| MeSH term | MeSH ID | Detail |
|---|---|---|
| Hypercholesterolemia | D006937 | 91 associated lipids |
| Weight Gain | D015430 | 101 associated lipids |
| Glioma | D005910 | 112 associated lipids |
| Hypertension | D006973 | 115 associated lipids |
| Inflammation | D007249 | 119 associated lipids |
| Cell Transformation, Neoplastic | D002471 | 126 associated lipids |
| Hemolysis | D006461 | 131 associated lipids |
| Carcinoma, Hepatocellular | D006528 | 140 associated lipids |
| Edema | D004487 | 152 associated lipids |
| Colonic Neoplasms | D003110 | 161 associated lipids |
Thromboxane b2
Thromboxane b2 is a lipid of Fatty Acyls (FA) class. Thromboxane b2 is associated with abnormalities such as endothelial dysfunction, Diabetes Mellitus, Non-Insulin-Dependent, Diabetes Mellitus, Ischemia and Thrombocytosis. The involved functions are known as Platelet Activation, Excretory function, Anabolism, Inflammation and mRNA Expression. Thromboxane b2 often locates in Endothelium, Hepatic and Microsomes, Liver. The associated genes with Thromboxane b2 are PTGS2 gene, prothrombin fragment 2 and CCL14 wt Allele.
Cross Reference
Introduction
To understand associated biological information of Thromboxane b2, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with Thromboxane b2?
Thromboxane b2 is suspected in endothelial dysfunction, Diabetes Mellitus, Non-Insulin-Dependent, Diabetes Mellitus, Ischemia, Thrombocytosis, Acute Coronary Syndrome and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
| Disease | Cross reference | Weighted score | Related literature |
|---|
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with Thromboxane b2
PubChem Associated disorders and diseases
What pathways are associated with Thromboxane b2
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with Thromboxane b2?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
|---|
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What functions are associated with Thromboxane b2?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
|---|
What lipids are associated with Thromboxane b2?
There are no associated biomedical information in the current reference collection.
What genes are associated with Thromboxane b2?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
|---|
What common seen animal models are associated with Thromboxane b2?
There are no associated biomedical information in the current reference collection.
NCBI Entrez Crosslinks
All references with Thromboxane b2
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Han P et al. | Inhibition of platelet function of antiarrhythmic drugs, verapamil and disopyramide. | 1982 | Thromb. Haemost. | pmid:7101234 |
| Miller KW and Keith JC | Effect of thromboxane synthetase inhibition on platelet function and morphology during ovine pregnancy-induced hypertension. | 1988 | Thromb. Haemost. | pmid:3238644 |
| Teng CM et al. | ADP-mimicking platelet aggregation caused by rugosin E, an ellagitannin isolated from Rosa rugosa Thunb. | 1997 | Thromb. Haemost. | pmid:9066010 |
| Santilli F et al. | Effects of high-amount-high-intensity exercise on in vivo platelet activation: modulation by lipid peroxidation and AGE/RAGE axis. | 2013 | Thromb. Haemost. | pmid:24030807 |
| Joseph S et al. | Effect of the polyamine-spermine on agonist-induced human platelet activation--specific inhibition of "aggregation-independent" events induced by thrombin, but not by collagen, thromboxane mimetic, phorbol ester or calcium ionophore. | 1987 | Thromb. Haemost. | pmid:3110996 |
| Pampolina C and McNicol A | Streptococcus sanguis-induced platelet activation involves two waves of tyrosine phosphorylation mediated by FcgammaRIIA and alphaIIbbeta3. | 2005 | Thromb. Haemost. | pmid:15886812 |
| Jilma-Stohlawetz P et al. | Impaired platelet function among platelet donors. | 2001 | Thromb. Haemost. | pmid:11583322 |
| Dejana E et al. | Bleeding time in rats: a comparison of different experimental conditions. | 1982 | Thromb. Haemost. | pmid:6753230 |
| Strano A et al. | Platelet sensitivity to prostacyclin and thromboxane production in hyperlipidemic patients. | 1982 | Thromb. Haemost. | pmid:6753232 |
| Lepäntalo A et al. | Polymorphisms of COX-1 and GPVI associate with the antiplatelet effect of aspirin in coronary artery disease patients. | 2006 | Thromb. Haemost. | pmid:16493486 |
| Carter AJ et al. | A comparison of human pulmonary arterial and venous prostacyclin and thromboxane synthesis--effect of a thromboxane synthase inhibitor. | 1984 | Thromb. Haemost. | pmid:6377567 |
| Gresele P et al. | Picotamide protects mice from death in a pulmonary embolism model by a mechanism independent from thromboxane suppression. | 1990 | Thromb. Haemost. | pmid:2274931 |
| Krishnamurthi S et al. | Effect of pyridoxal 5'-phosphate (PALP) on human platelet aggregation, dense granule release and thromboxane B2 generation--role of Schiff base formation. | 1982 | Thromb. Haemost. | pmid:6891107 |
| Essien EM et al. | Blood changes and enhanced thromboxane and 6-keto prostaglandin F1 alpha production in experimental acute Plasmodium bergei infection in hamsters. | 1984 | Thromb. Haemost. | pmid:6388013 |
| Chen SL et al. | Chlorobutanol, a preservative of desmopressin, inhibits human platelet aggregation and release in vitro. | 1990 | Thromb. Haemost. | pmid:2096493 |
| Martinuzzo ME et al. | Antiphospholipid antibodies enhance thrombin-induced platelet activation and thromboxane formation. | 1993 | Thromb. Haemost. | pmid:8115993 |
| Stratta P et al. | Warning: platelet factor 4, beta-thromboglobulin and thromboxane in donor's plasma units. | 1983 | Thromb. Haemost. | pmid:6189235 |
| Larson MK et al. | Effects of omega-3 acid ethyl esters and aspirin, alone and in combination, on platelet function in healthy subjects. | 2008 | Thromb. Haemost. | pmid:18841286 |
| Cattaneo M et al. | Human platelet aggregation and release reaction induced by platelet activating factor (PAF-acether)--effects of acetylsalicylic acid and external ionized calcium. | 1985 | Thromb. Haemost. | pmid:3927505 |
| Davì G et al. | Increased thromboxane metabolites excretion in liver cirrhosis. | 1998 | Thromb. Haemost. | pmid:9569186 |
| Sheu JR et al. | Mechanisms involved in the antiplatelet activity of Staphylococcus aureus lipoteichoic acid in human platelets. | 2000 | Thromb. Haemost. | pmid:10823277 |
| Landolfi R et al. | Effects of unfractionated and low molecular weight heparins on platelet thromboxane biosynthesis "in vivo". | 1994 | Thromb. Haemost. | pmid:7740468 |
| Homoncik M et al. | Monitoring of aspirin (ASA) pharmacodynamics with the platelet function analyzer PFA-100. | 2000 | Thromb. Haemost. | pmid:10739392 |
| Eldor A et al. | Effects of dipyrone on prostaglandin production by human platelets and cultured bovine aortic endothelial cells. | 1983 | Thromb. Haemost. | pmid:6346571 |
| Menys VC and Davies JA | Selective inhibition of thromboxane synthetase with dazoxiben - basis of its inhibitory effect on platelet adhesion. | 1983 | Thromb. Haemost. | pmid:6346575 |
| Foo LC et al. | Platelets of habitual smokers have reduced susceptibility to aggregating agent. | 1991 | Thromb. Haemost. | pmid:2048056 |
| Gordge MP et al. | Platelet function and the bleeding time in progressive renal failure. | 1988 | Thromb. Haemost. | pmid:3187950 |
| Lessiani G et al. | Inflammation, oxidative stress and platelet activation in aspirin-treated critical limb ischaemia: beneficial effects of iloprost. | 2011 | Thromb. Haemost. | pmid:21103664 |
| Turpeinen AM et al. | Replacement of dietary saturated by unsaturated fatty acids: effects of platelet protein kinase C activity, urinary content of 2,3-dinor-TXB2 and in vitro platelet aggregation in healthy man. | 1998 | Thromb. Haemost. | pmid:9798986 |
| Naesh O et al. | Platelet function in surgical stress. | 1985 | Thromb. Haemost. | pmid:2935969 |
| Michelson AD et al. | Reversible inhibition of human platelet activation by hypothermia in vivo and in vitro. | 1994 | Thromb. Haemost. | pmid:7522354 |
| Hornby EJ et al. | The inhibitory effect of GR32191, a thromboxane receptor blocking drug, on human platelet aggregation, adhesion and secretion. | 1989 | Thromb. Haemost. | pmid:2529661 |
| Bar J et al. | The regulation of platelet aggregation in vitro by interleukin-1beta and tumor necrosis factor-alpha: changes in pregnancy and in pre-eclampsia. | 1997 | Thromb. Haemost. | pmid:9364994 |
| Husted SE et al. | Intravenous acetylsalicylic acid--dose-related effects on platelet function and fibrinolysis in healthy males. | 1992 | Thromb. Haemost. | pmid:1412171 |
| Barrett PA and Butler KD | Shortening of platelet survival by induced hypercholesterolaemia in rabbits and its prolongation by anagrelide. | 1983 | Thromb. Haemost. | pmid:6648889 |
| Szczeklik A et al. | Prolonged bleeding time, reduced platelet aggregation, altered PAF-acether sensitivity and increased platelet mass are a trait of asthma and hay fever. | 1986 | Thromb. Haemost. | pmid:3563961 |
| Larsen SB et al. | Increased platelet aggregation and serum thromboxane levels in aspirin-treated patients with prior myocardial infarction. | 2012 | Thromb. Haemost. | pmid:22534977 |
| Cattaneo M et al. | Conditions influencing the interaction of asialo von Willebrand factor with human platelets--the effects of external ionized calcium concentration and the role of arachidonate pathway. | 1988 | Thromb. Haemost. | pmid:3146144 |
| De Caterina R et al. | Organic nitrates: direct antiplatelet effects and synergism with prostacyclin. Antiplatelet effects of organic nitrates. | 1988 | Thromb. Haemost. | pmid:3291182 |
| Teng CM and Ko FN | Comparison of the platelet aggregation induced by three thrombin-like enzymes of snake venoms and thrombin. | 1988 | Thromb. Haemost. | pmid:3291184 |
| Etulain J et al. | Acidosis downregulates platelet haemostatic functions and promotes neutrophil proinflammatory responses mediated by platelets. | 2012 | Thromb. Haemost. | pmid:22159527 |
| Rocca B et al. | Increased thromboxane biosynthesis in essential thrombocythemia. | 1995 | Thromb. Haemost. | pmid:8607099 |
| Spowart K et al. | Haemostatic effects of ketorolac with and without concomitant heparin in normal volunteers. | 1988 | Thromb. Haemost. | pmid:3266379 |
| Cerletti C et al. | Aspirin kinetics and inhibition of platelet thromboxane generation-relevance for a solution of the "aspirin dilemma". | 1985 | Thromb. Haemost. | pmid:4049312 |
| Aoki T et al. | Difference of (Ca2+)i movements in platelets stimulated by thrombin and TRAP: the involvement of alpha(IIb)beta3-mediated TXA2 synthesis. | 1998 | Thromb. Haemost. | pmid:9657446 |
| Larsen SB et al. | Reduced antiplatelet effect of aspirin is associated with low-grade inflammation in patients with coronary artery disease. | 2013 | Thromb. Haemost. | pmid:23407706 |
| De Caterina R et al. | Benefit/risk profile of combined antiplatelet therapy with ticlopidine and aspirin. | 1991 | Thromb. Haemost. | pmid:1871711 |
| de Boer A et al. | Interaction study between Org 10172, a low molecular weight heparinoid, and acetylsalicylic acid in healthy male volunteers. | 1991 | Thromb. Haemost. | pmid:1722918 |
| Blais N et al. | Response to aspirin in healthy individuals. Cross-comparison of light transmission aggregometry, VerifyNow system, platelet count drop, thromboelastography (TEG) and urinary 11-dehydrothromboxane B(2). | 2009 | Thromb. Haemost. | pmid:19652893 |
| Holme S et al. | The effect of albumin bound polyunsaturated fatty acids on human platelets. | 1984 | Thromb. Haemost. | pmid:6719386 |
| Carter AJ and Hanley SP | The effect of platelet number and haematocrit on whole blood thromboxane synthesis. | 1985 | Thromb. Haemost. | pmid:4024033 |
| Brox JH et al. | The effect of cod liver oil and corn oil on platelets and vessel wall in man. | 1981 | Thromb. Haemost. | pmid:7031981 |
| Strano A et al. | Thromboxane formation by platelets and platelet sensitivity to prostacyclin in patients with acute myocardial infarction. | 1981 | Thromb. Haemost. | pmid:7036402 |
| Ersöz G et al. | Effect of submaximal and incremental upper extremity exercise on platelet function and the role of blood shear stress. | 2002 | Thromb. Res. | pmid:12676189 |
| Saldeen P et al. | Increased synthesis of thromboxane B2 and 6-keto-PGF1 alpha in hand veins from patients with deep venous thrombosis. | 1983 | Thromb. Res. | pmid:6658723 |
| Bradlow BA and Chetty N | Dosage frequency for suppression of platelet function by low dose aspirin therapy. | 1982 | Thromb. Res. | pmid:7123514 |
| Buchanan MR et al. | Aspirin inhibits platelet function independent of the acetylation of cyclo-oxygenase. | 1982 | Thromb. Res. | pmid:7071811 |
| Teng CM et al. | Two antiplatelet agents from Magnolia officinalis. | 1988 | Thromb. Res. | pmid:3413728 |
| Tsuboi T et al. | Effect of gliclazide on prostaglandin and thromboxane synthesis in guinea-pig platelets. | 1981 Jan 1-15 | Thromb. Res. | pmid:7233394 |
| Hanasaki K and Arita H | Characterization of a new compound, S-145, as a specific TXA2 receptor antagonist in platelets. | 1988 | Thromb. Res. | pmid:2839912 |
| Gachályi B et al. | In vitro effect of cimetidine on ADP induced platelet aggregation and thromboxane A2 synthesis in man. | 1984 | Thromb. Res. | pmid:6474407 |
| Lages B and Weiss HJ | Inhibition of human platelet function in vitro and ex vivo by acetaminophen. | 1989 | Thromb. Res. | pmid:2499947 |
| Küster LJ et al. | Mechanism of PAF-induced platelet aggregation in man. | 1986 | Thromb. Res. | pmid:3764802 |
| Reimers HJ et al. | Impaired thromboxane synthesis in preactivated human blood platelets: agonist-specific, irreversible desensitization to thrombin. | 1987 | Thromb. Res. | pmid:3126557 |
| Ali M et al. | Synthesis of prostaglandin D2 and thromboxane B2 by human platelets. | 1977 | Thromb. Res. | pmid:918907 |
| Weide I et al. | Effects of cyclooxygenase inhibitors on ex vivo cysteinyl-leukotriene production by whole human blood allowed to clot spontaneously. Comparison to stimulated blood. | 1992 | Thromb. Res. | pmid:1440511 |
| Udvardy M et al. | Alterations of primary haemostasis in mixed connective tissue disease (MCTD). | 1991 | Thromb. Res. | pmid:1835548 |
| Marasini B et al. | Cigarette smoking and platelet function. | 1986 | Thromb. Res. | pmid:3787563 |
| Matsuo T et al. | A new thrombin inhibitor MD805 and thrombocytopenia encountered with heparin hemodialysis. | 1986 | Thromb. Res. | pmid:3787568 |
| Simmet T and Luck W | Clotting of whole human blood induces cysteinyl-leukotriene formation. | 1989 | Thromb. Res. | pmid:2549655 |
| Neiman J et al. | Composition of platelet phosphatidylinositol and phosphatidylcholine after ethanol withdrawal. | 1987 | Thromb. Res. | pmid:3603426 |
| Jørgensen KA et al. | The survival of pig to rabbit renal xenografts during inhibition of thromboxane synthesis. | 1983 | Thromb. Res. | pmid:6364449 |
| Naran NH and Chetty N | The in vitro effect of ridogrel on platelet function in normocholesterolaemic and familial hypercholesterolaemic type IIa subjects. | 1997 | Thromb. Res. | pmid:9556227 |
| Kudolo GB et al. | Effect of the ingestion of Ginkgo biloba extract on platelet aggregation and urinary prostanoid excretion in healthy and Type 2 diabetic subjects. | 2002 | Thromb. Res. | pmid:12590952 |
| Todd MH et al. | The involvement of prostaglandins and thromboxanes in the response to pulmonary embolism in anaesthetized rabbits and isolated perfused lungs. | 1983 | Thromb. Res. | pmid:6687961 |
| Dembinska-Kiec A et al. | Ticlopidine and platelet function in healthy volunteers. | 1992 | Thromb. Res. | pmid:1615496 |
| Teng CM et al. | Inhibition of thrombin- and collagen-induced phosphoinositides breakdown in rabbit platelets by a PAF antagonist--denudatin B, an isomer of kadsurenone. | 1990 | Thromb. Res. | pmid:2169076 |
| Igawa T et al. | Potentiation of anti-platelet aggregating activity of cilostazol with vascular endothelial cells. | 1990 | Thromb. Res. | pmid:2158154 |
| Thorwest M et al. | Dietary fish oil reduces microvascular thrombosis in a porcine experimental model. | 2000 | Thromb. Res. | pmid:10946095 |
| Dupin JP et al. | In vitro antiaggregant activity of paracetamol and derivatives. | 1988 | Thromb. Res. | pmid:3134743 |
| Togna GI et al. | Cisplatin triggers platelet activation. | 2000 | Thromb. Res. | pmid:10973681 |
| Vesterqvist O et al. | In vivo production of thromboxane in acute human myocardial infarction: a preliminary study. | 1985 | Thromb. Res. | pmid:3992528 |
| Chiang TM and Kang AH | The effect of platelet surface protein phosphorylation on collagen-platelet interaction. | 1986 | Thromb. Res. | pmid:3810565 |
| Kelton JG et al. | A study of the bioavailability and platelet inhibitory effects of a new enteric-coated acetylsalicylic acid preparation. | 1984 | Thromb. Res. | pmid:6740573 |
| Weide I et al. | Intravascular cysteinyl-leukotriene formation by clotting whole human blood. Evidence from clamped umbilical vein segments and thrombus specimens. | 1993 | Thromb. Res. | pmid:8122190 |
| Grimm LJ et al. | Inhibition of platelet thromboxane synthesis by 7-(1-imidazolyl) heptanoic acid: dissociation from inhibition of aggregation. | 1981 | Thromb. Res. | pmid:6801806 |
| Uyama O et al. | Plasma concentrations of 6-keto-prostaglandin F1 alpha in patients with hypertension, cerebrovascular disease or Takayasu's arteritis. | 1982 Jan 1-15 | Thromb. Res. | pmid:6121391 |
| Voss R et al. | In vitro and ex vivo effects of aspirin in patients on a low-dose aspirin therapy. | 1993 | Thromb. Res. | pmid:8122187 |
| Hashizume T et al. | Vinblastine inhibits platelet aggregation by a microtubule-independent mechanism, probably by its perturbing action on the plasma membrane. | 1988 | Thromb. Res. | pmid:3135636 |
| Chou TC et al. | The inhibitory effect of 2-thienyl 2'-hydroxyphenyl ketone (C85) on platelet thromboxane formation. | 1996 | Thromb. Res. | pmid:8897698 |
| Preston FE et al. | Low-dose aspirin inhibits platelet and venous cyclo-oxygenase in man. | 1982 | Thromb. Res. | pmid:6815823 |
| Bergqvist D et al. | The effect of inhibition of thromboxane synthesis in experimental thrombosis and hemostasis. | 1985 | Thromb. Res. | pmid:3838828 |
| De La Cruz JP et al. | Effect of DT-TX 30, a combined thromboxane synthase inhibitor and thromboxane receptor antagonist, on retinal vascularity in experimental diabetes mellitus. | 2000 | Thromb. Res. | pmid:10680643 |
| Domoto DT et al. | Combined aspirin and sulfinpyrazone in the prevention of recurrent hemodialysis vascular access thrombosis. | 1991 | Thromb. Res. | pmid:1926064 |
| Shatoor AS et al. | Effect of Hawthorn (Crataegus aronia syn. Azarolus (L)) on platelet function in albino Wistar rats. | 2012 | Thromb. Res. | pmid:22261477 |
| Küster LJ and Frölich JC | PAF-induced platelet aggregation and TXB2 formation. | 1989 | Thromb. Res. | pmid:2922704 |
| Zahavi M et al. | Enhanced platelet release reaction and increased thromboxane generation in esophageal achalasia and selective in vitro inhibition of arachidonic acid induced platelet aggregation by vasoactive intestinal peptide. | 1990 | Thromb. Res. | pmid:2146767 |
| Grignani G et al. | Activation of platelet prostaglandin biosynthesis pathway during neoplastic cell-induced platelet aggregation. | 1984 | Thromb. Res. | pmid:6729776 |
| Patterson WR et al. | Aggregation of killer whale platelets. | 1993 | Thromb. Res. | pmid:8327987 |
| Barbieri B et al. | p-Aminobenzoic acid, but not its metabolite p-acetamidobenzoic acid, inhibits thrombin induced thromboxane formation in human platelets in a non NSAID like manner. | 1997 | Thromb. Res. | pmid:9175234 |