Thromboxane b2 is a lipid of Fatty Acyls (FA) class. Thromboxane b2 is associated with abnormalities such as endothelial dysfunction, Diabetes Mellitus, Non-Insulin-Dependent, Diabetes Mellitus, Ischemia and Thrombocytosis. The involved functions are known as Platelet Activation, Excretory function, Anabolism, Inflammation and mRNA Expression. Thromboxane b2 often locates in Endothelium, Hepatic and Microsomes, Liver. The associated genes with Thromboxane b2 are PTGS2 gene, prothrombin fragment 2 and CCL14 wt Allele.
To understand associated biological information of Thromboxane b2, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
Thromboxane b2 is suspected in endothelial dysfunction, Diabetes Mellitus, Non-Insulin-Dependent, Diabetes Mellitus, Ischemia, Thrombocytosis, Acute Coronary Syndrome and other diseases in descending order of the highest number of associated sentences.
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We collected disease MeSH terms mapped to the references associated with Thromboxane b2
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
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Function | Cross reference | Weighted score | Related literatures |
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There are no associated biomedical information in the current reference collection.
Gene | Cross reference | Weighted score | Related literatures |
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There are no associated biomedical information in the current reference collection.
Authors | Title | Published | Journal | PubMed Link |
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Moodley J et al. | Amniotic fluid prostanoids in preeclampsia. | 1984 | Obstet Gynecol | pmid:6547518 |
Carter AJ et al. | Human pulmonary vessels obtained from necropsy produce less prostacyclin and thromboxane than fresh vessels obtained from operations. | 1984 | Thromb. Res. | pmid:6547546 |
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Cooper C et al. | Production of prostaglandins and thromboxane by isolated cells from intracranial tumours. | 1984 | J. Neurol. Neurosurg. Psychiatr. | pmid:6330309 |
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Block HU et al. | Estimation of thromboxane B2 in the clotting human whole blood by gas chromatography. | 1984 | Biomed. Biochim. Acta | pmid:6517904 |
Hornych A et al. | [Changes in plasma prostaglandins in normal subjects in an orthostatic position. Comparison with the response of the renin-aldosterone system]. | 1984 | Presse Med | pmid:6242503 |
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Tanganelli I et al. | Effects of somatostatin on the behavior of thromboxane B2 and B-thromboglobulin in type 1 diabetes. | 1984 | Boll. Soc. Ital. Biol. Sper. | pmid:6084513 |
Lewis GP and Smith JR | Prostaglandin endoperoxides and thromboxane A2 in thrombus formation in the hamster cheek pouch in vivo. | 1984 | Prostaglandins | pmid:6435186 |
Simberg N | Maternal aspirin administration inhibits pulmonary arachidonic acid metabolism in fetal rabbits. | 1984 | Prostaglandins Leukot Med | pmid:6425868 |
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Ylikorkala O and Tenhunen A | Follicular fluid prostaglandins in endometriosis and ovarian hyperstimulation. | 1984 | Fertil. Steril. | pmid:6363141 |
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Marks JG et al. | Contact urticaria and airway obstruction from carbonless copy paper. | 1984 Aug 24-31 | JAMA | pmid:6235381 |
MacNab MW et al. | The effects of a new thromboxane synthetase inhibitor, CGS-13080, in man. | 1984 Feb-Mar | J Clin Pharmacol | pmid:6371062 |
Buchanan MR and Hirsh J | Effect of aspirin and salicylate on platelet-vessel wall interactions in rabbits. | 1984 Jul-Aug | Arteriosclerosis | pmid:6380468 |
Paajanen H et al. | Modification of platelet aggregation and thromboxane synthesis by intravascular contrast media. | 1984 Jul-Aug | Invest Radiol | pmid:6434489 |
De Caterina R et al. | Thromboxane-B2 generation during ex-vivo platelet aggregation. | 1984 Jul-Sep | J. Nucl. Med. Allied Sci. | pmid:6530623 |
Egg D | Concentrations of prostaglandins D2, E2, F2 alpha, 6-keto-F1 alpha and thromboxane B2 in synovial fluid from patients with inflammatory joint disorders and osteoarthritis. | 1984 Mar-Apr | Z Rheumatol | pmid:6730731 |
Tanabe M et al. | Inhibition of coronary circulatory failure and thromboxane A2 release during coronary occlusion and reperfusion by 2-phenylaminoadenosine (CV-1808) in anesthetized dogs. | 1984 May-Jun | J. Cardiovasc. Pharmacol. | pmid:6202970 |
Laustiola K et al. | Exercise-induced increase in plasma arachidonic acid and thromboxane B2 in healthy men: effect of beta-adrenergic blockade. | 1984 May-Jun | J. Cardiovasc. Pharmacol. | pmid:6202971 |
Sturm M et al. | The measurement of plasma thromboxane B2 and the effect of smoking. | 1984 Nov-Dec | Clin. Exp. Pharmacol. Physiol. | pmid:6536421 |
Menitove JE et al. | Use of prostacyclin to inhibit activation of platelets during preparation of platelet concentrates. | 1984 Nov-Dec | Transfusion | pmid:6390814 |
Fisher M et al. | Selective thromboxane inhibition: a new approach to antiplatelet therapy. | 1984 Sep-Oct | Stroke | pmid:6474531 |
Uderman HD et al. | Thromboxane synthetase inhibitor UK38,485 lowers blood pressure in the adult spontaneously hypertensive rat. | 1984 Sep-Oct | J. Cardiovasc. Pharmacol. | pmid:6209508 |
Halushka PV et al. | Insulin and arachidonic acid metabolism in diabetes mellitus. | 1985 | Metab. Clin. Exp. | pmid:3934501 |
Kimura Y et al. | Effects of stilbenes on arachidonate metabolism in leukocytes. | 1985 | Biochim. Biophys. Acta | pmid:3922423 |
Bakhle YS et al. | Differential release of eicosanoids by bradykinin, arachidonic acid and calcium ionophore A23187 in guinea-pig isolated perfused lung. | 1985 | Br. J. Pharmacol. | pmid:2996675 |
Bakhle YS and Grantham CJ | Selective effect of pulmonary oedema on prostaglandin E2 pharmacokinetics in rat lung. | 1985 | Biochem. Pharmacol. | pmid:3935117 |
Hugli TE and Marceau F | Effects of the C5a anaphylatoxin and its relationship to cyclo-oxygenase metabolites in rabbit vascular strips. | 1985 | Br. J. Pharmacol. | pmid:3921089 |
Panse M et al. | An improved malondialdehyde assay for estimation of thromboxane synthase activity in washed human blood platelets. | 1985 | Prostaglandins | pmid:3937179 |
Toivanen J et al. | Differential inhibition of platelet thromboxane and lung prostacyclin production by sulphinpyrazone, acetylsalicylic acid and indomethacin by human tissues in vitro. | 1985 | Thromb. Res. | pmid:3920778 |
Heinz TR et al. | Radiation-induced alterations in cyclooxygenase product synthesis by isolated perfused rat lungs. | 1985 | Prog Biochem Pharmacol | pmid:3921980 |
Lauri D et al. | Amplification of primary response of human platelets to platelet-activating factor: aspirin-sensitive and aspirin-insensitive pathways. | 1985 | J. Lab. Clin. Med. | pmid:3923145 |
Yamaguchi M and Mori N | 6-Keto prostaglandin F1 alpha, thromboxane B2, and 13,14-dihydro-15-keto prostaglandin F concentrations of normotensive and preeclamptic patients during pregnancy, delivery, and the postpartum period. | 1985 | Am. J. Obstet. Gynecol. | pmid:3838119 |
Johnson A and Malik AB | Pulmonary transvascular fluid and protein exchange after thrombin-induced microembolism. Differential effects of cyclooxygenase inhibitors. | 1985 | Am. Rev. Respir. Dis. | pmid:3925828 |
Packham MA et al. | Duration of the effect of aspirin on the synthesis of thromboxane by density subpopulations of rabbit platelets stimulated with thrombin. | 1985 | Blood | pmid:3926022 |
Patrono C et al. | Functional significance of renal prostacyclin and thromboxane A2 production in patients with systemic lupus erythematosus. | 1985 | J. Clin. Invest. | pmid:3900132 |
Cattaneo M et al. | Human platelet aggregation and release reaction induced by platelet activating factor (PAF-acether)--effects of acetylsalicylic acid and external ionized calcium. | 1985 | Thromb. Haemost. | pmid:3927505 |
Aitokallio-Tallberg A et al. | Prostacyclin and thromboxane in breast cancer: relationship between steroid receptor status and medroxyprogesterone acetate. | 1985 | Br. J. Cancer | pmid:2986666 |
Callahan KS et al. | Enhancement of the antiaggregatory activity of prostacyclin by propranolol in human platelets. | 1985 | Circulation | pmid:2986877 |
Schmitz JM et al. | Vascular prostaglandin and thromboxane production in a canine model of myocardial ischemia. | 1985 | Circ. Res. | pmid:3926340 |
Apprill P et al. | Cyclic blood flow variations induced by platelet-activating factor in stenosed canine coronary arteries despite inhibition of thromboxane synthetase, serotonin receptors, and alpha-adrenergic receptors. | 1985 | Circulation | pmid:2988822 |
Wong C et al. | Effect of a body burn on the lung response to endotoxin. | 1985 | J Trauma | pmid:3880823 |
Khirabadi BS et al. | Urine immunoreactive thromboxane B2 in rat cardiac allograft rejection. | 1985 | Transplantation | pmid:3880966 |
Mehta J and Mehta P | Prostacyclin and thromboxane A2 production by human cardiac atrial tissues. | 1985 | Am. Heart J. | pmid:3880988 |
Friedrich T et al. | Follow-up of prostaglandin plasma levels after acute myocardial infarction. | 1985 | Am. Heart J. | pmid:3880994 |
Wilson TW and Tan LK | Low plasma renin activity in diabetes. Relation to urine prostaglandin excretion. | 1985 | Diabetes | pmid:3881302 |
Shephard EG et al. | Lung function and plasma levels of thromboxane B2, 6-ketoprostaglandin F1 alpha and beta-thromboglobulin in antigen-induced asthma before and after indomethacin pretreatment. | 1985 | Br J Clin Pharmacol | pmid:2581599 |
Addonizio VP et al. | Iloprost (ZK36374), a stable analogue of prostacyclin, preserves platelets during simulated extracorporeal circulation. | 1985 | J. Thorac. Cardiovasc. Surg. | pmid:2582210 |
McGowan HM et al. | The effect of dietary alteration of prostaglandin synthesis on blood pressure and the reversal of hypertension in the one-kidney, one-clip rat. | 1985 | Prostaglandins | pmid:3859891 |
Granström E et al. | Monitoring thromboxane production in vivo: metabolic and analytical aspects. | 1985 | Adv. Prostaglandin Thromboxane Leukot. Res. | pmid:2936194 |
FitzGerald GA et al. | Analysis of urinary metabolites of thromboxane and prostacyclin by negative-ion chemical-ionization gas chromatography/mass spectrometry. | 1985 | Adv. Prostaglandin Thromboxane Leukot. Res. | pmid:2936207 |
Kuzuya T et al. | Determination of plasma thromboxane B2 by radioimmunoassay: methodological problems and accuracy. | 1985 | Adv. Prostaglandin Thromboxane Leukot. Res. | pmid:2936210 |
Slotman GJ et al. | Thromboxane and prostacyclin in clinical acute respiratory failure. | 1985 | J. Surg. Res. | pmid:3892164 |
Hsu CY et al. | Alteration of thromboxane and prostacyclin levels in experimental spinal cord injury. | 1985 | Neurology | pmid:3892363 |
Morita I et al. | Effect of dietary protein level on platelet aggregation in rat. | 1985 | Prostaglandins Leukot Med | pmid:3892545 |
de Lorgeril M et al. | Acute influence of cigarette smoke in platelets, catecholamines and neurophysins in the normal conditions of daily life. | 1985 | Eur. Heart J. | pmid:2937635 |
Lelcuk S et al. | Prostacyclin and thromboxane A2 moderate postischemic renal failure. | 1985 | Surgery | pmid:3895535 |
Paajanen H and Kormano M | Prostacyclin (PGI2) and thromboxane (TXA2) levels during intravenous contrast medium administration in CT. | 1985 | Eur J Radiol | pmid:3896802 |
von Schacky C et al. | Long-term effects of dietary marine omega-3 fatty acids upon plasma and cellular lipids, platelet function, and eicosanoid formation in humans. | 1985 | J. Clin. Invest. | pmid:2997286 |
Codde JP and Beilin LJ | Dietary fish oil prevents dexamethasone induced hypertension in the rat. | 1985 | Clin. Sci. | pmid:3905217 |
Mundie TG et al. | Byssinosis: Release of prostaglandins, thromboxane, and 5-hydroxytryptamine in bronchopulmonary lavage fluid after inhalation of cotton dust extracts. | 1985 | Am. J. Pathol. | pmid:3966532 |
Higashihara M et al. | A monoclonal anti-human platelet antibody: a new platelet aggregating substance. | 1985 | Blood | pmid:3967086 |
Nawroth PP et al. | Thromboxane production by perturbed bovine aortic endothelial cells in culture. | 1985 | Blut | pmid:3967102 |
Martin JL et al. | Effect of high dose aspirin on coronary hemodynamics during pacing-induced myocardial ischemia. | 1985 | J. Am. Coll. Cardiol. | pmid:3968305 |
De Caterina R et al. | Inhibition of platelet aggregation and thromboxane B2 production during aspirin treatment: dependence on the dose of the aggregating agent. | 1985 | Thromb. Res. | pmid:3975876 |
Cook JA et al. | Exchange transfusions in rats with a perfluorated blood substitute: effect on thromboxane B2 levels during endotoxemia. | 1985 | Circ. Shock | pmid:3978769 |
Westenfelder C et al. | Renal function in calves with total artificial hearts. | 1985 | Trans Am Soc Artif Intern Organs | pmid:3837477 |
Schrör K et al. | [Inhibition of platelet aggregation and thromboxane formation by the calcium antagonist nisoldipine following a single oral dose of 10 mg. A double-blind study in healthy probands]. | 1985 | Klin. Wochenschr. | pmid:3838352 |
Bult H et al. | Modification of endotoxin-induced haemodynamic and haematological changes in the rabbit by methylprednisolone, F(ab')2 fragments and rosmarinic acid. | 1985 | Br. J. Pharmacol. | pmid:3838489 |
Lorenz RR and Vanhoutte PM | Prejunctional adrenergic inhibition by aggregating platelets in canine blood vessels. | 1985 | Am. J. Physiol. | pmid:4037113 |
Remuzzi G et al. | Increased glomerular thromboxane synthesis as a possible cause of proteinuria in experimental nephrosis. | 1985 | J. Clin. Invest. | pmid:4038407 |
Vinge E et al. | Single intravenous and oral doses of fenflumizole: pharmacokinetics and effects on prostanoid formation. | 1985 | Acta Pharmacol Toxicol (Copenh) | pmid:3840639 |
Mogensen F et al. | Effect of specific thromboxane-synthetase inhibition on thromboxane and prostaglandin synthesis in stable angina induced by exercise test. | 1985 | Thromb. Res. | pmid:4038824 |
Bennett A et al. | Carbenoxolone and deglycyrrhized liquorice have little or no effect on prostanoid synthesis by rat gastric mucosa ex vivo. | 1985 | Br. J. Pharmacol. | pmid:3840708 |
Tada M et al. | Augmented thromboxane A2 generation and efficacy of its blockade in acute myocardial infarction. | 1985 | Int. J. Cardiol. | pmid:4040500 |
Lorenzana RM et al. | Experimental T-2 toxicosis in swine. I. Changes in cardiac output, aortic mean pressure, catecholamines, 6-keto-PGF1 alpha, thromboxane B2, and acid-base parameters. | 1985 | Fundam Appl Toxicol | pmid:3840756 |
Wargovich T et al. | Reduction in blood flow in normal and narrowed coronary arteries of dogs by leukotriene C4. | 1985 | J. Am. Coll. Cardiol. | pmid:4045029 |
Feuerstein G et al. | Effects of nafazatrom on cardiovascular, sympathetic, and endocrine responses to hemorrhagic shock in conscious rats. | 1985 | Circ. Shock | pmid:3841032 |
Cerletti C et al. | Aspirin kinetics and inhibition of platelet thromboxane generation-relevance for a solution of the "aspirin dilemma". | 1985 | Thromb. Haemost. | pmid:4049312 |
Dejana E et al. | Differential salicylate-aspirin interaction on vascular prostacyclin and platelet thromboxane synthesis in patients undergoing saphenectomy. | 1985 | Proc. Soc. Exp. Biol. Med. | pmid:3841210 |
Fiedler VB et al. | The effects of nafazatrom in an acute occlusion-reperfusion model of canine myocardial injury. | 1985 | Naunyn Schmiedebergs Arch. Pharmacol. | pmid:3841382 |
Palmer RM and Salmon JA | Comparison of the effects of some compounds on human neutrophil degranulation and leukotriene B4 and thromboxane B2 synthesis. | 1985 | Biochem. Pharmacol. | pmid:2986647 |
Lynch TJ et al. | Carbon tetrachloride-induced eicosanoid synthesis and enzyme release from rat peritoneal leucocytes. | 1985 | Biochem. Pharmacol. | pmid:2986650 |
Armstrong RA et al. | Effect of the thromboxane receptor antagonist EP 092 on endotoxin shock in the sheep. | 1985 | Prostaglandins | pmid:2989977 |
Elliott GR et al. | Changes in resident rat peritoneal macrophage eicosanoid release, induced by altering the buffer K+/Na+ ratio, are Ca2+ dependent. | 1985 | Biochim. Biophys. Acta | pmid:3933563 |