Thromboxane b2 is a lipid of Fatty Acyls (FA) class. Thromboxane b2 is associated with abnormalities such as endothelial dysfunction, Diabetes Mellitus, Non-Insulin-Dependent, Diabetes Mellitus, Ischemia and Thrombocytosis. The involved functions are known as Platelet Activation, Excretory function, Anabolism, Inflammation and mRNA Expression. Thromboxane b2 often locates in Endothelium, Hepatic and Microsomes, Liver. The associated genes with Thromboxane b2 are PTGS2 gene, prothrombin fragment 2 and CCL14 wt Allele.
To understand associated biological information of Thromboxane b2, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
Thromboxane b2 is suspected in endothelial dysfunction, Diabetes Mellitus, Non-Insulin-Dependent, Diabetes Mellitus, Ischemia, Thrombocytosis, Acute Coronary Syndrome and other diseases in descending order of the highest number of associated sentences.
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We collected disease MeSH terms mapped to the references associated with Thromboxane b2
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
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Function | Cross reference | Weighted score | Related literatures |
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There are no associated biomedical information in the current reference collection.
Gene | Cross reference | Weighted score | Related literatures |
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There are no associated biomedical information in the current reference collection.
Authors | Title | Published | Journal | PubMed Link |
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Liao CH et al. | Antiplatelet effect of demethyldiisoeugenol. | 1996 | Can. J. Physiol. Pharmacol. | pmid:9022830 |
Ringdahl BE et al. | Effect of nicotine on arachidonic acid metabolites and epithelial parameters in rat oral mucosa. | 1997 | J. Oral Pathol. Med. | pmid:9021551 |
Matsumoto H et al. | Concordant induction of prostaglandin E2 synthase with cyclooxygenase-2 leads to preferred production of prostaglandin E2 over thromboxane and prostaglandin D2 in lipopolysaccharide-stimulated rat peritoneal macrophages. | 1997 | Biochem. Biophys. Res. Commun. | pmid:9020023 |
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Lewis DA et al. | Production of endothelium-derived factors from sodded expanded polytetrafluoroethylene grafts. | 1997 | J. Vasc. Surg. | pmid:9013924 |
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Yamamura S et al. | Prostaglandin levels of primary bone tumor tissues correlate with peritumoral edema demonstrated by magnetic resonance imaging. | 1997 | Cancer | pmid:9010098 |
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Isenring P et al. | Eicosanoid modulation of the norepinephrine effect on blood pressure and renal hemodynamics in humans. | 1996 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:8992495 |
Nagao T et al. | Effect of DP-1904, a thromboxane A2 synthase inhibitor, on passive Heymann nephritis in rats. | 1996 | Eur. J. Pharmacol. | pmid:8982653 |
Santini G et al. | Effects of flurbiprofen and flurbinitroxybutylester on prostaglandin endoperoxide synthases. | 1996 | Eur. J. Pharmacol. | pmid:8982652 |
Dayal S et al. | Increased ratio of thromboxane B2 and 6-keto PGF1 alpha in patients of hepatic venous outflow obstruction. | 1996 | Eur. J. Haematol. | pmid:8982298 |
Pregnolato P et al. | Effect of diets containing different amounts of precursor and derivative fatty acids on serum TXB2. | 1996 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:8981629 |
Fritsche KL and Cassity NA | Metabolism of [3H]arachidonic acid by n-3 polyunsaturated fatty acid-enriched piglet alveolar macrophages. | 1996 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:8981628 |
Matsumoto K et al. | Role of thromboxane-A2 and cholinergic mechanisms in bronchoconstriction induced by cigarette smoke in guinea-pigs. | 1996 | Eur. Respir. J. | pmid:8980955 |
Miyahara T et al. | Specific neutrophil elastase inhibitor does not attenuate acute lung injury induced by air embolism in awake sheep. | 1996 Nov-Dec | Exp. Lung Res. | pmid:8979046 |
Nanji AA et al. | Thromboxane inhibitors attenuate pathological changes in alcoholic liver disease in the rat. | 1997 | Gastroenterology | pmid:8978360 |
Mathieu P et al. | [Antiaggregant effect and tolerance of calcium carbasalate administrated immediately after aorto-coronary bypass. Results of a double-blind versus placebo study]. | 1996 | Pathol. Biol. | pmid:8977914 |
Sergeev PV et al. | [Human thrombocytes as a test system for the study of nongenomic effects of glucocorticoid hormones]. | 1996 | Biull Eksp Biol Med | pmid:8974481 |
Landoni MF and Lees P | Pharmacokinetics and pharmacodynamics of ketoprofen enantiomers in the horse. | 1996 | J. Vet. Pharmacol. Ther. | pmid:8971676 |
Li KL et al. | The effect of ketoprofen creams on periodontal disease in rhesus monkeys. | 1996 | J. Periodont. Res. | pmid:8971650 |
Fukushima C et al. | Inhibitory effect of thromboxane A2 synthetase inhibitor, DP-1904, on antigen-induced contraction of human lung parenchyma. | 1996 | Ann. Allergy Asthma Immunol. | pmid:8970439 |
Hirakata H et al. | Sevoflurane inhibits human platelet aggregation and thromboxane A2 formation, possibly by suppression of cyclooxygenase activity. | 1996 | Anesthesiology | pmid:8968193 |
Reilly M et al. | Modulation of oxidant stress in vivo in chronic cigarette smokers. | 1996 | Circulation | pmid:8964113 |
Gries A et al. | Lipoprotein(a) inhibits collagen-induced aggregation of thrombocytes. | 1996 | Arterioscler. Thromb. Vasc. Biol. | pmid:8963722 |
Serebruany VL et al. | Hemostatic changes after early versus late intracoronary magnesium during acute myocardial infarction in swine. | 1996 | J. Cardiovasc. Pharmacol. | pmid:8961080 |
Milani M et al. | Effects of two different HMG-CoA reductase inhibitors on thromboxane production in type IIA hypercholesterolemia. | 1996 | Biomed. Pharmacother. | pmid:8952866 |
Baenkler HW et al. | Eicosanoids from biopsy of normal and polypous nasal mucosa. | 1996 | Rhinology | pmid:8938887 |
Krämer HJ et al. | Fish oil fatty acids and human platelets: dose-dependent decrease in dienoic and increase in trienoic thromboxane generation. | 1996 | Biochem. Pharmacol. | pmid:8937428 |
Klosterhalfen B et al. | Influence of heat shock protein 70 and metallothionein induction by zinc-bis-(DL-hydrogenaspartate) on the release of inflammatory mediators in a porcine model of recurrent endotoxemia. | 1996 | Biochem. Pharmacol. | pmid:8937427 |
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Blache D | Enhanced arachidonic acid and calcium metabolism in cholesteryl sulfate-enriched rat platelets. | 1996 | J Lipid Mediat Cell Signal | pmid:8925194 |
Shibasaki T et al. | Mizoribine reduces urinary protein excretion in rats given puromycin aminonucleoside. | 1996 | Am. J. Nephrol. | pmid:8919236 |
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Szekacs B et al. | Prostacyclin and thromboxane production of rat and cat arterial tissue is altered independently by several vasoactive substances. | 1996 | Prostaglandins | pmid:8908622 |
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Schmid P et al. | Passive smoking and platelet thromboxane. | 1996 | Thromb. Res. | pmid:8907294 |
Berdeaux O et al. | Effects of a trans isomer of arachidonic acid on rat platelet aggregation and eicosanoid production. | 1996 | J. Lipid Res. | pmid:8906600 |
Nishisho T et al. | Experimental and clinical studies of eicosanoids in cerebrospinal fluid after spinal cord injury. | 1996 | Neurosurgery | pmid:8905750 |
Montuschi P et al. | Tachykinin NK2 receptor antagonists decrease eicosanoid release in lung anaphylaxis. | 1996 | Eur. J. Pharmacol. | pmid:8905345 |
Martin W et al. | Respiratory dysfunction and white cell activation following cardiopulmonary bypass: comparison of membrane and bubble oxygenators. | 1996 | Eur J Cardiothorac Surg | pmid:8905281 |
Parnas BL et al. | Isolation and structure of leukotriene-A4 hydrolase inhibitor: 8(S)-amino-2(R)-methyl-7-oxononanoic acid produced by Streptomyces diastaticus. | 1996 | J. Nat. Prod. | pmid:8904845 |
Serebruany VL et al. | Mac-1 inhibitor affects certain hemostatic parameters during myocardial stunning in swine. | 1996 | Pharmacology | pmid:8902873 |
Livingston ER et al. | Increased activation of the coagulation and fibrinolytic systems leads to hemorrhagic complications during left ventricular assist implantation. | 1996 | Circulation | pmid:8901751 |
Karck U et al. | PGE2 and PGF2 alpha release by human peritoneal macrophages in endometriosis. | 1996 | Prostaglandins | pmid:8900443 |
Harada Y et al. | Role of prostaglandin H synthase-2 in prostaglandin E2 formation in rat carrageenin-induced pleurisy. | 1996 | Prostaglandins | pmid:8900441 |
Chou TC et al. | The inhibitory effect of 2-thienyl 2'-hydroxyphenyl ketone (C85) on platelet thromboxane formation. | 1996 | Thromb. Res. | pmid:8897698 |
Myers SI et al. | Estrogen increases male rat aortic endothelial cell (RAEC) PGI2 release. | 1996 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:8888351 |
Stiris TA et al. | Effects of dexamethasone on retinal and choroidal blood flow during normoxia and hyperoxia in newborn piglets. | 1996 | Pediatr. Res. | pmid:8888288 |
Carbajal D et al. | Possible cytoprotective mechanism in rats of D-002, an anti-ulcerogenic product isolated from beeswax. | 1996 | J. Pharm. Pharmacol. | pmid:8887738 |
GarcÃa-Lafuente A et al. | Bacterial peptides enhance inflammatory activity in a rat model of colitis. | 1996 | Digestion | pmid:8886582 |
Ziyyat A et al. | Interactions between nitric oxide and prostanoids in isolated perfused kidneys of the rat. | 1996 | Br. J. Pharmacol. | pmid:8886425 |
Selley ML et al. | The effect of cholesterol oxidation products on human platelet aggregation. | 1996 | Thromb. Res. | pmid:8885139 |
Mustad V et al. | Seasonal variation in parameters related to coronary heart disease risk in young men. | 1996 | Atherosclerosis | pmid:8879440 |
Schaefer WR et al. | Urinary excretion of 2,3-dinor-6-keto-PGF1 alpha and 11-dehydro-TXB2 by the gravid spontaneously hypertensive rat. | 1996 | Prostaglandins | pmid:8875634 |
Siler-Khodr TM et al. | Dose-related action of estradiol on placental prostanoid prediction. | 1996 | Prostaglandins | pmid:8873234 |
Kanai H et al. | Serotonin metabolism in patients undergoing hemodialysis. | 1996 | Clin. Nephrol. | pmid:8861800 |
Pancera P et al. | Changes in peripheral hemodynamics and vasodilating prostaglandins after high-dose short-term ibuprofen in chronically treated hypertensive patients. | 1996 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:8860111 |
Bordia T et al. | An evaluation of garlic and onion as antithrombotic agents. | 1996 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:8860105 |
Reale M et al. | Human recombinant interleukin-1 beta induces thromboxane A2 release in polymorphonuclear leukocytes, macrophages and platelets: effect of IL-1 receptor antagonist. | 1996 | Mol. Cell. Biochem. | pmid:8858567 |
Quinn JV et al. | Evaluation of enzyme-linked immunosorbent assays for quantitation of eicosanoid mediators of sepsis syndrome. | 1996 | Shock | pmid:8856849 |
Chen SJ et al. | Antiplatelet and calcium inhibitory properties of eugenol and sodium eugenol acetate. | 1996 | Gen. Pharmacol. | pmid:8853295 |
Gabriel A et al. | Influence of prostaglandin E1 on tissue ischemia during surgical repair of the abdominal aorta. | 1996 | J. Cardiothorac. Vasc. Anesth. | pmid:8850397 |
Horiguchi T et al. | Pulmonary responses to heparin-protamine complexes: the effects of age and species. | 1996 | J. Appl. Physiol. | pmid:8847332 |