MeSH term | MeSH ID | Detail |
---|---|---|
Adenocarcinoma | D000230 | 166 associated lipids |
Lung Neoplasms | D008175 | 171 associated lipids |
Body Weight | D001835 | 333 associated lipids |
Thromboxane b2 is a lipid of Fatty Acyls (FA) class. Thromboxane b2 is associated with abnormalities such as endothelial dysfunction, Diabetes Mellitus, Non-Insulin-Dependent, Diabetes Mellitus, Ischemia and Thrombocytosis. The involved functions are known as Platelet Activation, Excretory function, Anabolism, Inflammation and mRNA Expression. Thromboxane b2 often locates in Endothelium, Hepatic and Microsomes, Liver. The associated genes with Thromboxane b2 are PTGS2 gene, prothrombin fragment 2 and CCL14 wt Allele.
To understand associated biological information of Thromboxane b2, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
Thromboxane b2 is suspected in endothelial dysfunction, Diabetes Mellitus, Non-Insulin-Dependent, Diabetes Mellitus, Ischemia, Thrombocytosis, Acute Coronary Syndrome and other diseases in descending order of the highest number of associated sentences.
Disease | Cross reference | Weighted score | Related literature |
---|
We collected disease MeSH terms mapped to the references associated with Thromboxane b2
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
Location | Cross reference | Weighted score | Related literatures |
---|
Function | Cross reference | Weighted score | Related literatures |
---|
There are no associated biomedical information in the current reference collection.
Gene | Cross reference | Weighted score | Related literatures |
---|
There are no associated biomedical information in the current reference collection.
Authors | Title | Published | Journal | PubMed Link |
---|---|---|---|---|
Lynch CM et al. | The role of thromboxane A(2) in the pathogenesis of intrauterine growth restriction associated with maternal smoking in pregnancy. | 2011 | Prostaglandins Other Lipid Mediat. | pmid:21723954 |
Yao X et al. | Effects of thyroid hormone status on metabolic pathways of arachidonic acid in mice and humans: A targeted metabolomic approach. | Prostaglandins Other Lipid Mediat. | pmid:25841349 | |
Rao GH et al. | Effect of Amrinone, a cardiotonic drug, on hemodynamics and platelet function. | 1981 | Prostaglandins Med | pmid:6784136 |
Gullner HG et al. | Correction of increased prostacyclin synthesis in Bartter's syndrome by indomethacin treatment. | 1980 | Prostaglandins Med | pmid:6994153 |
Rao GH et al. | Modification of human platelet response to sodium arachidonate by membrane modulation. | 1981 | Prostaglandins Med | pmid:6261286 |
Makheja AN et al. | Effects of onion (Allium cepa) extract on platelet aggregation and thromboxane synthesis. | 1979 | Prostaglandins Med | pmid:552092 |
Lefer AM et al. | Protective effects of a novel thromboxane analog in lethal traumatic shock. | 1979 | Prostaglandins Med | pmid:552102 |
Lewy RI et al. | Detection of thromboxane B2 in peripheral blood of patients with Prinzmetal's angina. | 1979 | Prostaglandins Med | pmid:575861 |
Ohuchi K et al. | Prostaglandins E2, F2 alpha, 6-keto-F1 alpha and thromboxane B2 levels in carrageenin-induced inflammatory exudates in the rat air-pouch granuloma. | 1979 | Prostaglandins Med | pmid:583576 |
Roy AC et al. | Effect of intravenous infusion of OKY-1581 (sodium-(E)-3-[4-(3-pyridylmethyl)phenyl] -2-methylacrylate) on circulatory thromboxane A2 and prostacyclin levels in anaesthetized baboon. | 1981 | Prostaglandins Med | pmid:7029585 |
Hwang DH | Aggregation and inhibition of rat platelets, and the formation of endoperoxide metabolites. | 1980 | Prostaglandins Med | pmid:7413850 |
Uyama O et al. | Plasma concentrations of thromboxane B2 in patients with hypertension or cerebrovascular disease. | 1981 | Prostaglandins Med | pmid:7302001 |
Matsumoto M et al. | Platelet aggregation induced by arachidonic acid and thromboxane generation in patients with hypertension or cerebrovascular disease. | 1981 | Prostaglandins Med | pmid:7323212 |
Gilani SH and Persaud TV | Embryopathic effects of thromboxane B2 in the chick. | 1981 | Prostaglandins Med | pmid:7267828 |
Ohuchi K et al. | Prostaglandin production by minced carrageenin granuloma tissue of rats and its inhibition by dexamethasone and cycloheximide. | 1980 | Prostaglandins Med | pmid:6893750 |
Oka M and Manku MS | Spironolactone decreases the formation of prostaglandins and related substances from arachidonic acid in rat vascular rings and human platelets. | 1980 | Prostaglandins Med | pmid:7394062 |
Karmali RA et al. | Intrarenal growth of the Walker 256 tumour and renal vein concentrations of PGE2, PGF 2 alpha, and TXB2: effects of diazepam. | 1980 | Prostaglandins Med | pmid:7394064 |
Ohnishi H et al. | Effects of trapidil on thromboxane A2-induced aggregation of platelets, ischemic changes in heart and biosynthesis of thromboxane A2. | 1981 | Prostaglandins Med | pmid:6894333 |
Rao GH et al. | Influence of epinephrine on the aggregation response of aspirin-treated platelets. | 1980 | Prostaglandins Med | pmid:7403340 |
Hamberg M et al. | A method for measurement of platelet regeneration in man. | 1978 | Prostaglandins Med | pmid:104315 |
Kinney EL and Demers LM | Plasma 6 keto PGE1 alpha concentration in Raynaud's phenomenon. | 1981 | Prostaglandins Med | pmid:6895673 |
Karmazyn M and Dhalla NS | Thromboxane B2: a cardiodepressant of isolated rat hearts and inhibitor of sarcolemma Na+ - K+ stimulated ATPase activity. | 1979 | Prostaglandins Med | pmid:233217 |
Ali M et al. | Inhibition of human platelet cyclooxygenase by alpha-tocopherol. | 1980 | Prostaglandins Med | pmid:6771778 |
Vassar MJ et al. | Measurement of 6-keto-PGF1 alpha and thromboxane B2 levels in critically ill surgical patients. | 1988 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:3174719 |
Navrátil L et al. | Changes of 6-keto PGF1 alpha concentration in plasma and vessel wall and TxB2 in plasma of whole-body irradiated rats in the early stage of irradiation. | 1990 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:2251295 |
Dogné JM et al. | Pharmacological evaluation of the novel thromboxane modulator BM-567 (I/II). Effects of BM-567 on platelet function. | 2003 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:12538090 |
Myers SI et al. | Estrogen increases male rat aortic endothelial cell (RAEC) PGI2 release. | 1996 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:8888351 |
Mikhailidis DP et al. | Platelet aggregation and thromboxane A2 release in primary biliary cirrhosis and effect of D-penicillamine treatment. | 1988 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:3375287 |
Pham HC et al. | Comparative effects on TXA2 biosynthesis of products extracted from Lippia multiflora Moldenke leaves. | 1988 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:3241820 |
Agnoli GC et al. | Volume-induced natriuresis in healthy women: renal metabolism of prostacyclin and thromboxane, and physiological role of prostanoids. | 2001 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:11237476 |
Al-Qattan KK et al. | Thromboxane-B2, prostaglandin-E2 and hypertension in the rat 2-kidney 1-clip model: a possible mechanism of the garlic induced hypotension. | 2001 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:11161580 |
Beitz A et al. | Lipoproteins from normolipidemic and dyslipidemic subjects modify the thromboxane A2 generation by platelets in clotting human blood. | 1993 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:8341726 |
Myers SI et al. | Long-term resuscitation of hemorrhage/reperfusion injury (H/R) stimulates renal PGE2 release. | 1996 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:8832762 |
Pascual J et al. | TXB2: cardiostimulant effect that involves beta-adrenoceptor and Na+ + K+-ATPase activity. | 1988 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:2847200 |
Sullivan MH et al. | Equivalent inhibition of in vivo platelet function by low dose and high dose aspirin treatment. | 1990 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:2353031 |
Beitz A et al. | Influence of iloprost on eicosanoid generation and lipid levels in experimental myocardial ischemia in dogs. | 1989 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:2469084 |
Nemr R et al. | Effects of nicotine on thromboxane/prostacyclin balance in myocardial ischemia. | 2003 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:12591002 |
Eatman D et al. | Influences of prostanoids and nitric oxide on post-suspension hypotension in female Sprague-Dawley rats. | 2003 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:12591003 |
Myers SI et al. | Bile duct ligation induced acute inflammation up-regulates cyclooxygenase-2 content and PGE2 release in guinea pig gallbladder smooth muscle cell cultures. | 2005 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:15850713 |
Mózes T and Wieszt E | Role of prostanoids in respiratory failure during circulatory shock of intestinal origin in dogs. | 1989 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:2780763 |
Okita M et al. | Effect of arachidonic acid-rich oil on lipids and arachidonate metabolites in ethanol- treated rats. | 2001 Apr-May | Prostaglandins Leukot. Essent. Fatty Acids | pmid:11418023 |
Sailaja Devi MM and Das UN | Effect of prostaglandins against alloxan-induced diabetes mellitus. | 2006 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:16297610 |
Wolfram R et al. | Daily prickly pear consumption improves platelet function. | 2003 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:12878452 |
Urquhart P et al. | Profile of eicosanoids produced by human saphenous vein endothelial cells and the effect of dietary fatty acids. | 2001 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:11487303 |
Agnoli GC et al. | Renal function and urinary prostanoid excretions in salt-depleted women: comparative effects of enalapril and indomethacin treatments. | 1999 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:10328327 |
Chahine R et al. | The anti-thromboxane A2 synthetase activity of myocardial tissue and its variation during ischemia and reperfusion in isolated rabbit heart. | 1999 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:10328329 |
Peredo HA and Filinger EJ | Effect of dipyridamole on prostanoid production in rat isolated atria. | 1999 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:10328333 |
Dołegowska B et al. | Metabolism of eicosanoids and their action on renal function during ischaemia and reperfusion: the effect of alprostadil. | 2006 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:17011760 |
Srivastava KC | Effect of onion and ginger consumption on platelet thromboxane production in humans. | 1989 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:2710801 |
Mentz P et al. | Interactions of prostanoids with the platelet activating factors. | 1992 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:1279731 |
Dahl-Puustinen ML et al. | Effects of repeated oral doses of fenflumizole on platelet aggregation and thromboxane formation in man ex vivo. | 1988 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:3357910 |
Ali M et al. | A potent thromboxane formation inhibitor in green tea leaves. | 1990 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:2274565 |
Vijaya Kumar M et al. | The anhydrous milk fat, ghee, lowers serum prostaglandins and secretion of leukotrienes by rat peritoneal macrophages. | 1999 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:10574649 |
Bacman S et al. | Antilaminin IgG releases TXB2 through activation of the cholinergic system. | 1990 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:2274567 |
Ali M et al. | Antithrombotic activity of garlic: its inhibition of the synthesis of thromboxane-B2 during infusion of arachidonic acid and collagen in rabbits. | 1990 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:2274570 |
Schonwetter DJ et al. | Type A behavior and alcohol consumption: effects on resting and post-exercise bleeding time thromboxane and prostacyclin metabolites. | 1993 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:8446651 |
Heidemann SM et al. | Ibuprofen attenuates cardiopulmonary dysfunction by modifying vascular tone in endotoxemia. | 1999 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:10359020 |
Kijima Y et al. | Transcardiac 8-iso-prostaglandin F(2 alpha)generation from acute myocardial infarction heart: insight into abrupt reperfusion and oxidant stress. | 2001 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:11334551 |
Engström K et al. | Effect of low-dose aspirin in combination with stable fish oil on whole blood production of eicosanoids. | 2001 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:11427037 |
Isenring P et al. | Eicosanoid modulation of the norepinephrine effect on blood pressure and renal hemodynamics in humans. | 1996 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:8992495 |
Leung S et al. | Isolation and purification of anticardiolipin antibody from plasma of a patient with antiphospholipid syndrome: induced generation of platelet thromboxane A2 synthesis. | 1996 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:9014216 |
Vranic II et al. | Adenosine cardioprotection study in clinical setting of paroxysmal supraventricular tachycardia. | 2006 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:16682179 |
Bell JG et al. | Growth, mortality, tissue histopathology and fatty acid compositions, eicosanoid production and response to stress, in juvenile turbot fed diets rich in gamma-linolenic acid in combination with eicosapentaenoic acid or docosahexaenoic acid. | 1998 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:9690713 |
Agnoli GC et al. | Renal synthesis of prostacyclin and thromboxane in healthy women: differential effects of a short-term saline loading. | 2000 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:10780876 |
Anfossi G et al. | Effects of diltiazem on thromboxane B2 production from platelet-rich plasma and whole blood. | 1991 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:1808624 |
Lueddeckens G et al. | Influence of aminophylline and ketotifen in comparison to the lipoxygenase inhibitors NDGA and esculetin and the PAF antagonists WEB 2170 [correction of 2107] and BN 52021 on endothelin-1 induced vaso- and bronchoconstriction. | 1991 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:1808625 |
Brose SA and Golovko MY | Eicosanoid post-mortem induction in kidney tissue is prevented by microwave irradiation. | 2013 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:24113545 |
van der Weiden RM et al. | Which prostanoid metabolites should be determined for the study of reproductive processes? | 1998 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:9610843 |
Beitz A | Influence of diet-modified lipoprotein fractions from rabbits on eicosanoid production and on proliferation of rabbit skin fibroblasts. | 1998 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:9610847 |
Agnoli GC et al. | Effects of experimental salt depletion on urinary prostanoid excretions in normal women. | 1998 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:9610848 |
Ali M and Thomson M | Consumption of a garlic clove a day could be beneficial in preventing thrombosis. | 1995 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:7480084 |
Myers SI et al. | Acute burn down regulates rabbit splanchnic and renal prostanoid release. | 1995 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:7480086 |
Darlametsos IE et al. | Effect of nifedipine in cyclosporine-induced nephrotoxicity in rats: roles of the thromboxane and endothelin systems. | 2000 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:11090252 |
Anfossi G et al. | Influence of propranolol on platelet aggregation and thromboxane B2 production from platelet-rich plasma and whole blood. | 1989 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:2525784 |
Karamouzis M et al. | The response of muscle interstitial prostaglandin E(2)(PGE(2)), prostacyclin I(2)(PGI(2)) and thromboxane A(2)(TXA(2)) levels during incremental dynamic exercise in humans determined by in vivo microdialysis. | 2001 Apr-May | Prostaglandins Leukot. Essent. Fatty Acids | pmid:11418021 |
Mita H et al. | Generation of thromboxane A2 from highly purified human sinus mast cells after immunological stimulation. | 1999 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:10359019 |
Ferretti A et al. | GC/MS/MS quantification of 11-dehydrothromboxane B2 in human urine. | 1992 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:1409763 |
Selg E et al. | Effects of selective and non-selective COX inhibitors on antigen-induced release of prostanoid mediators and bronchoconstriction in the isolated perfused and ventilated guinea pig lung. | 2008 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:18294831 |
Chang WC and Hsu FL | Inhibition of platelet activation and endothelial cell injury by flavan-3-ol and saikosaponin compounds. | 1991 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:1946562 |
Srivastava KC | Extracts from two frequently consumed spices--cumin (Cuminum cyminum) and turmeric (Curcuma longa)--inhibit platelet aggregation and alter eicosanoid biosynthesis in human blood platelets. | 1989 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:2503839 |
Nagase T et al. | Reduction of 15-hydroxyeicosatetraenoic acid (15-HETE) in tracheal fluid by high frequency oscillatory ventilation. | 1990 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:2402521 |
Peredo HA et al. | Prostanoid production in hypoxic rat isolated atria: influence of acute diabetes. | 1994 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:7846089 |
Moon CH et al. | Mechanism for antiplatelet effect of onion: AA release inhibition, thromboxane A(2)synthase inhibition and TXA(2)/PGH(2)receptor blockade. | 2000 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:10883058 |
Neuer A et al. | The effect of zearalenone and 17 beta-estradiol on prostacyclin and thromboxane production in cell cultures from human umbilical cord veins. | 1994 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:7846091 |
Lasserre B et al. | Modifications in the TXA(2) and PGI(2) plasma levels and some other biochemical parameters during the initiation and development of non-insulin-dependent diabetes mellitus (NIDDM) syndrome in the rabbit. | 2000 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:10883059 |
Norman JF and Miller CW | Prostacyclin, thromboxane A2, and atherosclerosis in young hypercholesterolemic swine. | 1994 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:7846098 |
Bereczki C et al. | The roles of platelet function, thromboxane, blood lipids and nitric oxide in hypertension of children and adolescents. | 2000 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:10883060 |
Rizk M and Abdel-Rahman MS | Salicylamide reverses the aspirin-antagonistic effect of salicylic acid on rat platelet cyclooxygenase. | 1994 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:7846108 |
Brunkwall JS et al. | Papaverine effects on PGI2 and TXA2 release from the canine vascular wall. | 1992 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:1508951 |
Arnold JH et al. | Production of platelet thromboxane A2 and arterial prostacyclin I2 from hypercholesterolemic rats. | 1992 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:1508954 |
Jung YS et al. | Antithrombotic effect of onion in streptozotocin-induced diabetic rat. | 2002 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:12054917 |
Sciulli MG et al. | Platelet activation in patients with colorectal cancer. | 2005 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:15626589 |
Bordia T et al. | An evaluation of garlic and onion as antithrombotic agents. | 1996 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:8860105 |
Gajdos M et al. | Effective long-term inhibition of thromboxane production but not of serotonin release in patients with coronary heart disease by 30 mg/d acetylsalicylic acid dosage. | 1998 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:9758203 |
Peredo HA et al. | Time-course of the alterations in prostanoid production and in contractile responses of mesenteric beds isolated from streptozotocin diabetic rats. | 1999 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:10397409 |
Sanigorski AJ et al. | n-3 fatty acids reduce in vitro thromboxane production while having little effect on in vitro prostacyclin production in the rat. | 1994 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:8066095 |
Srivastava KC and Malhotra N | Acetyl eugenol, a component of oil of cloves (Syzygium aromaticum L.) inhibits aggregation and alters arachidonic acid metabolism in human blood platelets. | 1991 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:2011614 |
Nagai H et al. | The effect of three novel thromboxane A2 receptor antagonists (S-1452, AA-2414 and ONO-3708) on the increase in pulmonary pressure caused by Forssman anaphylaxis in guinea-pigs. | 1992 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:1534171 |
Tsuruta LR et al. | Characterization of 11-dehydro-thromboxane B2 recombinant antibody obtained by phage display technology. | 2003 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:12628223 |
Gow JA et al. | The effect of regular and enteric-coated aspirin on bleeding time, thromboxane, and prostacyclin. | 1993 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:8361987 |