| MeSH term | MeSH ID | Detail |
|---|---|---|
| Fever | D005334 | 35 associated lipids |
| Anaphylaxis | D000707 | 35 associated lipids |
| Infarction, Middle Cerebral Artery | D020244 | 35 associated lipids |
| Liver Cirrhosis, Experimental | D008106 | 36 associated lipids |
| Heart Failure | D006333 | 36 associated lipids |
| Lung Diseases | D008171 | 37 associated lipids |
| Diabetic Retinopathy | D003930 | 39 associated lipids |
| Zellweger Syndrome | D015211 | 39 associated lipids |
| Diabetic Nephropathies | D003928 | 39 associated lipids |
| Hypotension | D007022 | 41 associated lipids |
Thromboxane b2
Thromboxane b2 is a lipid of Fatty Acyls (FA) class. Thromboxane b2 is associated with abnormalities such as endothelial dysfunction, Diabetes Mellitus, Non-Insulin-Dependent, Diabetes Mellitus, Ischemia and Thrombocytosis. The involved functions are known as Platelet Activation, Excretory function, Anabolism, Inflammation and mRNA Expression. Thromboxane b2 often locates in Endothelium, Hepatic and Microsomes, Liver. The associated genes with Thromboxane b2 are PTGS2 gene, prothrombin fragment 2 and CCL14 wt Allele.
Cross Reference
Introduction
To understand associated biological information of Thromboxane b2, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with Thromboxane b2?
Thromboxane b2 is suspected in endothelial dysfunction, Diabetes Mellitus, Non-Insulin-Dependent, Diabetes Mellitus, Ischemia, Thrombocytosis, Acute Coronary Syndrome and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
| Disease | Cross reference | Weighted score | Related literature |
|---|
Loading... please refresh the page if content is not showing up.
Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with Thromboxane b2
PubChem Associated disorders and diseases
What pathways are associated with Thromboxane b2
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with Thromboxane b2?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
|---|
Loading... please refresh the page if content is not showing up.
What functions are associated with Thromboxane b2?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
|---|
What lipids are associated with Thromboxane b2?
There are no associated biomedical information in the current reference collection.
What genes are associated with Thromboxane b2?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
|---|
What common seen animal models are associated with Thromboxane b2?
There are no associated biomedical information in the current reference collection.
NCBI Entrez Crosslinks
All references with Thromboxane b2
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Simmons PM et al. | The release of leukotriene B4 during experimental inflammation. | 1983 | Biochem. Pharmacol. | pmid:6305369 |
| Chang J et al. | Effects of thiazinamium chloride, promethazine and chlorpromazine on thromboxane B2 synthesis, phagocytosis and respiratory burst by rat alveolar macrophages. | 1983 | Biochem. Pharmacol. | pmid:6138040 |
| Deckmyn H et al. | Manipulation of the local thromboxane and prostacyclin balance in vivo by the antithrombotic compounds dazoxiben, acetylsalicylic acid and nafazatrom. | 1983 | Biochem. Pharmacol. | pmid:6578796 |
| Pestel S et al. | Inhibition of prostaglandin D2 clearance in rat hepatocytes by the thromboxane receptor antagonists daltroban and ifetroban and the thromboxane synthase inhibitor furegrelate. | 2003 | Biochem. Pharmacol. | pmid:12906929 |
| Llopis J et al. | Eicosanoids released following inhibition of the endoplasmic reticulum Ca2+ pump stimulate Ca2+ efflux in the perfused rat liver. | 1993 | Biochem. Pharmacol. | pmid:8390834 |
| Takayasu-Okishio M et al. | Endothelin-1 and platelet activating factor stimulate thromboxane A2 biosynthesis in rat vascular smooth muscle cells. | 1990 | Biochem. Pharmacol. | pmid:2260994 |
| Krämer HJ et al. | Fish oil fatty acids and human platelets: dose-dependent decrease in dienoic and increase in trienoic thromboxane generation. | 1996 | Biochem. Pharmacol. | pmid:8937428 |
| Patscheke H | Thromboxane synthase inhibition potentiates washed platelet activation by endogenous and exogenous arachidonic acid. | 1985 | Biochem. Pharmacol. | pmid:3922373 |
| Segarnick DJ et al. | Precursor- and pool-dependent differential effects of ethanol on human platelet prostanoid synthesis. | 1985 | Biochem. Pharmacol. | pmid:3922375 |
| Satoh K et al. | Effects of sulfonylurea agents on platelet arachidonic acid metabolism; study on platelet homogenates. | 1994 | Biochem. Pharmacol. | pmid:8093094 |
| Best LC et al. | Strontium ions induce production of thromboxane B2 and secretion of 5-hydroxytryptamine in washed human platelets. | 1981 | Biochem. Pharmacol. | pmid:6268118 |
| Vanderhoek JY et al. | Inhibitory potencies of fish oil hydroxy fatty acids on cellular lipoxygenases and platelet aggregation. | 1991 | Biochem. Pharmacol. | pmid:1831021 |
| Cerletti C et al. | Requirement of ADP for arachidonic acid-induced platelet aggregation: studies with selective thromboxane-synthase inhibitors. | 1986 | Biochem. Pharmacol. | pmid:3083818 |
| Krishnamurthi S et al. | Regulation of human platelet activation--analysis of cyclooxygenase and cyclic AMP-dependent pathways. | 1984 | Biochem. Pharmacol. | pmid:6091666 |
| Kanda N and Watanabe S | Suppressive effects of antimycotics on tumor necrosis factor-alpha-induced CCL27, CCL2, and CCL5 production in human keratinocytes. | 2006 | Biochem. Pharmacol. | pmid:16784723 |
| Yu SM et al. | Dicentrine, a novel antiplatelet agent inhibiting thromboxane formation and increasing the cyclic AMP level of rabbit platelets. | 1992 | Biochem. Pharmacol. | pmid:1310852 |
| Spaethe SM et al. | Guinea pig whole blood 5-lipoxygenase assay: utility in the assessment of potential 5-lipoxygenase inhibitors. | 1992 | Biochem. Pharmacol. | pmid:1310855 |
| Tolman EL and Fuller BL | Inhibition of thromboxane synthesis in guinea pig lung and human platelets by clotrimazole and other imidazole antifungals. | 1983 | Biochem. Pharmacol. | pmid:6316985 |
| Kusner EJ et al. | Inhibition by REV-5901 of leukotriene release from guinea-pig and human lung tissue in vitro. | 1989 | Biochem. Pharmacol. | pmid:2557041 |
| Oishi K and Yamaguchi M | Regulatory effect of arachidonic acid on the calcium transport system in rat liver nuclei. | 1993 | Biochem. Pharmacol. | pmid:8385946 |
| Tanizawa H and Tai HH | Synergism between chemotactic peptide and platelet-activating factor in stimulating thromboxane B2 and leukotriene B4 biosynthesis in human neutrophils. | 1989 | Biochem. Pharmacol. | pmid:2547385 |
| Covatto RH and Niewiarowski S | Platelet thromboxane A2/prostaglandin H2 receptors in human volunteers on low doses of aspirin. | 1990 | Biochem. Pharmacol. | pmid:2145839 |
| Faili A et al. | Reduction by arachidonic acid of prostaglandin I2-induced cyclic AMP formation. Involvement of prostaglandins E2 and F2 alpha. | 1993 | Biochem. Pharmacol. | pmid:8388209 |
| Huang TF et al. | Halysin, an antiplatelet Arg-Gly-Asp-containing snake venom peptide, as fibrinogen receptor antagonist. | 1991 | Biochem. Pharmacol. | pmid:1888330 |
| Grieve EM et al. | The reversal of experimental cyclosporin A nephrotoxicity by thromboxane synthetase inhibition. | 1993 | Biochem. Pharmacol. | pmid:8466554 |
| Wald M et al. | Role of thromboxanes in alterations of the diabetic beta-adrenergic system. | 1989 | Biochem. Pharmacol. | pmid:2554922 |
| Salmon JA et al. | Benoxaprofen does not inhibit formation of leukotriene B4 in a model of acute inflammation. | 1984 | Biochem. Pharmacol. | pmid:6089840 |
| Gresele P et al. | L-652,343, a novel dual cyclo/lipoxygenase inhibitor, inhibits LTB4-production by stimulated human polymorphonuclear cells but not by stimulated human whole blood. | 1987 | Biochem. Pharmacol. | pmid:2823826 |
| Fischer S et al. | In vivo and in vitro effects of nafazatrom (Bay g 6575), an antithrombotic compound, on arachidonic acid metabolism in platelets and vascular tissue. | 1983 | Biochem. Pharmacol. | pmid:6688182 |
| Maynard PM et al. | Effect of glutathione depletion on tissue and plasma prostacyclin and thromboxane in rats. | 1992 | Biochem. Pharmacol. | pmid:1554377 |
| Yuk DY et al. | Antithrombotic and antiplatelet activities of 2-chloro-3-[4-(ethylcarboxy)-phenyl]-amino-1,4-naphthoquinone (NQ12), a newly synthesized 1,4-naphthoquinone derivative. | 2000 | Biochem. Pharmacol. | pmid:10974210 |
| Lloret S and Moreno JJ | In vitro and in vivo effects of the anti-inflammatory peptides, antiflammins. | 1992 | Biochem. Pharmacol. | pmid:1417964 |
| Chou TC et al. | Antiplatelet effect of amlodipine: a possible mechanism through a nitric oxide-mediated process. | 1999 | Biochem. Pharmacol. | pmid:10535758 |
| Koehler L et al. | Glucocorticoid-induced reduction of prostanoid synthesis in TPA-differentiated U937 cells is mainly due to a reduced cyclooxygenase activity. | 1990 | Biochem. Pharmacol. | pmid:2119586 |
| Rajtar G et al. | Prostaglandins and human platelet aggregation. Implications for the anti-aggregating activity of thromboxane-synthase inhibitors. | 1985 | Biochem. Pharmacol. | pmid:3918536 |
| Shih CY and Chou TC | The antiplatelet activity of magnolol is mediated by PPAR-β/γ. | 2012 | Biochem. Pharmacol. | pmid:22750553 |
| Chang TS et al. | Thromboxane A2 synthase inhibition and thromboxane A2 receptor blockade by 2-[(4-cyanophenyl)amino]-3-chloro-1,4-naphthalenedione (NQ-Y15) in rat platelets. | 1997 | Biochem. Pharmacol. | pmid:9271330 |
| Suntres ZE and Shek PN | Prophylaxis against lipopolysaccharide-induced lung injuries by liposome-entrapped dexamethasone in rats. | 2000 | Biochem. Pharmacol. | pmid:10704946 |
| Alanko J et al. | Catechol estrogens as inhibitors of leukotriene synthesis. | 1998 | Biochem. Pharmacol. | pmid:9413936 |
| Rothberg KG and Hitchcock M | In vitro biosynthesis of cyclooxygenase metabolites in ovalbumin-sensitized and control lungs of guinea pigs. | 1982 | Biochem. Pharmacol. | pmid:6812589 |
| Liu FC et al. | A new insight of anti-platelet effects of sirtinol in platelets aggregation via cyclic AMP phosphodiesterase. | 2009 | Biochem. Pharmacol. | pmid:19426675 |
| Joseph S and MacDermot J | Stimulation of U937 human monocytic cells by thrombin results in inositol trisphosphate formation and the mobilisation of intracellular Ca2+ but not the synthesis of thromboxane B2. | 1991 | Biochem. Soc. Trans. | pmid:1889682 |
| Bone EA et al. | The effects of strontium and calcium ions on 5-hydroxytryptamine secretion and thromboxane B2 biosynthesis in washed human platelets. | 1980 | Biochem. Soc. Trans. | pmid:7450206 |
| Mitchell MD | Prostaglandins at parturition and in the neonatal infant. | 1980 | Biochem. Soc. Trans. | pmid:7450282 |
| Chiabrando C et al. | Urinary excretion of thromboxane and prostacyclin metabolites during chronic low-dose aspirin: evidence for an extrarenal origin of urinary thromboxane B2 and 6-keto-prostaglandin F1 alpha in healthy subjects. | 1992 | Biochim. Biophys. Acta | pmid:1737057 |
| Best LC et al. | Lanthanum stimulates the accumulation of cyclic AMP and inhibits secretion and thromboxane B2 formation in human platelets. | 1980 | Biochim. Biophys. Acta | pmid:6251913 |
| Powell WS | Metabolism of prostaglandins, prostaglandin analogs and thromboxane B2 by lung and liver microsomes from pregnant rabbits. | 1979 | Biochim. Biophys. Acta | pmid:518891 |
| Teng CM et al. | Biphasic effect on platelet aggregation by phospholipase a purified from Vipera russellii snake venom. | 1984 | Biochim. Biophys. Acta | pmid:6426517 |
| Kimura Y et al. | Effects of stilbenes on arachidonate metabolism in leukocytes. | 1985 | Biochim. Biophys. Acta | pmid:3922423 |
| Bellan JA et al. | Concentration-activity profile of the modulation of cyclooxygenase product formation by reduced glutathione in microsomal fractions from the goat lung. | 1990 | Biochim. Biophys. Acta | pmid:2114178 |
| Fischer S et al. | Formation of prostacyclin and thromboxane in man as measured by the main urinary metabolites. | 1986 | Biochim. Biophys. Acta | pmid:3754157 |
| Bartolini G et al. | Regulation of thromboxane A2 biosynthesis in platelet-free human monocytes and the possible role of polypeptide growth factor(s) in the induction of cyclooxygenase system. | 1986 | Biochim. Biophys. Acta | pmid:3085720 |
| Grundfest CC et al. | Acrolein: a potent modulator of lung macrophage arachidonic acid metabolism. | 1982 | Biochim. Biophys. Acta | pmid:6814492 |
| Murota SI et al. | Transformation of arachidonic acid into thromboxane B2 by the homogenates of activated macrophages. | 1978 | Biochim. Biophys. Acta | pmid:638172 |
| Aharony D et al. | Regulation of arachidonate-induced platelet aggregation by the lipoxygenase product, 12-hydroperoxyeicosatetraenoic acid. | 1982 | Biochim. Biophys. Acta | pmid:6814496 |
| Croft KD et al. | Dietary modification of fatty acid and prostaglandin synthesis in the rat. Effect of variations in the level of dietary fat. | 1984 | Biochim. Biophys. Acta | pmid:6548159 |
| Cathcart MC et al. | Thromboxane synthase expression and correlation with VEGF and angiogenesis in non-small cell lung cancer. | 2014 | Biochim. Biophys. Acta | pmid:24480048 |
| Geisel J et al. | Endotoxin-induced arachidonic acid metabolism requires de novo protein synthesis and protein kinase C activation. | 1991 | Biochim. Biophys. Acta | pmid:1909897 |
| Du JT et al. | Sex differences in arachidonate cyclo-oxygenase products in elicited rat peritoneal macrophages. | 1984 | Biochim. Biophys. Acta | pmid:6428458 |
| Cook-Johnson RJ et al. | Endothelial cell COX-2 expression and activity in hypoxia. | 2006 | Biochim. Biophys. Acta | pmid:17046322 |
| Maguire MH and Csonka-Khalifah L | Vinca alkaloids inhibit conversion of arachidonic acid to thromboxane by human platelet microsomes: comparison with other microtubule-active drugs. | 1987 | Biochim. Biophys. Acta | pmid:3117116 |
| Murota SI et al. | The effects of thromboxane B2 and 6-ketoprostaglandin F1alpha on cultured fibroblasts. | 1977 | Biochim. Biophys. Acta | pmid:911847 |
| Heemskerk JW et al. | Influence of dietary fatty acids on membrane fluidity and activation of rat platelets. | 1989 | Biochim. Biophys. Acta | pmid:2752022 |
| Ciabattoni G et al. | Fractional conversion of thromboxane B2 to urinary 11-dehydrothromboxane B2 in man. | 1989 | Biochim. Biophys. Acta | pmid:2752040 |
| Patrignani P et al. | Fractional conversion of thromboxane A2 and B2 to urinary 2,3-dinor-thromboxane B2 and 11-dehydrothromboxane B2 in the cynomolgus monkey. | 1989 | Biochim. Biophys. Acta | pmid:2752041 |
| Ody C et al. | 6-Ketoprostaglandin F1 alpha, prostaglandins E2, F2 alpha and thromboxane B2 production by endothelial cells, smooth muscle cells and fibroblasts cultured from piglet aorta. | 1982 | Biochim. Biophys. Acta | pmid:6214281 |
| Wu P et al. | Purification and characterization of an NAD(+)-dependent dehydrogenase that catalyzes the oxidation of thromboxane B2 at C-11 from porcine liver. Development and application of 11-dehydro-thromboxane B2 radioimmunoassay to enzyme assay. | 1990 | Biochim. Biophys. Acta | pmid:2223826 |
| Malemud CJ et al. | Prostaglandin biosynthesis by lapine articular chondrocytes in culture. | 1981 | Biochim. Biophys. Acta | pmid:6894251 |
| Bishai I and Coceani F | Transformations of prostaglandin H2 in the cat brain. | 1981 | Biochim. Biophys. Acta | pmid:6894549 |
| Blache D et al. | Occurrence and biological effects of cholesteryl sulfate on blood platelets. | 1995 | Biochim. Biophys. Acta | pmid:8541337 |
| Orlandi M et al. | Thromboxane A2 synthase activity in platelet free human monocytes. | 1994 | Biochim. Biophys. Acta | pmid:7811713 |
| Truitt A et al. | Antiplatelet effects of conjugated linoleic acid isomers. | 1999 | Biochim. Biophys. Acta | pmid:10320806 |
| Huang TF et al. | Characterization of a potent platelet aggregation inhibitor from Agkistrodon rhodostoma snake venom. | 1987 | Biochim. Biophys. Acta | pmid:3620499 |
| Gorman RR et al. | Independence of the cyclic AMP-lowering activity of thromboxane A2 from the platelet release reaction. | 1979 | Biochim. Biophys. Acta | pmid:216409 |
| Fitzpatrick FA and Gorman RR | Regulatory role of cyclic adenosine 3',5'-monophosphate on the platelet cyclooxygenase and platelet function. | 1979 | Biochim. Biophys. Acta | pmid:216415 |
| Fuse I and Tai HH | Does protein kinase C activation mediate thrombin-induced arachidonate release in human platelets? | 1988 | Biochim. Biophys. Acta | pmid:3140902 |
| Surya II et al. | Enhancement of platelet functions by low density lipoproteins. | 1992 | Biochim. Biophys. Acta | pmid:1420343 |
| Yamaguchi A et al. | Secondary signals mediated by GPIIb/IIIa in thrombin-activated platelets. | 1990 | Biochim. Biophys. Acta | pmid:2116909 |
| Coffee KA et al. | Altered responses to modulators of guanine nucleotide binding protein activity in endotoxin tolerance. | 1990 | Biochim. Biophys. Acta | pmid:2118385 |
| Mayeux PR et al. | Evidence for a bidirectional prostaglandin endoperoxide shunt between platelets and the bovine coronary artery. | 1989 | Biochim. Biophys. Acta | pmid:2493809 |
| Huang TF et al. | Antiplatelet protease, kistomin, selectively cleaves human platelet glycoprotein Ib. | 1993 | Biochim. Biophys. Acta | pmid:8251530 |
| Robinson C and Hoult JR | Thromboxane A2 analogues inhibit the metabolism of thromboxane B2 in perfused guinea-pig lung. | 1983 | Biochim. Biophys. Acta | pmid:6652102 |
| Teng CM et al. | Antiplatelet effect of butylidenephthalide. | 1987 | Biochim. Biophys. Acta | pmid:3109495 |
| Bottje W et al. | Indomethacin attenuation of hepatic perfusion and plasma 6-ketoPGF1 alpha elevations following glutathione depletion in rabbits. | 1991 | Biochim. Biophys. Acta | pmid:1991131 |
| Tsunomori M et al. | 15-Hydroperoxyeicosapentaenoic acid inhibits arachidonic acid metabolism in rabbit platelets more potently than eicosapentaenoic acid. | 1996 | Biochim. Biophys. Acta | pmid:8679681 |
| Hettasch JM and Le Breton GC | Modulation of Ca2+ fluxes in isolated platelet vesicles: effects of cAMP-dependent protein kinase and protein kinase inhibitor on Ca2+ sequestration and release. | 1987 | Biochim. Biophys. Acta | pmid:2820511 |
| Mobley A et al. | Selective inhibition of 5-lipoxygenase pathway in rat pulmonary alveolar macrophages by cigarette smoking. | 1987 | Biochim. Biophys. Acta | pmid:3030439 |
| Bernoud-Hubac N et al. | Low concentrations of reactive gamma-ketoaldehydes prime thromboxane-dependent human platelet aggregation via p38-MAPK activation. | 2009 | Biochim. Biophys. Acta | pmid:19233311 |
| Kimura Y et al. | Effects of stilbene derivatives on arachidonate metabolism in leukocytes. | 1985 | Biochim. Biophys. Acta | pmid:3931689 |
| Cerletti C et al. | Non-steroidal anti-inflammatory drugs react with two sites on platelet cyclo-oxygenase. Evidence from "in vivo" drug interaction studies in rats. | 1982 | Biochim. Biophys. Acta | pmid:6799004 |
| Chiabrando C et al. | Metabolism of thromboxane B2 in the isolated perfused rat kidney: mass spectrometric identification of urinary products. | 1989 | Biochim. Biophys. Acta | pmid:2597664 |
| Nieuwenhuys CM and Hornstra G | The effects of purified eicosapentaenoic and docosahexaenoic acids on arterial thrombosis tendency and platelet function in rats. | 1998 | Biochim. Biophys. Acta | pmid:9487152 |
| Lorenz RL et al. | A critical evaluation of urinary immunoreactive thromboxane: feasibility of its determination as a potential vascular risk indicator. | 1989 | Biochim. Biophys. Acta | pmid:2597697 |
| Elliott GR et al. | Changes in resident rat peritoneal macrophage eicosanoid release, induced by altering the buffer K+/Na+ ratio, are Ca2+ dependent. | 1985 | Biochim. Biophys. Acta | pmid:3933563 |
| Turk J et al. | Arachidonic acid metabolism in isolated pancreatic islets. I. Identification and quantitation of lipoxygenase and cyclooxygenase products. | 1984 | Biochim. Biophys. Acta | pmid:6329307 |
| Oglesby TD and Gorman RR | The inhibition of arachidonic acid metabolism in human platelets by RHC 80267, a diacylglycerol lipase inhibitor. | 1984 | Biochim. Biophys. Acta | pmid:6424715 |
| Ciabattoni G et al. | Radioimmunoassay of 11-dehydrothromboxane B2 in human plasma and urine. | 1987 | Biochim. Biophys. Acta | pmid:3567215 |
| Barrow SE et al. | Cigarette smoking: profiles of thromboxane- and prostacyclin-derived products in human urine. | 1989 | Biochim. Biophys. Acta | pmid:2679889 |
| Robinson C et al. | Thromboxane B2 uptake and metabolism in isolated perfused lung. Identification and comparison with prostaglandin F2 alpha. | 1982 | Biochim. Biophys. Acta | pmid:6751406 |
| Schafer AI et al. | Platelet lipoxygenase-dependent oxygen burst. Evidence for differential activation of lipoxygenase in intact and disrupted human platelets. | 1982 | Biochim. Biophys. Acta | pmid:6812645 |