| MeSH term | MeSH ID | Detail |
|---|---|---|
| Adenocarcinoma | D000230 | 166 associated lipids |
| Lung Neoplasms | D008175 | 171 associated lipids |
| Body Weight | D001835 | 333 associated lipids |
Thromboxane b2
Thromboxane b2 is a lipid of Fatty Acyls (FA) class. Thromboxane b2 is associated with abnormalities such as endothelial dysfunction, Diabetes Mellitus, Non-Insulin-Dependent, Diabetes Mellitus, Ischemia and Thrombocytosis. The involved functions are known as Platelet Activation, Excretory function, Anabolism, Inflammation and mRNA Expression. Thromboxane b2 often locates in Endothelium, Hepatic and Microsomes, Liver. The associated genes with Thromboxane b2 are PTGS2 gene, prothrombin fragment 2 and CCL14 wt Allele.
Cross Reference
Introduction
To understand associated biological information of Thromboxane b2, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with Thromboxane b2?
Thromboxane b2 is suspected in endothelial dysfunction, Diabetes Mellitus, Non-Insulin-Dependent, Diabetes Mellitus, Ischemia, Thrombocytosis, Acute Coronary Syndrome and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
| Disease | Cross reference | Weighted score | Related literature |
|---|
Loading... please refresh the page if content is not showing up.
Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with Thromboxane b2
PubChem Associated disorders and diseases
What pathways are associated with Thromboxane b2
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with Thromboxane b2?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
|---|
Loading... please refresh the page if content is not showing up.
What functions are associated with Thromboxane b2?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
|---|
What lipids are associated with Thromboxane b2?
There are no associated biomedical information in the current reference collection.
What genes are associated with Thromboxane b2?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
|---|
What common seen animal models are associated with Thromboxane b2?
There are no associated biomedical information in the current reference collection.
NCBI Entrez Crosslinks
All references with Thromboxane b2
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Massicot F et al. | In vitro assessment of renal toxicity and inflammatory events of two protein phosphatase inhibitors cantharidin and nor-cantharidin. | 2005 | Basic Clin. Pharmacol. Toxicol. | pmid:15667592 |
| Calapai G et al. | Cardiovascular biomarkers in groups of established smokers after a decade of smoking. | 2009 | Basic Clin. Pharmacol. Toxicol. | pmid:19175368 |
| Faiman MD and Patton LM | Prostaglandins and leukotrienes in pulmonary O2 toxicity. | 1988 | Basic Life Sci. | pmid:3250547 |
| Heindl B et al. | The volatile anesthetic sevoflurane mitigates cardiodepressive effects of platelets in reperfused hearts. | 1999 | Basic Res. Cardiol. | pmid:10326658 |
| Röth E and Török B | Effect of the ultrashort-acting beta-blocker Brevibloc on free-radical-mediated injuries during the early reperfusion state. | 1991 Sep-Oct | Basic Res. Cardiol. | pmid:1685083 |
| Hartog JM et al. | The effects of dietary mackerel oil on plasma and cell membrane lipids, on hemodynamics and cardiac arrhythmias during recurrent acute ischemia in the pig. | 1986 Nov-Dec | Basic Res. Cardiol. | pmid:3814052 |
| Clement R et al. | Role of a nonsteroidal anti-inflammatory agent, ibuprofen, in coronary revascularization after acute myocardial infarction. | 1990 Jan-Feb | Basic Res. Cardiol. | pmid:2109599 |
| Kleinbongard P et al. | Acute vasomotor paralysis and potential downstream effects of paclitaxel from stents implanted for saphenous vein aorto-coronary bypass stenosis. | 2011 | Basic Res. Cardiol. | pmid:21472462 |
| Jolly SR et al. | Platelet depletion in experimental myocardial infarction. | 1985 May-Jun | Basic Res. Cardiol. | pmid:4026785 |
| Dion PR et al. | Aerobic fitness level (VO2max) moderates the increased cardiovascular function and basal thromboxane formation of young healthy Type A males. | 1992 | Behav Med | pmid:1591443 |
| Liu TF et al. | [Correlation between the level of the urinary 11-dehydrothromboxane B2 and the clinical efficacy of aspirin in patients with type 2 diabetes and coronary artery disease]. | 2015 | Beijing Da Xue Xue Bao | pmid:26679651 |
| Varma D et al. | Comparison of UHPLC and HPLC methods for the assay of prostanoids: "are the methods equivalent in terms of accuracy and precision?". | 2011 | Bioanalysis | pmid:21510759 |
| Subbiah MT and Dietemeyer D | Altered synthesis of prostaglandins in platelet and aorta from spontaneously diabetic Wistar rats. | 1980 | Biochem Med | pmid:6893150 |
| Aviram M et al. | Plasma lipoproteins affect platelet malondialdehyde and thromboxane B2 production. | 1985 | Biochem Med | pmid:4052061 |
| Held HD et al. | Phosphodiesterase inhibitors prevent endothelin-1-induced vasoconstriction, bronchoconstriction, and thromboxane release in perfused rat lung. | 1997 | Biochem. Biophys. Res. Commun. | pmid:9070212 |
| McCluskey ER et al. | In vivo inhibition of thromboxane synthetase in infarcted canine myocardium. | 1984 | Biochem. Biophys. Res. Commun. | pmid:6539597 |
| RodrÃguez-Puyol D et al. | Lack of a direct regulatory effect of atrial natriuretic factor on prostaglandins and renin release by isolated rat glomeruli. | 1986 | Biochem. Biophys. Res. Commun. | pmid:2943276 |
| Quilley CP and Rifkind AB | Prostaglandin release by the chick embryo heart is increased by 2,3,7,8-tetrachlorodibenzo-p-dioxin and by other cytochrome P-448 inducers. | 1986 | Biochem. Biophys. Res. Commun. | pmid:3085671 |
| Kaneko I et al. | Prostaglandin F(2alpha) regulates cytokine responses of mast cells through the receptors for prostaglandin E. | 2008 | Biochem. Biophys. Res. Commun. | pmid:18190789 |
| Gonchar MV et al. | Lack of direct connection between arachidonic acid release and prostanoid synthesis upon differentiation of U937 cell. | 1998 | Biochem. Biophys. Res. Commun. | pmid:9731221 |
| Wassef NM et al. | Prostaglandin and thromboxane in liposomes: suppression of the primary immune response to liposomal antigens. | 1989 | Biochem. Biophys. Res. Commun. | pmid:2719681 |
| Resink TJ et al. | Histamine-induced phosphoinositide metabolism in cultured human umbilical vein endothelial cells. Association with thromboxane and prostacyclin release. | 1987 | Biochem. Biophys. Res. Commun. | pmid:3034250 |
| Wientroub S et al. | Changes in tissue concentration of prostaglandins during endochondral bone differentiation. | 1983 | Biochem. Biophys. Res. Commun. | pmid:6582850 |
| Matsumoto H et al. | Concordant induction of prostaglandin E2 synthase with cyclooxygenase-2 leads to preferred production of prostaglandin E2 over thromboxane and prostaglandin D2 in lipopolysaccharide-stimulated rat peritoneal macrophages. | 1997 | Biochem. Biophys. Res. Commun. | pmid:9020023 |
| López-Farré A et al. | Glomeruli from ischemic rat kidneys produce increased amounts of platelet activating factor. | 1988 | Biochem. Biophys. Res. Commun. | pmid:3358756 |
| Lagarde M et al. | Inhibition of thrombin-induced platelet arachidonic acid release by 15-hydroperoxy-arachidonic acid. | 1981 | Biochem. Biophys. Res. Commun. | pmid:7259783 |
| Chignard M et al. | Synthesis of thromboxane B2 in incubates of dog platelet-rich plasma with arachidonic acid and its inhibition by different drugs. | 1978 | Biochem. Biophys. Res. Commun. | pmid:743319 |
| Wong PY and Cheung WY | Calmodulin stimulates human platelet phospholipase A2. | 1979 | Biochem. Biophys. Res. Commun. | pmid:116656 |
| Rola-Pleszczynski M et al. | Inhibition of human lymphocyte proliferation and interleukin 2 production by platelet activating factor (PAF-acether): reversal by a specific antagonist, BN 52021. | 1987 | Biochem. Biophys. Res. Commun. | pmid:3493773 |
| Best LC et al. | Evidence that extracellular calcium ions inhibit thromboxane B2 biosynthesis by human platelets. | 1979 | Biochem. Biophys. Res. Commun. | pmid:117802 |
| Mobley A and Tai HH | Synergistic stimulation of thromboxane biosynthesis by calcium ionophore and phorbol ester or thrombin in human platelets. | 1985 | Biochem. Biophys. Res. Commun. | pmid:3927908 |
| Poll C et al. | Activation of protein kinase C inhibits sodium fluoride-induced elevation of human platelet cytosolic free calcium and thromboxane B2 generation. | 1986 | Biochem. Biophys. Res. Commun. | pmid:3085668 |
| Ashmore RC et al. | Aggregating platelets increase intracellular calcium in endothelial cells through release of adenine nucleotides. | 1990 | Biochem. Biophys. Res. Commun. | pmid:2302246 |
| O'Sullivan MG et al. | Lipopolysaccharide-induced expression of prostaglandin H synthase-2 in alveolar macrophages is inhibited by dexamethasone but not by aspirin. | 1993 | Biochem. Biophys. Res. Commun. | pmid:8466506 |
| Crawford A et al. | Rat osteogenic sarcoma cells: comparison of the effects of prostaglandins E1, E2, I2 (prostacyclin), 6-keto F1alpha and thromboxane B2 on cyclic AMP production and adenylate cyclase activity. | 1978 | Biochem. Biophys. Res. Commun. | pmid:212039 |
| Remick DG et al. | Stimulation of prostaglandin E2 and thromboxane B2 production by human monocytes in response to interleukin-2. | 1987 | Biochem. Biophys. Res. Commun. | pmid:3498487 |
| Saeed SA et al. | Dual inhibition of cyclooxygenase and lipoxygenase by human haptoglobin: its polymorphism and relation to hemoglobin binding. | 2007 | Biochem. Biophys. Res. Commun. | pmid:17198677 |
| Ku EC et al. | Characterization of imidazo[1,5-a]pyridine-5-hexanoic acid (CGS 13080) as a selective thromboxane synthetase inhibitor using in vitro and in vivo biochemical models. | 1983 | Biochem. Biophys. Res. Commun. | pmid:6687803 |
| Balduini CL et al. | Interrelation of platelet aggregation, release reaction and thromboxane A2 production. | 1988 | Biochem. Biophys. Res. Commun. | pmid:3190682 |
| Hashimoto Y et al. | Time-dependent inhibition of the cyclooxygenase pathway by 12-hydroperoxy-5,8,10,14-eicosatetraenoic acid. | 1985 | Biochem. Biophys. Res. Commun. | pmid:3927909 |
| Velardo B and Lagarde M | Differential effect of external calcium on the oxygenated metabolism of endogenous and exogenous arachidonic acid in platelets. | 1985 | Biochem. Biophys. Res. Commun. | pmid:3927915 |
| Yamaja Setty BN et al. | 13-Hydroxyoctadeca-9,11-dienoic acid (13-HODE) inhibits thromboxane A2 synthesis, and stimulates 12-HETE production in human platelets. | 1987 | Biochem. Biophys. Res. Commun. | pmid:3120708 |
| Elander N et al. | Genetic deletion of mPGES-1 accelerates intestinal tumorigenesis in APC(Min/+) mice. | 2008 | Biochem. Biophys. Res. Commun. | pmid:18485889 |
| Yamamoto T et al. | Production of prostanoids and nitric oxide by infarcted heart in situ and the effect of aspirin. | 1999 | Biochem. Biophys. Res. Commun. | pmid:10198239 |
| Pace-Asciak CR and Edwards NS | Tetranor thromboxane B2 is the principal urinary catabolite formed after i.v. infusion of thromboxane B2 in the rat. | 1980 | Biochem. Biophys. Res. Commun. | pmid:7458943 |
| Hamazaki T et al. | The infusion of trieicosapentaenoyl-glycerol into humans and the in vivo formation of prostaglandin I3 and thromboxane A3. | 1988 | Biochem. Biophys. Res. Commun. | pmid:3281674 |
| Higashihara M et al. | Interaction of Solanum tuberosum agglutinin with human platelets. | 1984 | Biochem. Biophys. Res. Commun. | pmid:6732807 |
| Fujimoto Y et al. | Monochloramine potently inhibits arachidonic acid metabolism in rat platelets. | 2006 | Biochem. Biophys. Res. Commun. | pmid:16615995 |
| Lecompte T et al. | Interference of transmethylation inhibitors with thromboxane synthesis in rat platelets. | 1982 | Biochem. Biophys. Res. Commun. | pmid:6809005 |
| Honn KV and Meyer J | Thromboxanes and prostacyclin: positive and negative modulators of tumor growth. | 1981 | Biochem. Biophys. Res. Commun. | pmid:6274330 |
| Stimler NP | Spasmogenic activity of C5adesArg anaphylatoxin on guinea pig lung parenchymal strips: sensitivity of the leukotriene-mediated component to cyclooxygenase inhibitors. | 1984 | Biochem. Biophys. Res. Commun. | pmid:6440564 |
| Crutchley DJ | Effects of inhibitors of arachidonic acid metabolism on thromboplastin activity in human monocytes. | 1984 | Biochem. Biophys. Res. Commun. | pmid:6422935 |
| Maccarrone M et al. | Activation of different lipoxygenase isozymes induces apoptosis in human erythroleukemia and neuroblastoma cells. | 2000 | Biochem. Biophys. Res. Commun. | pmid:10833416 |
| Igarashi K et al. | Effect of polyamines on prostaglandin synthesis in various cell-free systems. | 1981 | Biochem. Biophys. Res. Commun. | pmid:6800368 |
| Gairola C and Tai HH | Selective inhibition of leukotriene B4 biosynthesis in rat pulmonary alveolar macrophages by dietary selenium deficiency. | 1985 | Biochem. Biophys. Res. Commun. | pmid:2998361 |
| Sane DC et al. | Cyclic GMP analogs inhibit gamma thrombin-induced arachidonic acid release in human platelets. | 1989 | Biochem. Biophys. Res. Commun. | pmid:2557018 |
| Miller JL et al. | Arachidonic acid metabolism in guinea pig megakaryocytes. | 1982 | Biochem. Biophys. Res. Commun. | pmid:6812584 |
| Walenga RW et al. | Recovery of megakaryocyte thromboxane production in vitro after aspirin inhibition. | 1984 | Biochem. Biophys. Res. Commun. | pmid:6712680 |
| Fuse I and Tai HH | Stimulations of arachidonate release and inositol-1,4,5-triphosphate formation are mediated by distinct G-proteins in human platelets. | 1987 | Biochem. Biophys. Res. Commun. | pmid:3113425 |
| Dratewka-Kos E et al. | Unsaturated fatty acids inhibit ADP- arachidonate-induced platelet aggregation without affecting thromboxane synthesis. | 1986 | Biochem. Cell Biol. | pmid:3778664 |
| Ariyoshi H et al. | Characteristics of various synthetic peptide calpain inhibitors and their application for the analysis of platelet reaction. | 1991 | Biochem. Int. | pmid:1953797 |
| GarcÃa-Sáinz JA et al. | Melittin stimulates liver glycogenolysis and the release of prostaglandin D2 and thromboxane B2. | 1990 | Biochem. J. | pmid:2375756 |
| Tai HH et al. | Transformation of arachidonate into 6-oxoprostaglandin F1 alpha, thromboxane B2 and prostaglandin E2 by sheep lung microsomal fraction. | 1978 | Biochem. J. | pmid:637853 |
| vom Dahl S et al. | Stimulation of release of prostaglandin D2 and thromboxane B2 from perfused rat liver by extracellular adenosine. | 1990 | Biochem. J. | pmid:2396991 |
| Penning LC et al. | Ca(2+)-mediated prostaglandin E2 induction reduces haematoporphyrin-derivative-induced cytotoxicity of T24 human bladder transitional carcinoma cells in vitro. | 1993 | Biochem. J. | pmid:8503851 |
| Krug HF et al. | Mechanism of inhibition of cyclo-oxygenase in human blood platelets by carbamate insecticides. | 1988 | Biochem. J. | pmid:3128272 |
| Calzada C et al. | Low concentrations of lipid hydroperoxides prime human platelet aggregation specifically via cyclo-oxygenase activation. | 1997 | Biochem. J. | pmid:9230133 |
| McMillan RM et al. | Malonaldehyde formation in intact platelets is catalysed by thromboxane synthase. | 1978 | Biochem. J. | pmid:743261 |
| Rendu F et al. | How does fluoroaluminate activate human platelets? | 1990 | Biochem. J. | pmid:2302176 |
| Ko FN et al. | Daphnoretin, a new protein kinase C activator isolated from Wikstroemia indica C.A. Mey. | 1993 | Biochem. J. | pmid:8216237 |
| Krishnamurthi S et al. | Synergistic potentiation of 5-hydroxytryptamine secretion by platelet agonists and phorbol myristate acetate despite inhibition of agonist-induced arachidonate/thromboxane and beta-thromboglobulin release and Ca2+ mobilization by phorbol myristate acetate. | 1986 | Biochem. J. | pmid:2948494 |
| Kowalska MA et al. | High concentrations of exogenous arachidonate inhibit calcium mobilization in platelets by stimulation of adenylate cyclase. | 1988 | Biochem. J. | pmid:2458717 |
| Karniguian A et al. | Collagen-induced platelet activation mainly involves the protein kinase C pathway. | 1990 | Biochem. J. | pmid:2163606 |
| Sun L et al. | Kallikrein stimulates arachidonic acid release and production of prostaglandins from TEA3A1 endocrine thymic epithelial cells. | 1989 | Biochem. J. | pmid:2495791 |
| Huang TF et al. | Aggretin, a novel platelet-aggregation inducer from snake (Calloselasma rhodostoma) venom, activates phospholipase C by acting as a glycoprotein Ia/IIa agonist. | 1995 | Biochem. J. | pmid:7639679 |
| Murphy CT and Westwick J | Selective inhibition of protein kinase C. Effect on platelet-activating-factor-induced platelet functional responses. | 1992 | Biochem. J. | pmid:1567363 |
| Murphy CT et al. | The relationship between cytosolic Ca2+, sn-1,2-diacylglycerol and inositol 1,4,5-trisphosphate elevation in platelet-activating-factor-stimulated rabbit platelets. Influence of protein kinase C on production of signal molecules. | 1991 | Biochem. J. | pmid:1883334 |
| Chakraborti T et al. | Age-dependent change in arachidonic acid metabolic capacity in rat alveolar macrophages. | 1999 | Biochem. Mol. Biol. Int. | pmid:10204087 |
| Patscheke H | Thromboxane synthase inhibition potentiates washed platelet activation by endogenous and exogenous arachidonic acid. | 1985 | Biochem. Pharmacol. | pmid:3922373 |
| Segarnick DJ et al. | Precursor- and pool-dependent differential effects of ethanol on human platelet prostanoid synthesis. | 1985 | Biochem. Pharmacol. | pmid:3922375 |
| Bakhle YS and Grantham CJ | Selective effect of pulmonary oedema on prostaglandin E2 pharmacokinetics in rat lung. | 1985 | Biochem. Pharmacol. | pmid:3935117 |
| Kanda N and Watanabe S | Suppressive effects of antimycotics on tumor necrosis factor-alpha-induced CCL27, CCL2, and CCL5 production in human keratinocytes. | 2006 | Biochem. Pharmacol. | pmid:16784723 |
| Chang WC et al. | Inhibition of thromboxane B2 and 6-ketoprostaglandin F1 alpha formation by anti-inflammatory drugs in carrageenin-induced granuloma. | 1978 | Biochem. Pharmacol. | pmid:619892 |
| Yu SM et al. | Dicentrine, a novel antiplatelet agent inhibiting thromboxane formation and increasing the cyclic AMP level of rabbit platelets. | 1992 | Biochem. Pharmacol. | pmid:1310852 |
| Spaethe SM et al. | Guinea pig whole blood 5-lipoxygenase assay: utility in the assessment of potential 5-lipoxygenase inhibitors. | 1992 | Biochem. Pharmacol. | pmid:1310855 |
| Tolman EL and Fuller BL | Inhibition of thromboxane synthesis in guinea pig lung and human platelets by clotrimazole and other imidazole antifungals. | 1983 | Biochem. Pharmacol. | pmid:6316985 |
| Medini L et al. | Diets rich in n-9, n-6 and n-3 fatty acids differentially affect the generation of inositol phosphates and of thromboxane by stimulated platelets, in the rabbit. | 1990 | Biochem. Pharmacol. | pmid:2105092 |
| Covatto RH and Niewiarowski S | Platelet thromboxane A2/prostaglandin H2 receptors in human volunteers on low doses of aspirin. | 1990 | Biochem. Pharmacol. | pmid:2145839 |
| Fischer S et al. | In vivo and in vitro effects of nafazatrom (Bay g 6575), an antithrombotic compound, on arachidonic acid metabolism in platelets and vascular tissue. | 1983 | Biochem. Pharmacol. | pmid:6688182 |
| de Gaetano G et al. | Low dose aspirin does not prevent fibrinolytic response to venous occlusion. | 1986 | Biochem. Pharmacol. | pmid:3755907 |
| Larsen LN et al. | Alpha- and beta- alkyl-substituted eicosapentaenoic acids: incorporation into phospholipids and effects on prostaglandin H synthase and 5-lipoxygenase. | 1998 | Biochem. Pharmacol. | pmid:9514074 |
| Bauer J et al. | Arzanol, a prenylated heterodimeric phloroglucinyl pyrone, inhibits eicosanoid biosynthesis and exhibits anti-inflammatory efficacy in vivo. | 2011 | Biochem. Pharmacol. | pmid:20933508 |
| Gairola CG and Tai HH | Cigarette smoke-induced alterations in the release of arachidonate metabolites by pulmonary alveolar macrophage from selenium-fed and selenium-deficient rats. | 1986 | Biochem. Pharmacol. | pmid:3015150 |
| Chou TC et al. | Antiplatelet effect of amlodipine: a possible mechanism through a nitric oxide-mediated process. | 1999 | Biochem. Pharmacol. | pmid:10535758 |
| Lorenz RL et al. | Effects on prostanoid formation and pharmacokinetics of dazmegrel (UK-38,485), a novel thromboxane synthase inhibitor, in man. | 1986 | Biochem. Pharmacol. | pmid:3513767 |
| Opas EE et al. | Pharmacological modulation of eicosanoid levels and hyperalgesia in yeast-induced inflammation. | 1987 | Biochem. Pharmacol. | pmid:3103625 |
| Matsuoka I et al. | Inhibitory effect of 8-bromo cyclic GMP on an extracellular Ca2+-dependent arachidonic acid liberation in collagen-stimulated rabbit platelets. | 1989 | Biochem. Pharmacol. | pmid:2544181 |
| Palmer RM and Salmon JA | Comparison of the effects of some compounds on human neutrophil degranulation and leukotriene B4 and thromboxane B2 synthesis. | 1985 | Biochem. Pharmacol. | pmid:2986647 |
| Alanko J et al. | Catechol estrogens as inhibitors of leukotriene synthesis. | 1998 | Biochem. Pharmacol. | pmid:9413936 |
| Lynch TJ et al. | Carbon tetrachloride-induced eicosanoid synthesis and enzyme release from rat peritoneal leucocytes. | 1985 | Biochem. Pharmacol. | pmid:2986650 |