Thromboxane b2

Thromboxane b2 is a lipid of Fatty Acyls (FA) class. Thromboxane b2 is associated with abnormalities such as endothelial dysfunction, Diabetes Mellitus, Non-Insulin-Dependent, Diabetes Mellitus, Ischemia and Thrombocytosis. The involved functions are known as Platelet Activation, Excretory function, Anabolism, Inflammation and mRNA Expression. Thromboxane b2 often locates in Endothelium, Hepatic and Microsomes, Liver. The associated genes with Thromboxane b2 are PTGS2 gene, prothrombin fragment 2 and CCL14 wt Allele.

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Introduction

To understand associated biological information of Thromboxane b2, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.

What diseases are associated with Thromboxane b2?

Thromboxane b2 is suspected in endothelial dysfunction, Diabetes Mellitus, Non-Insulin-Dependent, Diabetes Mellitus, Ischemia, Thrombocytosis, Acute Coronary Syndrome and other diseases in descending order of the highest number of associated sentences.

Related references are mostly published in these journals:

Disease Cross reference Weighted score Related literature
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Possible diseases from mapped MeSH terms on references

We collected disease MeSH terms mapped to the references associated with Thromboxane b2

MeSH term MeSH ID Detail
Osteoblastoma D018215 1 associated lipids
Erythromelalgia D004916 1 associated lipids
Fibromuscular Dysplasia D005352 2 associated lipids
Atrial Premature Complexes D018880 1 associated lipids
Latex Hypersensitivity D020315 1 associated lipids
Drowning D004332 2 associated lipids
Jejunal Diseases D007579 3 associated lipids
Basal Ganglia Hemorrhage D020145 1 associated lipids
Radiculopathy D011843 1 associated lipids
Intracranial Hemorrhage, Hypertensive D020299 1 associated lipids
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PubChem Associated disorders and diseases

What pathways are associated with Thromboxane b2

There are no associated biomedical information in the current reference collection.

PubChem Biomolecular Interactions and Pathways

Link to PubChem Biomolecular Interactions and Pathways

What cellular locations are associated with Thromboxane b2?

Related references are published most in these journals:

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What functions are associated with Thromboxane b2?


Related references are published most in these journals:

Function Cross reference Weighted score Related literatures

What lipids are associated with Thromboxane b2?

There are no associated biomedical information in the current reference collection.

What genes are associated with Thromboxane b2?

Related references are published most in these journals:


Gene Cross reference Weighted score Related literatures

What common seen animal models are associated with Thromboxane b2?

There are no associated biomedical information in the current reference collection.

NCBI Entrez Crosslinks

All references with Thromboxane b2

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Authors Title Published Journal PubMed Link
Henriksson P et al. In vivo production of prostacyclin and thromboxane in patients with acute myocardial infarction. 1986 Br Heart J pmid:3521690
Adatia I et al. Abnormalities in the biosynthesis of thromboxane A2 and prostacyclin in children with cyanotic congenital heart disease. 1993 Br Heart J pmid:8435245
Adatia I et al. Effect of intracardiac repair on biosynthesis of thromboxane A2 and prostacyclin in children with a left to right shunt. 1994 Br Heart J pmid:7818962
Rasmanis G et al. Evidence of increased platelet activation after thrombolysis in patients with acute myocardial infarction. 1992 Br Heart J pmid:1449919
Neiman J Association of transient ischaemic attack in alcohol withdrawal with changes in haemostasis. 1988 Br J Addict pmid:3233412
Barbara J et al. Prevention of latex sensitization in guinea pigs by a bacterial and viral filter used in anaesthesia. 2005 Br J Anaesth pmid:15980041
Khazam A et al. Enhanced thromboxane synthesis with extradural anaesthesia. 1990 Br J Anaesth pmid:2317426
Munsterhjelm E et al. Influence on platelet aggregation of i.v. parecoxib and acetaminophen in healthy volunteers. 2006 Br J Anaesth pmid:16698862
Schweizer A et al. Aprotinin does not impair renal haemodynamics and function after cardiac surgery. 2000 Br J Anaesth pmid:10740541
Bellamy MC et al. Changes in inflammatory mediators during orthotopic liver transplantation. 1997 Br J Anaesth pmid:9389852
Schilling MK et al. Role of thromboxane and leukotriene B4 in patients with acute respiratory distress syndrome after oesophagectomy. 1998 Br J Anaesth pmid:9505775
Oelkers R et al. Disposition and effects of flurbiprofen enantiomers in human serum and blister fluid. 1997 Br J Clin Pharmacol pmid:9131946
Kirchheiner J et al. Pharmacokinetics of diclofenac and inhibition of cyclooxygenases 1 and 2: no relationship to the CYP2C9 genetic polymorphism in humans. 2003 Br J Clin Pharmacol pmid:12534640
Hayball PJ et al. The influence of renal function on the enantioselective pharmacokinetics and pharmacodynamics of ketoprofen in patients with rheumatoid arthritis. 1993 Br J Clin Pharmacol pmid:9114902
Rosenkranz B et al. Effects of salicylic and acetylsalicylic acid alone and in combination on platelet aggregation and prostanoid synthesis in man. 1986 Br J Clin Pharmacol pmid:3083851
Salvetti A et al. The influence of indomethacin and sulindac on some pharmacological actions of atenolol in hypertensive patients. 1984 Br J Clin Pharmacol pmid:6378233
Ferry N et al. Influence of renal insufficiency on the pharmacokinetics of cicletanine and its effects on the urinary excretion of electrolytes and prostanoids. 1988 Br J Clin Pharmacol pmid:3358898
Nieminen MM et al. Inhaled budesonide fails to inhibit the PAF-induced increase in plasma leukotriene B4 in man. 1992 Br J Clin Pharmacol pmid:1327049
Harlan J et al. Selective inhibition of thromboxane synthesis during experimental endotoxemia in the goat: effects on pulmonary haemodynamics and lung lymph flow. 1983 Br J Clin Pharmacol pmid:6337602
Ball HA et al. Effect of dazoxiben, a specific inhibitor of thromboxane synthetase, on acute pulmonary responses to E. coli endotoxin in anaesthetized cats. 1983 Br J Clin Pharmacol pmid:6337603
Dodd NJ et al. Use of a thromboxane synthetase inhibitor, dazoxiben, during haemodialysis. 1983 Br J Clin Pharmacol pmid:6337605
Pallapies D et al. Effects on platelet functions and pharmacokinetics of azapropazone and ketorolac tromethamine given as single parenteral doses. 1994 Br J Clin Pharmacol pmid:8018454
Parry MJ Effects of thromboxane synthetase inhibition on arachidonate metabolism and platelet behaviour. 1983 Br J Clin Pharmacol pmid:6401997
Kiff PS et al. Haemodynamic and metabolic effects of dazoxiben at rest and during atrial pacing. 1983 Br J Clin Pharmacol pmid:6681708
Hutton I et al. Effects of dazoxiben on transcardiac thromboxane levels and haemodynamics in coronary heart disease. 1983 Br J Clin Pharmacol pmid:6681709
Hawthorne AB et al. Aspirin-induced gastric mucosal damage: prevention by enteric-coating and relation to prostaglandin synthesis. 1991 Br J Clin Pharmacol pmid:1888645
Randall MJ and Wilding RI Acute arterial thrombosis in rabbits: reduced platelet accumulation after treatment with dazoxiben hydrochloride (UK 37,248-01). 1983 Br J Clin Pharmacol pmid:6687429
Shephard EG et al. Lung function and plasma levels of thromboxane B2, 6-ketoprostaglandin F1 alpha and beta-thromboglobulin in antigen-induced asthma before and after indomethacin pretreatment. 1985 Br J Clin Pharmacol pmid:2581599
Wallén NH et al. Effects of treatment with oral isosorbide dinitrate on platelet function in vivo; a double-blind placebo-controlled study in patients with stable angina pectoris. 1994 Br J Clin Pharmacol pmid:7946939
Villanueva M et al. Equipotent inhibition by R(-)-, S(+)- and racemic ibuprofen of human polymorphonuclear cell function in vitro. 1993 Br J Clin Pharmacol pmid:8385973
Barrow SE et al. Reduction of LDL cholesterol by pravastatin does not influence platelet activation in patients with mild hypercholesterolaemia at risk of coronary heart disease. 1991 Br J Clin Pharmacol pmid:1909541
van Kraaij DJ et al. A comparison of the effects of nabumetone vs meloxicam on serum thromboxane B2 and platelet function in healthy volunteers. 2002 Br J Clin Pharmacol pmid:12047490
Brown N et al. Comparison of antiplatelet activity of microencapsulated aspirin 162.5 Mg (Caspac XL), with enteric coated aspirin 75 mg and 150 mg in patients with atherosclerosis. 1999 Br J Clin Pharmacol pmid:10383561
Reuben SR et al. Effects of dazoxiben on exercise performance in chronic stable angina. 1983 Br J Clin Pharmacol pmid:6402000
Floyd CN et al. Increased platelet expression of glycoprotein IIIa following aspirin treatment in aspirin-resistant but not aspirin-sensitive subjects. 2014 Br J Clin Pharmacol pmid:25099258
Ritter JM et al. Differential effect of aspirin on thromboxane and prostaglandin biosynthesis in man. 1989 Br J Clin Pharmacol pmid:2590611
Shinkai Y and Cameron JS Trial of platelet-derived growth factor antagonist, trapidil, in accelerated nephrotoxic nephritis in the rabbit. 1987 Br J Exp Pathol pmid:3480754
Tissot M et al. Prostanoid release by macrophages at a distance from an inflammatory site. 1989 Br J Exp Pathol pmid:2818931
Rousselle MA et al. Effect of alkali treatment on physiological activity of cotton condensed tannin. 1990 Br J Ind Med pmid:2223662
Mitchell MD et al. Thromboxane B2 in amniotic fluid before and during labour. 1978 Br J Obstet Gynaecol pmid:656348
Roy AC et al. Thromboxane A2 and prostacyclin levels in molar pregnancy. 1984 Br J Obstet Gynaecol pmid:6383461
Smith AJ et al. Hypertensive and normal pregnancy: a longitudinal study of blood pressure, distensibility of dorsal hand veins and the ratio of the stable metabolites of thromboxane A2 and prostacyclin in plasma. 1995 Br J Obstet Gynaecol pmid:8534627
Ylikorkala O et al. Effect of vacuum curettage on the concentrations of plasma 6-keto-prostaglandin F1 alpha and serum thromboxane B2. 1983 Br J Obstet Gynaecol pmid:6338904
Louden KA et al. Neonatal platelet reactivity and serum thromboxane B2 production in whole blood: the effect of maternal low dose aspirin. 1994 Br J Obstet Gynaecol pmid:8193093
Greer IA et al. Immunoreactive prostacyclin and thromboxane metabolites in normal pregnancy and the puerperium. 1985 Br J Obstet Gynaecol pmid:3890936
Benedetto C et al. Production of prostacyclin, 6-keto-PGF1 alpha and thromboxane B2 by human umbilical vessels increases from the placenta towards the fetus. 1987 Br J Obstet Gynaecol pmid:3322374
Kilby MD Neonatal platelet reactivity and serum thromboxane B2 production in whole blood: the effect of maternal low dose aspirin and platelet activation in normotensive and hypertensive pregnancies complicated by intrauterine growth retardation. 1994 Br J Obstet Gynaecol pmid:7864999
McCowan LM et al. Administration of low-dose aspirin to mothers with small for gestational age fetuses and abnormal umbilical Doppler studies to increase birthweight: a randomised double-blind controlled trial. 1999 Br J Obstet Gynaecol pmid:10428519
Louden KA et al. Platelet reactivity and serum thromboxane B2 production in whole blood in gestational hypertension and pre-eclampsia. 1991 Br J Obstet Gynaecol pmid:1777456
Ahmed Y et al. Increased platelet turnover in a patient with previous recurrent pre-eclampsia and failure of aspirin therapy. Case report. 1991 Br J Obstet Gynaecol pmid:2004060
Kohout M et al. Cool perfusion solutions for skin flaps: a new mixture of pharmacological agents which improves skin flap viability. 1995 Br J Plast Surg pmid:7735675
Murphy RC et al. Surgical delay and arachidonic acid metabolites: evidence for an inflammatory mechanism: an experimental study in rats. 1985 Br J Plast Surg pmid:3921087
Blann AD et al. Changes in endothelial, leucocyte and platelet markers following contrast medium injection during angiography in patients with peripheral artery disease. 2001 Br J Radiol pmid:11560828
Barry MC et al. Immunological and physiological responses to aortic surgery: effect of reperfusion on neutrophil and monocyte activation and pulmonary function. 1997 Br J Surg pmid:9112905
Fletcher MS et al. Endotoxin, prostaglandins and renal fibrin deposition in obstructive jaundice. 1982 Br J Surg pmid:6751458
Webb PJ et al. Do prostacyclin and thromboxane play a role in endotoxic shock? 1981 Br J Surg pmid:7025959
Wilkinson D et al. Plasma eicosanoids, platelet function and cold sensitivity. 1989 Br J Surg pmid:2720355
Edwards AT et al. Systemic responses in patients with intermittent claudication after treadmill exercise. 1994 Br J Surg pmid:7827927
Yamaga H et al. Platelet aggregability after endoscopic intravariceal injection of 5 per cent ethanolamine oleate into oesophageal varices. 1989 Br J Surg pmid:2804591
Horgan PG et al. Extracorporeal shock wave lithotripsy induces the release of prostaglandins which increase ureteric peristalsis. 1993 Br J Urol pmid:8343888
Zwergel U et al. Eicosanoid synthesis in the isolated human renal pelvis, ureter and bladder. 1991 Br J Urol pmid:2021808
Ylikorkala O and Viinikka L Thromboxane A2 in pregnancy and puerperium. 1980 Br Med J pmid:7448530
Reilly IA et al. Biosynthesis of thromboxane in patients with systemic sclerosis and Raynaud's phenomenon. 1986 Br Med J (Clin Res Ed) pmid:3083991
Mikhailidis DP et al. Platelet function defects in chronic alcoholism. 1986 Br Med J (Clin Res Ed) pmid:3094624
Ylikorkala O et al. Prostacyclin and thromboxane in diabetes. 1981 Br Med J (Clin Res Ed) pmid:6794795
Lee SH et al. Prostacyclin and thromboxane A2 in thrombotic thrombocytopenic purpura. 1981 Br Med J (Clin Res Ed) pmid:6797537
Bennett A et al. Cancer in mice: effects of prednisolone or mepacrine alone and with cytotoxic drugs. 1987 Br. J. Cancer pmid:3580263
Aitokallio-Tallberg A et al. Urinary excretion of prostacyclin and thromboxane degradation products in patients with ovarian malignancy: effect of cytostatic treatment. 1989 Br. J. Cancer pmid:2803956
Laekeman GM et al. Prostacyclin and thromboxane in benign and malignant breast tumours. 1986 Br. J. Cancer pmid:3530307
Aitokallio-Tallberg A et al. Prostacyclin and thromboxane in breast cancer: relationship between steroid receptor status and medroxyprogesterone acetate. 1985 Br. J. Cancer pmid:2986666
Stamford IF et al. Survival of mice with NC carcinoma is unchanged by drugs that are thought to inhibit thromboxane synthesis or increase prostacyclin formation. 1986 Br. J. Cancer pmid:3755610
Karmali RA et al. Prostaglandins in breast cancer: relationship to disease stage and hormone status. 1983 Br. J. Cancer pmid:6416285
Izaki S et al. Platelet-activating factor and arachidonic acid metabolites in psoriatic inflammation. 1996 Br. J. Dermatol. pmid:8763425
Schalin-Karrila M et al. Evening primrose oil in the treatment of atopic eczema: effect on clinical status, plasma phospholipid fatty acids and circulating blood prostaglandins. 1987 Br. J. Dermatol. pmid:3307886
Maurice PD et al. The effects of dietary supplementation with fish oil in patients with psoriasis. 1987 Br. J. Dermatol. pmid:3689678
Cartwright IJ et al. A haemorrhagic platelet disorder associated with altered stimulus-response coupling and abnormal membrane phospholipid composition. 1994 Br. J. Haematol. pmid:7803235
Dragani A et al. Clinical and laboratory phenotype associated with the aspirin-like defect. 2010 Br. J. Haematol. pmid:19814736
Sheu JR et al. Mechanisms involved in the antiplatelet activity of Escherichia coli lipopolysaccharide in human platelets. 1998 Br. J. Haematol. pmid:9792285
Martinuzzo ME et al. Increased lipid peroxidation correlates with platelet activation but not with markers of endothelial cell and blood coagulation activation in patients with antiphospholipid antibodies. 2001 Br. J. Haematol. pmid:11564073
Kurantsin-Mills J et al. Elevated urinary levels of thromboxane and prostacyclin metabolities in sickle cell disease reflects activated platelets in the circulation. 1994 Br. J. Haematol. pmid:7993800
Lages B and Weiss HJ Heterogeneous defects of platelet secretion and responses to weak agonists in patients with bleeding disorders. 1988 Br. J. Haematol. pmid:3345296
Borowska A et al. Impairment of primary haemostasis by low molecular weight heparins in rats. 1988 Br. J. Haematol. pmid:3355792
Chong BH et al. Heparin-induced thrombocytopenia: effect of heparin platelet antibody on platelets. 1981 Br. J. Haematol. pmid:7317283
Walker ID et al. A double blind study of prostacyclin in cardiopulmonary bypass surgery. 1981 Br. J. Haematol. pmid:6457624
Dullemond-Westland AC et al. Cryopreservation disturbs stimulus-response coupling in a platelet subpopulation. 1987 Br. J. Haematol. pmid:3689695
van Prooijen HC et al. Evaluation of a new UVB source for irradiation of platelet concentrates. 1990 Br. J. Haematol. pmid:2145030
Jakubowski JA et al. Arachidonic acid metabolism by platelets of differing size. 1983 Br. J. Haematol. pmid:6402003
Lagarde M et al. Impairment of platelet thromboxane A2 generation and of the platelet release reaction in two patients with congenital deficiency of platelet cyclo-oxygenase. 1978 Br. J. Haematol. pmid:205238
Kaaja R et al. Increased thromboxane production in women with a history of venous thromboembolic event: effect of heparins. 2001 Br. J. Haematol. pmid:11552994
Jandrot-Perrus M et al. The common pathway for alpha- and gamma-thrombin-induced platelet activation is independent of GPIb: a study of Bernard-Soulier platelets. 1990 Br. J. Haematol. pmid:2167123
Dubé JN et al. Characterization of a partial prostaglandin endoperoxide H synthase-1 deficiency in a patient with a bleeding disorder. 2001 Br. J. Haematol. pmid:11442478
Dejana E et al. Impaired thromboxane production by newly formed platelets after aspirin administration to thrombocytopenic rats. 1980 Br. J. Haematol. pmid:7448129
Low-dose aspirin in polycythaemia vera: a pilot study. Gruppo Italiano Studio Policitemia (GISP). 1997 Br. J. Haematol. pmid:9163613
Pan IQ et al. Alteration of platelet responses to metabolites of arachidonic acid by oral contraceptives. 1984 Br. J. Haematol. pmid:6089860
Michelson AD et al. The effects of aspirin and hypothermia on platelet function in vivo. 1999 Br. J. Haematol. pmid:10027713
van Genderen PJ et al. Thromboxane-dependent platelet activation in vivo precedes arterial thrombosis in thrombocythaemia: a rationale for the use of low-dose aspirin as an antithrombotic agent. 1999 Br. J. Haematol. pmid:10086775
Hornby EJ et al. Activation of human platelets by exposure to a monoclonal antibody, PM6/248, to glycoprotein IIb-IIIa. 1991 Br. J. Haematol. pmid:1958486
Faili A et al. Dissociation between the phospholipases C and A2 activities in stimulated platelets and their involvement in the arachidonic acid liberation. 1994 Br. J. Haematol. pmid:7803237
Waring P et al. The effects of leukaemia inhibitory factor on platelet function. 1993 Br. J. Haematol. pmid:8435339
Rousson D et al. Increased in vivo biosynthesis of prostacyclin and thromboxane A2 in chronic idiopathic thrombocytopenic purpura. 1989 Br. J. Haematol. pmid:2669929