Thromboxane b2

Thromboxane b2 is a lipid of Fatty Acyls (FA) class. Thromboxane b2 is associated with abnormalities such as endothelial dysfunction, Diabetes Mellitus, Non-Insulin-Dependent, Diabetes Mellitus, Ischemia and Thrombocytosis. The involved functions are known as Platelet Activation, Excretory function, Anabolism, Inflammation and mRNA Expression. Thromboxane b2 often locates in Endothelium, Hepatic and Microsomes, Liver. The associated genes with Thromboxane b2 are PTGS2 gene, prothrombin fragment 2 and CCL14 wt Allele.

Cross Reference

Introduction

To understand associated biological information of Thromboxane b2, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.

What diseases are associated with Thromboxane b2?

Thromboxane b2 is suspected in endothelial dysfunction, Diabetes Mellitus, Non-Insulin-Dependent, Diabetes Mellitus, Ischemia, Thrombocytosis, Acute Coronary Syndrome and other diseases in descending order of the highest number of associated sentences.

Related references are mostly published in these journals:

Disease Cross reference Weighted score Related literature
Loading... please refresh the page if content is not showing up.

Possible diseases from mapped MeSH terms on references

We collected disease MeSH terms mapped to the references associated with Thromboxane b2

MeSH term MeSH ID Detail
Carcinoma, Non-Small-Cell Lung D002289 72 associated lipids
Hyperlipidemias D006949 73 associated lipids
Stomach Ulcer D013276 75 associated lipids
Diabetes Mellitus, Experimental D003921 85 associated lipids
Atherosclerosis D050197 85 associated lipids
Arteriosclerosis D001161 86 associated lipids
Seizures D012640 87 associated lipids
Diabetes Mellitus, Type 2 D003924 87 associated lipids
Brain Ischemia D002545 89 associated lipids
Diabetes Mellitus D003920 90 associated lipids
Per page 10 20 50 100 | Total 293

PubChem Associated disorders and diseases

What pathways are associated with Thromboxane b2

There are no associated biomedical information in the current reference collection.

PubChem Biomolecular Interactions and Pathways

Link to PubChem Biomolecular Interactions and Pathways

What cellular locations are associated with Thromboxane b2?

Related references are published most in these journals:

Location Cross reference Weighted score Related literatures
Loading... please refresh the page if content is not showing up.

What functions are associated with Thromboxane b2?


Related references are published most in these journals:

Function Cross reference Weighted score Related literatures

What lipids are associated with Thromboxane b2?

There are no associated biomedical information in the current reference collection.

What genes are associated with Thromboxane b2?

Related references are published most in these journals:


Gene Cross reference Weighted score Related literatures

What common seen animal models are associated with Thromboxane b2?

There are no associated biomedical information in the current reference collection.

NCBI Entrez Crosslinks

All references with Thromboxane b2

Download all related citations
Per page 10 20 50 100 | Total 6367
Authors Title Published Journal PubMed Link
Yousefipour Z et al. Ciglitazone, a peroxisome proliferator-activated receptor gamma inducer, ameliorates renal preglomerular production and activity of angiotensin II and thromboxane A2 in glycerol-induced acute renal failure. 2007 J. Pharmacol. Exp. Ther. pmid:17494862
Lee CR et al. Cyclooxygenase polymorphisms and risk of cardiovascular events: the Atherosclerosis Risk in Communities (ARIC) study. 2008 Clin. Pharmacol. Ther. pmid:17495879
Aïd S and Bosetti F Gene expression of cyclooxygenase-1 and Ca(2+)-independent phospholipase A(2) is altered in rat hippocampus during normal aging. 2007 Brain Res. Bull. pmid:17499644
Heizer ML et al. 14,15-Epoxyeicosatrienoic acid inhibits platelet aggregation in mouse cerebral arterioles. 1991 Stroke pmid:1750047
Wang YP et al. Maternal levels of prostacyclin, thromboxane, vitamin E, and lipid peroxides throughout normal pregnancy. 1991 Am. J. Obstet. Gynecol. pmid:1750461
Wang YP et al. The imbalance between thromboxane and prostacyclin in preeclampsia is associated with an imbalance between lipid peroxides and vitamin E in maternal blood. 1991 Am. J. Obstet. Gynecol. pmid:1750462
Myatt L et al. Endothelin-1-induced vasoconstriction is not mediated by thromboxane release and action in the human fetal-placental circulation. 1991 Am. J. Obstet. Gynecol. pmid:1750466
Kang IS et al. Dose-related action of gonadotropin-releasing hormone on basal prostanoid production from the human term placenta. 1991 Am. J. Obstet. Gynecol. pmid:1750474
Markham SM et al. The effect of the menstrual cycle and of decompression stress on arachidonic acid-induced platelet aggregation and on intrinsic platelet thromboxane production in women compared with men. 1991 Am. J. Obstet. Gynecol. pmid:1750481
Bergman A et al. The role of prostaglandins in detrusor instability. 1991 Am. J. Obstet. Gynecol. pmid:1750483
Allais G et al. Naproxen sodium in short-term prophylaxis of pure menstrual migraine: pathophysiological and clinical considerations. 2007 Neurol. Sci. pmid:17508177
Amrani DL et al. Hemostatic evaluation of Sarns/3M-VAD implantation in calves. 1991 Jul-Sep ASAIO Trans pmid:1751163
Wong PC et al. Platelet aggregometry and receptor binding to predict the magnitude of antithrombotic and bleeding time effects of clopidogrel in rabbits. 2007 J. Cardiovasc. Pharmacol. pmid:17513951
Hohlfeld T et al. Variable platelet response to aspirin in patients with ischemic stroke. 2007 Cerebrovasc. Dis. pmid:17519543
Miyamoto K et al. [Effects of differently composed liposomes on pulmonary arterial pressure in sheep--involvement of pulmonary intravascular macrophages]. 1991 Nihon Kyobu Shikkan Gakkai Zasshi pmid:1753504
He B et al. [Effect of salt-loading on prostacyclin and thromboxane metabolism in kidney]. 1991 Sheng Li Xue Bao pmid:1754905
Crescente M et al. Gallic acid, a dietary polyphenolic component, blunts the inhibition of platelet COX-1 by aspirin: preliminary in-vitro findings. 2007 Thromb. Haemost. pmid:17549313
Undas A et al. Lack of aspirin-induced decrease in thrombin formation in subjects resistant to aspirin. 2007 Thromb. Haemost. pmid:17549314
Rostagno C et al. In vitro effects of two novel calcium antagonists (nitrendipine and nisoldipine) on intraplatelet calcium redistribution, platelet aggregation and thromboxane A2 formation. Comparison with diltiazem, nifedipine and verapamil. 1991 Thromb. Res. pmid:1754998
Chakroun T et al. Screening for aspirin resistance in stable coronary artery patients by three different tests. 2007 Thromb. Res. pmid:17553552
Pucsok JM et al. Effect of exercise on levels of cyclo-oxygenase mediators in exhaled breath condensate in elite athletes. 2007 J Sports Med Phys Fitness pmid:17557063
Hsiao G et al. Characterization of a novel and potent collagen antagonist, caffeic acid phenethyl ester, in human platelets: in vitro and in vivo studies. 2007 Cardiovasc. Res. pmid:17560560
Basselin M et al. Flurbiprofen, a cyclooxygenase inhibitor, reduces the brain arachidonic acid signal in response to the cholinergic muscarinic agonist, arecoline, in awake rats. 2007 Neurochem. Res. pmid:17562170
Aras-Lopéz R et al. Dexamethasone decreases contraction to electrical field stimulation in mesenteric arteries from spontaneously hypertensive rats through decreases in thromboxane A2 release. 2007 J. Pharmacol. Exp. Ther. pmid:17562850
Gurbel PA et al. Evaluation of dose-related effects of aspirin on platelet function: results from the Aspirin-Induced Platelet Effect (ASPECT) study. 2007 Circulation pmid:17562955
Tu CT et al. Antifibrotic activity of rofecoxib in vivo is associated with reduced portal hypertension in rats with carbon tetrachloride-induced liver injury. 2007 J. Gastroenterol. Hepatol. pmid:17565644
Atzori L et al. Thiol modification in H2O2- and thromboxane-induced vaso- and bronchoconstriction in rat perfused lung. 1991 J. Appl. Physiol. pmid:1757354
Fujioka K et al. Thromboxane synthase inhibition and cardiopulmonary function during endotoxemia in sheep. 1991 J. Appl. Physiol. pmid:1757360
Graff J et al. Effects of parecoxib and dipyrone on platelet aggregation in patients undergoing meniscectomy: a double-blind, randomized, parallel-group study. 2007 Clin Ther pmid:17577465
González-Correa JA et al. Gender differences in the effect of aspirin on retinal ischemia, prostanoid synthesis and nitric oxide production in experimental type 1-like diabetes. 2007 Aug-Sep Vascul. Pharmacol. pmid:17581795
Greenstein A et al. The role of oxygen free radicals and prostaglandins in reperfusion injury to warm ischemic kidneys. 1991 Urol. Res. pmid:1759334
Abbas NA et al. Thromboxane plasma level in kappa-carrageenin-induced acronecrosis of the tail in rats. 1991 Biomed. Biochim. Acta pmid:1759973
Jiang J et al. Endothelin-1 blockade prevents COX2 induction and TXA2 production in the fructose hypertensive rat. 2007 Mar-Apr Can. J. Physiol. Pharmacol. pmid:17612651
Otani Y et al. Effects of the COX-2 inhibitor FK3311 on ischemia - reperfusion injury in the rat lung. 2007 May-Jun J Invest Surg pmid:17613692
FitzGerald GA et al. Presystemic acetylation of platelets by aspirin: reduction in rate of drug delivery to improve biochemical selectivity for thromboxane A2. 1991 J. Pharmacol. Exp. Ther. pmid:1762060
Schulman G et al. Complement activation retards resolution of acute ischemic renal failure in the rat. 1991 Kidney Int. pmid:1762308
Basselin M et al. Chronic carbamazepine administration reduces N-methyl-D-aspartate receptor-initiated signaling via arachidonic acid in rat brain. 2007 Biol. Psychiatry pmid:17628508
Mike I et al. The differences in 12-hydroxyeicosatetraenoic acid and thromboxane B2 release from guinea pig platelets. 1991 Prostaglandins pmid:1763200
Nádasy GL et al. Role of endothelium, oxygen and ionic milieu in the prostacyclin and thromboxane production of rat aortic tissue slices. 1991 Acta Physiol Hung pmid:1763652
Chang MC et al. Hydroxychavicol, a novel betel leaf component, inhibits platelet aggregation by suppression of cyclooxygenase, thromboxane production and calcium mobilization. 2007 Br. J. Pharmacol. pmid:17641677
González-Correa JA et al. Differences in the influence of the interaction between acetylsalicylic acid and salicylic acid on platelet function in whole blood and isolated platelets: influence of neutrophils. 2007 Pharmacol. Res. pmid:17644353
Gendron ME and Thorin E A change in the redox environment and thromboxane A2 production precede endothelial dysfunction in mice. 2007 Am. J. Physiol. Heart Circ. Physiol. pmid:17644574
Gonzalez-Revalderia J et al. Usefulness of thromboxane B2 in diagnosis of renal transplant rejection. 1991 Clin. Chem. pmid:1764806
Kim YJ and Chung HY Antioxidative and anti-inflammatory actions of docosahexaenoic acid and eicosapentaenoic acid in renal epithelial cells and macrophages. 2007 J Med Food pmid:17651056
Weber AA et al. Effects of selective cyclooxygenase isoform inhibition on systemic prostacyclin synthesis and on platelet function at rest and after exercise in healthy volunteers. 2007 Platelets pmid:17654308
Bray PF et al. Heritability of platelet function in families with premature coronary artery disease. 2007 J. Thromb. Haemost. pmid:17663734
Pritze S et al. Effect of platelet-activating factor on porcine pulmonary blood vessels in vitro. 1991 Naunyn Schmiedebergs Arch. Pharmacol. pmid:1766475
Li XM et al. [Physiological effects of cold and cool Chinese herbal medicine of channel tropism of stomach on rats with stomach-heat syndrome]. 2007 Zhongguo Zhong Yao Za Zhi pmid:17672345
Shizukuda Y et al. Effect of prednisolone on myocardial infarct healing: characteristics and comparison with indomethacin. 1991 Can J Cardiol pmid:1768984
Xing X and Li H Isolated liver perfusion for regional chemotherapy in rats. 2007 HBPD INT pmid:17690035
Nocun M et al. French maritime pine bark extract Pycnogenol reduces thromboxane generation in blood from diabetic male rats. 2008 Biomed. Pharmacother. pmid:17698319
Sha JP et al. [Effect of the recombinant staphylokinase on pancreatic ischemia in severe acute pancreatitis of rats]. 2007 Zhongguo Wei Zhong Bing Ji Jiu Yi Xue pmid:17708840
Silvanto M et al. Effect of 3 g of intravenous paracetamol on post-operative analgesia, platelet function and liver enzymes in patients undergoing tonsillectomy under local anaesthesia. 2007 Acta Anaesthesiol Scand pmid:17711562
Spurney RF et al. Physiologic role for enhanced renal thromboxane production in murine lupus nephritis. 1991 Prostaglandins pmid:1771236
Morello A et al. A chemiluminescent immunoassay for urinary thromboxane B2. 1991 Prostaglandins pmid:1771240
Doube A et al. Effect of misoprostol on concentrations of prostaglandins in synovial fluid. 1991 Ann. Rheum. Dis. pmid:1772296
Park MK et al. Antiplatelet and antithrombotic activity of indole-3-carbinol in vitro and in vivo. 2008 Phytother Res pmid:17724769
Weber C et al. Production of thromboxane and prostaglandins in human blood in the presence of thromboxane synthase inhibitors: a comparison of RIA and GC/MS determinations. 1991 Blood Coagul. Fibrinolysis pmid:1773000
Huang HF and Wang M [Effects of gossypol and GnRHa on the prostaglandins contents of endometriotic cell and in situ]. 1991 Zhong Xi Yi Jie He Za Zhi pmid:1773465
Xi ZQ [Clinical application and prospect of bulbus Allii for relieving asthma]. 1991 Zhong Xi Yi Jie He Za Zhi pmid:1773477
Agren JJ et al. Fish diet and physical fitness in relation to membrane and serum lipids, prostanoid metabolism and platelet aggregation in female students. 1991 Eur J Appl Physiol Occup Physiol pmid:1773818
Neulen J et al. Arachidonic acid metabolism and prostaglandin production by primate preimplantation blastocysts. 1991 Prostaglandins pmid:1775634
Tzeng SH et al. Inhibition of platelet aggregation by some flavonoids. 1991 Thromb. Res. pmid:1776142
Louden KA et al. Platelet reactivity and serum thromboxane B2 production in whole blood in gestational hypertension and pre-eclampsia. 1991 Br J Obstet Gynaecol pmid:1777456
Pittet JF and Morel DR Imbalance between plasma levels of thromboxane B2 and 6-keto-prostaglandin F1 alpha during subacute endotoxin-induced hyperdynamic sepsis or multiple organ failure syndrome in sheep. 1991 Circ. Shock pmid:1777948
Enzan K et al. Pulmonary hemodynamic reaction to foreign blood in goats and rabbits. 1991 J. Appl. Physiol. pmid:1778918
Hidaka T et al. Arachidonate metabolism in bovine gallbladder mucosa. 1991 Kurume Med J pmid:1779599
Wang YL et al. Effect of ubiquinone on ischemic arrhythmia in conscious rats. 1991 Zhongguo Yao Li Xue Bao pmid:1781279
Zhang YL et al. [Protective action of sophoridine on acute myocardial infarction in anesthetized dogs]. 1991 Zhongguo Yao Li Xue Bao pmid:1781291
Jiang YY et al. [Effects of econazole and clotrimazole on TXB2 and PGE2 production in calcimycin-stimulated neutrophils and arachidonic acid-stimulated platelets]. 1991 Zhongguo Yao Li Xue Bao pmid:1781294
Anfossi G et al. Calcium-channel blocking agents verapamil and diltiazem are inhibitors of vasopressin-induced human platelet activation. 1991 Clin. Exp. Pharmacol. Physiol. pmid:1782723
DiChiara J et al. The effect of aspirin dosing on platelet function in diabetic and nondiabetic patients: an analysis from the aspirin-induced platelet effect (ASPECT) study. 2007 Diabetes pmid:17848625
Kalaitzis C et al. Role of eicosanoids of the contralateral kidney in maintenance of two-kidney, one-clip renovascular hypertension in rats. 2007 Scand. J. Urol. Nephrol. pmid:17853043
Mitsuhashi T et al. [Alteration of leukotriene C4 levels in experimental spinal cord injury]. 1991 Nippon Seikeigeka Gakkai Zasshi pmid:1787345
Eizayaga FX et al. Modifications produced by selective inhibitors of cyclooxygenase and ultra low dose aspirin on platelet activity in portal hypertension. 2007 World J. Gastroenterol. pmid:17876871
Sergienko AA [The content of stable forms of prostacyclin I2 and thromboxane A2 in the blood plasma in diabetic angiopathies]. 1991 Jul-Aug Probl Endokrinol (Mosk) pmid:1788186
Yokoyama Y et al. Up-regulated thromboxane production in the rat liver with biliary obstruction does not contribute to promote hepatic injury. 2008 Shock pmid:17885643
Heistein LC et al. Aspirin resistance in children with heart disease at risk for thromboembolism: prevalence and possible mechanisms. 2008 Pediatr Cardiol pmid:17896127
Sekine S et al. Lowering systolic blood pressure and increases in vasodilator levels in SHR with oral alpha-linolenic acid administration. 2007 J Oleo Sci pmid:17898500
Csanyi G et al. Lack of endothelium-derived hyperpolarizing factor (EDHF) up-regulation in endothelial dysfunction in aorta in diabetic rats. 2007 Jul-Aug Pharmacol Rep pmid:17901574
Schonwetter DJ et al. The interactive effects of Type A behavior and hostility on bleeding time thromboxane and prostacyclin formation. 1991 J Psychosom Res pmid:1791578
Ansari HR et al. Involvement of COX-1 in A3 adenosine receptor-mediated contraction through endothelium in mice aorta. 2007 Am. J. Physiol. Heart Circ. Physiol. pmid:17921329
Schwartz JI et al. Effects of etoricoxib and comparator nonsteroidal anti-inflammatory drugs on urinary sodium excretion, blood pressure, and other renal function indicators in elderly subjects consuming a controlled sodium diet. 2007 J Clin Pharmacol pmid:17925592
Holma R et al. Prophylactic potential of montelukast against mild colitis induced by dextran sulphate sodium in rats. 2007 J. Physiol. Pharmacol. pmid:17928642
Meen O et al. No case of COX-1-related aspirin resistance found in 289 patients with symptoms of stable CHD remitted for coronary angiography. 2008 Scand. J. Clin. Lab. Invest. pmid:17934975
Zhao S et al. Predominant basal directional release of thromboxane, but not prostacyclin, by placental trophoblasts from normal and preeclamptic pregnancies. 2008 Placenta pmid:17936899
Vacas MI et al. Inhibition of human platelet aggregation and thromboxane B2 production by melatonin. Correlation with plasma melatonin levels. 1991 Oct-Nov J. Pineal Res. pmid:1795222
Shushliapin OI et al. [Pharmacological correction by roxicam of the prostacyclin-thromboxane system in acute myocardial infarction complicated by heart failure]. 1991 Kardiologiia pmid:1795470
Fouke JM et al. Effects of ozone on lung mechanics and cyclooxygenase metabolites in dogs. 1991 Prostaglandins pmid:1796149
D'Orléans-Juste P et al. Different pharmacological profiles of big-endothelin-3 and big-endothelin-1 in vivo and in vitro. 1991 Br. J. Pharmacol. pmid:1797310
Suzuki S et al. Changes of plasma thromboxane level in subarachnoid haemorrhage. A study with 11-dehydro-TXB2 as measuring index. 1991 Acta Neurochir (Wien) pmid:1799160
Cheuk BL and Cheng SW Can local secretion of prostaglandin E2, thromboxane B2, and interleukin-6 play a role in ruptured abdominal aortic aneurysm? 2008 World J Surg pmid:17992560
Sun LQ et al. [Relationship between syndrome differentiation of traditional Chinese medicine and vascular endothelial function in patients with diabetic arterial occlusion of lower extremities]. 2007 Zhong Xi Yi Jie He Xue Bao pmid:17997934
Joseph S and MacDermot J Thrombin signalling in U937 human monocytic cells is coupled to inositol phosphate formation but not to thromboxane B2 synthesis nor to inhibition of adenylate cyclase: distinct differences in thrombin signalling between U937 cells and platelets. 1991 Eur. J. Pharmacol. pmid:1800126
Kawamura M et al. Enhancement of endogenous prostaglandin I2 (prostacyclin) generation in vivo by a phenolic anti-inflammatory agent in the rabbit. 1991 Jpn. J. Pharmacol. pmid:1800794
Fernandes AJ et al. Mechanisms of thrombocytopenia in the acute phase of antigen-induced arthritis in rabbits. 1991 Prostaglandins pmid:1801060
Peskar BM et al. Effects of pure enantiomers of flurbiprofen in comparison to racemic flurbiprofen on eicosanoid release from various rat organs ex vivo. 1991 Prostaglandins pmid:1801061
Torres-Duarte A and Amezcua JL Thromboxane and prostacyclin generation by human umbilical veins after thrombin. 1991 Prostaglandins pmid:1801064
Brezitskaia ON and Sedov KR [Status of the thrombocytic-vascular component of the hemostasis system in the population of the Far North]. 1991 Vestn. Akad. Med. Nauk SSSR pmid:1801462
Watanabe M et al. Effect of endothelin-3 (ET-3) on renal function in rat perfused kidney. 1991 Endocrinol. Jpn. pmid:1802684