Thromboxane b2 is a lipid of Fatty Acyls (FA) class. Thromboxane b2 is associated with abnormalities such as endothelial dysfunction, Diabetes Mellitus, Non-Insulin-Dependent, Diabetes Mellitus, Ischemia and Thrombocytosis. The involved functions are known as Platelet Activation, Excretory function, Anabolism, Inflammation and mRNA Expression. Thromboxane b2 often locates in Endothelium, Hepatic and Microsomes, Liver. The associated genes with Thromboxane b2 are PTGS2 gene, prothrombin fragment 2 and CCL14 wt Allele.
To understand associated biological information of Thromboxane b2, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
Thromboxane b2 is suspected in endothelial dysfunction, Diabetes Mellitus, Non-Insulin-Dependent, Diabetes Mellitus, Ischemia, Thrombocytosis, Acute Coronary Syndrome and other diseases in descending order of the highest number of associated sentences.
Disease | Cross reference | Weighted score | Related literature |
---|
We collected disease MeSH terms mapped to the references associated with Thromboxane b2
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
Location | Cross reference | Weighted score | Related literatures |
---|
Function | Cross reference | Weighted score | Related literatures |
---|
There are no associated biomedical information in the current reference collection.
Gene | Cross reference | Weighted score | Related literatures |
---|
There are no associated biomedical information in the current reference collection.
Authors | Title | Published | Journal | PubMed Link |
---|---|---|---|---|
Böhm E et al. | 11-Dehydro-thromboxane B2, a stable thromboxane metabolite, is a full agonist of chemoattractant receptor-homologous molecule expressed on TH2 cells (CRTH2) in human eosinophils and basophils. | 2004 | J. Biol. Chem. | pmid:14668348 |
Persico N et al. | Transdermal hormone replacement therapy and Doppler findings in normal and overweight postmenopausal patients. | 2004 | Gynecol. Endocrinol. | pmid:15726916 |
Kudolo GB et al. | The ingestion of Ginkgo biloba extract (EGb 761) inhibits arachidonic acid-mediated platelet aggregation and thromboxane B2 production in healthy volunteers. | 2004 | J Herb Pharmacother | pmid:15927922 |
Hennekens CH et al. | Terms and conditions: semantic complexity and aspirin resistance. | 2004 | Circulation | pmid:15381661 |
Zhao GR et al. | [Clinical study on relationship between sluggishness of lung-defensive qi and levels of vasoactive intestinal polypeptide and thromboxane B2]. | 2004 | Zhong Xi Yi Jie He Xue Bao | pmid:15383251 |
Fiorucci S et al. | Co-administration of nitric oxide-aspirin (NCX-4016) and aspirin prevents platelet and monocyte activation and protects against gastric damage induced by aspirin in humans. | 2004 | J. Am. Coll. Cardiol. | pmid:15358033 |
Ishitsuka Y et al. | Involvement of thromboxane A2 (TXA2) in the early stages of oleic acid-induced lung injury and the preventive effect of ozagrel, a TXA2 synthase inhibitor, in guinea-pigs. | 2004 | J. Pharm. Pharmacol. | pmid:15099446 |
Dinev D and Andonova M | The effect of general anesthesia and abdominal surgery upon plasma thromboxane B concentrations in horses. | 2004 | Vet Anaesth Analg | pmid:15053753 |
Menzies-Gow NJ et al. | Endotoxin-induced digital vasoconstriction in horses: associated changes in plasma concentrations of vasoconstrictor mediators. | 2004 | Equine Vet. J. | pmid:15147137 |
Ghuysen A et al. | Effect of BM-573 [N-terbutyl-N'-[2-(4'-methylphenylamino)-5-nitro-benzenesulfonyl]urea], a dual thromboxane synthase inhibitor and thromboxane receptor antagonist, in a porcine model of acute pulmonary embolism. | 2004 | J. Pharmacol. Exp. Ther. | pmid:15121765 |
Caprani A et al. | Experimental evidence of a potentially increased thrombo-embolic disease risk by domestic electromagnetic field exposure. | 2004 | Bioelectromagnetics | pmid:15114641 |
Di Minno G and Violi F | Aspirin resistance and diabetic angiopathy: back to the future. | 2004 | Thromb. Res. | pmid:15115664 |
de La Puerta Vázquez R et al. | Effects of different dietary oils on inflammatory mediator generation and fatty acid composition in rat neutrophils. | 2004 | Metab. Clin. Exp. | pmid:14681843 |
Minuz P et al. | Determinants of platelet activation in human essential hypertension. | 2004 | Hypertension | pmid:14656953 |
Liu P et al. | [Effects of the extracts from decoction for resuscitation and its component herbs on PGI2, TXA2 and NO release from rat vascular endothelial cells under hypoxia in vitro]. | 2004 | Zhongguo Zhong Yao Za Zhi | pmid:15631091 |
Yang JP et al. | [Changes of the platelet function and serum anticardiolipin antibody in patients with pulmonary thromboembolism]. | 2004 | Zhonghua Jie He He Hu Xi Za Zhi | pmid:15634381 |
Wang MS et al. | [The effects of lupus anticoagulant on pulmonary thromboembolism]. | 2004 | Zhonghua Jie He He Hu Xi Za Zhi | pmid:15634384 |
Franz KB | A functional biological marker is needed for diagnosing magnesium deficiency. | 2004 | J Am Coll Nutr | pmid:15637224 |
DÃaz AM et al. | Phenylpropanoid glycosides from Scrophularia scorodonia: in vitro anti-inflammatory activity. | 2004 | Life Sci. | pmid:15010262 |
Guay J et al. | Carrageenan-induced paw edema in rat elicits a predominant prostaglandin E2 (PGE2) response in the central nervous system associated with the induction of microsomal PGE2 synthase-1. | 2004 | J. Biol. Chem. | pmid:15044444 |
Véricel E et al. | Diabetic patients without vascular complications display enhanced basal platelet activation and decreased antioxidant status. | 2004 | Diabetes | pmid:15047620 |
Yugar-Toledo JC et al. | Uncontrolled hypertension, uncompensated type II diabetes, and smoking have different patterns of vascular dysfunction. | 2004 | Chest | pmid:15006938 |
Kawata K et al. | The effects of a selective cyclooxygenase-2 inhibitor on small bowel ischemia-reperfusion injury. | 2003 Nov-Dec | Hepatogastroenterology | pmid:14696445 |
Tuleja E et al. | Effects of cyclooxygenases inhibitors on vasoactive prostanoids and thrombin generation at the site of microvascular injury in healthy men. | 2003 | Arterioscler. Thromb. Vasc. Biol. | pmid:12730088 |
Leese PT et al. | The COX-2 selective inhibitor, valdecoxib, does not impair platelet function in the elderly: results of a randomized controlled trial. | 2003 | J Clin Pharmacol | pmid:12751271 |
Lang I et al. | Heterogeneity of microvascular endothelial cells isolated from human term placenta and macrovascular umbilical vein endothelial cells. | 2003 | Eur. J. Cell Biol. | pmid:12751902 |
Molina V et al. | Synergistic effect of D-003 and aspirin on experimental thrombosis models. | 2003 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:12711246 |
ChavarrÃa ME et al. | Prostacyclin/thromboxane early changes in pregnancies that are complicated by preeclampsia. | 2003 | Am. J. Obstet. Gynecol. | pmid:12712098 |
Dogné JM et al. | Pharmacological evaluation of the novel thromboxane modulator BM-567 (I/II). Effects of BM-567 on platelet function. | 2003 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:12538090 |
Pestel S et al. | Inhibition of prostaglandin D2 clearance in rat hepatocytes by the thromboxane receptor antagonists daltroban and ifetroban and the thromboxane synthase inhibitor furegrelate. | 2003 | Biochem. Pharmacol. | pmid:12906929 |
De La Cruz P et al. | Effects of clopidogrel and ticlopidine on experimental diabetic ischemic retinopathy in rats. | 2003 | Naunyn Schmiedebergs Arch. Pharmacol. | pmid:12595963 |
Uchida M et al. | Changes in cerebral microcirculation during and after abdominal aortic cross-clamping in rabbits: the role of thromboxane A2 receptor. | 2003 | Anesth. Analg. | pmid:12598238 |
Zaitsu M et al. | Thromboxane synthesis is increased by upregulation of cytosolic phospholipase A2 and cyclooxygenase-2 in peripheral polymorphonuclear leukocytes during bacterial infection in childhood. | 2003 | Am. J. Hematol. | pmid:12555215 |
von Aulock S et al. | Determination of the eicosanoid response to inflammatory stimuli in whole blood and its pharmacological modulation ex vivo. | 2003 | J. Immunol. Methods | pmid:12799039 |
Yregård L et al. | Influence of local anaesthetics on inflammatory activity postburn. | 2003 | Burns | pmid:12781610 |
Hausman N et al. | Antenatal administration of celecoxib, a selective cyclooxygenase (COX)-2 inhibitor, appears to improve placental perfusion in the pregnant rabbit. | 2003 | Prostaglandins Other Lipid Mediat. | pmid:12611495 |
Basta M et al. | F(ab)'2-mediated neutralization of C3a and C5a anaphylatoxins: a novel effector function of immunoglobulins. | 2003 | Nat. Med. | pmid:12612546 |
Fiorucci S et al. | Gastrointestinal safety of NO-aspirin (NCX-4016) in healthy human volunteers: a proof of concept endoscopic study. | 2003 | Gastroenterology | pmid:12612897 |
Vigorita MG et al. | Chiral 3,3'-(1,2-ethanediyl)-bis[2-(3,4-dimethoxyphenyl)-4-thiazolidinones] with anti-inflammatory activity. Part 11: evaluation of COX-2 selectivity and modelling. | 2003 | Bioorg. Med. Chem. | pmid:12614885 |
Vass G et al. | Comparison of nasal and oral inhalation during exhaled breath condensate collection. | 2003 | Am. J. Respir. Crit. Care Med. | pmid:12493648 |
Bosetti F et al. | Valproic acid down-regulates the conversion of arachidonic acid to eicosanoids via cyclooxygenase-1 and -2 in rat brain. | 2003 | J. Neurochem. | pmid:12694395 |
Gama de Abreu M et al. | One-lung ventilation with high tidal volumes and zero positive end-expiratory pressure is injurious in the isolated rabbit lung model. | 2003 | Anesth. Analg. | pmid:12505956 |
Szebeni J et al. | Complement activation during hemorrhagic shock and resuscitation in swine. | 2003 | Shock | pmid:14501949 |
Tanaka Y et al. | Effects of exercise on platelet and aortic functions in aged rats. | 2003 | Acta Physiol. Scand. | pmid:14510779 |
Vani G et al. | Histone H1 modulates immune status in experimental breast cancer. | 2003 | Chemotherapy | pmid:14504437 |
Sidhu P et al. | Tissue chamber model of acute inflammation in farm animal species. | 2003 | Res. Vet. Sci. | pmid:12507568 |
Xia Z et al. | Antioxidant therapy with Salvia miltiorrhiza decreases plasma endothelin-1 and thromboxane B2 after cardiopulmonary bypass in patients with congenital heart disease. | 2003 | J. Thorac. Cardiovasc. Surg. | pmid:14666012 |
Rossoni G et al. | Nitric oxide-releasing aspirin inhibits vasoconstriction in perfused tail artery of normotensive and spontaneously hypertensive rats. | 2003 | Eur. J. Pharmacol. | pmid:14512099 |
Chen L et al. | Cyclooxygenase inhibitor blocks rebound response after NO inhalation in an endotoxin model. | 2003 | Am. J. Physiol. Heart Circ. Physiol. | pmid:12485821 |
Wolfram R et al. | Daily prickly pear consumption improves platelet function. | 2003 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:12878452 |
Yokoyama Y et al. | Role of thromboxane in producing portal hypertension following trauma-hemorrhage. | 2003 | Am. J. Physiol. Gastrointest. Liver Physiol. | pmid:14613921 |
Yu CC and Lai YL | Chronic hypoxia attenuates ischemia-reperfusion-induced increase in pulmonary vascular resistance. | 2003 | Life Sci. | pmid:12927588 |
Zhuang HP et al. | [Effect of aspirin combined with perindopril on prostacyclin, thromboxone A2, and norepinephrine in the blood of arteriosclerosis rabbit models and the cardiac function]. | 2003 | Hunan Yi Ke Da Xue Xue Bao | pmid:12934393 |
Castellani S et al. | Thromboxane inhibition improves renal perfusion and excretory function in severe congestive heart failure. | 2003 | J. Am. Coll. Cardiol. | pmid:12849673 |
Pettus BJ et al. | Ceramide kinase mediates cytokine- and calcium ionophore-induced arachidonic acid release. | 2003 | J. Biol. Chem. | pmid:12855693 |
Shimada N et al. | Increased endothelin: nitric oxide ratio is associated with erythropoietin-induced hypertension in hemodialysis patients. | 2003 | Ren Fail | pmid:12911161 |
Yi H et al. | [Protective effect of selective cyclooxygenase-2 inhibitor on alcohol-induced liver injury in rats]. | 2003 | Zhonghua Gan Zang Bing Za Zhi | pmid:14636441 |
Kankuri E et al. | Effects of phenacetin and its metabolite p-phenetidine on COX-1 and COX-2 activities and expression in vitro. | 2003 | Thromb. Res. | pmid:14592552 |
Zhang C et al. | Inflammation is involved in the organ damage induced by sinoaortic denervation in rats. | 2003 | J. Hypertens. | pmid:14597858 |
Wang ZF et al. | The role of inflammatory mediators in severe acute pancreatitis and regulation of glucocorticoids. | 2003 | HBPD INT | pmid:14599960 |
Eder K et al. | Conjugated linoleic acids lower the release of eicosanoids and nitric oxide from human aortic endothelial cells. | 2003 | J. Nutr. | pmid:14652352 |
Ziser A et al. | Propofol does not induce pulmonary dysfunction in stressed endotoxic pigs receiving Intralipid. | 2003 | Crit. Care Med. | pmid:12847400 |
Li JS et al. | [Change in intestinal free radical and prostaglandin metabolism in the aged rats with pneumococcus pneumonia]. | 2003 | Zhongguo Wei Zhong Bing Ji Jiu Yi Xue | pmid:14552688 |
Lombard JH et al. | High-salt diet impairs vascular relaxation mechanisms in rat middle cerebral arteries. | 2003 | Am. J. Physiol. Heart Circ. Physiol. | pmid:12456391 |
Chen Z et al. | [Correlation between TXB2, 6-Keto-PGF1alpha and liver metastasis in rats model with blood stasis]. | 2003 | Zhong Xi Yi Jie He Xue Bao | pmid:15339561 |
He LQ et al. | [Effect and mechanism of Tangshenning Recipe on micro-albuminuria in rats with early diabetic nephropathy]. | 2003 | Zhong Xi Yi Jie He Xue Bao | pmid:15339583 |
Al-Waili NS and Boni NS | Natural honey lowers plasma prostaglandin concentrations in normal individuals. | 2003 | J Med Food | pmid:12935324 |
Gu L et al. | [Advances in the study on molecular mechanism of diabetic nephropathy treated with Rheum officinale]. | 2003 | Zhongguo Zhong Yao Za Zhi | pmid:15224660 |
Jones AE et al. | Inhibition of prostaglandin synthesis during polystyrene microsphere-induced pulmonary embolism in the rat. | 2003 | Am. J. Physiol. Lung Cell Mol. Physiol. | pmid:12639842 |
Davì G et al. | Enhanced lipid peroxidation and platelet activation in the early phase of type 1 diabetes mellitus: role of interleukin-6 and disease duration. | 2003 | Circulation | pmid:12810609 |
Sheu JR et al. | Inhibitory mechanisms of metallothionein on platelet aggregation in in vitro and platelet plug formation in in vivo experiments. | 2003 | Exp. Biol. Med. (Maywood) | pmid:14681547 |
Bellou A et al. | Constitutive nitric oxide synthase inhibition combined with histamine and serotonin receptor blockade improves the initial ovalbumin-induced arterial hypotension but decreases the survival time in brown norway rats anaphylactic shock. | 2003 | Shock | pmid:12558148 |
De León EJ et al. | A new chloroquinolinyl chalcone derivative as inhibitor of inflammatory and immune response in mice and rats. | 2003 | J. Pharm. Pharmacol. | pmid:14604476 |
Dong WG et al. | Ameliorative effects of sodium ferulate on experimental colitis and their mechanisms in rats. | 2003 | World J. Gastroenterol. | pmid:14606091 |
De La Cruz JP et al. | Differences in the effects of extended-release aspirin and plain-formulated aspirin on prostanoids and nitric oxide in healthy volunteers. | 2003 | Fundam Clin Pharmacol | pmid:12803576 |
Guyton K et al. | Peroxisome proliferator-activated receptor-gamma agonists modulate macrophage activation by gram-negative and gram-positive bacterial stimuli. | 2003 | Shock | pmid:12813370 |
Montuschi P et al. | Exhaled leukotrienes and prostaglandins in COPD. | 2003 | Thorax | pmid:12832671 |
Fujimoto Y et al. | Effects of endocrine disruptors on arachidonic acid metabolism in rabbit platelets. | 2003 | Toxicol. Appl. Pharmacol. | pmid:12781627 |
Stephenson AH et al. | Differential effects of 5,6-EET on segmental pulmonary vasoactivity in the rabbit. | 2003 | Am. J. Physiol. Heart Circ. Physiol. | pmid:12609822 |
Beck-Speier I et al. | Sulfur-related air pollutants induce the generation of platelet-activating factor, 5-lipoxygenase- and cyclooxygenase-products in canine alveolar macrophages via activation of phospholipases A2. | 2003 | Prostaglandins Other Lipid Mediat. | pmid:14518563 |
Cipollone F et al. | Modulation of aspirin-insensitive eicosanoid biosynthesis by 6-methylprednisolone in unstable angina. | 2003 | Circulation | pmid:12515743 |
Fike CD et al. | Arachidonic acid metabolites and an early stage of pulmonary hypertension in chronically hypoxic newborn pigs. | 2003 | Am. J. Physiol. Lung Cell Mol. Physiol. | pmid:12388340 |
Halushka MK et al. | Genetic variation in cyclooxygenase 1: effects on response to aspirin. | 2003 | Clin. Pharmacol. Ther. | pmid:12545150 |
Yokoyama Y et al. | Role of thromboxane A2 in early BDL-induced portal hypertension. | 2003 | Am. J. Physiol. Gastrointest. Liver Physiol. | pmid:12431905 |
Li D et al. | Diet rich in saturated fat decreases the ratio of thromboxane/prostacyclin in healthy men. | 2003 | Biomed. Environ. Sci. | pmid:15011964 |
Huang RJ et al. | [Effect of tetramethylpyrazine on endothelin, von Willebrand factor and thromboxane A2 during cardiopulmonary bypass in patients of congenital heart disease with pulmonary hypertension]. | 2003 | Zhongguo Zhong Xi Yi Jie He Za Zhi | pmid:12764908 |
Li ZG et al. | [Progress on study of experimental physico-chemical indexes related with ischemic stroke]. | 2003 | Zhongguo Zhong Xi Yi Jie He Za Zhi | pmid:12764922 |
Lei D et al. | Antioxidative and antiplatelet effects of aqueous inflorescence Piper betle extract. | 2003 | J. Agric. Food Chem. | pmid:12643677 |
Park WH et al. | The antiplatelet activity of Geiji-Bokryung-Hwan, Korean traditional formulation, is mediated through inhibition of phospholipase C and inhibition of TxB(2) synthetase activity. | 2003 | Int. Immunopharmacol. | pmid:12810354 |
Hou X et al. | Increased platelet-activating factor-induced periventricular brain microvascular constriction associated with immaturity. | 2003 | Am. J. Physiol. Regul. Integr. Comp. Physiol. | pmid:12626359 |
Dionne RA et al. | Dexamethasone suppresses peripheral prostanoid levels without analgesia in a clinical model of acute inflammation. | 2003 | J. Oral Maxillofac. Surg. | pmid:12966473 |
Tsipas G and Morphake P | Beneficial effects of a diet rich in a mixture of n - 6/n - 3 essential fatty acids and of their metabolites on cyclosporine - nephrotoxicity. | 2003 | J. Nutr. Biochem. | pmid:12948879 |
Nagase T et al. | A potent inhibitor of cytosolic phospholipase A2, arachidonyl trifluoromethyl ketone, attenuates LPS-induced lung injury in mice. | 2003 | Am. J. Physiol. Lung Cell Mol. Physiol. | pmid:12505870 |
Cerletti C et al. | Pharmacokinetic and pharmacodynamic differences between two low dosages of aspirin may affect therapeutic outcomes. | 2003 | Clin Pharmacokinet | pmid:12959636 |
Dai H et al. | Effects of diltiazem on platelet activation and cytosolic calcium during percutaneous transluminal coronary angioplasty. | 2003 | Postgrad Med J | pmid:13679549 |
Liu H et al. | Clinical implication of the changes of cAMP, TXA2 and PGI2 in CSF of asphyxiated newborns. | 2003 | J. Huazhong Univ. Sci. Technol. Med. Sci. | pmid:12973949 |
Hart RG et al. | Aspirin dosage and thromboxane synthesis in patients with vascular disease. | 2003 | Pharmacotherapy | pmid:12741431 |
Pfeiffer S et al. | Hyperacute lung rejection in the pig-to-human model. III. Platelet receptor inhibitors synergistically modulate complement activation and lung injury. | 2003 | Transplantation | pmid:12698079 |
Arifah AK et al. | Pharmacodynamics, chiral pharmacokinetics and PK-PD modelling of ketoprofen in the goat. | 2003 | J. Vet. Pharmacol. Ther. | pmid:12667184 |
Ji Y et al. | Thrombosis and its significance after experimental pulmonary thromboembolism. | 2003 | Chin. Med. J. | pmid:12667387 |