Thromboxane b2 is a lipid of Fatty Acyls (FA) class. Thromboxane b2 is associated with abnormalities such as endothelial dysfunction, Diabetes Mellitus, Non-Insulin-Dependent, Diabetes Mellitus, Ischemia and Thrombocytosis. The involved functions are known as Platelet Activation, Excretory function, Anabolism, Inflammation and mRNA Expression. Thromboxane b2 often locates in Endothelium, Hepatic and Microsomes, Liver. The associated genes with Thromboxane b2 are PTGS2 gene, prothrombin fragment 2 and CCL14 wt Allele.
To understand associated biological information of Thromboxane b2, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
Thromboxane b2 is suspected in endothelial dysfunction, Diabetes Mellitus, Non-Insulin-Dependent, Diabetes Mellitus, Ischemia, Thrombocytosis, Acute Coronary Syndrome and other diseases in descending order of the highest number of associated sentences.
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We collected disease MeSH terms mapped to the references associated with Thromboxane b2
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
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Function | Cross reference | Weighted score | Related literatures |
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There are no associated biomedical information in the current reference collection.
Gene | Cross reference | Weighted score | Related literatures |
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There are no associated biomedical information in the current reference collection.
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Lumley P et al. | Maximal blockade of TxA2 without compromised PGI2 formation; a superior profile of the TxA2 receptor blocking drug GR32191 over aspirin. | 1991 | Adv. Prostaglandin Thromboxane Leukot. Res. | pmid:1825385 |
Patrono C et al. | Thromboxane-dependent platelet activation as a transducer of enhanced risk of coronary and cerebral thrombosis. | 1991 | Adv. Prostaglandin Thromboxane Leukot. Res. | pmid:1825389 |
Zhao Y et al. | Thromboxane and leukotriene generation by mononuclearcytes from cardiac transplant patients. | 1991 | Adv. Prostaglandin Thromboxane Leukot. Res. | pmid:1825392 |
Vial JH et al. | Rebound elevation in urinary thromboxane B2 and 6-keto-PGF1 alpha excretion after aspirin withdrawal. | 1991 | Adv. Prostaglandin Thromboxane Leukot. Res. | pmid:1825534 |
Ritter JM et al. | On the mechanism of the prolonged action in man of GR32191, a thromboxane receptor antagonist. | 1991 | Adv. Prostaglandin Thromboxane Leukot. Res. | pmid:1825568 |
Foegh ML et al. | Eicosanoids, gamma-interferon and inflammatory cells in kidney transplant patients. | 1986 | Adv. Prostaglandin Thromboxane Leukot. Res. | pmid:2949550 |
Nihei C et al. | Clinical study on effect of thromboxane A2 synthetase inhibitor (OKY-046) to clarify the regulation of cerebral blood flow in cerebral thrombosis. | 1987 | Adv. Prostaglandin Thromboxane Leukot. Res. | pmid:2960210 |
Nishikawa K et al. | (E)-7-Phenyl-7-(3-pyridyl)-6-heptenoic acid (CV-4151): a potent, specific thromboxane A2 synthetase inhibitor. | 1985 | Adv. Prostaglandin Thromboxane Leukot. Res. | pmid:2936160 |
Takagi S and Den K | Prostacyclin and thromboxane A2 in preeclamptic umbilical circulation. | 1985 | Adv. Prostaglandin Thromboxane Leukot. Res. | pmid:2936183 |
Granström E et al. | Monitoring thromboxane production in vivo: metabolic and analytical aspects. | 1985 | Adv. Prostaglandin Thromboxane Leukot. Res. | pmid:2936194 |
FitzGerald GA et al. | Analysis of urinary metabolites of thromboxane and prostacyclin by negative-ion chemical-ionization gas chromatography/mass spectrometry. | 1985 | Adv. Prostaglandin Thromboxane Leukot. Res. | pmid:2936207 |
Kuzuya T et al. | Determination of plasma thromboxane B2 by radioimmunoassay: methodological problems and accuracy. | 1985 | Adv. Prostaglandin Thromboxane Leukot. Res. | pmid:2936210 |
Yamamoto S et al. | Enzyme immunoassay of thromboxane B2 and 6-keto-prostaglandin F1 alpha as a substitute for radioimmunoassay. | 1983 | Adv. Prostaglandin Thromboxane Leukot. Res. | pmid:6221523 |
Weerasekera DA et al. | Chemiluminescence immunoassay of thromboxane B2. | 1983 | Adv. Prostaglandin Thromboxane Leukot. Res. | pmid:6221524 |
Ito T et al. | Effects of a selective inhibitor of thromboxane synthetase (OKY-1581) in humans. | 1983 | Adv. Prostaglandin Thromboxane Leukot. Res. | pmid:6221531 |
FitzGerald GA et al. | Aspirin inhibits endogenous prostacyclin and thromboxane biosynthesis in man. | 1983 | Adv. Prostaglandin Thromboxane Leukot. Res. | pmid:6221534 |
van der Giessen WJ et al. | Acute effect of cigarette smoking on cardiac prostaglandin synthesis and platelet behavior in patients with coronary heart disease. | 1983 | Adv. Prostaglandin Thromboxane Leukot. Res. | pmid:6221546 |
Bach MK et al. | In vivo and in vitro actions of a new selective inhibitor of leukotriene C and D synthesis. | 1983 | Adv. Prostaglandin Thromboxane Leukot. Res. | pmid:6221551 |
Patrignani P et al. | Characterization of the cyclooxygenase activity of human blood prostaglandin endoperoxide synthases. | 1995 | Adv. Prostaglandin Thromboxane Leukot. Res. | pmid:7732817 |
Foegh ML et al. | Urinary thromboxane has diagnostic value in myocardial infarction. | 1995 | Adv. Prostaglandin Thromboxane Leukot. Res. | pmid:7732879 |