Thromboxane b2 is a lipid of Fatty Acyls (FA) class. Thromboxane b2 is associated with abnormalities such as endothelial dysfunction, Diabetes Mellitus, Non-Insulin-Dependent, Diabetes Mellitus, Ischemia and Thrombocytosis. The involved functions are known as Platelet Activation, Excretory function, Anabolism, Inflammation and mRNA Expression. Thromboxane b2 often locates in Endothelium, Hepatic and Microsomes, Liver. The associated genes with Thromboxane b2 are PTGS2 gene, prothrombin fragment 2 and CCL14 wt Allele.
To understand associated biological information of Thromboxane b2, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
Thromboxane b2 is suspected in endothelial dysfunction, Diabetes Mellitus, Non-Insulin-Dependent, Diabetes Mellitus, Ischemia, Thrombocytosis, Acute Coronary Syndrome and other diseases in descending order of the highest number of associated sentences.
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We collected disease MeSH terms mapped to the references associated with Thromboxane b2
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
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Function | Cross reference | Weighted score | Related literatures |
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There are no associated biomedical information in the current reference collection.
Gene | Cross reference | Weighted score | Related literatures |
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There are no associated biomedical information in the current reference collection.
Authors | Title | Published | Journal | PubMed Link |
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Yamanobe S et al. | Analysis of urinary 11-dehydrothromboxane B2 in patients with occluded retinal vein using GC/SIM. | 1998 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:9482168 |
Chang MC et al. | Antithrombotic effect of crotalin, a platelet membrane glycoprotein Ib antagonist from venom of Crotalus atrox. | 1998 | Blood | pmid:9473223 |
Fujita M et al. | Effects of a specific cysteinyl leukotriene antagonist, pranlukast, on antigen-induced cysteinyl leukotriene-mediated rhinitis in guinea pigs. | 1997 | Jpn. J. Pharmacol. | pmid:9469640 |
Fadok VA et al. | Macrophages that have ingested apoptotic cells in vitro inhibit proinflammatory cytokine production through autocrine/paracrine mechanisms involving TGF-beta, PGE2, and PAF. | 1998 | J. Clin. Invest. | pmid:9466984 |
Kruse-Elliott KT et al. | Role of lipid-derived mediators in tumor necrosis factor-induced endothelin-1 release in vivo. | 1998 | Shock | pmid:9466472 |
Liao CH et al. | Bakkenolide G, a natural PAF-receptor antagonist. | 1997 | J. Pharm. Pharmacol. | pmid:9466352 |
Keen HL et al. | Maintenance of baseline angiotensin II potentiates insulin hypertension in rats. | 1998 | Hypertension | pmid:9461234 |
Forastiero R et al. | Anti-beta2 glycoprotein I antibodies and platelet activation in patients with antiphospholipid antibodies: association with increased excretion of platelet-derived thromboxane urinary metabolites. | 1998 | Thromb. Haemost. | pmid:9459320 |
Robbins DL et al. | Effect of anticardiolipin/beta2-glycoprotein I complexes on production of thromboxane A2 by platelets from patients with the antiphospholipid syndrome. | 1998 | J. Rheumatol. | pmid:9458202 |
Hanaoka M et al. | Effect of post-treatment with granulocyte colony-stimulating factor on endotoxin-induced lung injury in sheep. | 1998 Jan-Feb | Exp. Lung Res. | pmid:9457466 |
Chiba Y et al. | Effects of depletion of leukocytes and platelets on cardiac dysfunction after cardiopulmonary bypass. | 1998 | Ann. Thorac. Surg. | pmid:9456104 |
Erez E et al. | Thromboxane production in human lung during cardiopulmonary bypass: beneficial effect of aspirin? | 1998 | Ann. Thorac. Surg. | pmid:9456103 |
Yanagisawa H et al. | Ureteral obstruction enhances eicosanoid production in cortical and medullary tubules of rat kidneys. | 1997 | Kidney Blood Press. Res. | pmid:9453451 |
Parra T et al. | Cyclosporine A nephrotoxicity: role of thromboxane and reactive oxygen species. | 1998 | J. Lab. Clin. Med. | pmid:9452128 |
Moore RM et al. | Effect of platelet-activating factor antagonist L-691,880 on low-flow ischemia-reperfusion injury of the large colon in horses. | 1998 Jan-Feb | Vet Surg | pmid:9449176 |
Dent G et al. | Protein kinase C inhibition enhances platelet-activating factor-induced eicosanoid production in human eosinophils. | 1998 | Am. J. Respir. Cell Mol. Biol. | pmid:9448055 |
Snapper JR et al. | Role of endothelin in endotoxin-induced sustained pulmonary hypertension in sheep. | 1998 | Am. J. Respir. Crit. Care Med. | pmid:9445282 |
Kurosawa M et al. | Heterogeneity of mast cells in mastocytosis and inhibitory effect of ketotifen and ranitidine on indolent systemic mastocytosis. | 1997 | J. Allergy Clin. Immunol. | pmid:9440541 |
Sorem KA and Siler-Khodr TM | Effect of IGF-I on placental thromboxane and prostacyclin release in severe intrauterine growth retardation. | 1997 Nov-Dec | J Matern Fetal Med | pmid:9438218 |
Sheu JR et al. | Triflavin inhibits platelet-induced vasoconstriction in de-endothelialized aorta. | 1997 | Arterioscler. Thromb. Vasc. Biol. | pmid:9437193 |
Qureshi MA and Gore AB | Vitamin E exposure modulates prostaglandin and thromboxane production by avian cells of the mononuclear phagocytic system. | 1997 | Immunopharmacol Immunotoxicol | pmid:9436047 |
Akarsu ES et al. | Effect of ciliary neurotrophic factor on body temperature and cerebrospinal fluid prostanoids in the cat. | 1998 | Brain Res. Bull. | pmid:9434196 |
Famaey JP | In vitro and in vivo pharmacological evidence of selective cyclooxygenase-2 inhibition by nimesulide: an overview. | 1997 | Inflamm. Res. | pmid:9427063 |
Gresele P et al. | Platelet activation markers in patients with peripheral arterial disease--a prospective comparison of different platelet function tests. | 1997 | Thromb. Haemost. | pmid:9423790 |
Moutquin JM et al. | Do prostacyclin and thromboxane contribute to the "protective effect" of pregnancies with chronic hypertension? A preliminary prospective longitudinal study. | 1997 | Am. J. Obstet. Gynecol. | pmid:9423755 |
Oosaki R et al. | Urinary excretion of leukotriene E4 and 11-dehydrothromboxane B2 in patients with spontaneous asthma attacks. | 1997 | Int. Arch. Allergy Immunol. | pmid:9414142 |
Alanko J et al. | Catechol estrogens as inhibitors of leukotriene synthesis. | 1998 | Biochem. Pharmacol. | pmid:9413936 |
Davì G et al. | Enhanced thromboxane biosynthesis in patients with chronic obstructive pulmonary disease. The Chronic Obstructive Bronchitis and Haemostasis Study Group. | 1997 | Am. J. Respir. Crit. Care Med. | pmid:9412557 |
Gerdemann R et al. | [Effect of flunixin meglumine on plasma prostanoid concentrations in horses with colic in the perioperative period]. | 1997 | DTW. Dtsch. Tierarztl. Wochenschr. | pmid:9410724 |
Davi G et al. | In vivo formation of 8-Epi-prostaglandin F2 alpha is increased in hypercholesterolemia. | 1997 | Arterioscler. Thromb. Vasc. Biol. | pmid:9409316 |
Byrne A et al. | Continued thromboxane A2 formation despite administration of a platelet glycoprotein IIb/IIIa antagonist in patients undergoing coronary angioplasty. | 1997 | Arterioscler. Thromb. Vasc. Biol. | pmid:9409315 |
Vezza R et al. | Antivasoconstrictor and antiaggregatory activities of picotamide unrelated to thromboxane A2 antagonism. | 1997 | Thromb. Haemost. | pmid:9408024 |
Knowles SO and Donaldson WE | Lead disrupts eicosanoid metabolism, macrophage function, and disease resistance in birds. | 1997 Oct-Nov | Biol Trace Elem Res | pmid:9404672 |
Wettstein M and Häussinger D | Cytoprotection by the osmolytes betaine and taurine in ischemia-reoxygenation injury in the perfused rat liver. | 1997 | Hepatology | pmid:9397998 |
Bellamy MC et al. | Changes in inflammatory mediators during orthotopic liver transplantation. | 1997 | Br J Anaesth | pmid:9389852 |
Li T et al. | [Observation on TXB2 and 6-keto-PGF1 alpha in serum of patients with cor pulmonale]. | 1996 | Hua Xi Yi Ke Da Xue Xue Bao | pmid:9389073 |
Liu Z | [Effects of acupuncture on lipid, TXB2, 6-keto-PGF, alpha in simple obese patients complicated with hyperlipidemia]. | 1996 | Zhen Ci Yan Jiu | pmid:9388312 |
Han JA and Hu WY | [Progress in the study on protective effect of saponins Panax notoginseng on ischemic brain damage]. | 1996 | Zhongguo Zhong Xi Yi Jie He Za Zhi | pmid:9387754 |
Sang Y et al. | [Effects of tangshenkang capsule on diabetic nephropathy]. | 1996 | Zhongguo Zhong Xi Yi Jie He Za Zhi | pmid:9387731 |
Xiao X et al. | Effect of captopril on renal hemodynamics and renal prostaglandins in early type II diabetic patients with normo-or microalbuminuria. | 1996 | Chin. Med. Sci. J. | pmid:9387403 |
Nygaard OP et al. | The inflammatory properties of contained and noncontained lumbar disc herniation. | 1997 | Spine | pmid:9383853 |
Kobayashi T et al. | Changes in platelet calcium concentration by thromboxane A2 stimulation in patients with nephrotic syndrome of childhood. | 1997 | Nephron | pmid:9375825 |
Savla U et al. | Cyclic stretch of airway epithelium inhibits prostanoid synthesis. | 1997 | Am. J. Physiol. | pmid:9374729 |
Farker K et al. | Measurements of urinary prostaglandins in young ovulatory women during the menstrual cycle and in postmenopausal women. | 1997 | Prostaglandins | pmid:9373880 |
Siler-Khodr TM et al. | The effect of dexamethasone on CRH and prostanoid production from human term placenta. | 1997 | Prostaglandins | pmid:9373879 |
Capponi A et al. | Indomethacin modifies the fetal hemodynamic response induced by percutaneous umbilical blood sampling. | 1997 | Am. J. Obstet. Gynecol. | pmid:9369815 |
John H and Schlegel W | Reversed-phase high-performance liquid chromatographic method for the determination of the 11-hydroxythromboxane B2 anomers equilibrium. | 1997 | J. Chromatogr. B Biomed. Sci. Appl. | pmid:9367188 |
Riendeau D et al. | Comparison of the cyclooxygenase-1 inhibitory properties of nonsteroidal anti-inflammatory drugs (NSAIDs) and selective COX-2 inhibitors, using sensitive microsomal and platelet assays. | 1997 | Can. J. Physiol. Pharmacol. | pmid:9365818 |
Walker JS et al. | Nonsteroidal antiinflammatory drugs in rheumatoid arthritis and osteoarthritis: support for the concept of "responders" and "nonresponders". | 1997 | Arthritis Rheum. | pmid:9365082 |
Bar J et al. | The regulation of platelet aggregation in vitro by interleukin-1beta and tumor necrosis factor-alpha: changes in pregnancy and in pre-eclampsia. | 1997 | Thromb. Haemost. | pmid:9364994 |