Thromboxane b2

Thromboxane b2 is a lipid of Fatty Acyls (FA) class. Thromboxane b2 is associated with abnormalities such as endothelial dysfunction, Diabetes Mellitus, Non-Insulin-Dependent, Diabetes Mellitus, Ischemia and Thrombocytosis. The involved functions are known as Platelet Activation, Excretory function, Anabolism, Inflammation and mRNA Expression. Thromboxane b2 often locates in Endothelium, Hepatic and Microsomes, Liver. The associated genes with Thromboxane b2 are PTGS2 gene, prothrombin fragment 2 and CCL14 wt Allele.

Cross Reference

Introduction

To understand associated biological information of Thromboxane b2, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.

What diseases are associated with Thromboxane b2?

Thromboxane b2 is suspected in endothelial dysfunction, Diabetes Mellitus, Non-Insulin-Dependent, Diabetes Mellitus, Ischemia, Thrombocytosis, Acute Coronary Syndrome and other diseases in descending order of the highest number of associated sentences.

Related references are mostly published in these journals:

Disease Cross reference Weighted score Related literature
Loading... please refresh the page if content is not showing up.

Possible diseases from mapped MeSH terms on references

We collected disease MeSH terms mapped to the references associated with Thromboxane b2

MeSH term MeSH ID Detail
Hypotension D007022 41 associated lipids
Ischemic Attack, Transient D002546 42 associated lipids
Arrhythmias, Cardiac D001145 42 associated lipids
Hyperalgesia D006930 42 associated lipids
Lupus Erythematosus, Systemic D008180 43 associated lipids
Metabolic Syndrome D024821 44 associated lipids
Coronary Artery Disease D003324 47 associated lipids
Fatty Liver D005234 48 associated lipids
Thrombosis D013927 49 associated lipids
Kidney Failure, Chronic D007676 51 associated lipids
Per page 10 20 50 100 | Total 293

PubChem Associated disorders and diseases

What pathways are associated with Thromboxane b2

There are no associated biomedical information in the current reference collection.

PubChem Biomolecular Interactions and Pathways

Link to PubChem Biomolecular Interactions and Pathways

What cellular locations are associated with Thromboxane b2?

Related references are published most in these journals:

Location Cross reference Weighted score Related literatures
Loading... please refresh the page if content is not showing up.

What functions are associated with Thromboxane b2?


Related references are published most in these journals:

Function Cross reference Weighted score Related literatures

What lipids are associated with Thromboxane b2?

There are no associated biomedical information in the current reference collection.

What genes are associated with Thromboxane b2?

Related references are published most in these journals:


Gene Cross reference Weighted score Related literatures

What common seen animal models are associated with Thromboxane b2?

There are no associated biomedical information in the current reference collection.

NCBI Entrez Crosslinks

All references with Thromboxane b2

Download all related citations
Per page 10 20 50 100 | Total 6367
Authors Title Published Journal PubMed Link
Massicot F et al. In vitro assessment of renal toxicity and inflammatory events of two protein phosphatase inhibitors cantharidin and nor-cantharidin. 2005 Basic Clin. Pharmacol. Toxicol. pmid:15667592
Markuszewski L et al. Reduced blood platelet sensitivity to aspirin in coronary artery disease: are dyslipidaemia and inflammatory states possible factors predisposing to sub-optimal platelet response to aspirin? 2006 Basic Clin. Pharmacol. Toxicol. pmid:16635110
Faiman MD and Patton LM Prostaglandins and leukotrienes in pulmonary O2 toxicity. 1988 Basic Life Sci. pmid:3250547
Heindl B et al. The volatile anesthetic sevoflurane mitigates cardiodepressive effects of platelets in reperfused hearts. 1999 Basic Res. Cardiol. pmid:10326658
Röth E and Török B Effect of the ultrashort-acting beta-blocker Brevibloc on free-radical-mediated injuries during the early reperfusion state. 1991 Sep-Oct Basic Res. Cardiol. pmid:1685083
Hartog JM et al. The effects of dietary mackerel oil on plasma and cell membrane lipids, on hemodynamics and cardiac arrhythmias during recurrent acute ischemia in the pig. 1986 Nov-Dec Basic Res. Cardiol. pmid:3814052
Clement R et al. Role of a nonsteroidal anti-inflammatory agent, ibuprofen, in coronary revascularization after acute myocardial infarction. 1990 Jan-Feb Basic Res. Cardiol. pmid:2109599
Kleinbongard P et al. Acute vasomotor paralysis and potential downstream effects of paclitaxel from stents implanted for saphenous vein aorto-coronary bypass stenosis. 2011 Basic Res. Cardiol. pmid:21472462
Jolly SR et al. Platelet depletion in experimental myocardial infarction. 1985 May-Jun Basic Res. Cardiol. pmid:4026785
Dion PR et al. Aerobic fitness level (VO2max) moderates the increased cardiovascular function and basal thromboxane formation of young healthy Type A males. 1992 Behav Med pmid:1591443
Liu TF et al. [Correlation between the level of the urinary 11-dehydrothromboxane B2 and the clinical efficacy of aspirin in patients with type 2 diabetes and coronary artery disease]. 2015 Beijing Da Xue Xue Bao pmid:26679651
Varma D et al. Comparison of UHPLC and HPLC methods for the assay of prostanoids: "are the methods equivalent in terms of accuracy and precision?". 2011 Bioanalysis pmid:21510759
Subbiah MT and Dietemeyer D Altered synthesis of prostaglandins in platelet and aorta from spontaneously diabetic Wistar rats. 1980 Biochem Med pmid:6893150
Aviram M et al. Plasma lipoproteins affect platelet malondialdehyde and thromboxane B2 production. 1985 Biochem Med pmid:4052061
Held HD et al. Phosphodiesterase inhibitors prevent endothelin-1-induced vasoconstriction, bronchoconstriction, and thromboxane release in perfused rat lung. 1997 Biochem. Biophys. Res. Commun. pmid:9070212
McCluskey ER et al. In vivo inhibition of thromboxane synthetase in infarcted canine myocardium. 1984 Biochem. Biophys. Res. Commun. pmid:6539597
Rodríguez-Puyol D et al. Lack of a direct regulatory effect of atrial natriuretic factor on prostaglandins and renin release by isolated rat glomeruli. 1986 Biochem. Biophys. Res. Commun. pmid:2943276
Quilley CP and Rifkind AB Prostaglandin release by the chick embryo heart is increased by 2,3,7,8-tetrachlorodibenzo-p-dioxin and by other cytochrome P-448 inducers. 1986 Biochem. Biophys. Res. Commun. pmid:3085671
Kaneko I et al. Prostaglandin F(2alpha) regulates cytokine responses of mast cells through the receptors for prostaglandin E. 2008 Biochem. Biophys. Res. Commun. pmid:18190789
Gonchar MV et al. Lack of direct connection between arachidonic acid release and prostanoid synthesis upon differentiation of U937 cell. 1998 Biochem. Biophys. Res. Commun. pmid:9731221
Wassef NM et al. Prostaglandin and thromboxane in liposomes: suppression of the primary immune response to liposomal antigens. 1989 Biochem. Biophys. Res. Commun. pmid:2719681
Resink TJ et al. Histamine-induced phosphoinositide metabolism in cultured human umbilical vein endothelial cells. Association with thromboxane and prostacyclin release. 1987 Biochem. Biophys. Res. Commun. pmid:3034250
Wientroub S et al. Changes in tissue concentration of prostaglandins during endochondral bone differentiation. 1983 Biochem. Biophys. Res. Commun. pmid:6582850
Matsumoto H et al. Concordant induction of prostaglandin E2 synthase with cyclooxygenase-2 leads to preferred production of prostaglandin E2 over thromboxane and prostaglandin D2 in lipopolysaccharide-stimulated rat peritoneal macrophages. 1997 Biochem. Biophys. Res. Commun. pmid:9020023
López-Farré A et al. Glomeruli from ischemic rat kidneys produce increased amounts of platelet activating factor. 1988 Biochem. Biophys. Res. Commun. pmid:3358756
Lagarde M et al. Inhibition of thrombin-induced platelet arachidonic acid release by 15-hydroperoxy-arachidonic acid. 1981 Biochem. Biophys. Res. Commun. pmid:7259783
Chignard M et al. Synthesis of thromboxane B2 in incubates of dog platelet-rich plasma with arachidonic acid and its inhibition by different drugs. 1978 Biochem. Biophys. Res. Commun. pmid:743319
Wong PY and Cheung WY Calmodulin stimulates human platelet phospholipase A2. 1979 Biochem. Biophys. Res. Commun. pmid:116656
Rola-Pleszczynski M et al. Inhibition of human lymphocyte proliferation and interleukin 2 production by platelet activating factor (PAF-acether): reversal by a specific antagonist, BN 52021. 1987 Biochem. Biophys. Res. Commun. pmid:3493773
Best LC et al. Evidence that extracellular calcium ions inhibit thromboxane B2 biosynthesis by human platelets. 1979 Biochem. Biophys. Res. Commun. pmid:117802
Mobley A and Tai HH Synergistic stimulation of thromboxane biosynthesis by calcium ionophore and phorbol ester or thrombin in human platelets. 1985 Biochem. Biophys. Res. Commun. pmid:3927908
Poll C et al. Activation of protein kinase C inhibits sodium fluoride-induced elevation of human platelet cytosolic free calcium and thromboxane B2 generation. 1986 Biochem. Biophys. Res. Commun. pmid:3085668
Ashmore RC et al. Aggregating platelets increase intracellular calcium in endothelial cells through release of adenine nucleotides. 1990 Biochem. Biophys. Res. Commun. pmid:2302246
O'Sullivan MG et al. Lipopolysaccharide-induced expression of prostaglandin H synthase-2 in alveolar macrophages is inhibited by dexamethasone but not by aspirin. 1993 Biochem. Biophys. Res. Commun. pmid:8466506
Crawford A et al. Rat osteogenic sarcoma cells: comparison of the effects of prostaglandins E1, E2, I2 (prostacyclin), 6-keto F1alpha and thromboxane B2 on cyclic AMP production and adenylate cyclase activity. 1978 Biochem. Biophys. Res. Commun. pmid:212039
Remick DG et al. Stimulation of prostaglandin E2 and thromboxane B2 production by human monocytes in response to interleukin-2. 1987 Biochem. Biophys. Res. Commun. pmid:3498487
Saeed SA et al. Dual inhibition of cyclooxygenase and lipoxygenase by human haptoglobin: its polymorphism and relation to hemoglobin binding. 2007 Biochem. Biophys. Res. Commun. pmid:17198677
Ku EC et al. Characterization of imidazo[1,5-a]pyridine-5-hexanoic acid (CGS 13080) as a selective thromboxane synthetase inhibitor using in vitro and in vivo biochemical models. 1983 Biochem. Biophys. Res. Commun. pmid:6687803
Balduini CL et al. Interrelation of platelet aggregation, release reaction and thromboxane A2 production. 1988 Biochem. Biophys. Res. Commun. pmid:3190682
Hashimoto Y et al. Time-dependent inhibition of the cyclooxygenase pathway by 12-hydroperoxy-5,8,10,14-eicosatetraenoic acid. 1985 Biochem. Biophys. Res. Commun. pmid:3927909
Velardo B and Lagarde M Differential effect of external calcium on the oxygenated metabolism of endogenous and exogenous arachidonic acid in platelets. 1985 Biochem. Biophys. Res. Commun. pmid:3927915
Yamaja Setty BN et al. 13-Hydroxyoctadeca-9,11-dienoic acid (13-HODE) inhibits thromboxane A2 synthesis, and stimulates 12-HETE production in human platelets. 1987 Biochem. Biophys. Res. Commun. pmid:3120708
Elander N et al. Genetic deletion of mPGES-1 accelerates intestinal tumorigenesis in APC(Min/+) mice. 2008 Biochem. Biophys. Res. Commun. pmid:18485889
Yamamoto T et al. Production of prostanoids and nitric oxide by infarcted heart in situ and the effect of aspirin. 1999 Biochem. Biophys. Res. Commun. pmid:10198239
Pace-Asciak CR and Edwards NS Tetranor thromboxane B2 is the principal urinary catabolite formed after i.v. infusion of thromboxane B2 in the rat. 1980 Biochem. Biophys. Res. Commun. pmid:7458943
Hamazaki T et al. The infusion of trieicosapentaenoyl-glycerol into humans and the in vivo formation of prostaglandin I3 and thromboxane A3. 1988 Biochem. Biophys. Res. Commun. pmid:3281674
Higashihara M et al. Interaction of Solanum tuberosum agglutinin with human platelets. 1984 Biochem. Biophys. Res. Commun. pmid:6732807
Fujimoto Y et al. Monochloramine potently inhibits arachidonic acid metabolism in rat platelets. 2006 Biochem. Biophys. Res. Commun. pmid:16615995
Lecompte T et al. Interference of transmethylation inhibitors with thromboxane synthesis in rat platelets. 1982 Biochem. Biophys. Res. Commun. pmid:6809005
Honn KV and Meyer J Thromboxanes and prostacyclin: positive and negative modulators of tumor growth. 1981 Biochem. Biophys. Res. Commun. pmid:6274330
Stimler NP Spasmogenic activity of C5adesArg anaphylatoxin on guinea pig lung parenchymal strips: sensitivity of the leukotriene-mediated component to cyclooxygenase inhibitors. 1984 Biochem. Biophys. Res. Commun. pmid:6440564
Crutchley DJ Effects of inhibitors of arachidonic acid metabolism on thromboplastin activity in human monocytes. 1984 Biochem. Biophys. Res. Commun. pmid:6422935
Maccarrone M et al. Activation of different lipoxygenase isozymes induces apoptosis in human erythroleukemia and neuroblastoma cells. 2000 Biochem. Biophys. Res. Commun. pmid:10833416
Igarashi K et al. Effect of polyamines on prostaglandin synthesis in various cell-free systems. 1981 Biochem. Biophys. Res. Commun. pmid:6800368
Gairola C and Tai HH Selective inhibition of leukotriene B4 biosynthesis in rat pulmonary alveolar macrophages by dietary selenium deficiency. 1985 Biochem. Biophys. Res. Commun. pmid:2998361
Sane DC et al. Cyclic GMP analogs inhibit gamma thrombin-induced arachidonic acid release in human platelets. 1989 Biochem. Biophys. Res. Commun. pmid:2557018
Miller JL et al. Arachidonic acid metabolism in guinea pig megakaryocytes. 1982 Biochem. Biophys. Res. Commun. pmid:6812584
Walenga RW et al. Recovery of megakaryocyte thromboxane production in vitro after aspirin inhibition. 1984 Biochem. Biophys. Res. Commun. pmid:6712680
Fuse I and Tai HH Stimulations of arachidonate release and inositol-1,4,5-triphosphate formation are mediated by distinct G-proteins in human platelets. 1987 Biochem. Biophys. Res. Commun. pmid:3113425
Dratewka-Kos E et al. Unsaturated fatty acids inhibit ADP- arachidonate-induced platelet aggregation without affecting thromboxane synthesis. 1986 Biochem. Cell Biol. pmid:3778664
Ariyoshi H et al. Characteristics of various synthetic peptide calpain inhibitors and their application for the analysis of platelet reaction. 1991 Biochem. Int. pmid:1953797
García-Sáinz JA et al. Melittin stimulates liver glycogenolysis and the release of prostaglandin D2 and thromboxane B2. 1990 Biochem. J. pmid:2375756
Tai HH et al. Transformation of arachidonate into 6-oxoprostaglandin F1 alpha, thromboxane B2 and prostaglandin E2 by sheep lung microsomal fraction. 1978 Biochem. J. pmid:637853
vom Dahl S et al. Stimulation of release of prostaglandin D2 and thromboxane B2 from perfused rat liver by extracellular adenosine. 1990 Biochem. J. pmid:2396991
Penning LC et al. Ca(2+)-mediated prostaglandin E2 induction reduces haematoporphyrin-derivative-induced cytotoxicity of T24 human bladder transitional carcinoma cells in vitro. 1993 Biochem. J. pmid:8503851
Krug HF et al. Mechanism of inhibition of cyclo-oxygenase in human blood platelets by carbamate insecticides. 1988 Biochem. J. pmid:3128272
Calzada C et al. Low concentrations of lipid hydroperoxides prime human platelet aggregation specifically via cyclo-oxygenase activation. 1997 Biochem. J. pmid:9230133
McMillan RM et al. Malonaldehyde formation in intact platelets is catalysed by thromboxane synthase. 1978 Biochem. J. pmid:743261
Rendu F et al. How does fluoroaluminate activate human platelets? 1990 Biochem. J. pmid:2302176
Ko FN et al. Daphnoretin, a new protein kinase C activator isolated from Wikstroemia indica C.A. Mey. 1993 Biochem. J. pmid:8216237
Krishnamurthi S et al. Synergistic potentiation of 5-hydroxytryptamine secretion by platelet agonists and phorbol myristate acetate despite inhibition of agonist-induced arachidonate/thromboxane and beta-thromboglobulin release and Ca2+ mobilization by phorbol myristate acetate. 1986 Biochem. J. pmid:2948494
Kowalska MA et al. High concentrations of exogenous arachidonate inhibit calcium mobilization in platelets by stimulation of adenylate cyclase. 1988 Biochem. J. pmid:2458717
Karniguian A et al. Collagen-induced platelet activation mainly involves the protein kinase C pathway. 1990 Biochem. J. pmid:2163606
Sun L et al. Kallikrein stimulates arachidonic acid release and production of prostaglandins from TEA3A1 endocrine thymic epithelial cells. 1989 Biochem. J. pmid:2495791
Huang TF et al. Aggretin, a novel platelet-aggregation inducer from snake (Calloselasma rhodostoma) venom, activates phospholipase C by acting as a glycoprotein Ia/IIa agonist. 1995 Biochem. J. pmid:7639679
Murphy CT and Westwick J Selective inhibition of protein kinase C. Effect on platelet-activating-factor-induced platelet functional responses. 1992 Biochem. J. pmid:1567363
Murphy CT et al. The relationship between cytosolic Ca2+, sn-1,2-diacylglycerol and inositol 1,4,5-trisphosphate elevation in platelet-activating-factor-stimulated rabbit platelets. Influence of protein kinase C on production of signal molecules. 1991 Biochem. J. pmid:1883334
Chakraborti T et al. Age-dependent change in arachidonic acid metabolic capacity in rat alveolar macrophages. 1999 Biochem. Mol. Biol. Int. pmid:10204087
Pestel S et al. Inhibition of prostaglandin D2 clearance in rat hepatocytes by the thromboxane receptor antagonists daltroban and ifetroban and the thromboxane synthase inhibitor furegrelate. 2003 Biochem. Pharmacol. pmid:12906929
Llopis J et al. Eicosanoids released following inhibition of the endoplasmic reticulum Ca2+ pump stimulate Ca2+ efflux in the perfused rat liver. 1993 Biochem. Pharmacol. pmid:8390834
Takayasu-Okishio M et al. Endothelin-1 and platelet activating factor stimulate thromboxane A2 biosynthesis in rat vascular smooth muscle cells. 1990 Biochem. Pharmacol. pmid:2260994
Ko FN et al. Inhibition of collagen-induced platelet aggregation and adhesion by a pseudocyanide derivative of avicine isolated from Zanthoxylum integrifoliolum Merr. 1993 Biochem. Pharmacol. pmid:8216367
Satoh K et al. Effects of sulfonylurea agents on platelet arachidonic acid metabolism; study on platelet homogenates. 1994 Biochem. Pharmacol. pmid:8093094
Krishnamurthi S et al. Regulation of human platelet activation--analysis of cyclooxygenase and cyclic AMP-dependent pathways. 1984 Biochem. Pharmacol. pmid:6091666
Klosterhalfen B et al. Influence of heat shock protein 70 and metallothionein induction by zinc-bis-(DL-hydrogenaspartate) on the release of inflammatory mediators in a porcine model of recurrent endotoxemia. 1996 Biochem. Pharmacol. pmid:8937427
Chang WC et al. Inhibition of thromboxane B2 and 6-ketoprostaglandin F1 alpha formation by anti-inflammatory drugs in carrageenin-induced granuloma. 1978 Biochem. Pharmacol. pmid:619892
Kusner EJ et al. Inhibition by REV-5901 of leukotriene release from guinea-pig and human lung tissue in vitro. 1989 Biochem. Pharmacol. pmid:2557041
Tanizawa H and Tai HH Synergism between chemotactic peptide and platelet-activating factor in stimulating thromboxane B2 and leukotriene B4 biosynthesis in human neutrophils. 1989 Biochem. Pharmacol. pmid:2547385
Erman A et al. The role of eicosanoids in cyclosporine nephrotoxicity in the rat. 1989 Biochem. Pharmacol. pmid:2735953
Wald M et al. Role of thromboxanes in alterations of the diabetic beta-adrenergic system. 1989 Biochem. Pharmacol. pmid:2554922
De La Cruz JP et al. Effects of S-adenosyl-L-methionine on platelet thromboxane and vascular prostacyclin. 1997 Biochem. Pharmacol. pmid:9264331
Weisman SM et al. Differential effect of platelet-activating factor (PAF) receptor antagonists on peptide and PAF-stimulated prostaglandin release in unilateral ureteral obstruction. 1988 Biochem. Pharmacol. pmid:2840083
Chou TC et al. Antiplatelet effect of amlodipine: a possible mechanism through a nitric oxide-mediated process. 1999 Biochem. Pharmacol. pmid:10535758
Koehler L et al. Glucocorticoid-induced reduction of prostanoid synthesis in TPA-differentiated U937 cells is mainly due to a reduced cyclooxygenase activity. 1990 Biochem. Pharmacol. pmid:2119586
Kerry R et al. Beta-adrenoceptor antagonists and human platelets: relationship of effects to lipid solubility. 1984 Biochem. Pharmacol. pmid:6147145
Rajtar G et al. Prostaglandins and human platelet aggregation. Implications for the anti-aggregating activity of thromboxane-synthase inhibitors. 1985 Biochem. Pharmacol. pmid:3918536
Shih CY and Chou TC The antiplatelet activity of magnolol is mediated by PPAR-β/γ. 2012 Biochem. Pharmacol. pmid:22750553
Williamson EM et al. Studies on the mechanism of action of 12-deoxyphorbolphenylacetate, a potent platelet aggregating tigliane ester. 1981 Biochem. Pharmacol. pmid:6794576
Lorenz RL et al. Effects on prostanoid formation and pharmacokinetics of dazmegrel (UK-38,485), a novel thromboxane synthase inhibitor, in man. 1986 Biochem. Pharmacol. pmid:3513767
Sumner H et al. Inhibition of 5-lipoxygenase and cyclo-oxygenase in leukocytes by feverfew. Involvement of sesquiterpene lactones and other components. 1992 Biochem. Pharmacol. pmid:1319159