Thromboxane b2 is a lipid of Fatty Acyls (FA) class. Thromboxane b2 is associated with abnormalities such as endothelial dysfunction, Diabetes Mellitus, Non-Insulin-Dependent, Diabetes Mellitus, Ischemia and Thrombocytosis. The involved functions are known as Platelet Activation, Excretory function, Anabolism, Inflammation and mRNA Expression. Thromboxane b2 often locates in Endothelium, Hepatic and Microsomes, Liver. The associated genes with Thromboxane b2 are PTGS2 gene, prothrombin fragment 2 and CCL14 wt Allele.
To understand associated biological information of Thromboxane b2, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
Thromboxane b2 is suspected in endothelial dysfunction, Diabetes Mellitus, Non-Insulin-Dependent, Diabetes Mellitus, Ischemia, Thrombocytosis, Acute Coronary Syndrome and other diseases in descending order of the highest number of associated sentences.
Disease | Cross reference | Weighted score | Related literature |
---|
We collected disease MeSH terms mapped to the references associated with Thromboxane b2
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
Location | Cross reference | Weighted score | Related literatures |
---|
Function | Cross reference | Weighted score | Related literatures |
---|
There are no associated biomedical information in the current reference collection.
Gene | Cross reference | Weighted score | Related literatures |
---|
There are no associated biomedical information in the current reference collection.
Authors | Title | Published | Journal | PubMed Link |
---|---|---|---|---|
Krausz MM et al. | Adverse effects of prostacyclin used to perfuse isolated lung lobes. | 1982 | Am. J. Physiol. | pmid:7044149 |
Düsing R et al. | Dietary linoleic acid deprivation: effects on blood pressure and PGI2 synthesis. | 1983 | Am. J. Physiol. | pmid:6337507 |
Dobner P and Engelmann B | Low-density lipoproteins supply phospholipid-bound arachidonic acid for platelet eicosanoid production. | 1998 | Am. J. Physiol. | pmid:9814996 |
Perlman MB et al. | Ibuprofen prevents thrombin-induced lung vascular injury: mechanism of effect. | 1987 | Am. J. Physiol. | pmid:3030141 |
Scharschmidt LA et al. | Angiotensin II and eicosanoids in the control of glomerular size in the rat and human. | 1986 | Am. J. Physiol. | pmid:2936254 |
Wagerle LC et al. | Effect of dexamethasone on cerebral prostanoid formation and pial arteriolar reactivity to CO2 in newborn pigs. | 1991 | Am. J. Physiol. | pmid:1901460 |
Ahlquist DA et al. | Factors influencing metabolism of arachidonic acid in guinea pig gastric mucosa. | 1983 | Am. J. Physiol. | pmid:6401937 |
Klotman PE et al. | Thromboxane synthetase inhibition improves function of hydronephrotic rat kidneys. | 1986 | Am. J. Physiol. | pmid:3456211 |
Martin SE et al. | Neuropeptide Y and coronary vasoconstriction: role of thromboxane A2. | 1992 | Am. J. Physiol. | pmid:1415751 |
Cohen RA et al. | 5-Hydroxytryptamine can mediate endothelium-dependent relaxation of coronary arteries. | 1983 | Am. J. Physiol. | pmid:6660308 |
Gyenes M and De Groot H | Prostanoid release by Kupffer cells upon hypoxia-reoxygenation: role of pHi and Cai2+. | 1993 | Am. J. Physiol. | pmid:8384798 |
Brown GP and Venuto RC | In vitro renal eicosanoid production during pregnancy in rabbits. | 1988 | Am. J. Physiol. | pmid:3287949 |
Prosdocimi M et al. | Coronary and systemic 6-ketoprostaglandin F1 alpha and thromboxane B2 during myocardial ischemia in dog. | 1985 | Am. J. Physiol. | pmid:3838623 |
Farman N et al. | PGE2, PGF2 alpha, 6-keto-PGF1 alpha, and TxB2 synthesis along the rabbit nephron. | 1987 | Am. J. Physiol. | pmid:3101513 |
Yokoyama Y et al. | Role of thromboxane in producing portal hypertension following trauma-hemorrhage. | 2003 | Am. J. Physiol. Gastrointest. Liver Physiol. | pmid:14613921 |
Yokoyama Y et al. | Role of thromboxane A2 in early BDL-induced portal hypertension. | 2003 | Am. J. Physiol. Gastrointest. Liver Physiol. | pmid:12431905 |
Yang YY et al. | Roles of anandamide in the hepatic microcirculation in cirrhotic rats. | 2006 | Am. J. Physiol. Gastrointest. Liver Physiol. | pmid:16407591 |
Tanigawa T et al. | Anti-inflammatory effect of two isoforms of COX in H. pylori-induced gastritis in mice: possible involvement of PGE2. | 2004 | Am. J. Physiol. Gastrointest. Liver Physiol. | pmid:12958020 |
Kleinbongard P et al. | Aspirate from human stented native coronary arteries vs. saphenous vein grafts: more endothelin but less particulate debris. | 2013 | Am. J. Physiol. Heart Circ. Physiol. | pmid:23934849 |
Chen L et al. | Cyclooxygenase inhibitor blocks rebound response after NO inhalation in an endotoxin model. | 2003 | Am. J. Physiol. Heart Circ. Physiol. | pmid:12485821 |
Lombard JH et al. | High-salt diet impairs vascular relaxation mechanisms in rat middle cerebral arteries. | 2003 | Am. J. Physiol. Heart Circ. Physiol. | pmid:12456391 |
Ansari HR et al. | Involvement of COX-1 in A3 adenosine receptor-mediated contraction through endothelium in mice aorta. | 2007 | Am. J. Physiol. Heart Circ. Physiol. | pmid:17921329 |
Saito Y et al. | Disruption of group IVA cytosolic phospholipase A(2) attenuates myocardial ischemia-reperfusion injury partly through inhibition of TNF-α-mediated pathway. | 2012 | Am. J. Physiol. Heart Circ. Physiol. | pmid:22427514 |
Gendron ME and Thorin E | A change in the redox environment and thromboxane A2 production precede endothelial dysfunction in mice. | 2007 | Am. J. Physiol. Heart Circ. Physiol. | pmid:17644574 |
Stephenson AH et al. | Differential effects of 5,6-EET on segmental pulmonary vasoactivity in the rabbit. | 2003 | Am. J. Physiol. Heart Circ. Physiol. | pmid:12609822 |
Momen A et al. | Local prostaglandin blockade attenuates muscle mechanoreflex-mediated renal vasoconstriction during muscle stretch in humans. | 2008 | Am. J. Physiol. Heart Circ. Physiol. | pmid:18326807 |
Cui J et al. | Cyclooxygenase inhibition attenuates sympathetic responses to muscle stretch in humans. | 2008 | Am. J. Physiol. Heart Circ. Physiol. | pmid:18441194 |
Muscará MN et al. | Antihypertensive properties of a nitric oxide-releasing naproxen derivative in two-kidney, one-clip rats. | 2000 | Am. J. Physiol. Heart Circ. Physiol. | pmid:10924050 |
Drew RC et al. | Healthy older humans exhibit augmented carotid-cardiac baroreflex sensitivity with aspirin during muscle mechanoreflex and metaboreflex activation. | 2015 | Am. J. Physiol. Heart Circ. Physiol. | pmid:26371168 |
Jones AE et al. | Inhibition of prostaglandin synthesis during polystyrene microsphere-induced pulmonary embolism in the rat. | 2003 | Am. J. Physiol. Lung Cell Mol. Physiol. | pmid:12639842 |
Fike CD et al. | Arachidonic acid metabolites and an early stage of pulmonary hypertension in chronically hypoxic newborn pigs. | 2003 | Am. J. Physiol. Lung Cell Mol. Physiol. | pmid:12388340 |
Shinohara M et al. | Cell-cell interactions and bronchoconstrictor eicosanoid reduction with inhaled carbon monoxide and resolvin D1. | 2014 | Am. J. Physiol. Lung Cell Mol. Physiol. | pmid:25217660 |
Nagase T et al. | A potent inhibitor of cytosolic phospholipase A2, arachidonyl trifluoromethyl ketone, attenuates LPS-induced lung injury in mice. | 2003 | Am. J. Physiol. Lung Cell Mol. Physiol. | pmid:12505870 |
Suliman HB et al. | Prevention of influenza-induced lung injury in mice overexpressing extracellular superoxide dismutase. | 2001 | Am. J. Physiol. Lung Cell Mol. Physiol. | pmid:11133496 |
Nørregaard R et al. | Urinary tract obstruction induces transient accumulation of COX-2-derived prostanoids in kidney tissue. | 2010 | Am. J. Physiol. Regul. Integr. Comp. Physiol. | pmid:20147610 |
Venuto R et al. | Enhanced vascular effects of the Ca(2+) channel agonist Bay K 8644 in pregnant rabbits. | 2002 | Am. J. Physiol. Regul. Integr. Comp. Physiol. | pmid:11893597 |
Yan Q et al. | Female ROMK null mice manifest more severe Bartter II phenotype on renal function and higher PGE2 production. | 2008 | Am. J. Physiol. Regul. Integr. Comp. Physiol. | pmid:18579648 |
Seta F et al. | Renal and cardiovascular characterization of COX-2 knockdown mice. | 2009 | Am. J. Physiol. Regul. Integr. Comp. Physiol. | pmid:19357295 |
Hou X et al. | Increased platelet-activating factor-induced periventricular brain microvascular constriction associated with immaturity. | 2003 | Am. J. Physiol. Regul. Integr. Comp. Physiol. | pmid:12626359 |
Salazar F et al. | Renal effects induced by prolonged mPGES1 inhibition. | 2014 | Am. J. Physiol. Renal Physiol. | pmid:24197070 |
Llinás MT et al. | Role of COX-2-derived metabolites in regulation of the renal hemodynamic response to norepinephrine. | 2001 | Am. J. Physiol. Renal Physiol. | pmid:11592955 |
Osmond DA et al. | Clopidogrel preserves whole kidney autoregulatory behavior in ANG II-induced hypertension. | 2014 | Am. J. Physiol. Renal Physiol. | pmid:24477682 |
Francois H et al. | A role for the thromboxane receptor in L-NAME hypertension. | 2008 | Am. J. Physiol. Renal Physiol. | pmid:18684890 |
Bautista-Pérez R et al. | Involvement of neutral sphingomyelinase in the angiotensin II signaling pathway. | 2015 | Am. J. Physiol. Renal Physiol. | pmid:25354938 |
Kawada N et al. | TP receptors regulate renal hemodynamics during angiotensin II slow pressor response. | 2004 | Am. J. Physiol. Renal Physiol. | pmid:15213069 |
Edwin SS et al. | Cyclosporin A attenuates increased prostaglandin and thromboxane production in response to various stimuli in human decidua. | 1993 Sep-Oct | Am. J. Reprod. Immunol. | pmid:8311924 |
Yoss EB et al. | Arachidonic acid metabolism in normal human alveolar macrophages: stimulus specificity for mediator release and phospholipid metabolism, and pharmacologic modulation in vitro and in vivo. | 1990 | Am. J. Respir. Cell Mol. Biol. | pmid:2155013 |
Badesch DB et al. | Decreased arterial wall prostaglandin production in neonatal calves with severe chronic pulmonary hypertension. | 1989 | Am. J. Respir. Cell Mol. Biol. | pmid:2517777 |
Sporn PH et al. | Complex effects of in vitro hyperoxia on alveolar macrophage arachidonic acid metabolism. | 1990 | Am. J. Respir. Cell Mol. Biol. | pmid:2155014 |
Shellito J and Sniezek M | Altered release of eicosanoids by rat alveolar macrophages during granulomatous pulmonary inflammation. | 1990 | Am. J. Respir. Cell Mol. Biol. | pmid:2155633 |
Sayers BC et al. | Role of cyclooxygenase-2 in exacerbation of allergen-induced airway remodeling by multiwalled carbon nanotubes. | 2013 | Am. J. Respir. Cell Mol. Biol. | pmid:23642096 |
Dent G et al. | Protein kinase C inhibition enhances platelet-activating factor-induced eicosanoid production in human eosinophils. | 1998 | Am. J. Respir. Cell Mol. Biol. | pmid:9448055 |
Panos RJ et al. | Alterations in eicosanoid production by rat alveolar type II cells isolated after silica-induced lung injury. | 1992 | Am. J. Respir. Cell Mol. Biol. | pmid:1312852 |
Ciabattoni G et al. | In vivo lipid peroxidation and platelet activation in cystic fibrosis. | 2000 | Am. J. Respir. Crit. Care Med. | pmid:11029317 |
Mitra A et al. | Thromboxane-mediated alveolar responses to acute obstruction of the pulmonary vasculature. | 1997 | Am. J. Respir. Crit. Care Med. | pmid:9117035 |
Vass G et al. | Comparison of nasal and oral inhalation during exhaled breath condensate collection. | 2003 | Am. J. Respir. Crit. Care Med. | pmid:12493648 |
Okazawa A et al. | 8-Epi-PGF2alpha induces airflow obstruction and airway plasma exudation in vivo. | 1997 | Am. J. Respir. Crit. Care Med. | pmid:9032175 |
Pavord ID et al. | Induced sputum eicosanoid concentrations in asthma. | 1999 | Am. J. Respir. Crit. Care Med. | pmid:10588604 |
Kataoka M et al. | A long-acting prostacyclin agonist with thromboxane inhibitory activity for pulmonary hypertension. | 2005 | Am. J. Respir. Crit. Care Med. | pmid:16192456 |
Snapper JR et al. | Role of endothelin in endotoxin-induced sustained pulmonary hypertension in sheep. | 1998 | Am. J. Respir. Crit. Care Med. | pmid:9445282 |
Chen CR et al. | Platelet-activating factor potentiates protamine-induced lung edema. Role of eicosanoids. | 1994 | Am. J. Respir. Crit. Care Med. | pmid:8111595 |
Jankov RP et al. | Thromboxane A(2) receptors mediate pulmonary hypertension in 60% oxygen-exposed newborn rats by a cyclooxygenase-independent mechanism. | 2002 | Am. J. Respir. Crit. Care Med. | pmid:12119234 |
Gust R et al. | Role of cyclooxygenase-2 in oleic acid-induced acute lung injury. | 1999 | Am. J. Respir. Crit. Care Med. | pmid:10508803 |
Mayer K et al. | Acute lung injury is reduced in fat-1 mice endogenously synthesizing n-3 fatty acids. | 2009 | Am. J. Respir. Crit. Care Med. | pmid:19136374 |
Gust R et al. | Synergistic hemodynamic effects of low-dose endotoxin and acute lung injury. | 1998 | Am. J. Respir. Crit. Care Med. | pmid:9620928 |
O'Connor BJ et al. | Inhibitory effect of UK,74505, a potent and specific oral platelet activating factor (PAF) receptor antagonist, on airway and systemic responses to inhaled PAF in humans. | 1994 | Am. J. Respir. Crit. Care Med. | pmid:8025768 |
Davì G et al. | Enhanced thromboxane biosynthesis in patients with chronic obstructive pulmonary disease. The Chronic Obstructive Bronchitis and Haemostasis Study Group. | 1997 | Am. J. Respir. Crit. Care Med. | pmid:9412557 |
Jiang XW et al. | Effects of low-dose Beraprost sodium, a stable prostaglandin I2 analogue, on reperfusion injury to rabbit lungs. | 1998 | Am. J. Respir. Crit. Care Med. | pmid:9817723 |
Praticò D et al. | Chronic obstructive pulmonary disease is associated with an increase in urinary levels of isoprostane F2alpha-III, an index of oxidant stress. | 1998 | Am. J. Respir. Crit. Care Med. | pmid:9847257 |
Gust R et al. | Response to inhaled nitric oxide in acute lung injury depends on distribution of pulmonary blood flow prior to its administration. | 1999 | Am. J. Respir. Crit. Care Med. | pmid:9927374 |
Imai Y et al. | Inflammatory chemical mediators during conventional ventilation and during high frequency oscillatory ventilation. | 1994 | Am. J. Respir. Crit. Care Med. | pmid:7952613 |
Degges RD et al. | Pulmonary hypertensive effect of heparin and protamine interaction: evidence for thromboxane B2 release from the lung. | 1987 | Am. J. Surg. | pmid:3425821 |
Myers SI and Hernandez R | Leukotriene C4 regulation of splanchnic blood flow during ischemia. | 1994 | Am. J. Surg. | pmid:8209929 |
O'Neill PA et al. | Role of renal sympathetic nerve activity in renal failure associated with obstructive jaundice in the rat. | 1991 | Am. J. Surg. | pmid:1862825 |
Tanowitz HB et al. | Enhanced platelet adherence and aggregation in Chagas' disease: a potential pathogenic mechanism for cardiomyopathy. | 1990 | Am. J. Trop. Med. Hyg. | pmid:2121055 |
Bottoms GD et al. | Thromboxane, prostaglandin I2 (epoprostenol), and the hemodynamic changes in equine endotoxin shock. | 1982 | Am. J. Vet. Res. | pmid:7049018 |
MacKay RJ et al. | Effect of a conjugate of polymyxin B-dextran 70 in horses with experimentally induced endotoxemia. | 1999 | Am. J. Vet. Res. | pmid:9918150 |
Giraudel JM et al. | Development of in vitro assays for the evaluation of cyclooxygenase inhibitors and predicting selectivity of nonsteroidal anti-inflammatory drugs in cats. | 2005 | Am. J. Vet. Res. | pmid:15900953 |
Emau P et al. | Function of prostaglandins, thromboxane A2, and histamine in hypersensitivity reaction to experimental bluetongue disease in calves. | 1984 | Am. J. Vet. Res. | pmid:6093650 |
Grauer GF et al. | Effects of dietary n-3 fatty acid supplementation versus thromboxane synthetase inhibition on gentamicin-induced nephrotoxicosis in healthy male dogs. | 1996 | Am. J. Vet. Res. | pmid:8725828 |
Hoh CM et al. | Evaluation of effects of low-dose aspirin administration on urinary thromboxane metabolites in healthy dogs. | 2011 | Am. J. Vet. Res. | pmid:21801060 |
Semrad SD et al. | Pharmacokinetics of and serum thromboxane suppression by flunixin meglumine in healthy foals during the first month of life. | 1993 | Am. J. Vet. Res. | pmid:8116942 |
Gerros TC et al. | Effect of dose and method of administration of endotoxin on cell mediator release in neonatal calves. | 1993 | Am. J. Vet. Res. | pmid:8116949 |
Semrad SD et al. | Hypertension in bulls and steers anesthetized with guaifenesin-thiobarbiturate-halothane combination. | 1986 | Am. J. Vet. Res. | pmid:3740628 |
Streppa HK et al. | Cyclooxygenase selectivity of nonsteroidal anti-inflammatory drugs in canine blood. | 2002 | Am. J. Vet. Res. | pmid:16206787 |
Ward DS et al. | Equine endotoxemia: cardiovascular, eicosanoid, hematologic, blood chemical, and plasma enzyme alterations. | 1987 | Am. J. Vet. Res. | pmid:3307560 |
Baskett A et al. | Effect of pentoxifylline, flunixin meglumine, and their combination on a model of endotoxemia in horses. | 1997 | Am. J. Vet. Res. | pmid:9361895 |
Barton MH et al. | Effects of pentoxifylline infusion on response of horses to in vivo challenge exposure with endotoxin. | 1997 | Am. J. Vet. Res. | pmid:9361896 |
Stick JA et al. | Thromboxane and prostacyclin production in ponies with colonic volvulus. | 1992 | Am. J. Vet. Res. | pmid:1586029 |
Davidson MG et al. | Vascular permeability and coagulation during Rickettsia rickettsii infection in dogs. | 1990 | Am. J. Vet. Res. | pmid:2105679 |
Gershwin LJ and Giri SN | Effects of allergen challenge on plasma concentrations of prostaglandins, thromboxane B2, and histamine in calves infected with bovine respiratory syncytial virus. | 1992 | Am. J. Vet. Res. | pmid:1416375 |
Semrad SD et al. | Effects of concurrent administration of phenylbutazone and flunixin meglumine on pharmacokinetic variables and in vitro generation of thromboxane B2 in mares. | 1993 | Am. J. Vet. Res. | pmid:8291770 |
Semrad SD et al. | Pharmacokinetics and effects of repeated administration of phenylbutazone in neonatal calves. | 1993 | Am. J. Vet. Res. | pmid:8291771 |
Wooten JG et al. | Cyclooxygenase expression and prostanoid production in pyloric and duodenal mucosae in dogs after administration of nonsteroidal anti-inflammatory drugs. | 2008 | Am. J. Vet. Res. | pmid:18380576 |
Swaim SF et al. | Evaluation of the dermal effects of cast padding in coaptation casts on dogs. | 1992 | Am. J. Vet. Res. | pmid:1497201 |
Cargile JL et al. | Effects of tumor necrosis factor blockade on interleukin 6, lactate, thromboxane, and prostacyclin responses in miniature horses given endotoxin. | 1995 | Am. J. Vet. Res. | pmid:8585654 |
Jones CJ et al. | In vivo effects of meloxicam and aspirin on blood, gastric mucosal, and synovial fluid prostanoid synthesis in dogs. | 2002 | Am. J. Vet. Res. | pmid:12428662 |
Ricketts AP et al. | Evaluation of selective inhibition of canine cyclooxygenase 1 and 2 by carprofen and other nonsteroidal anti-inflammatory drugs. | 1998 | Am. J. Vet. Res. | pmid:9829404 |
Semrad SD et al. | Flunixin meglumine given in small doses: pharmacokinetics and prostaglandin inhibition in healthy horses. | 1985 | Am. J. Vet. Res. | pmid:4083579 |
Templeton CB et al. | Hemodynamics, plasma eicosanoid concentrations, and plasma biochemical changes in calves given multiple injections of Escherichia coli endotoxin. | 1988 | Am. J. Vet. Res. | pmid:3281526 |