Thromboxane b2 is a lipid of Fatty Acyls (FA) class. Thromboxane b2 is associated with abnormalities such as endothelial dysfunction, Diabetes Mellitus, Non-Insulin-Dependent, Diabetes Mellitus, Ischemia and Thrombocytosis. The involved functions are known as Platelet Activation, Excretory function, Anabolism, Inflammation and mRNA Expression. Thromboxane b2 often locates in Endothelium, Hepatic and Microsomes, Liver. The associated genes with Thromboxane b2 are PTGS2 gene, prothrombin fragment 2 and CCL14 wt Allele.
To understand associated biological information of Thromboxane b2, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
Thromboxane b2 is suspected in endothelial dysfunction, Diabetes Mellitus, Non-Insulin-Dependent, Diabetes Mellitus, Ischemia, Thrombocytosis, Acute Coronary Syndrome and other diseases in descending order of the highest number of associated sentences.
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We collected disease MeSH terms mapped to the references associated with Thromboxane b2
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
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Function | Cross reference | Weighted score | Related literatures |
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There are no associated biomedical information in the current reference collection.
Gene | Cross reference | Weighted score | Related literatures |
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There are no associated biomedical information in the current reference collection.
Authors | Title | Published | Journal | PubMed Link |
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Bockman RS | Prostaglandin production by human blood monocytes and mouse peritoneal macrophages: synthesis dependent on in vitro culture conditions. | 1981 | Prostaglandins | pmid:6782622 |
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Shaw JO et al. | Activation of rabbit platelet phospholipase and thromboxane synthesis by 1-O-hexadecyl/octadecyl-2-acetyl-sn-glyceryl-3-phosphorylcholine (platelet activating factor). | 1981 | Biochim. Biophys. Acta | pmid:7213765 |
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Stuart MJ | Effect of endotoxin on arachidonic acid release and thromboxane B2 production by human platelets. | 1981 | Am. J. Hematol. | pmid:7030066 |
Dembélé-Duchesne MJ et al. | Some new prospects in the mechanism of control of arachidonate metabolism in human placenta and amnion. | 1981 | Prostaglandins | pmid:6801732 |
Lorenz R et al. | Effects of very low versus standard dose acetyl salicylic acid, dipyridamole and sulfinpyrazone on platelet function and thromboxane formation in man. | 1981 | Eur. J. Pharmacol. | pmid:7238575 |
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Townsend ER et al. | Preservation of platelets during extracorporeal circulation in sheep. A comparison between aspirin and sulfinpyrazone. | 1981 | Circ. Res. | pmid:7249281 |
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Coker SJ et al. | Aspirin inhibits the early myocardial release of thromboxane B2 and ventricular ectopic activity following acute coronary artery occlusion in dogs. | 1981 | Br. J. Pharmacol. | pmid:7284679 |
Bishai I and Coceani F | Transformations of prostaglandin H2 in the cat brain. | 1981 | Biochim. Biophys. Acta | pmid:6894549 |
Drake TS et al. | Peritoneal fluid thromboxane B2 and 6-keto-prostaglandin F1 alpha in endometriosis. | 1981 | Am. J. Obstet. Gynecol. | pmid:6894667 |
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Feuerstein N et al. | Leukotrienes C4 and D4 induce prostaglandin and thromboxane release from rat peritoneal macrophages. | 1981 | Br. J. Pharmacol. | pmid:6894882 |
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Morrison AR and Benabe JE | Prostaglandins in vascular tone in experimental obstructive nephropathy. | 1981 | Kidney Int. | pmid:6894950 |
Bombardieri S et al. | The synovial prostaglandin system in chronic inflammatory arthritis: differential effects of steroidal and nonsteroidal anti-inflammatory drugs. | 1981 | Br. J. Pharmacol. | pmid:6895043 |
Harms BA et al. | Prostaglandin release and altered microvascular integrity after burn injury. | 1981 | J. Surg. Res. | pmid:6895238 |
Ylikorkala O et al. | Amniotic fluid prostacyclin and thromboxane in normal, preeclamptic, and some other complicated pregnancies. | 1981 | Am. J. Obstet. Gynecol. | pmid:6895277 |
Defreyn G et al. | Familial bleeding tendency with partial platelet thromboxane synthetase deficiency: reorientation of cyclic endoperoxide metabolism. | 1981 | Br. J. Haematol. | pmid:6268139 |
Prancan A et al. | Platelet thromboxane production during endotoxin shock. | 1981 | Agents Actions | pmid:7340458 |
Hwang DH | Characteristics of the aggregation of platelets and the formation of prostaglandins (PGs) in rat. | 1981 | Prog. Lipid Res. | pmid:7342108 |
Agradi E et al. | In vitro effects of synthetic antioxidants and vitamin E on arachidonic acid metabolism and thromboxane formation in human platelets and on platelet aggregation. | 1981 | Prostaglandins | pmid:6794104 |
Halushka PV et al. | Increased platelet thromboxane synthesis in diabetes mellitus. | 1981 | J. Lab. Clin. Med. | pmid:7452084 |
Laviolette M et al. | Human alveolar macrophages: a lesion in arachidonic acid metabolism in cigarette smokers. | 1981 | Am. Rev. Respir. Dis. | pmid:6794395 |
Grimm LJ et al. | Inhibition of platelet thromboxane synthesis by 7-(1-imidazolyl) heptanoic acid: dissociation from inhibition of aggregation. | 1981 | Thromb. Res. | pmid:6801806 |
Worthington RE and Nakeff A | Thromboxane synthesis in megakaryocytes isolated by centrifugal elutriation. | 1981 | Blood | pmid:6786393 |
Igarashi K et al. | Effect of polyamines on prostaglandin synthesis in various cell-free systems. | 1981 | Biochem. Biophys. Res. Commun. | pmid:6800368 |
Landgraf-Leurs MM et al. | Aggregation and thromboxane B2 formation in platelets and vascular prostacyclin production from genetically obese rats. | 1981 | Prostaglandins | pmid:6798637 |
Tsuboi T et al. | Effect of gliclazide on prostaglandin and thromboxane synthesis in guinea-pig platelets. | 1981 Jan 1-15 | Thromb. Res. | pmid:7233394 |
Randall MJ et al. | UK-37, 248, a novel, selective thromboxane synthetase inhibitor with platelet anti-aggregatory and anti-thrombotic activity. | 1981 Jul 1-15 | Thromb. Res. | pmid:6795753 |
Kelton JG et al. | Sex-related differences in the efficacy of acetylsalicylic acid (ASA) : the absorption of ASA and its effect on collagen-induced thromboxane B2 generation. | 1981 Oct 1-15 | Thromb. Res. | pmid:7330835 |
Fitzpatrick FA | A radioimmunoassay for thromboxane B2. | 1982 | Meth. Enzymol. | pmid:7132759 |
Maas RL et al. | Quantitative assay of urinary 2,3-dinor thromboxane B2 by GC-MS. | 1982 | Meth. Enzymol. | pmid:7132771 |
Martin JF et al. | Effect of acetylsalicylic acid on platelet aggregation and thromboxane B2 production in flowing aortic blood in the rat studied with a filter loop technique. | 1982 | Thromb. Res. | pmid:6814004 |
Goldsmith JC and Needleman SW | A comparative study of thromboxane and prostacyclin release from ex vivo and cultured bovine vascular endothelium. | 1982 | Prostaglandins | pmid:6815717 |
Blackwell GJ et al. | Prostacyclin prolongs viability of washed human platelets. | 1982 | Biochim. Biophys. Acta | pmid:6291622 |
Karmali RA et al. | Prostaglandin regulation of murine mammary tumor virus production: a basis for some of the glucocorticoid and prolactin actions on mammary tumor cell cultures. | 1982 | Prostaglandins Leukot Med | pmid:6296884 |
Castaldi PA et al. | Evidence for a platelet membrane defect in the myeloproliferative syndromes. | 1982 | Thromb. Res. | pmid:6960545 |
Ody C et al. | 6-Ketoprostaglandin F1 alpha, prostaglandins E2, F2 alpha and thromboxane B2 production by endothelial cells, smooth muscle cells and fibroblasts cultured from piglet aorta. | 1982 | Biochim. Biophys. Acta | pmid:6214281 |
Casey LC et al. | Prevention of endotoxin-induced pulmonary hypertension in primates by the use of a selective thromboxane synthetase inhibitor, OKY 1581. | 1982 | J. Pharmacol. Exp. Ther. | pmid:6896528 |
Mehta J and Mehta P | Effects of propranolol therapy on platelet release and prostaglandin generation in patients with coronary heart disease. | 1982 | Circulation | pmid:6216027 |
Mehta P et al. | Thromboxane and prostacyclin generation by intact human vessels in response to balloon catheter trauma. | 1982 | Prostaglandins Leukot Med | pmid:6217465 |
Miller JL et al. | Arachidonic acid metabolism in guinea pig megakaryocytes. | 1982 | Biochem. Biophys. Res. Commun. | pmid:6812584 |