Thromboxane b2

Thromboxane b2 is a lipid of Fatty Acyls (FA) class. Thromboxane b2 is associated with abnormalities such as endothelial dysfunction, Diabetes Mellitus, Non-Insulin-Dependent, Diabetes Mellitus, Ischemia and Thrombocytosis. The involved functions are known as Platelet Activation, Excretory function, Anabolism, Inflammation and mRNA Expression. Thromboxane b2 often locates in Endothelium, Hepatic and Microsomes, Liver. The associated genes with Thromboxane b2 are PTGS2 gene, prothrombin fragment 2 and CCL14 wt Allele.

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Introduction

To understand associated biological information of Thromboxane b2, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.

What diseases are associated with Thromboxane b2?

Thromboxane b2 is suspected in endothelial dysfunction, Diabetes Mellitus, Non-Insulin-Dependent, Diabetes Mellitus, Ischemia, Thrombocytosis, Acute Coronary Syndrome and other diseases in descending order of the highest number of associated sentences.

Related references are mostly published in these journals:

Disease Cross reference Weighted score Related literature
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Possible diseases from mapped MeSH terms on references

We collected disease MeSH terms mapped to the references associated with Thromboxane b2

MeSH term MeSH ID Detail
Asthma D001249 52 associated lipids
Kidney Diseases D007674 29 associated lipids
Femoral Fractures D005264 7 associated lipids
Weight Gain D015430 101 associated lipids
Hyperemia D006940 25 associated lipids
Cardiovascular Diseases D002318 24 associated lipids
Acidosis D000138 13 associated lipids
Glioma D005910 112 associated lipids
Staphylococcal Infections D013203 15 associated lipids
Cell Transformation, Neoplastic D002471 126 associated lipids
Ulcer D014456 16 associated lipids
Hypercholesterolemia D006937 91 associated lipids
Thrombosis D013927 49 associated lipids
Hypertension, Pulmonary D006976 32 associated lipids
Endometriosis D004715 29 associated lipids
Uterine Neoplasms D014594 18 associated lipids
Myocardial Infarction D009203 21 associated lipids
Proteinuria D011507 30 associated lipids
Arteriosclerosis D001161 86 associated lipids
Magnesium Deficiency D008275 9 associated lipids
Carcinoma, Hepatocellular D006528 140 associated lipids
Liver Cirrhosis D008103 67 associated lipids
Fibrosis D005355 23 associated lipids
Anemia, Sickle Cell D000755 34 associated lipids
Fetal Diseases D005315 8 associated lipids
Glomerulonephritis D005921 35 associated lipids
Cerebral Hemorrhage D002543 13 associated lipids
Sepsis D018805 11 associated lipids
Leukopenia D007970 9 associated lipids
Respiratory Insufficiency D012131 10 associated lipids
Erectile Dysfunction D007172 19 associated lipids
Infarction, Middle Cerebral Artery D020244 35 associated lipids
Stroke D020521 32 associated lipids
Liver Cirrhosis, Biliary D008105 12 associated lipids
Hyperlipoproteinemia Type II D006938 22 associated lipids
Hyperlipoproteinemia Type IV D006953 6 associated lipids
Nephrotic Syndrome D009404 11 associated lipids
Brain Ischemia D002545 89 associated lipids
Leukemia, Myeloid D007951 52 associated lipids
Respiratory Distress Syndrome, Adult D012128 15 associated lipids
Seizures D012640 87 associated lipids
Peptic Ulcer D010437 19 associated lipids
Birth Weight D001724 23 associated lipids
Hypertension D006973 115 associated lipids
Ischemic Attack, Transient D002546 42 associated lipids
Glomerulosclerosis, Focal Segmental D005923 4 associated lipids
Cerebrovascular Disorders D002561 25 associated lipids
Thromboembolism D013923 6 associated lipids
Nasal Polyps D009298 26 associated lipids
Gastrointestinal Diseases D005767 20 associated lipids
Per page 10 20 50 100 | Total 293

PubChem Associated disorders and diseases

What pathways are associated with Thromboxane b2

There are no associated biomedical information in the current reference collection.

PubChem Biomolecular Interactions and Pathways

Link to PubChem Biomolecular Interactions and Pathways

What cellular locations are associated with Thromboxane b2?

Related references are published most in these journals:

Location Cross reference Weighted score Related literatures
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What functions are associated with Thromboxane b2?


Related references are published most in these journals:

Function Cross reference Weighted score Related literatures

What lipids are associated with Thromboxane b2?

There are no associated biomedical information in the current reference collection.

What genes are associated with Thromboxane b2?

Related references are published most in these journals:


Gene Cross reference Weighted score Related literatures

What common seen animal models are associated with Thromboxane b2?

There are no associated biomedical information in the current reference collection.

NCBI Entrez Crosslinks

All references with Thromboxane b2

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Per page 10 20 50 100 | Total 6367
Authors Title Published Journal PubMed Link
Bockman RS Prostaglandin production by human blood monocytes and mouse peritoneal macrophages: synthesis dependent on in vitro culture conditions. 1981 Prostaglandins pmid:6782622
Singh D et al. Evidence for the generation of hydroxyl radical during arachidonic acid metabolism by human platelets. 1981 Am. J. Hematol. pmid:6274189
Rittenhouse-Simmons S Differential activation of platelet phospholipases by thrombin and ionophore A23187. 1981 J. Biol. Chem. pmid:6783655
Galli C et al. Differential effects of dietary fatty acids on the accumulation of arachidonic acid and its metabolic conversion through the cyclooxygenase and lipoxygenase in platelets and vascular tissue. 1981 Lipids pmid:6783805
Rao GH et al. Effect of Amrinone, a cardiotonic drug, on hemodynamics and platelet function. 1981 Prostaglandins Med pmid:6784136
Strand JC et al. Effect of imidazole on renal function in unilateral ureteral-obstructed rat kidneys. 1981 Am. J. Physiol. pmid:6787931
Smith EF and Lefer AM Stabilization of cardiac lysosomal and cellular membranes in protection of ischemic myocardium due to coronary occlusion:efficacy of the nonsteroidal anti-inflammatory agent, naproxen. 1981 Am. Heart J. pmid:7211667
Stuart MJ et al. Abnormal platelet function and arachidonate metabolism in chronic idiopathic thrombocytopenic purpura. 1981 Blood pmid:6788109
Shaw JO et al. Activation of rabbit platelet phospholipase and thromboxane synthesis by 1-O-hexadecyl/octadecyl-2-acetyl-sn-glyceryl-3-phosphorylcholine (platelet activating factor). 1981 Biochim. Biophys. Acta pmid:7213765
Kass MA et al. Prostaglandin and thromboxane synthesis by microsomes of inflamed rabbit ciliary body--iris. 1981 Invest. Ophthalmol. Vis. Sci. pmid:7216665
Sakio H et al. [Release of thromboxane A2 during hemorrhagic shock (author's transl)]. 1981 Masui pmid:7218508
Kawaguchi H et al. Thromboxane B2 biosynthesis and phospholipids hydrolysis in platelets from hypercholesterolemic rabbits. 1981 Lipids pmid:7219079
Sirois P et al. Comparative effects of leukotriene B4, prostaglandins I2 and E2, 6-keto-PGF1 alpha thromboxane B2 and histamine on selected smooth muscle preparations. 1981 J. Pharm. Pharmacol. pmid:6115037
Handin RI and Alexander RW Humoral heartache -- do platelets have a role? 1981 N. Engl. J. Med. pmid:7010170
Robertson RM et al. Thromboxane A2 in vasotonic angina pectoris: evidence from direct measurements and inhibitor trials. 1981 N. Engl. J. Med. pmid:7010173
Hladovec J Prostaglandins and endothelial stability. 1981 Arzneimittelforschung pmid:7011332
Sananès N et al. A role for prostaglandins in decidualization of the rat uterus. 1981 J. Endocrinol. pmid:7012263
Kadowitz PJ et al. Pulmonary vascular responses to prostaglandins. 1981 Fed. Proc. pmid:7014258
Ingerman-Wojenski C et al. Bovine endothelial cells in culture produce thromboxane as well as prostacyclin. 1981 J. Clin. Invest. pmid:7014633
Roy AC et al. Effect of intravenous infusion of OKY-1581 (sodium-(E)-3-[4-(3-pyridylmethyl)phenyl] -2-methylacrylate) on circulatory thromboxane A2 and prostacyclin levels in anaesthetized baboon. 1981 Prostaglandins Med pmid:7029585
Stuart MJ Effect of endotoxin on arachidonic acid release and thromboxane B2 production by human platelets. 1981 Am. J. Hematol. pmid:7030066
Lorenz R et al. Effects of very low versus standard dose acetyl salicylic acid, dipyridamole and sulfinpyrazone on platelet function and thromboxane formation in man. 1981 Eur. J. Pharmacol. pmid:7238575
Polley MJ et al. Human complement in the arachidonic acid transformation pathway in platelets. 1981 J. Exp. Med. pmid:7241047
Greenberg S et al. Pulmonary vascular smooth muscle function in porcine splanchnic arterial occlusion shock. 1981 Am. J. Physiol. pmid:7246787
Townsend ER et al. Preservation of platelets during extracorporeal circulation in sheep. A comparison between aspirin and sulfinpyrazone. 1981 Circ. Res. pmid:7249281
McCann DS et al. Radioimmunoassay for plasma thromboxane B2. 1981 Clin. Chem. pmid:7273401
Coker SJ et al. Aspirin inhibits the early myocardial release of thromboxane B2 and ventricular ectopic activity following acute coronary artery occlusion in dogs. 1981 Br. J. Pharmacol. pmid:7284679
Tyler HM et al. Administration to man of UK-37,248-01, a selective inhibitor of thromboxane synthetase. 1981 Lancet pmid:6110861
Vermylen J et al. Thromboxane synthetase inhibition as antithrombotic strategy. 1981 Lancet pmid:6112447
Feuerstein N et al. 3-deazaadenosine, a transmethylase inhibitor, suppresses the effect of lipopolysaccharide on release of prostacyclin and thromboxane. 1981 J. Pharm. Pharmacol. pmid:6115021
Fasce L et al. [Effects of glucocorticoids on the gastrointestinal tract of normal rats and rats deficient in endogenous prostaglandins]. 1981 Boll. Soc. Ital. Biol. Sper. pmid:7295403
Tada M et al. Elevation of thromboxane B2 levels in patients with classic and variant angina Pectoris. 1981 Circulation pmid:7296786
Foegh ML et al. Urine i-TXB2 in renal allograft rejection. 1981 Lancet pmid:6115199
McManus LM et al. Acetyl glyceryl ether phosphorylcholine. Intravascular alterations following intravenous infusion into the baboon. 1981 Lab. Invest. pmid:7300244
Utsunomiya T et al. Maintenance of cardiodynamics with aspirin during abdominal aortic aneurysmectomy (AAA). 1981 Ann. Surg. pmid:6117260
Uyama O et al. Plasma concentrations of thromboxane B2 in patients with hypertension or cerebrovascular disease. 1981 Prostaglandins Med pmid:7302001
Mahoney DA et al. Urinary thromboxane B2 on allograft rejection. 1981 Lancet pmid:6118500
Smith JB and Jubiz W OKY-1581: a selective inhibitor of thromboxane synthesis in vivo and in vitro. 1981 Prostaglandins pmid:7302264
Allen JB et al. Irradiation decreases vascular prostacyclin formation with no concomitant effect on platelet thromboxane production. 1981 Lancet pmid:6118629
Rifkin BR and Tai HH Elevated thromboxane B2 levels in periodontal disease. 1981 J. Periodont. Res. pmid:6453981
Mehta J and Mehta P Significance of platelet function and thromboxane B2 levels across the human myocardial vascular bed. 1981 Acta Med. Scand. Suppl. pmid:6948499
Stenson WF et al. Metabolism of exogenous arachidonic acid by murine macrophage-like tumor cell lines. 1981 Prostaglandins pmid:6803301
Rubenstein MD et al. Platelet activation in clinical coronary artery disease and spasm. 1981 Am. Heart J. pmid:6455912
Walker ID et al. A double blind study of prostacyclin in cardiopulmonary bypass surgery. 1981 Br. J. Haematol. pmid:6457624
Bray MA et al. Prostaglandin generation by separated human blood mononuclear cell fractions. 1981 Int. J. Immunopharmacol. pmid:6949878
Capitanio A et al. Platelet abnormalities in renal transplantation. 1981 Proc Eur Dial Transplant Assoc pmid:6460244
Kelly KL and Laychock SG Prostaglandin synthesis and metabolism in isolated pancreatic islets of the rat. 1981 Prostaglandins pmid:6803305
Drake TS et al. Peritoneal fluid thromboxane B2 and 6-keto-prostaglandin F1 alpha in endometriosis. 1981 Am. J. Obstet. Gynecol. pmid:6894667
Halushka PV et al. Protective effects of aspirin in endotoxic shock. 1981 J. Pharmacol. Exp. Ther. pmid:6894770
Feuerstein N et al. Leukotrienes C4 and D4 induce prostaglandin and thromboxane release from rat peritoneal macrophages. 1981 Br. J. Pharmacol. pmid:6894882
Ylikorkala O and Viinikka L Prostacyclin, thromboxane, and prostaglandin F2 alpha in maternal plasma during breast-feeding. 1981 Am. J. Obstet. Gynecol. pmid:7011034
Karmazyn M et al. Comparative effects of acetylsalicylic acid (ASA) and sulfinpyrazone on isoproterenol-induced heart damage. 1981 J. Pharmacol. Exp. Ther. pmid:6894943
Morrison AR and Benabe JE Prostaglandins in vascular tone in experimental obstructive nephropathy. 1981 Kidney Int. pmid:6894950
Bombardieri S et al. The synovial prostaglandin system in chronic inflammatory arthritis: differential effects of steroidal and nonsteroidal anti-inflammatory drugs. 1981 Br. J. Pharmacol. pmid:6895043
Harms BA et al. Prostaglandin release and altered microvascular integrity after burn injury. 1981 J. Surg. Res. pmid:6895238
Ylikorkala O et al. Amniotic fluid prostacyclin and thromboxane in normal, preeclamptic, and some other complicated pregnancies. 1981 Am. J. Obstet. Gynecol. pmid:6895277
Ishihara Y et al. [Effect of hypoxemia and pulmonary thromboembolism on plasma levels of 6-keto PGF 1 alpha, TxB, histamine and serotonin in anesthetized dogs (author's transl)]. 1981 Nihon Kyobu Shikkan Gakkai Zasshi pmid:6895531
Kinney EL and Demers LM Plasma 6 keto PGE1 alpha concentration in Raynaud's phenomenon. 1981 Prostaglandins Med pmid:6895673
Defreyn G et al. Familial bleeding tendency with partial platelet thromboxane synthetase deficiency: reorientation of cyclic endoperoxide metabolism. 1981 Br. J. Haematol. pmid:6268139
Barnett AH et al. Circulating prostanoid levels, both basal and during the chlorpropamide alcohol flush, in non-insulin dependent diabetes. 1981 Clin. Endocrinol. (Oxf) pmid:6895721
Hwang DH Characteristics of the aggregation of platelets and the formation of prostaglandins (PGs) in rat. 1981 Prog. Lipid Res. pmid:7342108
Morrison AR et al. Thromboxane A2 is the major arachidonic acid metabolite of human cortical hydronephrotic tissue. 1981 Prostaglandins pmid:6894498
She HS et al. Metabolism of prostaglandin endoperoxide by microsomes from cat lung. 1981 Prostaglandins pmid:6894797
Agradi E et al. In vitro effects of synthetic antioxidants and vitamin E on arachidonic acid metabolism and thromboxane formation in human platelets and on platelet aggregation. 1981 Prostaglandins pmid:6794104
Halushka PV et al. Increased platelet thromboxane synthesis in diabetes mellitus. 1981 J. Lab. Clin. Med. pmid:7452084
Russell NH et al. Platelet adenine nucleotides and arachidonic acid metabolism in the myeloproliferative disorders. 1981 Thromb. Res. pmid:6794179
Beck N and Shaw JO Thromboxane B2 and prostaglandin E2 in the K+-depleted rat kidney. 1981 Am. J. Physiol. pmid:7468800
Laviolette M et al. Human alveolar macrophages: a lesion in arachidonic acid metabolism in cigarette smokers. 1981 Am. Rev. Respir. Dis. pmid:6794395
Grimm LJ et al. Inhibition of platelet thromboxane synthesis by 7-(1-imidazolyl) heptanoic acid: dissociation from inhibition of aggregation. 1981 Thromb. Res. pmid:6801806
Hwang DH et al. In vitro and in vivo effects of ethanol on the formation of endoperoxide metabolites in rat platelets. 1981 Lipids pmid:6792442
Shaw JO Effects of extracellular Ca2+ and the intracellular Ca2+ antagonist 8-(n,n-diethylamino)octyl-3,4,5-trimethoxybenzoate on rabbit platelet conversion of arachidonic acid into thromboxane. 1981 Prostaglandins pmid:6789402
Tulenko TN The actions of prostaglandins and cyclo-oxygenase inhibition on the resistance vessels supplying the human fetal placenta. 1981 Prostaglandins pmid:6794096
Ingerman-Wojenski C et al. Prostacyclin production in rabbit arteries in situ: inhibition by arachidonic acid-induced endothelial cell damage or by low-dose aspirin. 1981 Prostaglandins pmid:6789404
Williamson EM et al. Studies on the mechanism of action of 12-deoxyphorbolphenylacetate, a potent platelet aggregating tigliane ester. 1981 Biochem. Pharmacol. pmid:6794576
Ylikorkala O et al. Prostacyclin and thromboxane in diabetes. 1981 Br Med J (Clin Res Ed) pmid:6794795
Lee SH et al. Prostacyclin and thromboxane A2 in thrombotic thrombocytopenic purpura. 1981 Br Med J (Clin Res Ed) pmid:6797537
Igarashi K et al. Effect of polyamines on prostaglandin synthesis in various cell-free systems. 1981 Biochem. Biophys. Res. Commun. pmid:6800368
Morris HG et al. Variables associated with radioimmunoassay of prostaglandins in plasma. 1981 Prostaglandins pmid:6803306
Landgraf-Leurs MM et al. Aggregation and thromboxane B2 formation in platelets and vascular prostacyclin production from genetically obese rats. 1981 Prostaglandins pmid:6798637
Feuerstein N and Ramwell PW OKY-1581, a potential selective thromboxane synthetase inhibitor. 1981 Eur. J. Pharmacol. pmid:7195815
Satoh H et al. Influence of angiotensins (I, II & III) on prostaglandin production by minced rat renal medulla. 1981 Prostaglandins pmid:7197382
Steinhauer HB and Hertting G Lowering of the convulsive threshold by non-steroidal anti-inflammatory drugs. 1981 Eur. J. Pharmacol. pmid:7202518
Robson MC and Heggers JP Evaluation of hand frostbite blister fluid as a clue to pathogenesis. 1981 J Hand Surg Am pmid:7204918
Wilhelm TE et al. Selective inhibitors of platelet lipoxygenase: 4,7,10,13-eicosatetraynoic acid and 5,8,11,14-henicosatetraynoic acid. 1981 Prostaglandins pmid:6784191
Subbiah MT et al. Effect of specific estrogens on prostaglandin synthesis in aorta and thrombocytes of female pigeons. 1981 Proc. Soc. Exp. Biol. Med. pmid:7208490
Tsuboi T et al. Effect of gliclazide on prostaglandin and thromboxane synthesis in guinea-pig platelets. 1981 Jan 1-15 Thromb. Res. pmid:7233394
Randall MJ et al. UK-37, 248, a novel, selective thromboxane synthetase inhibitor with platelet anti-aggregatory and anti-thrombotic activity. 1981 Jul 1-15 Thromb. Res. pmid:6795753
Kelton JG et al. Sex-related differences in the efficacy of acetylsalicylic acid (ASA) : the absorption of ASA and its effect on collagen-induced thromboxane B2 generation. 1981 Oct 1-15 Thromb. Res. pmid:7330835
Shohami E et al. [Thromboxane in rat brain following incomplete ischemia]. 1982 Harefuah pmid:7182317
Numano F et al. Changes in the plasma levels of thromboxane B2 and cyclic nucleotides in patients with Takayasu disease. 1982 Jpn. Circ. J. pmid:6119373
Davì G et al. [Effects of flurbiprofen on the platelet function in patients with ischemic cardiopathy]. 1982 Cardiologia pmid:6892383
De Caterina R et al. [Effects of isosorbide dinitrate on platelet aggregation and production of thromboxane B2]. 1982 Cardiologia pmid:6892461
Stuart MJ and Allen JB Arachidonic acid metabolism in the neonatal platelet. 1982 Pediatrics pmid:6804924
Koyama I et al. [Production of 6-keto-prostaglandin F1 alpha and thromboxane B2 in mouse peritoneal macrophages during preparation of the cells]. 1982 Yakugaku Zasshi pmid:6897423
Hwang DH and Donovan J In vitro and in vivo effects of vitamin E on arachidonic acid metabolism in rat platelets. 1982 J. Nutr. pmid:6806455
Rettkowski W et al. Studies of the influence of nitroglycerin on the synthesis of prostaglandins and thromboxane A2 and on platelet aggregation. 1982 Arzneimittelforschung pmid:6805480
Michelassi F et al. Leukotriene D4: a potent coronary artery vasoconstrictor associated with impaired ventricular contraction. 1982 Science pmid:6808665
Tai HH Assay of thromboxane A synthase inhibitors. 1982 Meth. Enzymol. pmid:6890139
Xiu RJ et al. Anisodamine inhibits thromboxane synthesis, granulocyte aggregation, and platelet aggregation. A possible mechanism for its efficacy in bacteremic shock. 1982 JAMA pmid:7057538
Kelton JG et al. Sex related differences in platelet function: the effect of aspirin. 1982 Blood pmid:7059670