Thromboxane b2

Thromboxane b2 is a lipid of Fatty Acyls (FA) class. Thromboxane b2 is associated with abnormalities such as endothelial dysfunction, Diabetes Mellitus, Non-Insulin-Dependent, Diabetes Mellitus, Ischemia and Thrombocytosis. The involved functions are known as Platelet Activation, Excretory function, Anabolism, Inflammation and mRNA Expression. Thromboxane b2 often locates in Endothelium, Hepatic and Microsomes, Liver. The associated genes with Thromboxane b2 are PTGS2 gene, prothrombin fragment 2 and CCL14 wt Allele.

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Introduction

To understand associated biological information of Thromboxane b2, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.

What diseases are associated with Thromboxane b2?

Thromboxane b2 is suspected in endothelial dysfunction, Diabetes Mellitus, Non-Insulin-Dependent, Diabetes Mellitus, Ischemia, Thrombocytosis, Acute Coronary Syndrome and other diseases in descending order of the highest number of associated sentences.

Related references are mostly published in these journals:

Disease Cross reference Weighted score Related literature
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Possible diseases from mapped MeSH terms on references

We collected disease MeSH terms mapped to the references associated with Thromboxane b2

MeSH term MeSH ID Detail
Asthma D001249 52 associated lipids
Kidney Diseases D007674 29 associated lipids
Femoral Fractures D005264 7 associated lipids
Weight Gain D015430 101 associated lipids
Hyperemia D006940 25 associated lipids
Cardiovascular Diseases D002318 24 associated lipids
Acidosis D000138 13 associated lipids
Glioma D005910 112 associated lipids
Staphylococcal Infections D013203 15 associated lipids
Cell Transformation, Neoplastic D002471 126 associated lipids
Ulcer D014456 16 associated lipids
Hypercholesterolemia D006937 91 associated lipids
Thrombosis D013927 49 associated lipids
Hypertension, Pulmonary D006976 32 associated lipids
Endometriosis D004715 29 associated lipids
Uterine Neoplasms D014594 18 associated lipids
Myocardial Infarction D009203 21 associated lipids
Proteinuria D011507 30 associated lipids
Arteriosclerosis D001161 86 associated lipids
Magnesium Deficiency D008275 9 associated lipids
Carcinoma, Hepatocellular D006528 140 associated lipids
Liver Cirrhosis D008103 67 associated lipids
Fibrosis D005355 23 associated lipids
Anemia, Sickle Cell D000755 34 associated lipids
Fetal Diseases D005315 8 associated lipids
Glomerulonephritis D005921 35 associated lipids
Cerebral Hemorrhage D002543 13 associated lipids
Sepsis D018805 11 associated lipids
Leukopenia D007970 9 associated lipids
Respiratory Insufficiency D012131 10 associated lipids
Erectile Dysfunction D007172 19 associated lipids
Infarction, Middle Cerebral Artery D020244 35 associated lipids
Stroke D020521 32 associated lipids
Liver Cirrhosis, Biliary D008105 12 associated lipids
Hyperlipoproteinemia Type II D006938 22 associated lipids
Hyperlipoproteinemia Type IV D006953 6 associated lipids
Nephrotic Syndrome D009404 11 associated lipids
Brain Ischemia D002545 89 associated lipids
Leukemia, Myeloid D007951 52 associated lipids
Respiratory Distress Syndrome, Adult D012128 15 associated lipids
Seizures D012640 87 associated lipids
Peptic Ulcer D010437 19 associated lipids
Birth Weight D001724 23 associated lipids
Hypertension D006973 115 associated lipids
Ischemic Attack, Transient D002546 42 associated lipids
Glomerulosclerosis, Focal Segmental D005923 4 associated lipids
Cerebrovascular Disorders D002561 25 associated lipids
Thromboembolism D013923 6 associated lipids
Nasal Polyps D009298 26 associated lipids
Gastrointestinal Diseases D005767 20 associated lipids
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PubChem Associated disorders and diseases

What pathways are associated with Thromboxane b2

There are no associated biomedical information in the current reference collection.

PubChem Biomolecular Interactions and Pathways

Link to PubChem Biomolecular Interactions and Pathways

What cellular locations are associated with Thromboxane b2?

Related references are published most in these journals:

Location Cross reference Weighted score Related literatures
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What functions are associated with Thromboxane b2?


Related references are published most in these journals:

Function Cross reference Weighted score Related literatures

What lipids are associated with Thromboxane b2?

There are no associated biomedical information in the current reference collection.

What genes are associated with Thromboxane b2?

Related references are published most in these journals:


Gene Cross reference Weighted score Related literatures

What common seen animal models are associated with Thromboxane b2?

There are no associated biomedical information in the current reference collection.

NCBI Entrez Crosslinks

All references with Thromboxane b2

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Per page 10 20 50 100 | Total 6367
Authors Title Published Journal PubMed Link
Stuart MJ et al. The influence of albumin and calcium on human platelet arachidonic acid metabolism. 1980 Blood pmid:6766753
Crutchley DJ et al. Enhanced thromboxane B2 release from challenged guinea pig lung after oxygen exposure. 1980 Am. Rev. Respir. Dis. pmid:6155814
Cella G et al. In vivo platelet release reaction in patients with heart valve prosthesis. 1980 Haemostasis pmid:6157609
Best LC et al. Lanthanum stimulates the accumulation of cyclic AMP and inhibits secretion and thromboxane B2 formation in human platelets. 1980 Biochim. Biophys. Acta pmid:6251913
Zapol WM et al. Plasma thromboxane and prostacyclin metabolites in sheep partial cardiopulmonary bypass. 1980 Trans Am Soc Artif Intern Organs pmid:7018060
Güllner HG et al. Correction of increased prostacyclin production in Bartter's syndrome by indomethacin. 1980 Trans. Assoc. Am. Physicians pmid:7018063
Wise WC et al. Protective effects of thromboxane synthetase inhibitors in rats in endotoxic shock. 1980 Circ. Res. pmid:7189697
Salmon JA Analysis of arachidonic acid metabolites by radioimmunoassay and physicochemical methods. 1980 Mater Med Pol pmid:7019588
Zamecnik J et al. Concentrations of thromboxane B2 and 6-oxo-prostaglandin F1 alpha in amniotic fluid, decidual tissue, and placenta in the later stages of pregnancy in the rat. 1980 Adv Prostaglandin Thromboxane Res pmid:6990719
Frame MH et al. Inhibition of acid secretion from the rat-isolated gastric mucosa by arachidonic acid and identification of major metabolites. 1980 Adv Prostaglandin Thromboxane Res pmid:6990724
Güllner HG et al. The principal metabolites of arachidonic acid are overproduced in Bartter's syndrome. 1980 Adv Prostaglandin Thromboxane Res pmid:6892749
Liggins GC et al. Production rates of prostaglandin F, 6-keto-PGF1 alpha and thromboxane B2 by perifused human endometrium. 1980 Prostaglandins pmid:6892962
Subbiah MT and Dietemeyer D Altered synthesis of prostaglandins in platelet and aorta from spontaneously diabetic Wistar rats. 1980 Biochem Med pmid:6893150
Ali M and McDonald JW Synthesis of thromboxane B2 and 6-keto-prostaglandin F1 alpha by bovine gastric mucosal and muscle microsomes. 1980 Prostaglandins pmid:6893365
Ohuchi K et al. Prostaglandin production by minced carrageenin granuloma tissue of rats and its inhibition by dexamethasone and cycloheximide. 1980 Prostaglandins Med pmid:6893750
Chiabrando C et al. Quantitative determination of 6-keto-PGF1 alpha released by rat aorta: comparison of mass fragmentography and high resolution gas chromatography with electron capture detection. 1980 Prostaglandins pmid:6894036
Gorman RR Biochemical and pharmacological evaluation of thromboxane synthetase inhibitors. 1980 Adv Prostaglandin Thromboxane Res pmid:6247892
Bishai I and Coceani F Metabolism of PGH2 in the feline brain. 1980 Adv Prostaglandin Thromboxane Res pmid:7376980
Galli C et al. Factors affecting brain prostaglandin formation. 1980 Adv Prostaglandin Thromboxane Res pmid:7376983
Blotman F et al. PGE2, PGF2 alpha, and TXB2 biosynthesis by human rheumatoid synovia. 1980 Adv Prostaglandin Thromboxane Res pmid:7377017
Katori M et al. Changes of prostaglandin and thromboxane levels in pleural fluid of rat carrageenin-induced pleurisy. 1980 Adv Prostaglandin Thromboxane Res pmid:7377020
Crutchley DJ et al. Potentiation of thromboxane B2 release from guinea pig lung during anaphylaxis following exposure to 100% O2. 1980 Adv Prostaglandin Thromboxane Res pmid:7377022
Morris HG and Sherman NA Prostaglandin-like substances in urine of asthmatic patients. 1980 Adv Prostaglandin Thromboxane Res pmid:7377024
Schoene NW et al. Effects of diets varying in fat and P/S ratio on arachidonic acid metabolism in human platelets. 1980 Adv Prostaglandin Thromboxane Res pmid:7377026
Smith EF et al. Influence of thromboxane inhibition on the severity of myocardial ischemia in cats. 1980 Can. J. Physiol. Pharmacol. pmid:7378931
Ellwood DA et al. Specific changes in the in vitro production of prostanoids by the ovine cervix at parturition. 1980 Prostaglandins pmid:7384553
Lagarde M et al. Nicergoline, an anti-aggregating agent which inhibits release of arachidonic acid from human platelet phospholipids. 1980 Prostaglandins pmid:7384555
Patrono C et al. Radioimmunoassay of serum thromboxane B2: a simple method of assessing pharmacologic effects on platelet function. 1980 Adv Prostaglandin Thromboxane Res pmid:7386257
Langs DA et al. Thromboxane molecules are not hairpin conformers. 1980 Adv Prostaglandin Thromboxane Res pmid:7386281
Lefer AM et al. Dissociation of vasoconstrictor and platelet aggregatory activities of thromboxane by carbocyclic thromboxane A2, a stable analog of thromboxane A2. 1980 Proc. Natl. Acad. Sci. U.S.A. pmid:6929517
Bailey JM Essential fatty acid requirements and metabolism of cells in tissue culture. 1980 Adv Prostaglandin Thromboxane Res pmid:7386288
Moretti RL and Lin CY Coronary vasoconstrictor extracted from blood plasma stimulates platelet lipoxidase activity. 1980 Prostaglandins pmid:6770419
Maggi FM et al. Prostaglandin synthetase activity in vascular tissue of male and female rats. 1980 Prostaglandins pmid:6770422
Feinstein MB et al. Serine-esterase (protease) inhibitors block stimulus-induced mobilization of arachidonate in platelets. 1980 Adv Prostaglandin Thromboxane Res pmid:6770602
Maclouf J et al. Interactions of prostaglandin H2 and thromboxane A2 with human serum albumin. 1980 Eur. J. Biochem. pmid:7408901
Hwang DW et al. Species variation in serum levels of prostaglandins and their precursor acids. 1980 Lipids pmid:7432104
Bolton HS et al. Prostaglandin synthesis by adult heart myocytes. 1980 J. Mol. Cell. Cardiol. pmid:7441771
Dejana E et al. Impaired thromboxane production by newly formed platelets after aspirin administration to thrombocytopenic rats. 1980 Br. J. Haematol. pmid:7448129
Ylikorkala O and Viinikka L Thromboxane A2 in pregnancy and puerperium. 1980 Br Med J pmid:7448530
Bone EA et al. The effects of strontium and calcium ions on 5-hydroxytryptamine secretion and thromboxane B2 biosynthesis in washed human platelets. 1980 Biochem. Soc. Trans. pmid:7450206
Mitchell MD Prostaglandins at parturition and in the neonatal infant. 1980 Biochem. Soc. Trans. pmid:7450282
Best LC et al. The relationship between the production of thromboxane B2 and malondialdehyde by human blood platelets. 1980 Clin. Sci. pmid:7190885
Heggers JP et al. Histological demonstration of prostaglandins and thromboxanes in burned tissue. 1980 J. Surg. Res. pmid:6987462
Vanderhoek JY et al. 15-hydroxy-5,8,11,13-eicosatetraenoic acid: A potent and selective inhibitor of platelet lipoxygenase. 1980 J. Biol. Chem. pmid:6771259
Ali M et al. Inhibition of human platelet cyclooxygenase by alpha-tocopherol. 1980 Prostaglandins Med pmid:6771778
Hagen AA et al. Synthesis of prostaglandins and thromboxane B2 by cerebral arteries. 1979 May-Jun Stroke pmid:462519
Anhut H et al. Thromboxane B2 release and 3H-noradrenaline accumulation by a synaptosomal fraction of rat brain. 1979 Jul-Aug Pol J Pharmacol Pharm pmid:523340
Pradalier A et al. [Measurement of plasma and serum values of PGE2, PGF2 alpha and TXB2 during aspirin induced bronchospasm in asthmatics (author's transl)]. 1979 Jul-Aug Therapie pmid:531778
Svensson J Structure and quantitative determination of the major urinary metabolite of thromboxane B2 in the guinea pig. 1979 Prostaglandins pmid:472333
Langs DA et al. Thromboxane molecules do not adopt the prostaglandin hairpin conformation. 1979 Nature pmid:481594
Jonsson CE et al. Prostaglandins and thromboxanes in burn injury in man. 1979 Scand J Plast Reconstr Surg pmid:451477
Bailey JM et al. Anti-inflammatory drugs in experimental atherosclerosis. Part 4. Inhibition of atherosclerosis in vivo and thromboxane synthesis and platelet aggregation in vitro. 1979 Atherosclerosis pmid:454516
Taylor L et al. Prostaglandin production by type II alveolar epithelial cells. 1979 Biochim. Biophys. Acta pmid:435506
Folkert VW and Schlondorff D Prostaglandin synthesis in isolated glomeruli. 1979 Prostaglandins pmid:441427
Parker CW et al. Formation of thromboxane B2 and hydroxyarachidonic acids in purified human lymphocytes in the presence and absence of PHA. 1979 J. Immunol. pmid:448099
Needleman P et al. Platelet and blood vessel arachidonate metabolism and interactions. 1979 J. Clin. Invest. pmid:372240
Morley J et al. Prostaglandin and thromboxane production by human and guinea-pig macrophages and leucocytes. 1979 Prostaglandins pmid:493559
Meyers KM et al. A dominant role of thromboxane formation in secondary aggregation of platelets. 1979 Nature pmid:503210
de Deckere EA et al. Influence of type of dietary fat on the prostaglandin release from isolated rabbit and rat hearts and from rat aortas. 1979 Prostaglandins pmid:504696
Powell WS Metabolism of prostaglandins, prostaglandin analogs and thromboxane B2 by lung and liver microsomes from pregnant rabbits. 1979 Biochim. Biophys. Acta pmid:518891
Spagnuolo C et al. Differential effects of probenecid on the levels of endogenous PGF2 alpha and TXB2 in brain cortex. 1979 Prostaglandins pmid:523683
Bennett A and Sanger GJ Trimethoquinol selectively antagonises longitudinal muscle contractions of rat isolated gastric fundus to thromboxane B2 and epoxymethano analogues of PGH2 [proceedings]. 1979 Br. J. Pharmacol. pmid:526738
Prancan AV et al. L8027 and 1-nonyl-imidazole as non-selective inhibitors of thromboxane synthesis. 1979 Eur. J. Pharmacol. pmid:527664
Makheja AN et al. Effects of onion (Allium cepa) extract on platelet aggregation and thromboxane synthesis. 1979 Prostaglandins Med pmid:552092
Lefer AM et al. Protective effects of a novel thromboxane analog in lethal traumatic shock. 1979 Prostaglandins Med pmid:552102
Lewy RI et al. Detection of thromboxane B2 in peripheral blood of patients with Prinzmetal's angina. 1979 Prostaglandins Med pmid:575861
Ohuchi K et al. Prostaglandins E2, F2 alpha, 6-keto-F1 alpha and thromboxane B2 levels in carrageenin-induced inflammatory exudates in the rat air-pouch granuloma. 1979 Prostaglandins Med pmid:583576
Daniel EE et al. Prostaglandins and myogenic control of tension in lower esophageal sphincter in vitro. 1979 Prostaglandins pmid:379920
Kanzaki Y et al. Thromboxane as possible trigger of liver regeneration. 1979 Cell Mol Biol Incl Cyto Enzymol pmid:535003
Lewy RI et al. Comparison of plasma concentrations of thromboxane B2 in Prinzmetal's variant angina and classical angina pectoris. 1979 Clin Cardiol pmid:544110
Russell FA and Deykin D The use of high pressure liquid chromatography (HPLC) for the separation of radiolabeled arachidonic acid and its metabolities produced by thrombin-treated human platelets. I. The validation of the technique. 1979 Prostaglandins pmid:523671
Roberts LJ et al. Prostaglandin thromboxane, and 12-hydroxy-5,8,10,14-eicosatetraenoic acid production by ionophore-stimulated rat serosal mast cells. 1979 Biochim. Biophys. Acta pmid:389290
Dutilh CE et al. Study of the two pathways for arachidonate oxygenation in blood platelets. 1979 Lipids pmid:34075
Kelly JP et al. Effect of inhibitors of arachidonic acid metabolism on mitogenesis in human lymphocytes: possible role of thromboxanes and products of the lipoxygenase pathway. 1979 J. Immunol. pmid:109510
Whittle BJ Prostaglandin synthetase inhibitors. Drugs which affect arachidonic acid metabolism. 1979 Acta Obstet Gynecol Scand Suppl pmid:111464
Robinson JS et al. Prostaglandin E, thromboxane B2 and 6-oxo-prostaglandin F1 alpha in amniotic fluid and maternal plasma of rhesus monkeys (Macaca mulatta) during the latter third of gestation. 1979 J. Endocrinol. pmid:112214
Burch RM et al. Vasopressin stimulates thromboxane synthesis in the toad urinary bladder: effects of imidazole. 1979 J. Pharmacol. Exp. Ther. pmid:113526
Patrono C et al. Inhibition of platelet cyclooxygenase by aspirin-like drugs: methods for in vitro and ex vivo assessment. 1979 Agents Actions Suppl. pmid:115255
Wong PY and Cheung WY Calmodulin stimulates human platelet phospholipase A2. 1979 Biochem. Biophys. Res. Commun. pmid:116656
Okuma M and Uchino H Altered arachidonate metabolism by platelets in patients with myeloproliferative disorders. 1979 Blood pmid:116695
Best LC et al. Evidence that extracellular calcium ions inhibit thromboxane B2 biosynthesis by human platelets. 1979 Biochem. Biophys. Res. Commun. pmid:117802
Oelz O [The arachidonic acid metabolites (prostaglandins, thromboxanes, prostacyclin, leucotrienes):basics and clinical implications (author's transl)]. 1979 Ther Umsch pmid:119331
Robak J and Kasperczyk H [Prostaglandin synthetase components (author's transl)]. 1979 Postepy Biochem. pmid:120943
Tremoli E et al. Platelet thromboxanes and serum-cholesterol. 1979 Lancet pmid:84115
Makheia AN et al. Inhibition of platelet aggregation and thromboxane synthesis by onion and garlic. 1979 Lancet pmid:86023
Lewy RI et al. Intravenous heparin initiates in-vivo synthesis and release of thromboxane in angina pectoris. 1979 Lancet pmid:87990
Güllner HG et al. Prostacyclin overproduction in Bartter's syndrome. 1979 Lancet pmid:90861
Davis TM et al. Prostacyclin and thromboxane metabolites in diabetes. 1979 Lancet pmid:90875
Miura Y and Fukui N Prostaglandins as possible triggers for liver regeneration after partial hepatectomy. A review. 1979 Cell Mol Biol Incl Cyto Enzymol pmid:44483
Ford-Hutchinson AW et al. The aggregation of rat neutrophils by arachidonic acid: a possible bioassay for lipoxygenase activity. 1979 J. Pharm. Pharmacol. pmid:43380
Gorman RR et al. Independence of the cyclic AMP-lowering activity of thromboxane A2 from the platelet release reaction. 1979 Biochim. Biophys. Acta pmid:216409
Dembińska-Kièć A et al. Prostacyclin-dependent differences in TXA2 formation by platelets from normal and atherosclerotic rabbits. 1979 Atherosclerosis pmid:224890
Fitzpatrick FA and Gorman RR Regulatory role of cyclic adenosine 3',5'-monophosphate on the platelet cyclooxygenase and platelet function. 1979 Biochim. Biophys. Acta pmid:216415
Best LC et al. Mode of action of dipyridamole on human platelets. 1979 Thromb. Res. pmid:229583
Marcus AJ The role of prostaglandins in platelet function. 1979 Prog Hematol pmid:230534
Spagnuolo C et al. PGF2 alpha, thromboxane B2 and HETE levels in gerbil brain cortex after ligation of common carotid arteries and decapitation. 1979 Prostaglandins pmid:230539
Jonsson CE et al. Efflux of cyclic AMP, prostaglandin E2 and F2 alpha and thromboxane B2 in leg lymph of rabbits after scalding injury. 1979 Acta Physiol. Scand. pmid:232367
Chignard M et al. Arachidonate-mediated bronchoconstriction and platelet activation are inhibited by microgram doses of compound L8027 which are not selective for thromboxane synthetase. 1979 Agents Actions Suppl. pmid:291306
Peskar BA and Holland A Plasma levels of immunoreactive 15-keto-13,14-dihydro-thromboxane B2 in guinea pigs during anaphylaxis and after histamine injection. 1979 Agents Actions Suppl. pmid:294148
Kass MA and Holmberg NJ Prostaglandin and thromboxane synthesis by microsomes of rabbit ocular tissues. 1979 Invest. Ophthalmol. Vis. Sci. pmid:761971