Thromboxane b2 is a lipid of Fatty Acyls (FA) class. Thromboxane b2 is associated with abnormalities such as endothelial dysfunction, Diabetes Mellitus, Non-Insulin-Dependent, Diabetes Mellitus, Ischemia and Thrombocytosis. The involved functions are known as Platelet Activation, Excretory function, Anabolism, Inflammation and mRNA Expression. Thromboxane b2 often locates in Endothelium, Hepatic and Microsomes, Liver. The associated genes with Thromboxane b2 are PTGS2 gene, prothrombin fragment 2 and CCL14 wt Allele.
To understand associated biological information of Thromboxane b2, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
Thromboxane b2 is suspected in endothelial dysfunction, Diabetes Mellitus, Non-Insulin-Dependent, Diabetes Mellitus, Ischemia, Thrombocytosis, Acute Coronary Syndrome and other diseases in descending order of the highest number of associated sentences.
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We collected disease MeSH terms mapped to the references associated with Thromboxane b2
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
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Function | Cross reference | Weighted score | Related literatures |
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There are no associated biomedical information in the current reference collection.
Gene | Cross reference | Weighted score | Related literatures |
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There are no associated biomedical information in the current reference collection.
Authors | Title | Published | Journal | PubMed Link |
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Parker CW et al. | Formation of thromboxane B2 and hydroxyarachidonic acids in purified human lymphocytes in the presence and absence of PHA. | 1979 | J. Immunol. | pmid:448099 |
Needleman P et al. | Platelet and blood vessel arachidonate metabolism and interactions. | 1979 | J. Clin. Invest. | pmid:372240 |
Morley J et al. | Prostaglandin and thromboxane production by human and guinea-pig macrophages and leucocytes. | 1979 | Prostaglandins | pmid:493559 |
Meyers KM et al. | A dominant role of thromboxane formation in secondary aggregation of platelets. | 1979 | Nature | pmid:503210 |
de Deckere EA et al. | Influence of type of dietary fat on the prostaglandin release from isolated rabbit and rat hearts and from rat aortas. | 1979 | Prostaglandins | pmid:504696 |
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Spagnuolo C et al. | Differential effects of probenecid on the levels of endogenous PGF2 alpha and TXB2 in brain cortex. | 1979 | Prostaglandins | pmid:523683 |
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Roberts LJ et al. | Prostaglandin thromboxane, and 12-hydroxy-5,8,10,14-eicosatetraenoic acid production by ionophore-stimulated rat serosal mast cells. | 1979 | Biochim. Biophys. Acta | pmid:389290 |
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Kelly JP et al. | Effect of inhibitors of arachidonic acid metabolism on mitogenesis in human lymphocytes: possible role of thromboxanes and products of the lipoxygenase pathway. | 1979 | J. Immunol. | pmid:109510 |
Whittle BJ | Prostaglandin synthetase inhibitors. Drugs which affect arachidonic acid metabolism. | 1979 | Acta Obstet Gynecol Scand Suppl | pmid:111464 |
Robinson JS et al. | Prostaglandin E, thromboxane B2 and 6-oxo-prostaglandin F1 alpha in amniotic fluid and maternal plasma of rhesus monkeys (Macaca mulatta) during the latter third of gestation. | 1979 | J. Endocrinol. | pmid:112214 |
Burch RM et al. | Vasopressin stimulates thromboxane synthesis in the toad urinary bladder: effects of imidazole. | 1979 | J. Pharmacol. Exp. Ther. | pmid:113526 |
Patrono C et al. | Inhibition of platelet cyclooxygenase by aspirin-like drugs: methods for in vitro and ex vivo assessment. | 1979 | Agents Actions Suppl. | pmid:115255 |
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Kass MA and Holmberg NJ | Prostaglandin and thromboxane synthesis by microsomes of rabbit ocular tissues. | 1979 | Invest. Ophthalmol. Vis. Sci. | pmid:761971 |
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Pradalier A et al. | [Measurement of plasma and serum values of PGE2, PGF2 alpha and TXB2 during aspirin induced bronchospasm in asthmatics (author's transl)]. | 1979 Jul-Aug | Therapie | pmid:531778 |
Hagen AA et al. | Synthesis of prostaglandins and thromboxane B2 by cerebral arteries. | 1979 May-Jun | Stroke | pmid:462519 |
Burch RM and Halushka PV | Thromboxane and stable prostaglandin endoperoxide analogs stimulate water permeability in the toad urinary bladder. | 1980 | J. Clin. Invest. | pmid:6777398 |
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Best LC et al. | Studies on the role of calcium in the control of thromboxane B2 production. | 1980 | Artery | pmid:6783015 |
Crutchley DJ et al. | Enhanced thromboxane B2 release from challenged guinea pig lung after oxygen exposure. | 1980 | Am. Rev. Respir. Dis. | pmid:6155814 |
Patrono C et al. | Radioimmunoassay measurement of stable metabolites of platelet arachidonic acid: a convenient method for the in vitro and ex vivo evaluation of cyclo-oxygenase inhibitors. | 1980 | Agents Actions Suppl. | pmid:6787852 |
Cella G et al. | In vivo platelet release reaction in patients with heart valve prosthesis. | 1980 | Haemostasis | pmid:6157609 |
Silver MJ et al. | A model system for studying initial events in atherosclerosis. | 1980 | Artery | pmid:7000044 |
Best LC et al. | Lanthanum stimulates the accumulation of cyclic AMP and inhibits secretion and thromboxane B2 formation in human platelets. | 1980 | Biochim. Biophys. Acta | pmid:6251913 |
Fitzpatrick TM et al. | Tromboxane B2 inhibits the pulmonary inactivation of prostaglandin E2 in the dog. | 1980 | Br. J. Pharmacol. | pmid:7000216 |
Poyser NL and Scott FM | Prostaglandin and thromboxane production by the rat uterus and ovary in vitro during the oestrous cycle. | 1980 | J. Reprod. Fertil. | pmid:7001011 |
Lands WE et al. | Recent concepts on platelet function and dietary lipids in coronary thrombosis, vasospasm and angina. | 1980 | Herz | pmid:7007191 |
Subbiah MT et al. | Enhancement of thrombocyte aggregation and thromboxane B2 synthesis by diethylstilbestrol. | 1980 | Pharmacology | pmid:7220591 |
Ali AE et al. | Prostaglandin and thromboxane production by fibroblasts and vascular endothelial cells. | 1980 | Prostaglandins | pmid:7008090 |
Ohtsu E and Matsuzawa T | Metabolic alterations in the endogenous formation of 6 keto-prostaglandin F1 alpha, thromboxane B2 and prostaglandin E2 in the brain-stem of stroke-resistant spontaneously hypertensive rats. | 1980 | J. Nutr. Sci. Vitaminol. | pmid:7229740 |
Vargaftig BB et al. | Activation of guinea-pig platelets induced by convulxin, a substance extracted from the venom of Crotalus durissus cascavella. | 1980 | Eur. J. Pharmacol. | pmid:7009169 |
Giri SN and Krishna GA | Development of a dual isotopes techniques and two-stage column chromatography to characterize the prostaglandin F2alpha, E2 and Thromboxane B2 formed by the guinea pig lung. | 1980 | J Pharmacol Methods | pmid:7009992 |
Zapol WM et al. | Plasma thromboxane and prostacyclin metabolites in sheep partial cardiopulmonary bypass. | 1980 | Trans Am Soc Artif Intern Organs | pmid:7018060 |
Güllner HG et al. | Correction of increased prostacyclin production in Bartter's syndrome by indomethacin. | 1980 | Trans. Assoc. Am. Physicians | pmid:7018063 |
Wise WC et al. | Protective effects of thromboxane synthetase inhibitors in rats in endotoxic shock. | 1980 | Circ. Res. | pmid:7189697 |
Salmon JA | Analysis of arachidonic acid metabolites by radioimmunoassay and physicochemical methods. | 1980 | Mater Med Pol | pmid:7019588 |
Zamecnik J et al. | Concentrations of thromboxane B2 and 6-oxo-prostaglandin F1 alpha in amniotic fluid, decidual tissue, and placenta in the later stages of pregnancy in the rat. | 1980 | Adv Prostaglandin Thromboxane Res | pmid:6990719 |
Frame MH et al. | Inhibition of acid secretion from the rat-isolated gastric mucosa by arachidonic acid and identification of major metabolites. | 1980 | Adv Prostaglandin Thromboxane Res | pmid:6990724 |
Harris RH et al. | Relationship of TXB2 and 6-keto PGF1 alpha to the hemodynamic changes during baboon endotoxic shock. | 1980 | Adv Prostaglandin Thromboxane Res | pmid:6768234 |
Jécsai G and Bagdány S | Quantitative determination of thromboxane synthesis in blood samples by video-densitometry. | 1980 | Acta Biochim. Biophys. Acad. Sci. Hung. | pmid:7282294 |
Hwang DH | Aggregation and inhibition of rat platelets, and the formation of endoperoxide metabolites. | 1980 | Prostaglandins Med | pmid:7413850 |
Cerskus AL et al. | Thromboxane B2 and 6-keto-prostaglandin F1 alpha synthesis during infusion of collagen and arachidonic acid in rabbits: inhibition by aspirin and sulfinpyrazone. | 1980 | Thromb. Res. | pmid:7414555 |
Tada M et al. | Significance of thromboxane A2 in myocardial ischemia in patients with coronary artery disease. | 1980 | Adv Myocardiol | pmid:7423053 |
Matsumoto M et al. | Thromboxane generation in patients with essential hypertension or cerebrovascular disease and effect of oral aspirin. | 1980 | Thromb. Haemost. | pmid:7423441 |
Davies GC et al. | Elevated plasma fibrinopeptide A and thromboxane B2 levels during cardiopulmonary bypass. | 1980 | Circulation | pmid:6965618 |
Kennedy MS et al. | In vitro synthesis of prostaglandins and related lipids by populations of human peripheral blood mononuclear cells. | 1980 | Prostaglandins | pmid:6967616 |
Galli C et al. | Modulation of prostaglandin production in tissues by dietary essential fatty acids. | 1980 | Acta Med. Scand. Suppl. | pmid:6935943 |
Wong PY et al. | The role of calmodulin in prostaglandin metabolism. | 1980 | Ann. N. Y. Acad. Sci. | pmid:6940495 |
Lefer AM and Crossley K | Mechanisms of the optimal protective effects of ibuprofen in acute myocardial ischemia. | 1980 | Adv Shock Res | pmid:7304314 |
Güllner HG et al. | The principal metabolites of arachidonic acid are overproduced in Bartter's syndrome. | 1980 | Adv Prostaglandin Thromboxane Res | pmid:6892749 |
Liggins GC et al. | Production rates of prostaglandin F, 6-keto-PGF1 alpha and thromboxane B2 by perifused human endometrium. | 1980 | Prostaglandins | pmid:6892962 |
Subbiah MT and Dietemeyer D | Altered synthesis of prostaglandins in platelet and aorta from spontaneously diabetic Wistar rats. | 1980 | Biochem Med | pmid:6893150 |
Ali M and McDonald JW | Synthesis of thromboxane B2 and 6-keto-prostaglandin F1 alpha by bovine gastric mucosal and muscle microsomes. | 1980 | Prostaglandins | pmid:6893365 |
Ohuchi K et al. | Prostaglandin production by minced carrageenin granuloma tissue of rats and its inhibition by dexamethasone and cycloheximide. | 1980 | Prostaglandins Med | pmid:6893750 |
Dupont J et al. | Effects of dietary essential fatty acid concentration upon prostanoid synthesis in rats. | 1980 | J. Nutr. | pmid:7400858 |
Rao GH et al. | Influence of epinephrine on the aggregation response of aspirin-treated platelets. | 1980 | Prostaglandins Med | pmid:7403340 |
Schrör K et al. | Preservation of ischemic myocardium by pinane thromboxane A2. | 1980 | Am. J. Physiol. | pmid:7356037 |
Hassid A and Dunn MJ | Microsomal prostaglandin biosynthesis of human kidney. | 1980 | J. Biol. Chem. | pmid:7358683 |
Kadowitz PJ and Hyman AL | Comparative effects of thromboxane B2 on the canine and feline pulmonary vascular bed. | 1980 | J. Pharmacol. Exp. Ther. | pmid:7365689 |
Schlondorff D and Folkert VW | Prostaglandin synthesis in glomeruli from rats with unilateral ureteral obstruction. | 1980 | Adv Prostaglandin Thromboxane Res | pmid:7369028 |
Van Praag D and Farber SJ | Prostaglandin biosynthesis in normal and ureteral obstructed rabbit kidney; formation of a novel metabolite. | 1980 | Adv Prostaglandin Thromboxane Res | pmid:7369029 |
Kot PA et al. | Modification of the cardiovascular actions of prostaglandins by thromboxane B2. | 1980 | Adv Prostaglandin Thromboxane Res | pmid:7369035 |
Gorman RR | Biochemical and pharmacological evaluation of thromboxane synthetase inhibitors. | 1980 | Adv Prostaglandin Thromboxane Res | pmid:6247892 |
Friedman LS et al. | Thromboxane B2 inhibits the pulmonary metabolism of PGE2 in the anesthetized dog. | 1980 | Adv Prostaglandin Thromboxane Res | pmid:7369063 |
Garfield RE et al. | Gap junction formation in myometrium: control by estrogens, progesterone, and prostaglandins. | 1980 | Am. J. Physiol. | pmid:7369350 |
Lewy RI | Effect of elevated plasma-free fatty acids on thromboxane release in patients with coronary artery disease. | 1980 | Haemostasis | pmid:7372200 |
Bishai I and Coceani F | Metabolism of PGH2 in the feline brain. | 1980 | Adv Prostaglandin Thromboxane Res | pmid:7376980 |
Galli C et al. | Factors affecting brain prostaglandin formation. | 1980 | Adv Prostaglandin Thromboxane Res | pmid:7376983 |
Blotman F et al. | PGE2, PGF2 alpha, and TXB2 biosynthesis by human rheumatoid synovia. | 1980 | Adv Prostaglandin Thromboxane Res | pmid:7377017 |
Powell WS | Rapid extraction of oxygenated metabolites of arachidonic acid from biological samples using octadecylsilyl silica. | 1980 | Prostaglandins | pmid:6258197 |
Katori M et al. | Changes of prostaglandin and thromboxane levels in pleural fluid of rat carrageenin-induced pleurisy. | 1980 | Adv Prostaglandin Thromboxane Res | pmid:7377020 |
Crutchley DJ et al. | Potentiation of thromboxane B2 release from guinea pig lung during anaphylaxis following exposure to 100% O2. | 1980 | Adv Prostaglandin Thromboxane Res | pmid:7377022 |
Morris HG and Sherman NA | Prostaglandin-like substances in urine of asthmatic patients. | 1980 | Adv Prostaglandin Thromboxane Res | pmid:7377024 |
Schoene NW et al. | Effects of diets varying in fat and P/S ratio on arachidonic acid metabolism in human platelets. | 1980 | Adv Prostaglandin Thromboxane Res | pmid:7377026 |
Smith EF et al. | Influence of thromboxane inhibition on the severity of myocardial ischemia in cats. | 1980 | Can. J. Physiol. Pharmacol. | pmid:7378931 |
Ellwood DA et al. | Specific changes in the in vitro production of prostanoids by the ovine cervix at parturition. | 1980 | Prostaglandins | pmid:7384553 |
Lefer AM et al. | Dissociation of vasoconstrictor and platelet aggregatory activities of thromboxane by carbocyclic thromboxane A2, a stable analog of thromboxane A2. | 1980 | Proc. Natl. Acad. Sci. U.S.A. | pmid:6929517 |
Moretti RL and Lin CY | Coronary vasoconstrictor extracted from blood plasma stimulates platelet lipoxidase activity. | 1980 | Prostaglandins | pmid:6770419 |
Hwang DW et al. | Species variation in serum levels of prostaglandins and their precursor acids. | 1980 | Lipids | pmid:7432104 |
Bolton HS et al. | Prostaglandin synthesis by adult heart myocytes. | 1980 | J. Mol. Cell. Cardiol. | pmid:7441771 |
Dejana E et al. | Impaired thromboxane production by newly formed platelets after aspirin administration to thrombocytopenic rats. | 1980 | Br. J. Haematol. | pmid:7448129 |
Ylikorkala O and Viinikka L | Thromboxane A2 in pregnancy and puerperium. | 1980 | Br Med J | pmid:7448530 |
Bone EA et al. | The effects of strontium and calcium ions on 5-hydroxytryptamine secretion and thromboxane B2 biosynthesis in washed human platelets. | 1980 | Biochem. Soc. Trans. | pmid:7450206 |
Mitchell MD | Prostaglandins at parturition and in the neonatal infant. | 1980 | Biochem. Soc. Trans. | pmid:7450282 |
Kent L et al. | Differential response of articular chondrocyte populations to thromboxane B2 and analogs of prostaglandin cyclic endoperoxides. | 1980 | Prostaglandins | pmid:7384546 |
Subbiah MT et al. | Studies of aggregation and thromboxane B2 synthesis in avian thrombocytes: comparison between atherosclerosis-susceptible and resistant breeds. | 1980 | Thromb. Haemost. | pmid:7455983 |
Pace-Asciak CR and Edwards NS | Tetranor thromboxane B2 is the principal urinary catabolite formed after i.v. infusion of thromboxane B2 in the rat. | 1980 | Biochem. Biophys. Res. Commun. | pmid:7458943 |
Viinikka L and Ylikorkala O | Measurement of thromboxane B2 in human plasma or serum by radioimmunoassay. | 1980 | Prostaglandins | pmid:7465865 |
Lagarde M et al. | Increase of platelet thromboxane A2 formation and of its plasmatic half-life in diabetes mellitus. | 1980 | Thromb. Res. | pmid:7466751 |
Lewy RI et al. | Thromboxane release during pacing-induced angina pectoris: possible vasoconstrictor influence on the coronary vasculature. | 1980 | Circulation | pmid:7371128 |
McManus LM et al. | Thromboxane B2 (TxB2) release during IgE anaphylaxis in the rabbit. | 1980 | J. Immunol. | pmid:7430618 |
Best LC et al. | The relationship between the production of thromboxane B2 and malondialdehyde by human blood platelets. | 1980 | Clin. Sci. | pmid:7190885 |
Heggers JP et al. | Histological demonstration of prostaglandins and thromboxanes in burned tissue. | 1980 | J. Surg. Res. | pmid:6987462 |
Meyers KM et al. | An evaluation of the arachidonate pathway of platelets from companion and food-producing animals, mink, and man. | 1980 | Thromb. Res. | pmid:7209869 |