| MeSH term | MeSH ID | Detail |
|---|---|---|
| Hypercholesterolemia | D006937 | 91 associated lipids |
| Weight Gain | D015430 | 101 associated lipids |
| Glioma | D005910 | 112 associated lipids |
| Hypertension | D006973 | 115 associated lipids |
| Inflammation | D007249 | 119 associated lipids |
| Cell Transformation, Neoplastic | D002471 | 126 associated lipids |
| Hemolysis | D006461 | 131 associated lipids |
| Carcinoma, Hepatocellular | D006528 | 140 associated lipids |
| Edema | D004487 | 152 associated lipids |
| Colonic Neoplasms | D003110 | 161 associated lipids |
Thromboxane b2
Thromboxane b2 is a lipid of Fatty Acyls (FA) class. Thromboxane b2 is associated with abnormalities such as endothelial dysfunction, Diabetes Mellitus, Non-Insulin-Dependent, Diabetes Mellitus, Ischemia and Thrombocytosis. The involved functions are known as Platelet Activation, Excretory function, Anabolism, Inflammation and mRNA Expression. Thromboxane b2 often locates in Endothelium, Hepatic and Microsomes, Liver. The associated genes with Thromboxane b2 are PTGS2 gene, prothrombin fragment 2 and CCL14 wt Allele.
Cross Reference
Introduction
To understand associated biological information of Thromboxane b2, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with Thromboxane b2?
Thromboxane b2 is suspected in endothelial dysfunction, Diabetes Mellitus, Non-Insulin-Dependent, Diabetes Mellitus, Ischemia, Thrombocytosis, Acute Coronary Syndrome and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
| Disease | Cross reference | Weighted score | Related literature |
|---|
Loading... please refresh the page if content is not showing up.
Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with Thromboxane b2
PubChem Associated disorders and diseases
What pathways are associated with Thromboxane b2
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with Thromboxane b2?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
|---|
Loading... please refresh the page if content is not showing up.
What functions are associated with Thromboxane b2?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
|---|
What lipids are associated with Thromboxane b2?
There are no associated biomedical information in the current reference collection.
What genes are associated with Thromboxane b2?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
|---|
What common seen animal models are associated with Thromboxane b2?
There are no associated biomedical information in the current reference collection.
NCBI Entrez Crosslinks
All references with Thromboxane b2
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Francois H et al. | A role for the thromboxane receptor in L-NAME hypertension. | 2008 | Am. J. Physiol. Renal Physiol. | pmid:18684890 |
| Mitsopoulos P et al. | Effectiveness of liposomal-N-acetylcysteine against LPS-induced lung injuries in rodents. | 2008 | Int J Pharm | pmid:18694812 |
| Muir AR et al. | Assessment of aspirin resistance varies on a temporal basis in patients with ischaemic heart disease. | 2009 | Heart | pmid:18697805 |
| Tanen DA et al. | Comparison of oral aspirin versus topical applied methyl salicylate for platelet inhibition. | 2008 | Ann Pharmacother | pmid:18698012 |
| Rogers LK et al. | Differential responses in the lungs of newborn mouse pups exposed to 85% or >95% oxygen. | 2009 | Pediatr. Res. | pmid:18703992 |
| Signore C et al. | Markers of oxidative stress and systemic vasoconstriction in pregnant women drinking > or =48 g of alcohol per day. | 2008 | Alcohol. Clin. Exp. Res. | pmid:18715278 |
| De Caterina R et al. | Benefit/risk profile of combined antiplatelet therapy with ticlopidine and aspirin. | 1991 | Thromb. Haemost. | pmid:1871711 |
| Pittet JF et al. | Protective effect of indomethacin in the development of the postreperfusion syndrome during liver transplantation in pigs. | 1991 | Transplant. Proc. | pmid:1871874 |
| Timmermans C et al. | Ridogrel in the setting of percutaneous transluminal coronary angioplasty. | 1991 | Am. J. Cardiol. | pmid:1872272 |
| Natarajan G et al. | Chorioamnionitis and ontogeny of circulating prostaglandin and thromboxane in preterm infants. | 2008 | Am J Perinatol | pmid:18726836 |
| Liu HY et al. | [Changes in parameters of hemorheology and circulation 6-keto-PGF1 alpha and TXB2 in dilated cardiomyopathy]. | 1991 | Zhonghua Nei Ke Za Zhi | pmid:1874088 |
| Su YC and Wang DX | Effects of cigarette smoking, hypoxia and vasoactive mediators on the production of PGI2 and TXA2 in cultured pulmonary artery endothelial cells. | 1991 | J. Tongji Med. Univ. | pmid:1875455 |
| Huntjens DR et al. | Differences in the sensitivity of behavioural measures of pain to the selectivity of cyclo-oxygenase inhibitors. | 2009 | Eur J Pain | pmid:18774319 |
| Correa JA et al. | Virgin olive oil polyphenol hydroxytyrosol acetate inhibits in vitro platelet aggregation in human whole blood: comparison with hydroxytyrosol and acetylsalicylic acid. | 2009 | Br. J. Nutr. | pmid:18775097 |
| Barnard JW et al. | Sustained effects of endothelin-1 on rabbit, dog, and rat pulmonary circulations. | 1991 | Am. J. Physiol. | pmid:1877674 |
| Hynninen VV et al. | Oral voriconazole and miconazole oral gel produce comparable effects on the pharmacokinetics and pharmacodynamics of etoricoxib. | 2009 | Eur. J. Clin. Pharmacol. | pmid:18777173 |
| Gross PL et al. | Platelet hypersensitivity in cholesterol-fed rabbits: enhancement of thromboxane A2-dependent and thrombin-induced, thromboxane A2-independent platelet responses. | 1991 | Atherosclerosis | pmid:1878012 |
| Du BY | [The effects of passive smoking on health]. | 1991 | Zhonghua Jie He He Hu Xi Za Zhi | pmid:1879020 |
| Ramos BF et al. | Mast cells are critical for the production of leukotrienes responsible for neutrophil recruitment in immune complex-induced peritonitis in mice. | 1991 | J. Immunol. | pmid:1880419 |
| Rao CV et al. | Pharmacokinetic and pharmacodynamic study of NO-donating aspirin in F344 rats. | 2008 | Int. J. Oncol. | pmid:18813794 |
| Rajec J et al. | Biochemical evaluation of the antiplatelet effect of aspirin in patients at different levels of cardiovascular risk. | 2008 | Bratisl Lek Listy | pmid:18814431 |
| RamÃrez M et al. | Effect of dietary nucleotides and orotate on the blood levels of prostacyclin (PGI2) and thromboxane (TXA2) in the weanling rat. | 1991 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:1881942 |
| Suganuma T et al. | [The effect of AH 21-132 on airway hyperresponsiveness induced by ozone exposure]. | 1991 | Arerugi | pmid:1883268 |
| Murphy CT et al. | The relationship between cytosolic Ca2+, sn-1,2-diacylglycerol and inositol 1,4,5-trisphosphate elevation in platelet-activating-factor-stimulated rabbit platelets. Influence of protein kinase C on production of signal molecules. | 1991 | Biochem. J. | pmid:1883334 |
| Hsu MF et al. | Blockade of cytosolic phospholipase A(2) and 5-lipoxygenase activation in neutrophils by a natural isoflavanquinone abruquinone A. | 2008 | Eur. J. Pharmacol. | pmid:18834875 |
| Toscano CD et al. | NMDA-induced seizure intensity is enhanced in COX-2 deficient mice. | 2008 | Neurotoxicology | pmid:18834901 |
| Eikelboom JW et al. | Incomplete inhibition of thromboxane biosynthesis by acetylsalicylic acid: determinants and effect on cardiovascular risk. | 2008 | Circulation | pmid:18838564 |
| Larson MK et al. | Effects of omega-3 acid ethyl esters and aspirin, alone and in combination, on platelet function in healthy subjects. | 2008 | Thromb. Haemost. | pmid:18841286 |
| Lin L and Nasjletti A | Role of endothelium-derived prostanoid in angiotensin-induced vasoconstriction. | 1991 | Hypertension | pmid:1885223 |
| Galbraith EA and McKellar QA | Pharmacokinetics and pharmacodynamics of piroxicam in dogs. | 1991 | Vet. Rec. | pmid:1887556 |
| Huang TF et al. | Halysin, an antiplatelet Arg-Gly-Asp-containing snake venom peptide, as fibrinogen receptor antagonist. | 1991 | Biochem. Pharmacol. | pmid:1888330 |
| Hawthorne AB et al. | Aspirin-induced gastric mucosal damage: prevention by enteric-coating and relation to prostaglandin synthesis. | 1991 | Br J Clin Pharmacol | pmid:1888645 |
| Zhao J | [Treatment of acute cerebral infarction with PGI2--evaluating the clinical effect and observation of dynamic changes in plasma TXB2 and 6-keto PGF1 alpha levels]. | 1991 | Zhonghua Shen Jing Jing Shen Ke Za Zhi | pmid:1889319 |
| Manning PJ et al. | The role of thromboxane in allergen-induced asthmatic responses. | 1991 | Eur. Respir. J. | pmid:1889493 |
| Joseph S and MacDermot J | Stimulation of U937 human monocytic cells by thrombin results in inositol trisphosphate formation and the mobilisation of intracellular Ca2+ but not the synthesis of thromboxane B2. | 1991 | Biochem. Soc. Trans. | pmid:1889682 |
| Kobayashi S | [Urinary 11-dehydro thromboxane B2 during toxemic pregnancies]. | 1991 | Nippon Sanka Fujinka Gakkai Zasshi | pmid:1890349 |
| Presser SC et al. | Simultaneous measurements of prostacyclin and thromboxane metabolites during the menstrual cycle. | 1991 | Am. J. Obstet. Gynecol. | pmid:1892191 |
| Manatt MW et al. | Studies of women eating diets with different fatty acid composition. II. Urinary eicosanoids and sodium, and blood pressure. | 1991 | J Am Coll Nutr | pmid:1894888 |
| Foudi N et al. | Selective cyclooxygenase-2 inhibition directly increases human vascular reactivity to norepinephrine during acute inflammation. | 2009 | Cardiovasc. Res. | pmid:18952694 |
| Banting A et al. | Efficacy of oral and parenteral ketoprofen in lactating cows with endotoxin-induced acute mastitis. | 2008 | Vet. Rec. | pmid:18953074 |
| Asai F et al. | In vitro antiplatelet profiles of the new thromboxane synthetase inhibitor sodium 2-(1-imidazolylmethyl)-4,5-dihydrobenzo[b]thiophene-6-carboxylate. | 1991 | Arzneimittelforschung | pmid:1898421 |
| Kapetanovic IM et al. | Comparison of pharmacokinetic and pharmacodynamic profiles of aspirin following oral gavage and diet dosing in rats. | 2009 | Chem. Biol. Interact. | pmid:18992230 |
| Klausner JM et al. | Interleukin-2-induced lung injury is mediated by oxygen free radicals. | 1991 | Surgery | pmid:1899491 |
| Ljungman AG et al. | Inhibition of cyclooxygenase metabolite production attenuates ischemia-reperfusion lung injury. | 1991 | Am. Rev. Respir. Dis. | pmid:1900402 |
| Jiang H et al. | The midnight-noon ebb-flow point selection for 30 cases of acute ischemic cerebrovascular diseases. | 2008 | J Tradit Chin Med | pmid:19004202 |
| Bui KC et al. | Plasma prostanoids in neonatal extracorporeal membrane oxygenation. Influence of meconium aspiration. | 1991 | J. Thorac. Cardiovasc. Surg. | pmid:1901122 |
| van der Zee H et al. | Thrombin-induced leukopenia and thrombocytopenia are attenuated by PAF antagonist WEB 2086. | 1991 | J. Lab. Clin. Med. | pmid:1901342 |
| Wagerle LC et al. | Effect of dexamethasone on cerebral prostanoid formation and pial arteriolar reactivity to CO2 in newborn pigs. | 1991 | Am. J. Physiol. | pmid:1901460 |
| Duda MK et al. | Fish oil, but not flaxseed oil, decreases inflammation and prevents pressure overload-induced cardiac dysfunction. | 2009 | Cardiovasc. Res. | pmid:19015135 |
| Hynninen VV et al. | Voriconazole increases while itraconazole decreases plasma meloxicam concentrations. | 2009 | Antimicrob. Agents Chemother. | pmid:19015346 |
| Ruan KH et al. | An active triple-catalytic hybrid enzyme engineered by linking cyclo-oxygenase isoform-1 to prostacyclin synthase that can constantly biosynthesize prostacyclin, the vascular protector. | 2008 | FEBS J. | pmid:19021758 |
| Parise P et al. | Generation of arachidonic acid metabolites from stimulated whole blood in patients with chronic myeloproliferative disorders. | 1991 | Acta Haematol. | pmid:1902615 |
| Wang T et al. | Synthesis of prostaglandins and thromboxane B2 by cholesterol-fed rabbits. | 1991 May-Jun | Arterioscler. Thromb. | pmid:1903062 |
| Post S et al. | Rapid increase in the activity of enzymes of eicosanoid synthesis in hepatic and extrahepatic tissues after experimental liver transplantation. | 1991 | Transplantation | pmid:1903222 |
| Yamada Y et al. | Possible mechanism of vascular reocclusion after initially successful thrombolysis with recombinant tissue-type plasminogen activator. | 1991 | Am. Heart J. | pmid:1903579 |
| Cambridge H et al. | Antithrombotic actions of aspirin in the horse. | 1991 | Equine Vet. J. | pmid:1904347 |
| Murray MJ et al. | Effects of a fish oil diet on pigs' cardiopulmonary response to bacteremia. | 1991 Mar-Apr | JPEN J Parenter Enteral Nutr | pmid:1904949 |
| Schepp W et al. | Fish oil reduces ethanol-induced damage of the duodenal mucosa in humans. | 1991 | Eur. J. Clin. Invest. | pmid:1905637 |
| Canales A et al. | Platelet aggregation, eicosanoid production and thrombogenic ratio in individuals at high cardiovascular risk consuming meat enriched in walnut paste. A crossover, placebo-controlled study. | 2009 | Br. J. Nutr. | pmid:19068151 |
| Numminen H et al. | Effects of exercise and ethanol ingestion on platelet thromboxane release in healthy men. | 1991 | Metab. Clin. Exp. | pmid:1908035 |
| Bailey SR et al. | Plasma concentrations of endotoxin and platelet activation in the developmental stage of oligofructose-induced laminitis. | 2009 | Vet. Immunol. Immunopathol. | pmid:19091426 |
| Barrow SE et al. | Reduction of LDL cholesterol by pravastatin does not influence platelet activation in patients with mild hypercholesterolaemia at risk of coronary heart disease. | 1991 | Br J Clin Pharmacol | pmid:1909541 |
| Geisel J et al. | Endotoxin-induced arachidonic acid metabolism requires de novo protein synthesis and protein kinase C activation. | 1991 | Biochim. Biophys. Acta | pmid:1909897 |
| O'Donnell ME et al. | The effects of cilostazol on exercise-induced ischaemia-reperfusion injury in patients with peripheral arterial disease. | 2009 | Eur J Vasc Endovasc Surg | pmid:19112032 |
| Lees P and Taylor PM | Pharmacodynamics and pharmacokinetics of flunixin in the cat. | 1991 Jul-Aug | Br. Vet. J. | pmid:1913126 |
| Mayer K et al. | Acute lung injury is reduced in fat-1 mice endogenously synthesizing n-3 fatty acids. | 2009 | Am. J. Respir. Crit. Care Med. | pmid:19136374 |
| Li B | [The observation of changes in plasma PGI2 and TXA2 levels and the therapeutic effect of tetramethylpyrazine in E. coli induced acute lung injury in rabbits]. | 1991 | Zhonghua Jie He He Hu Xi Za Zhi | pmid:1913959 |
| Krieger J et al. | Urinary excretion of prostanoids during sleep in obstructive sleep apnoea patients. | 1991 | Clin. Exp. Pharmacol. Physiol. | pmid:1914253 |
| Basselin M et al. | Imaging elevated brain arachidonic acid signaling in unanesthetized serotonin transporter (5-HTT)-deficient mice. | 2009 | Neuropsychopharmacology | pmid:19145225 |
| Wang A and Gu T | [The relation between coronary diseases and lipid peroxidation]. | 1991 | Zhonghua Xin Xue Guan Bing Za Zhi | pmid:1914860 |
| Kerola M et al. | Effects of nimesulide, acetylsalicylic acid, ibuprofen and nabumetone on cyclooxygenase-1- and cyclooxygenase-2-mediated prostanoid production in healthy volunteers ex vivo. | 2009 | Basic Clin. Pharmacol. Toxicol. | pmid:19152549 |
| Akagi T et al. | Salicylate treatment in Kawasaki disease: high dose or low dose? | 1991 | Eur. J. Pediatr. | pmid:1915517 |
| Giraudel JM et al. | Differential inhibition of cyclooxygenase isoenzymes in the cat by the NSAID robenacoxib. | 2009 | J. Vet. Pharmacol. Ther. | pmid:19161453 |
| Kanazawa S et al. | Effect of low-dose aspirin for skin rash associated with erlotinib therapy in patients with lung cancer. | 2009 | Platelets | pmid:19172526 |
| Calapai G et al. | Cardiovascular biomarkers in groups of established smokers after a decade of smoking. | 2009 | Basic Clin. Pharmacol. Toxicol. | pmid:19175368 |
| Goodman L et al. | Effects of firocoxib and tepoxalin on healing in a canine gastric mucosal injury model. | 2009 Jan-Feb | J. Vet. Intern. Med. | pmid:19175721 |
| Jespersen B et al. | Differential effects of immunosuppressive drugs on COX-2 activity in vitro and in kidney transplant patients in vivo. | 2009 | Nephrol. Dial. Transplant. | pmid:19193738 |
| Zhao L et al. | Low-dose oral sirolimus reduces atherogenesis, vascular inflammation and modulates plaque composition in mice lacking the LDL receptor. | 2009 | Br. J. Pharmacol. | pmid:19220291 |
| Santilli F et al. | Platelet cyclooxygenase inhibition by low-dose aspirin is not reflected consistently by platelet function assays: implications for aspirin "resistance". | 2009 | J. Am. Coll. Cardiol. | pmid:19232899 |
| Lev EI | Aspirin resistance transient laboratory finding or important clinical entity? | 2009 | J. Am. Coll. Cardiol. | pmid:19232900 |
| Bernoud-Hubac N et al. | Low concentrations of reactive gamma-ketoaldehydes prime thromboxane-dependent human platelet aggregation via p38-MAPK activation. | 2009 | Biochim. Biophys. Acta | pmid:19233311 |
| Chen SS et al. | Elevated plasma prostaglandins and acetylated histone in monocytes in Type 1 diabetes patients. | 2009 | Diabet. Med. | pmid:19236624 |
| Li L et al. | The anti-inflammatory effects of ZLJ-6, a novel dual cyclooxygenase/5-lipoxygenase inhibitor. | 2009 | Eur. J. Pharmacol. | pmid:19243697 |
| Cattaneo M et al. | In vitro effects of picotamide on human platelet aggregation, the release reaction and thromboxane B2 production. | 1991 | Thromb. Res. | pmid:1926062 |
| Domoto DT et al. | Combined aspirin and sulfinpyrazone in the prevention of recurrent hemodialysis vascular access thrombosis. | 1991 | Thromb. Res. | pmid:1926064 |
| Seelos R et al. | Prostaglandin synthesis and survival after orthotopic liver transplantation in pigs. | 1991 | Transplant. Proc. | pmid:1926413 |
| Guagnano MT et al. | Determinants of platelet activation in hypertensives with microalbuminuria. | 2009 | Free Radic. Biol. Med. | pmid:19280705 |
| Hepgül G et al. | Preventive effect of pentoxifylline on acute radiation damage via antioxidant and anti-inflammatory pathways. | 2010 | Dig. Dis. Sci. | pmid:19294507 |
| Dołegowska B et al. | Dynamics of thromboxane level changes during early phase of allograft reperfusion. | 2009 Sep-Oct | Clin Transplant | pmid:19298388 |
| Santi Cano MJ et al. | [Thrombogenic factors in the elderly. Evaluation of the plasma concentrations of thromboxane B2 and antithrombin III]. | 1991 | An Med Interna | pmid:1932488 |
| Bridges AB et al. | Circadian variation of endothelial cell function, red blood cell deformability and dehydro-thromboxane B2 in healthy volunteers. | 1991 | Blood Coagul. Fibrinolysis | pmid:1932530 |
| Ward PS et al. | Excretion of metabolites of prostacyclin and thromboxane by rats with nephrotoxic nephritis: effects of interleukin-1. | 1991 | Br. J. Pharmacol. | pmid:1933130 |
| Hynes N et al. | Leukotrienes in brain: natural occurrence and induced changes. | 1991 | Brain Res. | pmid:1933275 |
| Byrick RJ et al. | Prostanoid production and pulmonary hypertension after fat embolism are not modified by methylprednisolone. | 1991 | Can J Anaesth | pmid:1934222 |
| Montalescot G et al. | Evaluation of thromboxane production and complement activation during myocardial ischemia in patients with angina pectoris. | 1991 | Circulation | pmid:1934381 |
| Pettinella C et al. | Cyclooxygenase-1 haplotype C50T/A-842G does not affect platelet response to aspirin. | 2009 | Thromb. Haemost. | pmid:19350112 |
| Zhao HY and Fang WY | Antithrombotic effects of Andrographis paniculata nees in preventing myocardial infarction. | 1991 | Chin. Med. J. | pmid:1935360 |
| Seta F et al. | Renal and cardiovascular characterization of COX-2 knockdown mice. | 2009 | Am. J. Physiol. Regul. Integr. Comp. Physiol. | pmid:19357295 |
| Majchel AM et al. | Histamine stimulation of the nasal mucosa does not induce prostaglandin or leukotriene generation or induce methacholine hyperresponsiveness. | 1991 | Int. Arch. Allergy Appl. Immunol. | pmid:1937917 |
| Lin KC et al. | The role of aggregation of platelets in pregnancy-induced hypertension: a comprehensive and longitudinal study. | 1991 | Int. J. Cardiol. | pmid:1937968 |