Thromboxane b2 is a lipid of Fatty Acyls (FA) class. Thromboxane b2 is associated with abnormalities such as endothelial dysfunction, Diabetes Mellitus, Non-Insulin-Dependent, Diabetes Mellitus, Ischemia and Thrombocytosis. The involved functions are known as Platelet Activation, Excretory function, Anabolism, Inflammation and mRNA Expression. Thromboxane b2 often locates in Endothelium, Hepatic and Microsomes, Liver. The associated genes with Thromboxane b2 are PTGS2 gene, prothrombin fragment 2 and CCL14 wt Allele.
To understand associated biological information of Thromboxane b2, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
Thromboxane b2 is suspected in endothelial dysfunction, Diabetes Mellitus, Non-Insulin-Dependent, Diabetes Mellitus, Ischemia, Thrombocytosis, Acute Coronary Syndrome and other diseases in descending order of the highest number of associated sentences.
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We collected disease MeSH terms mapped to the references associated with Thromboxane b2
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
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Function | Cross reference | Weighted score | Related literatures |
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There are no associated biomedical information in the current reference collection.
Gene | Cross reference | Weighted score | Related literatures |
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There are no associated biomedical information in the current reference collection.
Authors | Title | Published | Journal | PubMed Link |
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Drake TS et al. | Peritoneal fluid prostanoids in unexplained infertility. | 1983 | Am. J. Obstet. Gynecol. | pmid:6614085 |
Deckmyn H et al. | Manipulation of the local thromboxane and prostacyclin balance in vivo by the antithrombotic compounds dazoxiben, acetylsalicylic acid and nafazatrom. | 1983 | Biochem. Pharmacol. | pmid:6578796 |
Goetzl EJ et al. | Enhancement of human neutrophil adherence by synthetic leukotriene constituents of the slow-reacting substance of anaphylaxis. | 1983 | Immunology | pmid:6193056 |
McManus LM et al. | Thromboxane B2 (TxB2) release following acetyl glyceryl ether phosphorylcholine (AGEPC) infusion in the rabbit. | 1983 | Immunopharmacology | pmid:6832960 |
Martin JL et al. | Effect of atrial pacing on intracoronary thromboxane production in coronary artery disease. | 1983 | J. Am. Coll. Cardiol. | pmid:6833660 |
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Margotat A et al. | A rapid and simple assay for the study of thromboxane B2 synthesis by intact human platelets. | 1983 | J Pharmacol Methods | pmid:6843139 |
Palmer RM and Salmon JA | Release of leukotriene B4 from human neutrophils and its relationship to degranulation induced by N-formyl-methionyl-leucyl-phenylalanine, serum-treated zymosan and the ionophore A23187. | 1983 | Immunology | pmid:6309653 |
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Menys VC and Davies JA | Inhibitory effects of ZK 36374, a stable prostacyclin analogue, on adhesion of rabbit platelets to damaged aorta and serotonin release by adherent platelets. | 1983 | Clin. Sci. | pmid:6190604 |
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Samuelsson B | From studies of biochemical mechanism to novel biological mediators: prostaglandin endoperoxides, thromboxanes, and leukotrienes. Nobel Lecture, 8 December 1982. | 1983 | Biosci. Rep. | pmid:6315101 |
Gorman RR et al. | Inhibition of platelet thromboxane A2 synthase activity by sodium 5-(3'-pyridinylmethyl)benzofuran-2-carboxylate. | 1983 | Prostaglandins | pmid:6316421 |
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Salmon JA et al. | The effects of BW755C and other anti-inflammatory drugs on eicosanoid concentrations and leukocyte accumulation in experimentally-induced acute inflammation. | 1983 | J. Pharm. Pharmacol. | pmid:6141244 |
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Williams GA et al. | Prostacyclin and thromboxane A2 derivatives in rhegmatogenous subretinal fluid. | 1983 | Arch. Ophthalmol. | pmid:6338873 |
Ylikorkala O et al. | Effect of vacuum curettage on the concentrations of plasma 6-keto-prostaglandin F1 alpha and serum thromboxane B2. | 1983 | Br J Obstet Gynaecol | pmid:6338904 |
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Mest HJ et al. | The influence of linseed oil diet on fatty acid pattern in phospholipids and thromboxane formation in platelets in man. | 1983 | Klin. Wochenschr. | pmid:6341702 |
Hartung HP et al. | Stimulation of prostaglandin E and thromboxane synthesis in macrophages by purified C3b. | 1983 | J. Immunol. | pmid:6343486 |
Deckmyn H et al. | Prostacyclin production by whole blood from children: impairment in the hemolytic uremic syndrome and excessive formation in chronic renal failure. | 1983 | Thromb. Res. | pmid:6344317 |
Ylikorkala O and Viinikka L | Prostaglandins and endometriosis. | 1983 | Acta Obstet Gynecol Scand Suppl | pmid:6344540 |
Ylikorkala O | Prostacyclin and thromboxane during human pregnancy. | 1983 | Acta Obstet Gynecol Scand Suppl | pmid:6344543 |
Qvist R and Larkins RG | Diminished production of thromboxane B2 and prostaglandin E by stimulated polymorphonuclear leukocytes from insulin-treated diabetic subjects. | 1983 | Diabetes | pmid:6345241 |
Newman JH et al. | Effects of 100% oxygen on lung vascular function in awake sheep. | 1983 | J Appl Physiol Respir Environ Exerc Physiol | pmid:6345493 |
Eldor A et al. | Effects of dipyrone on prostaglandin production by human platelets and cultured bovine aortic endothelial cells. | 1983 | Thromb. Haemost. | pmid:6346571 |
Sheng WY et al. | Kinetic comparison and regulation of the cascade of microsomal enzymes involved in renal arachidonate and endoperoxide metabolism. | 1983 | J. Biol. Chem. | pmid:6401732 |
Menys VC and Davies JA | Selective inhibition of thromboxane synthetase with dazoxiben - basis of its inhibitory effect on platelet adhesion. | 1983 | Thromb. Haemost. | pmid:6346575 |
Chetty N and Bradlow BA | The effects of a vegetarian diet on platelet function and fatty acids. | 1983 | Thromb. Res. | pmid:6612688 |
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Kawaguchi H | Thromboxane synthesis in hypercholesterolemic platelets--on the mechanism of increased thromboxane synthesis. | 1983 | Hokkaido Igaku Zasshi | pmid:6618425 |
Dubin NH et al. | Thromboxane production in the pregnant rat: differential recovery by platelets and uterus following aspirin administration. | 1983 | Biol. Reprod. | pmid:6626652 |
Nuotto E et al. | Effect of acetylsalicylic acid on plasma thromboxane B2 and platelet aggregation in man. | 1983 | Eur. J. Clin. Pharmacol. | pmid:6628518 |
Kiff PS et al. | Haemodynamic and metabolic effects of dazoxiben at rest and during atrial pacing. | 1983 | Br J Clin Pharmacol | pmid:6681708 |
Hutton I et al. | Effects of dazoxiben on transcardiac thromboxane levels and haemodynamics in coronary heart disease. | 1983 | Br J Clin Pharmacol | pmid:6681709 |
Feddersen CO et al. | Leukotriene E4 causes pulmonary vasoconstriction, not inhibited by meclofenamate. | 1983 | Prostaglandins | pmid:6098932 |
Socini A et al. | Fish oil administration lowers prostacyclin production and the antiaggregatory activity of aortic walls more effectively than platelet aggregation and thromboxane in the rat. | 1983 | Adv. Prostaglandin Thromboxane Leukot. Res. | pmid:6221591 |
Hornstra G et al. | Dietary-fat-induced changes in the formation of prostanoids of the 2 and 3 series in relation to arterial thrombosis (rat) and atherosclerosis (rabbit). | 1983 | Adv. Prostaglandin Thromboxane Leukot. Res. | pmid:6221593 |
Tremoli E et al. | North Karelian study: changes in dietary fat reduce thromboxane B2 formation by platelets only in male subjects--preliminary report. | 1983 | Adv. Prostaglandin Thromboxane Leukot. Res. | pmid:6221594 |
Basso N et al. | Gastric mucosal prostaglandin generation in rats with stress ulcer. | 1983 | Adv. Prostaglandin Thromboxane Leukot. Res. | pmid:6221618 |
Abiko Y et al. | The stimulation of macrophage prostaglandin E2 and thromboxane B2 secretion by Streptococcus mutans insoluble glucans. | 1983 | FEBS Lett. | pmid:6403385 |
Foegh M et al. | Prostacyclin and thromboxane release from human peritoneal macrophages. | 1983 | Adv. Prostaglandin Thromboxane Leukot. Res. | pmid:6221630 |
Westwick J et al. | Inhibition of thromboxane formation prevents endotoxin-induced renal fibrin deposition in jaundiced rats. | 1983 | Adv. Prostaglandin Thromboxane Leukot. Res. | pmid:6221642 |
Morita I et al. | Stimulation of eicosapentaenoic acid metabolism in washed human platelets by 12-hydroperoxyeicosatetraenoic acid. | 1983 | J. Biol. Chem. | pmid:6309794 |
Sakamoto T | [Studies on platelet function in toxemia of pregnancy]. | 1983 | Nippon Sanka Fujinka Gakkai Zasshi | pmid:6223964 |
Mehta P et al. | Inhibitory effects of diltiazem on platelet activation caused by ionophore A23187 plus ADP or epinephrine in subthreshold concentrations. | 1983 | J. Lab. Clin. Med. | pmid:6411841 |
Gordon PR et al. | Platelet arachidonate metabolism and platelet function in zinc-deficient rats. | 1983 | J. Nutr. | pmid:6403678 |
Winchester JF et al. | Early indicators of renal allograft rejection. | 1983 | Kidney Int. Suppl. | pmid:6224041 |
Okegawa T et al. | Endotoxin induces chronic prostaglandin and thromboxane synthesis from ureter-obstructed kidneys: role of inflammatory cells. | 1983 | J. Pharmacol. Exp. Ther. | pmid:6403696 |
Westwick J et al. | Platelet activation during steady state sickle cell disease. | 1983 | J Med | pmid:6224876 |
Ellsworth ML et al. | Pulmonary prostacyclin production with increased flow and sympathetic stimulation. | 1983 | J Appl Physiol Respir Environ Exerc Physiol | pmid:6415017 |
Dahl ML et al. | Sodium salicylate interferes with the inhibitory effects of aspirin and indomethacin on human platelets. | 1983 | Prostaglandins Leukot Med | pmid:6415666 |
Han P et al. | Verapamil and collagen-induced platelet reactions--evidence for a role for intracellular calcium in platelet activation. | 1983 | Thromb. Haemost. | pmid:6415847 |
Barnhart MI et al. | DDAVP: does the drug have a direct effect on the vessel wall? | 1983 | Thromb. Res. | pmid:6415852 |
Wallis RB | Mechanisms of action of sulphinpyrazone. | 1983 | Thromb. Res. Suppl. | pmid:6415857 |
Wilson L and Huang LS | Effects of the fetal-placental unit on uterine prostaglandin levels at term in the pregnant rat. | 1983 | Prostaglandins | pmid:6688474 |
Saldeen P and Saldeen T | 6-keto-prostaglandin F1 alpha/thromboxane B2 ratio in vascular and lung tissue. | 1983 | Thromb. Res. | pmid:6688484 |
Di Minno G et al. | Monitoring the entry of new platelets into the circulation after ingestion of aspirin. | 1983 | Blood | pmid:6404326 |
Wilson TW | Responses to furosemide in normotensive and hypertensive subjects. | 1983 | Clin. Pharmacol. Ther. | pmid:6688772 |
Gurtner GH et al. | Oxidant- and lipid-induced pulmonary vasoconstriction mediated by arachidonic acid metabolites. | 1983 | J Appl Physiol Respir Environ Exerc Physiol | pmid:6688802 |
van Rijk GL et al. | Long-term myocardial preservation: thromboxane production and coronary resistance. | 1983 | J. Surg. Res. | pmid:6688844 |
Miller JB et al. | Alterations in plasma and tissue prostaglandin levels in rabbits during luteal regression. | 1983 | Biol. Reprod. | pmid:6688954 |
Hidaka T et al. | Thromboxane formation from arachidonic acid and prostaglandin H2 in rabbit spleen. | 1983 | J. Biochem. | pmid:6404897 |
Davì G et al. | The effect of two low doses of aspirin on whole blood thromboxane and prostacyclin generation in healthy subjects. | 1983 | Thromb. Haemost. | pmid:6417815 |
Muccitelli RM et al. | Effect of inhibition of thromboxane production on the leukotriene D4-mediated bronchoconstriction in the guinea pig. | 1983 | Prostaglandins | pmid:6689082 |
Gerozissis K and Dray F | In-vitro prostanoid production by the rat vas deferens. | 1983 | J. Reprod. Fertil. | pmid:6572721 |
Dale J et al. | The effect of a thromboxane synthetase inhibitor, dazoxiben, and acetylsalicylic acid on platelet function and prostaglandin metabolism. | 1983 | Thromb. Haemost. | pmid:6689091 |
Schleimer RP et al. | Effects of dexamethasone on mediator release from human lung fragments and purified human lung mast cells. | 1983 | J. Clin. Invest. | pmid:6134755 |
Liu J | [Effect of Paeonia obovata 801 on metabolism of thromboxane B2 and arachidonic acid and on platelet aggregation in patients with coronary heart disease and cerebral thrombosis]. | 1983 | Zhonghua Yi Xue Za Zhi | pmid:6418338 |
Aehringhaus U et al. | Effect of inhibition of synthesis and receptor antagonism of SRS-A in cardiac anaphylaxis. | 1983 | Br. J. Pharmacol. | pmid:6689134 |
Kurata M | [Relation between mouse peritoneal macrophage functions and prostaglandins]. | 1983 | Rinsho Byori | pmid:6689184 |
Maguire ED and Wallis RB | In vivo redirection of prostaglandin endoperoxides into 6-keto PGF1 alpha formation by thromboxane synthetase inhibitors in the rat. | 1983 | Thromb. Res. | pmid:6689221 |
McDonald JW and Ali M | Recovery of cyclooxygenase activity after aspirin in populations of platelets separated on stractan density gradients. | 1983 | Prostaglandins Leukot Med | pmid:6419234 |
Zijlstra FJ and Vincent JE | Comparison of the determination of thromboxane A2 by bioassay on the rabbit mesenteric artery and in the form of TxB2 by radioimmunoassay. | 1983 | J Pharmacol Methods | pmid:6632924 |
Bryant RW and Hwang DH | Development of a radioimmunoassay for 15-HETE and its application to 15-HETE production by reticulocytes. | 1983 | Prostaglandins | pmid:6419285 |
Wilson L | Effects of estradiol and progesterone on uterine prostaglandin levels in the pregnant rat. | 1983 | Prostaglandins | pmid:6635211 |
Chong KP et al. | Vasopressin stimulates thromboxane synthesis in isolated hamster hepatocytes: relation to hepatocyte calcium content. | 1983 | Prostaglandins | pmid:6419286 |
Hartung HP et al. | Induction of thromboxane release from macrophages by anaphylatoxic peptide C3a of complement and synthetic hexapeptide C3a 72-77. | 1983 | J. Immunol. | pmid:6600482 |
Sautebin L et al. | Preferential utilization of endogenous arachidonate by cyclo-oxygenase in incubations of human platelets. | 1983 | FEBS Lett. | pmid:6407867 |
Zipser RD et al. | Urinary thromboxane B2 and prostaglandin E2 in the hepatorenal syndrome: evidence for increased vasoconstrictor and decreased vasodilator factors. | 1983 | Gastroenterology | pmid:6572162 |
Schenkelaars EJ and Bonta IL | Effect of leukotriene C4 on the release of secretory products by elicited populations of rat peritoneal macrophages. | 1983 | Eur. J. Pharmacol. | pmid:6572592 |
Rocklin RE et al. | Augmentation of prostaglandin and thromboxane production in vitro by monocytes exposed to histamine-induced suppressor factor (HSF). | 1983 | Cell. Immunol. | pmid:6573232 |
Ouwendijk RJ et al. | Raised plasma thromboxane B2 levels in alcoholic liver disease. | 1983 | Prostaglandins Leukot Med | pmid:6573682 |
Hornych A et al. | Thromboxane B2 in borderline and essential hypertensive patients. | 1983 | Prostaglandins Leukot Med | pmid:6573683 |
Flynn JT et al. | Effects of anesthesia and surgery on prostanoid concentrations in plasma and pulmonary lymph. | 1983 | Prostaglandins Leukot Med | pmid:6573688 |
Patel K and Bakhle YS | Thromboxane B2 (TxB2) metabolism in rat isolated lung and its inhibition by drugs. | 1983 | Prostaglandins Leukot Med | pmid:6573689 |
Hoult JR and Robinson C | Selective inhibition of thromboxane B2 accumulation and metabolism in perfused guinea-pig lung. | 1983 | Br. J. Pharmacol. | pmid:6824820 |
Hirsh PD et al. | Effects of provocation on transcardiac thromboxane in patients with coronary artery disease. | 1983 | Am. J. Cardiol. | pmid:6829431 |
Walinsky P et al. | Beneficial effects of ibuprofen in pacing-induced myocardial ischemia. | 1983 | Am. J. Cardiol. | pmid:6829434 |
Gimenez T et al. | Fetal-maternal secretion of prostaglandins in the cow. | 1983 | Prostaglandins | pmid:6576447 |
Hayashi Y et al. | Enzyme immunoassay of thromboxane B2. | 1983 | Biochim. Biophys. Acta | pmid:6407530 |
Poyser NL and Brydon LJ | Prostaglandin release from the guinea-pig uterus superfused in vitro. Effect of stage of estrous cycle, progesterone, estradiol, oxytocin and A23187. | 1983 | Prostaglandins | pmid:6408712 |
Butler RR et al. | Gentamicin and indomethacin in the treatment of septic shock: effects on prostacyclin and thromboxane A2 production. | 1983 | J. Pharmacol. Exp. Ther. | pmid:6339712 |
Laitinen O et al. | Plasma levels and urinary excretion of prostaglandins in patients with rheumatoid arthritis. | 1983 | Clin. Rheumatol. | pmid:6589104 |
Ouwendijk RJ et al. | Raised plasma levels of thromboxane B2 in systemic mastocytosis. | 1983 | Eur. J. Clin. Invest. | pmid:6409646 |
Snapper JR et al. | Effects of cyclooxygenase inhibitors on the alterations in lung mechanics caused by endotoxemia in the unanesthetized sheep. | 1983 | J. Clin. Invest. | pmid:6409930 |