipids are associated with Thromboxane b2?

There are no associated biomedical information in the current reference collection.

What genes are associated with Thromboxane b2?

Related references are published most in these journals:


Gene Cross reference Weighted score Related literatures

What common seen animal models are associated with Thromboxane b2?

There are no associated biomedical information in the current reference collection.

NCBI Entrez Crosslinks

All references with Thromboxane b2

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Per page 10 20 50 100 | Total 6367
Authors Title Published Journal PubMed Link
Lin CL et al. [Therapeutic mechanism of combination therapy of ligustrazine and nitrendipine in treating patients with chronic obstructive pulmonary disease]. 2001 Zhongguo Zhong Xi Yi Jie He Za Zhi pmid:12577373
Riendeau D et al. Etoricoxib (MK-0663): preclinical profile and comparison with other agents that selectively inhibit cyclooxygenase-2. 2001 J. Pharmacol. Exp. Ther. pmid:11160644
Al-Qattan KK et al. Thromboxane-B2, prostaglandin-E2 and hypertension in the rat 2-kidney 1-clip model: a possible mechanism of the garlic induced hypotension. 2001 Prostaglandins Leukot. Essent. Fatty Acids pmid:11161580
Sunose Y et al. Effects of FK3311 on pulmonary ischemia-reperfusion injury in a canine model. 2001 J. Surg. Res. pmid:11162041
Grace RF et al. Effects of diclofenac in the rat tail ischaemia--reperfusion injury model of acute hyperalgesia. 2001 Pain pmid:11166467
Watanabe T et al. Enhanced platelet sensitivity to prostacyclin in patients in an active stage of Takayasu arteritis. 2001 Thromb. Res. pmid:11672751
Ziegler BK et al. Incomplete thromboxane inhibition with 100 mg of intravenous acetylsalicylic acid in patients with acute ST elevation myocardial infarction: a placebo-controlled pilot trial. 2001 Thromb. Res. pmid:11672759
Nüsing RM et al. Pathogenetic role of cyclooxygenase-2 in hyperprostaglandin E syndrome/antenatal Bartter syndrome: therapeutic use of the cyclooxygenase-2 inhibitor nimesulide. 2001 Clin. Pharmacol. Ther. pmid:11673754
Llinás MT et al. Role of COX-2-derived metabolites in regulation of the renal hemodynamic response to norepinephrine. 2001 Am. J. Physiol. Renal Physiol. pmid:11592955
Kitamura R et al. Thiopental enhances human platelet aggregation by increasing arachidonic acid release. 2001 Can. J. Physiol. Pharmacol. pmid:11697744
Moreno JJ Antiflammin-2 prevents HL-60 adhesion to endothelial cells and prostanoid production induced by lipopolysaccharides. 2001 J. Pharmacol. Exp. Ther. pmid:11181920
Vagnoni KE et al. The influence of the phase of the estrous cycle on sheep endometrial tissue response to lipopolysaccharide. 2001 J. Anim. Sci. pmid:11219456
Iuliano L et al. Angioplasty increases coronary sinus F2-isoprostane formation: evidence for in vivo oxidative stress during PTCA. 2001 J. Am. Coll. Cardiol. pmid:11153776
Fritsma GA et al. Monitoring the antiplatelet action of aspirin. 2001 JAAPA pmid:11523339
Zoja C et al. Mycophenolate mofetil combined with a cyclooxygenase-2 inhibitor ameliorates murine lupus nephritis. 2001 Kidney Int. pmid:11473648
Cracowski JL et al. Enhanced in vivo lipid peroxidation in scleroderma spectrum disorders. 2001 Arthritis Rheum. pmid:11352247
Alcaraz A et al. Experimental kidney transplantation in pigs from non-heart-beating donors: evaluation of vasoactive substances and renal artery flow. 2001 Transplant. Proc. pmid:11543815
Wang ZY et al. Comparative study of platelet activation markers in diabetes mellitus patients complicated by cerebrovascular disease. 2001 Blood Coagul. Fibrinolysis pmid:11685040
Gloor B et al. Hydrocortisone treatment of early SIRS in acute experimental pancreatitis. 2001 Dig. Dis. Sci. pmid:11680590
Wang WJ and Huang TF A novel tetrameric venom protein, agglucetin from Agkistrodon acutus, acts as a glycoprotein Ib agonist. 2001 Thromb. Haemost. pmid:11686327
Stichtenoth DO et al. Effects of intravenous oxygen on prostacyclin and thromboxane formation in patients with peripheral occlusive arterial disease. 2001 Prostaglandins Leukot. Essent. Fatty Acids pmid:11728174
Sunose Y et al. Effect of a cyclooxygenase-2 inhibitor, FK3311, in a canine lung transplantation model. 2001 Ann. Thorac. Surg. pmid:11603431
Minuz P et al. NCX4016 (NO-Aspirin) has multiple inhibitory effects in LPS-stimulated human monocytes. 2001 Br. J. Pharmacol. pmid:11606332
Turull A et al. Acute effects of the anti-inflammatory cyclooxygenase-2 selective inhibitor, flosulide, on renal plasma flow and glomerular filtration rate in rats. 2001 Inflammation pmid:11321358
Oketani K et al. Effect of E3040, an inhibitor of 5-lipoxygenase and thromboxane synthase, on rat bowel damage induced by lipopolysaccharide. 2001 Eur. J. Pharmacol. pmid:11557269
Davì G et al. Oxidative stress and platelet activation in homozygous homocystinuria. 2001 Circulation pmid:11535567
Praticò D et al. Acceleration of atherogenesis by COX-1-dependent prostanoid formation in low density lipoprotein receptor knockout mice. 2001 Proc. Natl. Acad. Sci. U.S.A. pmid:11248083
Hishinuma T et al. Relationship between thromboxane/prostacyclin ratio and diabetic vascular complications. 2001 Prostaglandins Leukot. Essent. Fatty Acids pmid:11728171
Kaaja R et al. Increased thromboxane production in women with a history of venous thromboembolic event: effect of heparins. 2001 Br. J. Haematol. pmid:11552994
Dowd NP et al. Inhibition of cyclooxygenase-2 aggravates doxorubicin-mediated cardiac injury in vivo. 2001 J. Clin. Invest. pmid:11518732
Miyake K et al. Effects of olopatadine hydrochloride on the increase of histamine and peptide-leukotrienes concentrations in nasal lavage fluid following the antigen-antibody reaction in actively sensitized guinea pigs. 2001 Jpn. J. Pharmacol. pmid:11388650
Gossmann J et al. Pathophysiology of cyclosporine-induced nephrotoxicity in humans: a role for nitric oxide? 2001 Kidney Blood Press. Res. pmid:11435743
Cantaro S et al. Urinary excretion of vasoactive substances in chronic renal failure. 2001 Clin. Nephrol. pmid:11393385
Kurokawa K et al. Circadian characteristics of urinary leukotriene E(4) in healthy subjects and nocturnal asthmatic patients. 2001 Chest pmid:11742908
Feldman M et al. A comparison of every-third-day versus daily low-dose aspirin therapy on serum thromboxane concentrations in healthy men and women. 2001 Clin. Appl. Thromb. Hemost. pmid:11190906
Galipeau D et al. Chronic thromboxane synthase inhibition prevents fructose-induced hypertension. 2001 Hypertension pmid:11641301
Tubaro E et al. Anti-inflammatory and antiplatelet effects of amtolmetin guacyl, a new gastroprotective non-steroidal anti-inflammatory drug. 2001 Arzneimittelforschung pmid:11642006
Spinarová L et al. [Physical training in patients with chornic heart failure: haemodynamics, effects]. 2001 Vnitr Lek pmid:15635849
Machin KL et al. Pharmacodynamics of flunixin and ketoprofen in mallard ducks (Anas platyrhynchos). 2001 J. Zoo Wildl. Med. pmid:12790425
MalatyalioÄŸlu E et al. Levels of stable metabolites of prostacyclin and thromboxane A2 and their ratio in normotensive and preeclamptic pregnant women during the antepartum and postpartum periods. 2000 May-Jun J Matern Fetal Med pmid:10914626
Parker CR et al. Umbilical cord serum levels of thromboxane B2 in term infants of women who participated in a placebo-controlled trial of low-dose aspirin. 2000 Jul-Aug J Matern Fetal Med pmid:11048830
Mizutani T et al. Effects of a thromboxane receptor antagonist (NT-126) and a thromboxane synthase inhibitor (OKY-O46) on protamine-induced circulatory changes in dogs. 2000 J. Cardiothorac. Vasc. Anesth. pmid:11139110
Alric L et al. Reactive oxygen intermediates and eicosanoid production by kupffer cells and infiltrated macrophages in acute and chronic liver injury induced in rats by CCl4. 2000 Inflamm. Res. pmid:11211921
Demasi M et al. Assay of cyclooxygenase-1 and 2 in human monocytes. 2000 Inflamm. Res. pmid:11211927
Yang G et al. Effects of prostaglandins and leukotrienes on hypoxic pulmonary vasoconstriction in rats. 2000 J. Tongji Med. Univ. pmid:11215045
Tanus-Santos JE et al. The hemodynamic effects of endothelin receptor antagonism during a venous air infusion in dogs. 2000 Anesth. Analg. pmid:10624986
Heng W et al. [The role of platelet activation in the pathogenesis of asthma]. 2000 Zhonghua Jie He He Hu Xi Za Zhi pmid:11778515
Matsumoto H and Nakao T Elevated urinary excretion of thromboxane B2 in adults with minimal-change nephrotic syndrome. 2000 Clin. Nephrol. pmid:10661487
Leese PT et al. Effects of celecoxib, a novel cyclooxygenase-2 inhibitor, on platelet function in healthy adults: a randomized, controlled trial. 2000 J Clin Pharmacol pmid:10664917
Montini G et al. Renal glomerular response to the inhibition of prostaglandin E2 synthesis and protein loading after the relief of unilateral ureteropelvic junction obstruction. 2000 J. Urol. pmid:10647684
Xu L et al. [Clinical and experimental study on effect of Chanbei Kechuanping in treating bronchial asthma]. 2000 Zhongguo Zhong Xi Yi Jie He Za Zhi pmid:11789166
Agnoli GC et al. Renal synthesis of prostacyclin and thromboxane in healthy women: differential effects of a short-term saline loading. 2000 Prostaglandins Leukot. Essent. Fatty Acids pmid:10780876
Wakitani K et al. JTE-522 selectively inhibits cyclooxygenase-2-derived prostaglandin production in inflammatory tissues. 2000 Inflamm. Res. pmid:10807499
Liao CH et al. Antiplatelet effect of marchantinquinone, isolated from Reboulia hemisphaerica, in rabbit washed platelets. 2000 J. Pharm. Pharmacol. pmid:10757426
Prieto MA et al. Influence of triflusal on platelet activation after coronary artery bypass graft. 2000 Blood Coagul. Fibrinolysis pmid:10759013
Heller A et al. The complement regulators C1 inhibitor and soluble complement receptor 1 attenuate acute lung injury in rabbits. 2000 Shock pmid:10774617
Semenov AV et al. [Soluble P-selectin - a marker of platelet activation and vessel wall injury: increase of soluble P-selectin in plasma of patients with myocardial infarction, massive atherosclerosis and primary pulmonary hypertension]. 2000 Ter. Arkh. pmid:10833791
Jacobs C et al. 1-imidazolyl(alkyl)-substituted di- and tetrahydroquinolines and analogues: syntheses and evaluation of dual inhibitors of thromboxane A(2) synthase and aromatase. 2000 J. Med. Chem. pmid:10794700
Nenci GG and Paliani U [Diabetes, coagulation and vascular events]. 2000 Recenti Prog Med pmid:10748654
Bailey SR et al. Actions and interactions of ADP, 5- HT, histamine and PAF on equine platelets. 2000 Res. Vet. Sci. pmid:10756136
Thomson M et al. Thromboxane-B(2) levels in serum of rabbits receiving a single intravenous dose of aqueous extract of garlic and onion. 2000 Prostaglandins Leukot. Essent. Fatty Acids pmid:11049697
Qu X et al. Selenium deficiency-induced alterations in the vascular system of the rat. 2000 Biol Trace Elem Res pmid:11051602
Rahman K and Billington D Dietary supplementation with aged garlic extract inhibits ADP-induced platelet aggregation in humans. 2000 J. Nutr. pmid:11053504
Wang LL et al. Effects of MN-9202 on platelet aggregation, 5-HT release, TXB2 synthesis, and calcium mobilization in rabbit platelets in vitro. 2000 Acta Pharmacol. Sin. pmid:11360670
Coppola A et al. Homocysteine, coagulation, platelet function, and thrombosis. 2000 Semin. Thromb. Hemost. pmid:11011842
Kim WG et al. Is avoidance of air contact necessary for the in vitro evaluation of thrombogenicity in mechanical circulatory assist devices? 2000 Artif Organs pmid:11012543
Kim WG et al. Vasoconstrictive eicosanoid responses to extracorporeal circulation with or without an oxygenator in fetal lambs. 2000 Int J Artif Organs pmid:10941636
Porta C et al. Amifostine, a reactive oxigen species scavenger with radiation- and chemo-protective properties, inhibits in vitro platelet activation induced by ADP, collagen or PAF. 2000 Haematologica pmid:10942928
Krysztopik RJ et al. Lazaroid and pentoxifylline suppress sepsis-induced increases in renal vascular resistance via altered arachidonic acid metabolism. 2000 J. Surg. Res. pmid:10945946
Stanke-Labesque F et al. Angiotensin II-induced contractions in human internal mammary artery: effects of cyclooxygenase and lipoxygenase inhibition. 2000 Cardiovasc. Res. pmid:10946074
Thorwest M et al. Dietary fish oil reduces microvascular thrombosis in a porcine experimental model. 2000 Thromb. Res. pmid:10946095
McCann ME et al. Effect of intravenous infusion of omega-3 and omega-6 lipid emulsions on equine monocyte fatty acid composition and inflammatory mediator production in vitro. 2000 Shock pmid:10947170
Kamata K et al. Altered endothelium-dependent and -independent hyperpolarization and endothelium-dependent relaxation in carotid arteries isolated from streptozotocin-induced diabetic rats. 2000 Naunyn Schmiedebergs Arch. Pharmacol. pmid:10935533
Li JB et al. [A further research on physiopathological basis of "Liver Yang Forming Wind Syndrome"]. 2000 Hunan Yi Ke Da Xue Xue Bao pmid:12205996
Ohata T et al. Role of nitric oxide in a temperature dependent regulation of systemic vascular resistance in cardiopulmonary bypass. 2000 Eur J Cardiothorac Surg pmid:10973545
Togna GI et al. Cisplatin triggers platelet activation. 2000 Thromb. Res. pmid:10973681
Yuk DY et al. Antithrombotic and antiplatelet activities of 2-chloro-3-[4-(ethylcarboxy)-phenyl]-amino-1,4-naphthoquinone (NQ12), a newly synthesized 1,4-naphthoquinone derivative. 2000 Biochem. Pharmacol. pmid:10974210
Sabha M et al. Transdermal nicotine mimics the smoking-induced endothelial dysfunction. 2000 Clin. Pharmacol. Ther. pmid:10976548
van Haeringen NJ et al. Flurbiprofen and enantiomers in ophthalmic solution tested as inhibitors of prostanoid synthesis in human blood. 2000 J Ocul Pharmacol Ther pmid:10977130
WÅ‚odarczyk Z et al. Effects of pentoxifylline treatment on delayed graft function in cadaveric kidney recipients. 2000 Transplant. Proc. pmid:10995988
de Jong CL et al. Maternal thromboxane and prostacyclin levels in relation to fetal birth weight. 2000 Eur. J. Obstet. Gynecol. Reprod. Biol. pmid:11000507
Kowalska MA et al. Stromal cell-derived factor-1 and macrophage-derived chemokine: 2 chemokines that activate platelets. 2000 Blood pmid:10891429
Bailey SR et al. Differential activation of platelets from normal and allergic ponies by PAF and ADP. 2000 Inflamm. Res. pmid:10893045
Rao AR and Prabhakar MC Screening methods for antiasthmatic agents. 2000 Methods Find Exp Clin Pharmacol pmid:10893704
Cayatte AJ et al. The thromboxane receptor antagonist S18886 but not aspirin inhibits atherogenesis in apo E-deficient mice: evidence that eicosanoids other than thromboxane contribute to atherosclerosis. 2000 Arterioscler. Thromb. Vasc. Biol. pmid:10894809
Pärsson HN et al. Maintaining carotid flow by shunting during carotid endarterectomy diminishes the inflammatory response mediating ischaemic brain injury. 2000 Eur J Vasc Endovasc Surg pmid:10727360
Armstrong RA et al. No effect of dietary trans isomers of alpha-linolenic acid on platelet aggregation and haemostatic factors in european healthy men. The TRANSLinE study. 2000 Thromb. Res. pmid:11108899
Okada S et al. Perfusion of the hypothalamic paraventricular nucleus with N-methyl-D-aspartate produces thromboxane A2 and centrally activates adrenomedullary outflow in rats. 2000 Neuroscience pmid:10717438
Zaitsu M et al. Ulinastatin, an elastase inhibitor, inhibits the increased mRNA expression of prostaglandin H2 synthase-type 2 in Kawasaki disease. 2000 J. Infect. Dis. pmid:10720537
De La Cruz JP et al. Effect of DT-TX 30, a combined thromboxane synthase inhibitor and thromboxane receptor antagonist, on retinal vascularity in experimental diabetes mellitus. 2000 Thromb. Res. pmid:10680643
Nagano K et al. Prostanoids regulate proliferation of vascular smooth muscle cells induced by arginine vasopressin. 2000 Eur. J. Pharmacol. pmid:10686292
Weber AA et al. 40 mg of aspirin are not sufficient to inhibit platelet function under conditions of limited compliance. 2000 Thromb. Res. pmid:10709913
Okumura M et al. Renal production of thromboxane and prostaglandins in a rat model of type 2 diabetes. 2000 Life Sci. pmid:10670825
Wu TM et al. Inhibitory effect of hexapeptide (RGRHGD) on platelet aggregation. 2000 Thromb. Res. pmid:10674405
Tegeder I et al. Effects of selective and unselective cyclooxygenase inhibitors on prostanoid release from various rat organs. 2000 J. Pharmacol. Exp. Ther. pmid:10688636
Giedrojć J et al. [Interaction of platelets with monocytes with regard to arachidonic acid metabolites]. 2000 Prz. Lek. pmid:11199865
Ames PR et al. Antioxidant susceptibility of pathogenic pathways in subjects with antiphospholipid antibodies: a pilot study. 2000 Lupus pmid:11199924
Wang ZG et al. Can endothelial seeding enhance patency and inhibit neointimal hyperplasia? Experimental studies and clinical trial of endothelial seeded venous prostheses. 2000 Int Angiol pmid:11201596
MacKay RJ et al. Effect of eltenac in horses with induced endotoxaemia. 2000 Equine Vet J Suppl pmid:11202378
de la Riva IJ et al. Effect of oral L-arginine administration for three weeks in two kidney-two clip hypertensive rats. 2000 Arch. Physiol. Biochem. pmid:11262599