Thromboxane b2 is a lipid of Fatty Acyls (FA) class. Thromboxane b2 is associated with abnormalities such as endothelial dysfunction, Diabetes Mellitus, Non-Insulin-Dependent, Diabetes Mellitus, Ischemia and Thrombocytosis. The involved functions are known as Platelet Activation, Excretory function, Anabolism, Inflammation and mRNA Expression. Thromboxane b2 often locates in Endothelium, Hepatic and Microsomes, Liver. The associated genes with Thromboxane b2 are PTGS2 gene, prothrombin fragment 2 and CCL14 wt Allele.
To understand associated biological information of Thromboxane b2, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
Thromboxane b2 is suspected in endothelial dysfunction, Diabetes Mellitus, Non-Insulin-Dependent, Diabetes Mellitus, Ischemia, Thrombocytosis, Acute Coronary Syndrome and other diseases in descending order of the highest number of associated sentences.
Disease | Cross reference | Weighted score | Related literature |
---|
We collected disease MeSH terms mapped to the references associated with Thromboxane b2
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
Location | Cross reference | Weighted score | Related literatures |
---|
Function | Cross reference | Weighted score | Related literatures |
---|
There are no associated biomedical information in the current reference collection.
Gene | Cross reference | Weighted score | Related literatures |
---|
There are no associated biomedical information in the current reference collection.
Authors | Title | Published | Journal | PubMed Link |
---|---|---|---|---|
Gama de Abreu M et al. | Vaporized perfluorohexane attenuates ventilator-induced lung injury in isolated, perfused rabbit lungs. | 2005 | Anesthesiology | pmid:15731599 |
Sheu JR et al. | Mechanisms involved in the antiplatelet activity of midazolam in human platelets. | 2002 | Anesthesiology | pmid:11873041 |
Morel DR et al. | Adverse cardiopulmonary effects and increased plasma thromboxane concentrations following the neutralization of heparin with protamine in awake sheep are infusion rate-dependent. | 1990 | Anesthesiology | pmid:2098007 |
Hirakata H et al. | Sevoflurane inhibits human platelet aggregation and thromboxane A2 formation, possibly by suppression of cyclooxygenase activity. | 1996 | Anesthesiology | pmid:8968193 |
Shayevitz JR et al. | Inhalation anesthetics augment oxidant-induced pulmonary vasoconstriction: evidence for a membrane effect. | 1985 | Anesthesiology | pmid:3933385 |
Munsterhjelm E et al. | Dose-dependent inhibition of platelet function by acetaminophen in healthy volunteers. | 2005 | Anesthesiology | pmid:16192763 |
Horiguchi T et al. | Heparin-protamine complexes cause pulmonary hypertension in goats. | 1995 | Anesthesiology | pmid:7574058 |
Hirakata H et al. | Propofol has both enhancing and suppressing effects on human platelet aggregation in vitro. | 1999 | Anesthesiology | pmid:10551587 |
Heller A et al. | Pancreatitis-associated protein protects the lung from leukocyte-induced injury. | 1999 | Anesthesiology | pmid:10551593 |
Fratacci MD et al. | Inhaled nitric oxide. A selective pulmonary vasodilator of heparin-protamine vasoconstriction in sheep. | 1991 | Anesthesiology | pmid:1741521 |
Numano F et al. | Antiaggregative aspirin dosage at the affected vessel wall. | 1986 | Angiology | pmid:2876664 |
Bölke E et al. | Changes of gut barrier function during anesthesia and cardiac surgery. | 2001 | Angiology | pmid:11515987 |
Mikhailidis DP et al. | Platelet function in patients admitted with a diagnosis of myocardial infarction. | 1987 | Angiology | pmid:2880535 |
Vissinger H et al. | Platelet-derived growth factor release and antiplatelet treatment with low-dose acetylsalicylic acid. | 1993 | Angiology | pmid:8342880 |
Saitta A et al. | Effects of picotamide on release of endothelin-1, thromboxane and prostacycline after treadmill stress in patients with peripheral artery disease. | 1998 | Angiology | pmid:9822043 |
Jean T and Bodinier MC | Mediators involved in inflammation: effects of Daflon 500 mg on their release. | 1994 | Angiology | pmid:8203787 |
Nichols WW et al. | Reduced myocardial neutrophil accumulation and infarct size following thromboxane synthetase inhibitor or receptor antagonist. | 1989 | Angiology | pmid:2537051 |
Sinzinger H et al. | Platelet half-life, plasma thromboxane B2 and circulating endothelial-cells in peripheral vascular disease. | 1986 | Angiology | pmid:3954150 |
Nagano H et al. | Cerebral microcirculatory changes after cerebral embolization induced by glass bead injection in rabbits. | 1992 | Angiology | pmid:1632571 |
Takase B et al. | Arachidonic acid metabolites in acute myocardial infarction. | 1996 | Angiology | pmid:8686958 |
Oda H et al. | Alcohol and coronary spasm. | 1994 | Angiology | pmid:8129199 |
Kurita A et al. | The effects of orally administered atenolol on the coronary hemodynamics and prostaglandin metabolism in angina pectoris patients. | 1994 | Angiology | pmid:8129203 |
Fujinishi A et al. | Effects of nisoldipine on cytosolic calcium, platelet aggregation, and coagulation/fibrinolysis in patients with coronary artery disease. | 1997 | Angiology | pmid:9194537 |
Nishikata H et al. | Induction of bronchial hyperresponsiveness by Bordetella bronchiseptica infection in dogs. | 1989 | Ann Allergy | pmid:2643371 |
Kivioja A et al. | Platelet activation during acute phase after multiple trauma. | 1992 | Ann Chir Gynaecol | pmid:1456710 |
Lin TY et al. | The effect of YAG laser anterior capsulotomy on prostaglandin concentration in aqueous humor. | 1988 | Ann Ophthalmol | pmid:3400958 |
Mohri H and Ohkubo T | Single-dose effect of enteric-coated aspirin on platelet function and thromboxane generation in middle-aged men. | 1993 | Ann Pharmacother | pmid:8477113 |
Tanen DA et al. | Comparison of oral aspirin versus topical applied methyl salicylate for platelet inhibition. | 2008 | Ann Pharmacother | pmid:18698012 |
Angel MF et al. | The effect of prior elevation of skin flaps and ischemia on blood thromboxane levels. | 1989 | Ann Plast Surg | pmid:2751221 |
Edstrom LE et al. | Effect of ischemic skin flap elevation on tissue and plasma thromboxane A2 and prostacyclin production: modification by thromboxane synthetase inhibition. | 1988 | Ann Plast Surg | pmid:3281544 |
Paterson IS et al. | Reperfusion plasma contains a neutrophil activator. | 1993 | Ann Vasc Surg | pmid:8390848 |
Ascer E et al. | Interleukin-1 and thromboxane release after skeletal muscle ischemia and reperfusion. | 1992 | Ann Vasc Surg | pmid:1547081 |
Fukushima C et al. | In vitro responses to antigen stimulation: comparison between human lung parenchyma resected from asthmatic patients and non-asthmatic patients. | 1999 | Ann. Allergy Asthma Immunol. | pmid:10071522 |
Zhao Y et al. | Effect of a Chinese herbal formula, Shi-Bi-Lin, on an experimental model of allergic rhinitis. | 2006 | Ann. Allergy Asthma Immunol. | pmid:16802773 |
Fukushima C et al. | Effect of synthetase inhibitors and receptor antagonists in antigen-induced contraction of human lung parenchyma. | 1998 | Ann. Allergy Asthma Immunol. | pmid:9532973 |
Takao A et al. | Inhibitory effects of azelastine hydrochloride in alcohol-induced asthma. | 1999 | Ann. Allergy Asthma Immunol. | pmid:10227338 |
Fukushima C et al. | Inhibitory effect of thromboxane A2 synthetase inhibitor, DP-1904, on antigen-induced contraction of human lung parenchyma. | 1996 | Ann. Allergy Asthma Immunol. | pmid:8970439 |
Morris RH and Davies GG | Thin layer chromatographic identification of thromboxane B2 in serum, and platelet rich plasma stimulated by arachidonic acid and collagen. | 1993 | Ann. Clin. Biochem. | pmid:8466155 |
Nordøy A | Lipids and thrombogenesis. | 1981 | Ann. Clin. Res. | pmid:7018362 |
Ylikorkala O | Prostanoids in gynaecology. | 1984 | Ann. Clin. Res. | pmid:6398666 |
Vapaatalo H et al. | Prostanoids in blood pressure regulation and their role in the blood pressure lowering effects induced by changes in dietary fats. | 1984 | Ann. Clin. Res. | pmid:6398981 |
Elias M et al. | Stabilization of standard platelet concentrates and minimization of the platelet storage lesion by a prostacyclin analogue. | 1992 | Ann. Hematol. | pmid:1379080 |
Lee M et al. | Dose effects of aspirin on gastric prostaglandins and stomach mucosal injury. | 1994 | Ann. Intern. Med. | pmid:8273981 |
Whelton A et al. | Renal effects of ibuprofen, piroxicam, and sulindac in patients with asymptomatic renal failure. A prospective, randomized, crossover comparison. | 1990 | Ann. Intern. Med. | pmid:2183665 |
Emanuelli G et al. | [Effects of anti-adrenergic drugs on thrombin-induced platelet aggregation and thromboxane B2 production]. | 1988 Oct-Dec | Ann. Ital. Med. Int. | pmid:3275193 |
Osterud B and Hansen JB | Fatty acids, platelets and monocytes. Something to do with atherogenesis. | 1989 | Ann. Med. | pmid:2923703 |
Pratico D et al. | Cyclooxygenase-dependent formation of the isoprostane 8-epi prostaglandin F2 alpha. | 1994 | Ann. N. Y. Acad. Sci. | pmid:7825834 |
Feuerstein G | Eicosanoids in deteriorating stroke. Review of studies on the rabbit spinal cord ischemia and reperfusion model. | 1989 | Ann. N. Y. Acad. Sci. | pmid:2774403 |
Panganamala RV and Cornwell DG | The effects of vitamin E on arachidonic acid metabolism. | 1982 | Ann. N. Y. Acad. Sci. | pmid:6816121 |
Hansen TN and Carpenter JF | The role of platelets in chilling-induced injury. | 1994 | Ann. N. Y. Acad. Sci. | pmid:8017779 |
Wong PY et al. | The role of calmodulin in prostaglandin metabolism. | 1980 | Ann. N. Y. Acad. Sci. | pmid:6940495 |
Gryglewski RJ et al. | Prostacyclin, nitric oxide, and atherosclerosis. | 1995 | Ann. N. Y. Acad. Sci. | pmid:7695165 |
Numano F et al. | Prostacyclin and variant angina. | 1985 | Ann. N. Y. Acad. Sci. | pmid:3865605 |
Jesse RL et al. | Dehydroepiandrosterone inhibits human platelet aggregation in vitro and in vivo. | 1995 | Ann. N. Y. Acad. Sci. | pmid:8597466 |
Hartung HP et al. | Substance P stimulates release of arachidonic acid cyclooxygenation products from primary culture rat astrocytes. | 1988 | Ann. N. Y. Acad. Sci. | pmid:2462817 |
Takami M et al. | Effect of DP-1904, a new thromboxane A2 synthetase inhibitor, on guinea pig experimental asthma. | 1991 | Ann. N. Y. Acad. Sci. | pmid:1952565 |
Crinnion JN et al. | Neutrophils and the endothelium in post-ischemic alterations in skeletal muscle blood flow. | 1994 | Ann. N. Y. Acad. Sci. | pmid:8030907 |
Elmadfa I et al. | Influence of a single parenteral application of a 10% fish oil emulsion on plasma fatty acid pattern and the function of thrombocytes in young adult men. | 1993 | Ann. Nutr. Metab. | pmid:8470873 |
Cunnane SC | Vitamin E intake affects serum thromboxane and tissue essential fatty acid composition in the rat. | 1988 | Ann. Nutr. Metab. | pmid:3214140 |
Quoc KP and Pascaud M | Effects of dietary gamma-linolenic acid on the tissue phospholipid fatty acid composition and the synthesis of eicosanoids in rats. | 1996 | Ann. Nutr. Metab. | pmid:8773734 |
Masi I et al. | Diets rich in saturated, monounsaturated and polyunsaturated fatty acids differently affect plasma lipids, platelet and arterial wall eicosanoids in rabbits. | 1986 | Ann. Nutr. Metab. | pmid:3513691 |
Ferry DR et al. | A phase II study of the 5-lipoxygenase inhibitor, CV6504, in advanced pancreatic cancer: correlation of clinical data with pharmacokinetic and pharmacodynamic endpoints. | 2000 | Ann. Oncol. | pmid:11061613 |
Diven WF et al. | Expression of acute otitis media after receptor blockade of platelet activating factor, thromboxane, and leukotrienes in the chinchilla. | 1998 | Ann. Otol. Rhinol. Laryngol. | pmid:9525240 |
Herrick AL et al. | Von Willebrand factor, thrombomodulin, thromboxane, beta-thromboglobulin and markers of fibrinolysis in primary Raynaud's phenomenon and systemic sclerosis. | 1996 | Ann. Rheum. Dis. | pmid:8712862 |
Tishler M et al. | Salivary eicosanoid concentration in patients with Sjögren's syndrome. | 1996 | Ann. Rheum. Dis. | pmid:8712887 |
Katz JM et al. | Inhibition of prostaglandin action and bone resorption by copper. | 1984 | Ann. Rheum. Dis. | pmid:6441529 |
Tsai CY et al. | Effect of antibodies to double stranded DNA, purified from serum samples of patients with active systemic lupus erythematosus, on the glomerular mesangial cells. | 1992 | Ann. Rheum. Dis. | pmid:1550397 |
Salmon JA et al. | Synthesis of arachidonate cyclo-oxygenase products by rheumatoid and nonrheumatoid synovial lining in nonproliferative organ culture. | 1983 | Ann. Rheum. Dis. | pmid:6402992 |
Seitz M and Hunstein W | Enhanced prostanoid release from monocytes of patients with rheumatoid arthritis and active systemic lupus erythematosus. | 1985 | Ann. Rheum. Dis. | pmid:4026405 |
Doube A et al. | Effect of misoprostol on concentrations of prostaglandins in synovial fluid. | 1991 | Ann. Rheum. Dis. | pmid:1772296 |
Taha AS et al. | Effect on gastric and duodenal mucosal prostaglandins of repeated intake of therapeutic doses of naproxen and etodolac in rheumatoid arthritis. | 1990 | Ann. Rheum. Dis. | pmid:2143369 |
Welbourn R et al. | Involvement of thromboxane and neutrophils in multiple-system organ edema with interleukin-2. | 1990 | Ann. Surg. | pmid:2256765 |
Fletcher JR et al. | Platelet activating factor receptor antagonist improves survival and attenuates eicosanoid release in severe endotoxemia. | 1990 | Ann. Surg. | pmid:2178565 |
Anner H et al. | Pulmonary hypertension and leukosequestration after lower torso ischemia. | 1987 | Ann. Surg. | pmid:3675025 |
Klausner JM et al. | The rapid induction by interleukin-2 of pulmonary microvascular permeability. | 1989 | Ann. Surg. | pmid:2783363 |
Huval WV et al. | Role of serotonin in patients with acute respiratory failure. | 1984 | Ann. Surg. | pmid:6547816 |
Utsunomiya T et al. | Maintenance of cardiodynamics with aspirin during abdominal aortic aneurysmectomy (AAA). | 1981 | Ann. Surg. | pmid:6117260 |
Mackey WC et al. | Aspirin decreases platelet uptake on Dacron vascular grafts in baboons. | 1984 | Ann. Surg. | pmid:6233945 |
Myers SI et al. | Reperfusion inhibits elevated splanchnic prostanoid production after hemorrhagic shock. | 1990 | Ann. Surg. | pmid:2256760 |
Paterson IS et al. | Pulmonary edema after aneurysm surgery is modified by mannitol. | 1989 | Ann. Surg. | pmid:2511812 |
Klausner JM et al. | Limb ischemia-induced increase in permeability is mediated by leukocytes and leukotrienes. | 1988 | Ann. Surg. | pmid:3196098 |
Klausner JM et al. | Lower torso ischemia-induced lung injury is leukocyte dependent. | 1988 | Ann. Surg. | pmid:3196099 |
Fletcher JR et al. | Tumor necrosis factor-induced mortality is reversed with cyclooxygenase inhibition. | 1993 | Ann. Surg. | pmid:8507112 |
Valeri CR et al. | Hypothermia-induced reversible platelet dysfunction. | 1987 | Ann. Surg. | pmid:3813688 |
Rivkind AI et al. | Sequential patterns of eicosanoid, platelet, and neutrophil interactions in the evolution of the fulminant post-traumatic adult respiratory distress syndrome. | 1989 | Ann. Surg. | pmid:2549891 |
Klausner JM et al. | Vasodilating prostaglandins attenuate ischemic renal injury only if thromboxane is inhibited. | 1989 | Ann. Surg. | pmid:2644899 |
Gottlieb A et al. | The role of prostacyclin in the mesenteric traction syndrome during anesthesia for abdominal aortic reconstructive surgery. | 1989 | Ann. Surg. | pmid:2647052 |
Lelcuk S et al. | Thromboxane A2 moderates permeability after limb ischemia. | 1985 | Ann. Surg. | pmid:3840349 |
Welbourn R et al. | Interleukin-2 induces early multisystem organ edema mediated by neutrophils. | 1991 | Ann. Surg. | pmid:1867524 |
Li G et al. | Cardiac ischemic preconditioning improves lung preservation in valve replacement operations. | 2001 | Ann. Thorac. Surg. | pmid:11235719 |
Karwande SV et al. | Effect of preoperative antiplatelet drugs on vascular prostacyclin synthesis. | 1987 | Ann. Thorac. Surg. | pmid:3548616 |
DiSesa VJ et al. | Disadvantages of prostacyclin infusion during cardiopulmonary bypass: a double-blind study of 50 patients having coronary revascularization. | 1984 | Ann. Thorac. Surg. | pmid:6388516 |
DeCampli WM et al. | Pharmacological, hematological, and physiological effects of a new thromboxane synthetase inhibitor (CGS-13080) during cardiopulmonary bypass in dogs. | 1986 | Ann. Thorac. Surg. | pmid:3789860 |
Singh HP et al. | Prostacyclin and thromboxane levels in pleural space fluid during cardiopulmonary bypass. | 1995 | Ann. Thorac. Surg. | pmid:7887705 |
Tabuchi N et al. | Aprotinin preserves hemostasis in aspirin-treated patients undergoing cardiopulmonary bypass. | 1994 | Ann. Thorac. Surg. | pmid:7524460 |
Lappegård KT et al. | Differential effect of heparin coating and complement inhibition on artificial surface-induced eicosanoid production. | 2005 | Ann. Thorac. Surg. | pmid:15734405 |
Teoh KH et al. | Blood conservation with membrane oxygenators and dipyridamole. | 1987 | Ann. Thorac. Surg. | pmid:3300583 |
Hashimoto K et al. | Perfusion pressure control by adenosine triphosphate given during cardiopulmonary bypass. | 1993 | Ann. Thorac. Surg. | pmid:8417658 |
Schönberger JP et al. | Systemic blood activation during and after autotransfusion. | 1994 | Ann. Thorac. Surg. | pmid:8179396 |
Walenga JM et al. | Hemostatic abnormalities in total artificial heart patients as detected by specific blood markers. | 1992 | Ann. Thorac. Surg. | pmid:1570981 |