Thromboxane b2

Thromboxane b2 is a lipid of Fatty Acyls (FA) class. Thromboxane b2 is associated with abnormalities such as endothelial dysfunction, Diabetes Mellitus, Non-Insulin-Dependent, Diabetes Mellitus, Ischemia and Thrombocytosis. The involved functions are known as Platelet Activation, Excretory function, Anabolism, Inflammation and mRNA Expression. Thromboxane b2 often locates in Endothelium, Hepatic and Microsomes, Liver. The associated genes with Thromboxane b2 are PTGS2 gene, prothrombin fragment 2 and CCL14 wt Allele.

Cross Reference

Introduction

To understand associated biological information of Thromboxane b2, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.

What diseases are associated with Thromboxane b2?

Thromboxane b2 is suspected in endothelial dysfunction, Diabetes Mellitus, Non-Insulin-Dependent, Diabetes Mellitus, Ischemia, Thrombocytosis, Acute Coronary Syndrome and other diseases in descending order of the highest number of associated sentences.

Related references are mostly published in these journals:

Disease Cross reference Weighted score Related literature
Loading... please refresh the page if content is not showing up.

Possible diseases from mapped MeSH terms on references

We collected disease MeSH terms mapped to the references associated with Thromboxane b2

MeSH term MeSH ID Detail
Helicobacter Infections D016481 21 associated lipids
Infertility D007246 3 associated lipids
Embolism, Fat D004620 4 associated lipids
Polycystic Kidney Diseases D007690 12 associated lipids
Heart Septal Defects D006343 2 associated lipids
Hypertrophy, Left Ventricular D017379 12 associated lipids
Pneumonia, Viral D011024 3 associated lipids
Intermittent Claudication D007383 6 associated lipids
Aortic Aneurysm D001014 8 associated lipids
Hydatidiform Mole D006828 3 associated lipids
Per page 10 20 50 100 | Total 293

PubChem Associated disorders and diseases

What pathways are associated with Thromboxane b2

There are no associated biomedical information in the current reference collection.

PubChem Biomolecular Interactions and Pathways

Link to PubChem Biomolecular Interactions and Pathways

What cellular locations are associated with Thromboxane b2?

Related references are published most in these journals:

Location Cross reference Weighted score Related literatures
Loading... please refresh the page if content is not showing up.

What functions are associated with Thromboxane b2?


Related references are published most in these journals:

Function Cross reference Weighted score Related literatures

What lipids are associated with Thromboxane b2?

There are no associated biomedical information in the current reference collection.

What genes are associated with Thromboxane b2?

Related references are published most in these journals:


Gene Cross reference Weighted score Related literatures

What common seen animal models are associated with Thromboxane b2?

There are no associated biomedical information in the current reference collection.

NCBI Entrez Crosslinks

All references with Thromboxane b2

Download all related citations
Per page 10 20 50 100 | Total 6367
Authors Title Published Journal PubMed Link
Svenstrup Poulsen T et al. A critical appraisal of the phenomenon of aspirin resistance. 2005 Cardiology pmid:16020925
Walsh DS et al. Characterization of circulating monocytes expressing HLA-DR or CD71 and related soluble factors for 2 weeks after severe, non-thermal injury. 2005 J. Surg. Res. pmid:16045935
Rodrigue ME et al. Cyclooxygenase inhibition with acetylsalicylic acid unmasks a role for prostacyclin in erythropoietin-induced hypertension in uremic rats. 2005 Can. J. Physiol. Pharmacol. pmid:16049546
Esser R et al. Preclinical pharmacology of lumiracoxib: a novel selective inhibitor of cyclooxygenase-2. 2005 Br. J. Pharmacol. pmid:15655513
Sullivan JC et al. Sexual dimorphism in renal production of prostanoids in spontaneously hypertensive rats. 2005 Hypertension pmid:15699443
Chan CP et al. Inhibition of cyclooxygenase activity, platelet aggregation and thromboxane B2 production by two environmental toxicants: m- and o-cresol. 2005 Toxicology pmid:15664436
Massicot F et al. In vitro assessment of renal toxicity and inflammatory events of two protein phosphatase inhibitors cantharidin and nor-cantharidin. 2005 Basic Clin. Pharmacol. Toxicol. pmid:15667592
Lee GY et al. Antiplatelet activity of BRX-018, (6aS,cis)-malonic acid 3-acetoxy-6a9-bis-(2-methoxycarbonyl-acetoxy)-6,6a,7,11b-tetrahydro-indeno[2,1-c]chromen-10-yl ester methylester. 2005 Thromb. Res. pmid:15668191
Gama de Abreu M et al. Vaporized perfluorohexane attenuates ventilator-induced lung injury in isolated, perfused rabbit lungs. 2005 Anesthesiology pmid:15731599
Ye T et al. [Insulin resistance and effects of intravenous acute saline load on renal production of prostaglandin I2 and thromboxane A2 in salt-sensitive hypertensive patients]. 2005 Di Yi Jun Yi Da Xue Xue Bao pmid:15684012
Al Kadi H et al. A prospective, longitudinal study of the renin-angiotensin system, prostacyclin and thromboxane in the first trimester of normal human pregnancy: association with birthweight. 2005 Hum. Reprod. pmid:16006463
Beretta C et al. COX-1 and COX-2 inhibition in horse blood by phenylbutazone, flunixin, carprofen and meloxicam: an in vitro analysis. 2005 Pharmacol. Res. pmid:15939622
Klein Gunnewiek JM et al. The influence of acetylsalicylic acid intake by healthy volunteers on duplicate PFA-100 measurements. 2005 Blood Coagul. Fibrinolysis pmid:15970717
Visioli F et al. Virgin Olive Oil Study (VOLOS): vasoprotective potential of extra virgin olive oil in mildly dyslipidemic patients. 2005 Eur J Nutr pmid:15309433
Jin YR et al. Antiplatelet activity of J78 (2-Chloro-3-[2'-bromo, 4'-fluoro-phenyl]-amino-8-hydroxy-1,4-naphthoquinone), an antithrombotic agent, is mediated by thromboxane (TX) A2 receptor blockade with TXA2 synthase inhibition and suppression of cytosolic Ca2+ mobilization. 2005 J. Pharmacol. Exp. Ther. pmid:15328379
Perini JA et al. Influence of CYP2C9 genotypes on the pharmacokinetics and pharmacodynamics of piroxicam. 2005 Clin. Pharmacol. Ther. pmid:16198655
Davì G et al. Helicobacter pylori infection causes persistent platelet activation in vivo through enhanced lipid peroxidation. 2005 Arterioscler. Thromb. Vasc. Biol. pmid:15472127
Maree AO et al. Platelet response to low-dose enteric-coated aspirin in patients with stable cardiovascular disease. 2005 J. Am. Coll. Cardiol. pmid:16198840
Kataoka M et al. A long-acting prostacyclin agonist with thromboxane inhibitory activity for pulmonary hypertension. 2005 Am. J. Respir. Crit. Care Med. pmid:16192456
Munsterhjelm E et al. Dose-dependent inhibition of platelet function by acetaminophen in healthy volunteers. 2005 Anesthesiology pmid:16192763
Hsiao G et al. Inhibitory effects of lycopene on in vitro platelet activation and in vivo prevention of thrombus formation. 2005 J. Lab. Clin. Med. pmid:16194683
Xiaorong C et al. Effects of medicinal cake-separated moxibustion on plasma 6-keto-PGF1alpha and TXB2 contents in the rabbit of hyperlipemia. 2005 J Tradit Chin Med pmid:16136949
Oliveira RL et al. Postmenopausal hormone replacement therapy increases plasmatic thromboxane beta 2. 2005 Int. J. Cardiol. pmid:15771927
Cryer B et al. Double-blind, randomized, parallel, placebo-controlled study of ibuprofen effects on thromboxane B2 concentrations in aspirin-treated healthy adult volunteers. 2005 Clin Ther pmid:15811481
Watanabe H et al. Effects of salt loading on blood pressure in mice lacking the prostanoid receptor gene. 2005 Circ. J. pmid:15635218
Maruyama T et al. Thromboxane-dependent portopulmonary hypertension. 2005 Am. J. Med. pmid:15639216
Falco A et al. Inhibition of thromboxane biosynthesis by triflusal in type 2 diabetes mellitus. 2005 Atherosclerosis pmid:16285996
Noguchi M et al. Enzymologic and pharmacologic profile of loxoprofen sodium and its metabolites. 2005 Biol. Pharm. Bull. pmid:16272692
Ando K [Synthesis of 2-, 4- and 5-(2-alkylcarbamoyl-1-methylvinyl)-7-alkyloxybenzo[b]furans and their leukotriene B4 receptor antagonistic activity]. 2005 Yakugaku Zasshi pmid:16272807
de Sotomayor MA et al. Improvement of age-related endothelial dysfunction by simvastatin: effect on NO and COX pathways. 2005 Br. J. Pharmacol. pmid:16231003
Chang Y et al. Mechanisms involved in the antiplatelet activity of ketamine in human platelets. 2004 Nov-Dec J. Biomed. Sci. pmid:15591773
Barrière G et al. PHGPx overexpression induces an increase in COX-2 activity in colon carcinoma cells. 2004 May-Jun Anticancer Res. pmid:15274299
Böhm E et al. 11-Dehydro-thromboxane B2, a stable thromboxane metabolite, is a full agonist of chemoattractant receptor-homologous molecule expressed on TH2 cells (CRTH2) in human eosinophils and basophils. 2004 J. Biol. Chem. pmid:14668348
Gross GJ and Moore J Effect of COX-1/COX-2 inhibition versus selective COX-2 inhibition on coronary vasodilator responses to arachidonic acid and acetylcholine. 2004 Pharmacology pmid:15161995
Suzuki N et al. Quantitative liquid chromatography-tandem mass spectrometric analysis of 11-dehydro TXB2 in urine. 2004 Prostaglandins Other Lipid Mediat. pmid:15165035
Xu L et al. [Effects of effective component from "qing kai ling" on endothelial cell of microvessel in MCAO rats]. 2004 Zhong Yao Cai pmid:15376390
Perneby C et al. Prothrombotic responses to exercise are little influenced by clopidogrel treatment. 2004 Thromb. Res. pmid:15381386
Hennekens CH et al. Terms and conditions: semantic complexity and aspirin resistance. 2004 Circulation pmid:15381661
Zhao GR et al. [Clinical study on relationship between sluggishness of lung-defensive qi and levels of vasoactive intestinal polypeptide and thromboxane B2]. 2004 Zhong Xi Yi Jie He Xue Bao pmid:15383251
Fiorucci S et al. Co-administration of nitric oxide-aspirin (NCX-4016) and aspirin prevents platelet and monocyte activation and protects against gastric damage induced by aspirin in humans. 2004 J. Am. Coll. Cardiol. pmid:15358033
Ming HX et al. [Influence of single leaf Asarum himalaicum on renal function of rabbits]. 2004 Zhong Xi Yi Jie He Xue Bao pmid:15339444
Dey A et al. Altered kidney CYP2C and cyclooxygenase-2 levels are associated with obesity-related albuminuria. 2004 Obes. Res. pmid:15340111
Sheu JR et al. Expression of matrix metalloproteinase-9 in human platelets: regulation of platelet activation in in vitro and in vivo studies. 2004 Br. J. Pharmacol. pmid:15289295
Toth B et al. Insights into the role of interleukin-6 in the induction of hepatic injury after trauma-hemorrhagic shock. 2004 J. Appl. Physiol. pmid:15298985
Craft JA et al. Increased platelet-derived microparticles in the coronary circulation of percutaneous transluminal coronary angioplasty patients. 2004 Blood Coagul. Fibrinolysis pmid:15311156
Devi MM and Das UN Effect of prostaglandins against alloxan-induced cytotoxicity to insulin secreting insulinoma RIN cells in vitro. 2004 Prostaglandins Leukot. Essent. Fatty Acids pmid:15380818
Ferroni P et al. Platelet activation in type 2 diabetes mellitus. 2004 J. Thromb. Haemost. pmid:15304032
Di Nunno L et al. Novel synthesis of 3,4-diarylisoxazole analogues of valdecoxib: reversal cyclooxygenase-2 selectivity by sulfonamide group removal. 2004 J. Med. Chem. pmid:15369392
Mak IT et al. Cardiac pathologic effects of azidothymidine (AZT) in Mg-deficient mice. 2004 Cardiovasc. Toxicol. pmid:15371632
Valeri CR et al. In vitro effects of poly-N-acetyl glucosamine on the activation of platelets in platelet-rich plasma with and without red blood cells. 2004 J Trauma pmid:15280746
Singer P and Wirth M Can n-3 PUFA reduce cardiac arrhythmias? Results of a clinical trial. 2004 Prostaglandins Leukot. Essent. Fatty Acids pmid:15253884
Aikawa K et al. Effects of antioxidants on coronary microvascular spasm induced by epicardial coronary artery endothelial injury in pigs. 2004 Coron. Artery Dis. pmid:15201617
Lorenzoni R et al. Short-term prevention of thromboembolic complications in patients with atrial fibrillation with aspirin plus clopidogrel: the Clopidogrel-Aspirin Atrial Fibrillation (CLAAF) pilot study. 2004 Am. Heart J. pmid:15215815
Korkushko OV et al. [Some mechanisms of the development of endothelial disfunction in aging]. 2004 Fiziol Zh pmid:15174205
Kawano T et al. Acetaldehyde induces histamine release from human airway mast cells to cause bronchoconstriction. 2004 Int. Arch. Allergy Immunol. pmid:15178893
Ishitsuka Y et al. Involvement of thromboxane A2 (TXA2) in the early stages of oleic acid-induced lung injury and the preventive effect of ozagrel, a TXA2 synthase inhibitor, in guinea-pigs. 2004 J. Pharm. Pharmacol. pmid:15099446
Zhang L et al. Effects of thiol antioxidant on reduced nicotinamide adenine dinucleotide phosphate oxidase in hypertensive Dahl salt-sensitive rats. 2004 Free Radic. Biol. Med. pmid:15528040
Dinev D and Andonova M The effect of general anesthesia and abdominal surgery upon plasma thromboxane B concentrations in horses. 2004 Vet Anaesth Analg pmid:15053753
Menzies-Gow NJ et al. Endotoxin-induced digital vasoconstriction in horses: associated changes in plasma concentrations of vasoconstrictor mediators. 2004 Equine Vet. J. pmid:15147137
Ghuysen A et al. Effect of BM-573 [N-terbutyl-N'-[2-(4'-methylphenylamino)-5-nitro-benzenesulfonyl]urea], a dual thromboxane synthase inhibitor and thromboxane receptor antagonist, in a porcine model of acute pulmonary embolism. 2004 J. Pharmacol. Exp. Ther. pmid:15121765
Caprani A et al. Experimental evidence of a potentially increased thrombo-embolic disease risk by domestic electromagnetic field exposure. 2004 Bioelectromagnetics pmid:15114641
Di Minno G and Violi F Aspirin resistance and diabetic angiopathy: back to the future. 2004 Thromb. Res. pmid:15115664
Torsney E et al. Thrombosis and neointima formation in vein grafts are inhibited by locally applied aspirin through endothelial protection. 2004 Circ. Res. pmid:15117816
Wang YY et al. Inhibition of platelet aggregation by polyaspartoyl L-arginine and its mechanism. 2004 Acta Pharmacol. Sin. pmid:15066215
Harizi H et al. Inhibition of IL-6, TNF-alpha, and cyclooxygenase-2 protein expression by prostaglandin E2-induced IL-10 in bone marrow-derived dendritic cells. 2004 Cell. Immunol. pmid:15219461
Park HS et al. Dietary conjugated linoleic acid increases the mRNA ratio of Bax/Bcl-2 in the colonic mucosa of rats. 2004 J. Nutr. Biochem. pmid:15068816
Zhang C et al. Inhibition of inflammation contributes to organ protection of atenolol in sinoaortic-denervated rats. 2004 J. Cardiovasc. Pharmacol. pmid:15071353
Bruno A et al. Serial urinary 11-dehydrothromboxane B2, aspirin dose, and vascular events in blacks after recent cerebral infarction. 2004 Stroke pmid:14963281
Kwak SH et al. Effects of propofol on endotoxin-induced acute lung injury in rabbit. 2004 J. Korean Med. Sci. pmid:14966342
Scott G et al. Lumiracoxib: pharmacokinetic and pharmacodynamic profile when coadministered with fluconazole in healthy subjects. 2004 J Clin Pharmacol pmid:14747429
Arrebola MM et al. In vitro effects of clopidogrel on the platelet-subendothelium interaction, platelet thromboxane and endothelial prostacyclin production, and nitric oxide synthesis. 2004 J. Cardiovasc. Pharmacol. pmid:14668571
Freitas CF et al. Role of endothelin-1 and thromboxane A2 in the pulmonary hypertension induced by heparin-protamine interaction in anesthetized dogs. 2004 J. Cardiovasc. Pharmacol. pmid:14668575
Cotter G et al. Lack of aspirin effect: aspirin resistance or resistance to taking aspirin? 2004 Am. Heart J. pmid:14760328
Park WH et al. Anti-inflammatory effects of a traditional Korean herbal formulation, Silsosangami, consisting of seven medicinal herbs: effect on hemolysis, neutrophil function, and gene expressions of iNOS and COX-2. 2004 Vascul. Pharmacol. pmid:15664882
Vainio M et al. Prostacyclin, thromboxane A and the effect of low-dose ASA in pregnancies at high risk for hypertensive disorders. 2004 Acta Obstet Gynecol Scand pmid:15548142
Capone ML et al. Clinical pharmacology of platelet, monocyte, and vascular cyclooxygenase inhibition by naproxen and low-dose aspirin in healthy subjects. 2004 Circulation pmid:15037526
Liu P et al. [Effects of the extracts from decoction for resuscitation and its component herbs on PGI2, TXA2 and NO release from rat vascular endothelial cells under hypoxia in vitro]. 2004 Zhongguo Zhong Yao Za Zhi pmid:15631091
Yang JP et al. [Changes of the platelet function and serum anticardiolipin antibody in patients with pulmonary thromboembolism]. 2004 Zhonghua Jie He He Hu Xi Za Zhi pmid:15634381
Ganafa AA et al. Amlodipine attenuates oxidative stress-induced hypertension. 2004 Am. J. Hypertens. pmid:15363814
Berrougui H et al. Argan (Argania spinosa) oil lowers blood pressure and improves endothelial dysfunction in spontaneously hypertensive rats. 2004 Br. J. Nutr. pmid:15613254
Fan JG et al. [Dynamic changes of plasma levels of prostacycline and thromboxane A2 and their correlation with the severity of hepatic injury in rats with nonalcoholic fatty liver disease]. 2004 Zhonghua Gan Zang Bing Za Zhi pmid:15623379
Díaz AM et al. Phenylpropanoid glycosides from Scrophularia scorodonia: in vitro anti-inflammatory activity. 2004 Life Sci. pmid:15010262
Tsai CY et al. Proinflammatory cytokines enhance COX-1 gene expression in cultured rat glomerular mesangial cells. 2004 Int. Immunopharmacol. pmid:14975359
Smalling WE et al. Protective effect of pentoxifylline on volume-induced lung injury in newborn piglets. 2004 Biol. Neonate pmid:14981352
Ikonomidis I et al. Reduction of daily life ischaemia by aspirin in patients with angina: underlying link between thromboxane A2 and macrophage colony stimulating factor. 2004 Heart pmid:15020512
Dippel DW et al. What is the lowest dose of aspirin for maximum suppression of in vivo thromboxane production after a transient ischemic attack or ischemic stroke? 2004 Cerebrovasc. Dis. pmid:15026612
Rotondo S et al. Licofelone, an inhibitor of cyclooxygenase and 5-lipoxygenase, specifically inhibits cyclooxygenase-1-dependent platelet activation. 2004 Eur. J. Pharmacol. pmid:15044038
Akbiyik F et al. Human bone marrow megakaryocytes and platelets express PPARgamma, and PPARgamma agonists blunt platelet release of CD40 ligand and thromboxanes. 2004 Blood pmid:15130939
Vega-Ostertag M et al. Intracellular events in platelet activation induced by antiphospholipid antibodies in the presence of low doses of thrombin. 2004 Arthritis Rheum. pmid:15457460
Noverr MC and Huffnagle GB Regulation of Candida albicans morphogenesis by fatty acid metabolites. 2004 Infect. Immun. pmid:15501745
Tanigawa T et al. Anti-inflammatory effect of two isoforms of COX in H. pylori-induced gastritis in mice: possible involvement of PGE2. 2004 Am. J. Physiol. Gastrointest. Liver Physiol. pmid:12958020
Rocca B et al. Modulation of the expression and activity of cyclooxygenases in normal and accelerated erythropoiesis. 2004 Exp. Hematol. pmid:15504548
Chou DS et al. Low concentration of oxidized low density lipoprotein suppresses platelet reactivity in vitro: an intracellular study. 2004 Lipids pmid:15506238
He W et al. Effects of the Chinese drugs for activating blood circulation on plasma TXB2 and 6-keto-PGF1alpha contents in rabbits with glucocorticoid-induced femoral head necrosis. 2004 J Tradit Chin Med pmid:15510809
Chiang N et al. Aspirin triggers antiinflammatory 15-epi-lipoxin A4 and inhibits thromboxane in a randomized human trial. 2004 Proc. Natl. Acad. Sci. U.S.A. pmid:15471991
Park WH et al. Inhibitory effect of GBH on platelet aggregation through inhibition of intracellular Ca2+ mobilization in activated human platelets. 2004 Life Sci. pmid:15474558
Chen BN et al. [Characteristic changes of vascular tension factors in diabetic arterial occlusion of lower extremities]. 2004 Zhongguo Zhong Xi Yi Jie He Za Zhi pmid:15495823
Horani MH et al. Cyclooxygenase inhibition is associated with downregulation of apolipoprotein AI promoter activity in cultured hepatoma cell line HepG2. 2004 Metab. Clin. Exp. pmid:14767868
Kawada N et al. TP receptors regulate renal hemodynamics during angiotensin II slow pressor response. 2004 Am. J. Physiol. Renal Physiol. pmid:15213069
Peck OM et al. Staphylococcus aureus and lipopolysaccharide induce homologous tolerance but heterologous priming: role of interferon-gamma. 2004 Shock pmid:14770039