Thromboxane b2

Thromboxane b2 is a lipid of Fatty Acyls (FA) class. Thromboxane b2 is associated with abnormalities such as endothelial dysfunction, Diabetes Mellitus, Non-Insulin-Dependent, Diabetes Mellitus, Ischemia and Thrombocytosis. The involved functions are known as Platelet Activation, Excretory function, Anabolism, Inflammation and mRNA Expression. Thromboxane b2 often locates in Endothelium, Hepatic and Microsomes, Liver. The associated genes with Thromboxane b2 are PTGS2 gene, prothrombin fragment 2 and CCL14 wt Allele.

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Introduction

To understand associated biological information of Thromboxane b2, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.

What diseases are associated with Thromboxane b2?

Thromboxane b2 is suspected in endothelial dysfunction, Diabetes Mellitus, Non-Insulin-Dependent, Diabetes Mellitus, Ischemia, Thrombocytosis, Acute Coronary Syndrome and other diseases in descending order of the highest number of associated sentences.

Related references are mostly published in these journals:

Disease Cross reference Weighted score Related literature
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Possible diseases from mapped MeSH terms on references

We collected disease MeSH terms mapped to the references associated with Thromboxane b2

MeSH term MeSH ID Detail
Adenocarcinoma D000230 166 associated lipids
Lung Neoplasms D008175 171 associated lipids
Body Weight D001835 333 associated lipids
Per page 10 20 50 100 | Total 293

PubChem Associated disorders and diseases

What pathways are associated with Thromboxane b2

There are no associated biomedical information in the current reference collection.

PubChem Biomolecular Interactions and Pathways

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What cellular locations are associated with Thromboxane b2?

Related references are published most in these journals:

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What functions are associated with Thromboxane b2?


Related references are published most in these journals:

Function Cross reference Weighted score Related literatures

What lipids are associated with Thromboxane b2?

There are no associated biomedical information in the current reference collection.

What genes are associated with Thromboxane b2?

Related references are published most in these journals:


Gene Cross reference Weighted score Related literatures

What common seen animal models are associated with Thromboxane b2?

There are no associated biomedical information in the current reference collection.

NCBI Entrez Crosslinks

All references with Thromboxane b2

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Per page 10 20 50 100 | Total 6367
Authors Title Published Journal PubMed Link
Lynch CM et al. The role of thromboxane A(2) in the pathogenesis of intrauterine growth restriction associated with maternal smoking in pregnancy. 2011 Prostaglandins Other Lipid Mediat. pmid:21723954
Yao X et al. Effects of thyroid hormone status on metabolic pathways of arachidonic acid in mice and humans: A targeted metabolomic approach. Prostaglandins Other Lipid Mediat. pmid:25841349
Rao GH et al. Effect of Amrinone, a cardiotonic drug, on hemodynamics and platelet function. 1981 Prostaglandins Med pmid:6784136
Gullner HG et al. Correction of increased prostacyclin synthesis in Bartter's syndrome by indomethacin treatment. 1980 Prostaglandins Med pmid:6994153
Rao GH et al. Modification of human platelet response to sodium arachidonate by membrane modulation. 1981 Prostaglandins Med pmid:6261286
Makheja AN et al. Effects of onion (Allium cepa) extract on platelet aggregation and thromboxane synthesis. 1979 Prostaglandins Med pmid:552092
Lefer AM et al. Protective effects of a novel thromboxane analog in lethal traumatic shock. 1979 Prostaglandins Med pmid:552102
Lewy RI et al. Detection of thromboxane B2 in peripheral blood of patients with Prinzmetal's angina. 1979 Prostaglandins Med pmid:575861
Ohuchi K et al. Prostaglandins E2, F2 alpha, 6-keto-F1 alpha and thromboxane B2 levels in carrageenin-induced inflammatory exudates in the rat air-pouch granuloma. 1979 Prostaglandins Med pmid:583576
Roy AC et al. Effect of intravenous infusion of OKY-1581 (sodium-(E)-3-[4-(3-pyridylmethyl)phenyl] -2-methylacrylate) on circulatory thromboxane A2 and prostacyclin levels in anaesthetized baboon. 1981 Prostaglandins Med pmid:7029585
Hwang DH Aggregation and inhibition of rat platelets, and the formation of endoperoxide metabolites. 1980 Prostaglandins Med pmid:7413850
Uyama O et al. Plasma concentrations of thromboxane B2 in patients with hypertension or cerebrovascular disease. 1981 Prostaglandins Med pmid:7302001
Matsumoto M et al. Platelet aggregation induced by arachidonic acid and thromboxane generation in patients with hypertension or cerebrovascular disease. 1981 Prostaglandins Med pmid:7323212
Gilani SH and Persaud TV Embryopathic effects of thromboxane B2 in the chick. 1981 Prostaglandins Med pmid:7267828
Ohuchi K et al. Prostaglandin production by minced carrageenin granuloma tissue of rats and its inhibition by dexamethasone and cycloheximide. 1980 Prostaglandins Med pmid:6893750
Oka M and Manku MS Spironolactone decreases the formation of prostaglandins and related substances from arachidonic acid in rat vascular rings and human platelets. 1980 Prostaglandins Med pmid:7394062
Karmali RA et al. Intrarenal growth of the Walker 256 tumour and renal vein concentrations of PGE2, PGF 2 alpha, and TXB2: effects of diazepam. 1980 Prostaglandins Med pmid:7394064
Ohnishi H et al. Effects of trapidil on thromboxane A2-induced aggregation of platelets, ischemic changes in heart and biosynthesis of thromboxane A2. 1981 Prostaglandins Med pmid:6894333
Rao GH et al. Influence of epinephrine on the aggregation response of aspirin-treated platelets. 1980 Prostaglandins Med pmid:7403340
Hamberg M et al. A method for measurement of platelet regeneration in man. 1978 Prostaglandins Med pmid:104315
Kinney EL and Demers LM Plasma 6 keto PGE1 alpha concentration in Raynaud's phenomenon. 1981 Prostaglandins Med pmid:6895673
Karmazyn M and Dhalla NS Thromboxane B2: a cardiodepressant of isolated rat hearts and inhibitor of sarcolemma Na+ - K+ stimulated ATPase activity. 1979 Prostaglandins Med pmid:233217
Ali M et al. Inhibition of human platelet cyclooxygenase by alpha-tocopherol. 1980 Prostaglandins Med pmid:6771778
Vassar MJ et al. Measurement of 6-keto-PGF1 alpha and thromboxane B2 levels in critically ill surgical patients. 1988 Prostaglandins Leukot. Essent. Fatty Acids pmid:3174719
Navrátil L et al. Changes of 6-keto PGF1 alpha concentration in plasma and vessel wall and TxB2 in plasma of whole-body irradiated rats in the early stage of irradiation. 1990 Prostaglandins Leukot. Essent. Fatty Acids pmid:2251295
Dogné JM et al. Pharmacological evaluation of the novel thromboxane modulator BM-567 (I/II). Effects of BM-567 on platelet function. 2003 Prostaglandins Leukot. Essent. Fatty Acids pmid:12538090
Myers SI et al. Estrogen increases male rat aortic endothelial cell (RAEC) PGI2 release. 1996 Prostaglandins Leukot. Essent. Fatty Acids pmid:8888351
Mikhailidis DP et al. Platelet aggregation and thromboxane A2 release in primary biliary cirrhosis and effect of D-penicillamine treatment. 1988 Prostaglandins Leukot. Essent. Fatty Acids pmid:3375287
Pham HC et al. Comparative effects on TXA2 biosynthesis of products extracted from Lippia multiflora Moldenke leaves. 1988 Prostaglandins Leukot. Essent. Fatty Acids pmid:3241820
Agnoli GC et al. Volume-induced natriuresis in healthy women: renal metabolism of prostacyclin and thromboxane, and physiological role of prostanoids. 2001 Prostaglandins Leukot. Essent. Fatty Acids pmid:11237476
Al-Qattan KK et al. Thromboxane-B2, prostaglandin-E2 and hypertension in the rat 2-kidney 1-clip model: a possible mechanism of the garlic induced hypotension. 2001 Prostaglandins Leukot. Essent. Fatty Acids pmid:11161580
Beitz A et al. Lipoproteins from normolipidemic and dyslipidemic subjects modify the thromboxane A2 generation by platelets in clotting human blood. 1993 Prostaglandins Leukot. Essent. Fatty Acids pmid:8341726
Myers SI et al. Long-term resuscitation of hemorrhage/reperfusion injury (H/R) stimulates renal PGE2 release. 1996 Prostaglandins Leukot. Essent. Fatty Acids pmid:8832762
Pascual J et al. TXB2: cardiostimulant effect that involves beta-adrenoceptor and Na+ + K+-ATPase activity. 1988 Prostaglandins Leukot. Essent. Fatty Acids pmid:2847200
Sullivan MH et al. Equivalent inhibition of in vivo platelet function by low dose and high dose aspirin treatment. 1990 Prostaglandins Leukot. Essent. Fatty Acids pmid:2353031
Beitz A et al. Influence of iloprost on eicosanoid generation and lipid levels in experimental myocardial ischemia in dogs. 1989 Prostaglandins Leukot. Essent. Fatty Acids pmid:2469084
Nemr R et al. Effects of nicotine on thromboxane/prostacyclin balance in myocardial ischemia. 2003 Prostaglandins Leukot. Essent. Fatty Acids pmid:12591002
Eatman D et al. Influences of prostanoids and nitric oxide on post-suspension hypotension in female Sprague-Dawley rats. 2003 Prostaglandins Leukot. Essent. Fatty Acids pmid:12591003
Myers SI et al. Bile duct ligation induced acute inflammation up-regulates cyclooxygenase-2 content and PGE2 release in guinea pig gallbladder smooth muscle cell cultures. 2005 Prostaglandins Leukot. Essent. Fatty Acids pmid:15850713
Mózes T and Wieszt E Role of prostanoids in respiratory failure during circulatory shock of intestinal origin in dogs. 1989 Prostaglandins Leukot. Essent. Fatty Acids pmid:2780763
Okita M et al. Effect of arachidonic acid-rich oil on lipids and arachidonate metabolites in ethanol- treated rats. 2001 Apr-May Prostaglandins Leukot. Essent. Fatty Acids pmid:11418023
Sailaja Devi MM and Das UN Effect of prostaglandins against alloxan-induced diabetes mellitus. 2006 Prostaglandins Leukot. Essent. Fatty Acids pmid:16297610
Wolfram R et al. Daily prickly pear consumption improves platelet function. 2003 Prostaglandins Leukot. Essent. Fatty Acids pmid:12878452
Urquhart P et al. Profile of eicosanoids produced by human saphenous vein endothelial cells and the effect of dietary fatty acids. 2001 Prostaglandins Leukot. Essent. Fatty Acids pmid:11487303
Agnoli GC et al. Renal function and urinary prostanoid excretions in salt-depleted women: comparative effects of enalapril and indomethacin treatments. 1999 Prostaglandins Leukot. Essent. Fatty Acids pmid:10328327
Chahine R et al. The anti-thromboxane A2 synthetase activity of myocardial tissue and its variation during ischemia and reperfusion in isolated rabbit heart. 1999 Prostaglandins Leukot. Essent. Fatty Acids pmid:10328329
Peredo HA and Filinger EJ Effect of dipyridamole on prostanoid production in rat isolated atria. 1999 Prostaglandins Leukot. Essent. Fatty Acids pmid:10328333
Dołegowska B et al. Metabolism of eicosanoids and their action on renal function during ischaemia and reperfusion: the effect of alprostadil. 2006 Prostaglandins Leukot. Essent. Fatty Acids pmid:17011760
Srivastava KC Effect of onion and ginger consumption on platelet thromboxane production in humans. 1989 Prostaglandins Leukot. Essent. Fatty Acids pmid:2710801
Mentz P et al. Interactions of prostanoids with the platelet activating factors. 1992 Prostaglandins Leukot. Essent. Fatty Acids pmid:1279731
Dahl-Puustinen ML et al. Effects of repeated oral doses of fenflumizole on platelet aggregation and thromboxane formation in man ex vivo. 1988 Prostaglandins Leukot. Essent. Fatty Acids pmid:3357910
Ali M et al. A potent thromboxane formation inhibitor in green tea leaves. 1990 Prostaglandins Leukot. Essent. Fatty Acids pmid:2274565
Vijaya Kumar M et al. The anhydrous milk fat, ghee, lowers serum prostaglandins and secretion of leukotrienes by rat peritoneal macrophages. 1999 Prostaglandins Leukot. Essent. Fatty Acids pmid:10574649
Bacman S et al. Antilaminin IgG releases TXB2 through activation of the cholinergic system. 1990 Prostaglandins Leukot. Essent. Fatty Acids pmid:2274567
Ali M et al. Antithrombotic activity of garlic: its inhibition of the synthesis of thromboxane-B2 during infusion of arachidonic acid and collagen in rabbits. 1990 Prostaglandins Leukot. Essent. Fatty Acids pmid:2274570
Schonwetter DJ et al. Type A behavior and alcohol consumption: effects on resting and post-exercise bleeding time thromboxane and prostacyclin metabolites. 1993 Prostaglandins Leukot. Essent. Fatty Acids pmid:8446651
Heidemann SM et al. Ibuprofen attenuates cardiopulmonary dysfunction by modifying vascular tone in endotoxemia. 1999 Prostaglandins Leukot. Essent. Fatty Acids pmid:10359020
Kijima Y et al. Transcardiac 8-iso-prostaglandin F(2 alpha)generation from acute myocardial infarction heart: insight into abrupt reperfusion and oxidant stress. 2001 Prostaglandins Leukot. Essent. Fatty Acids pmid:11334551
Engström K et al. Effect of low-dose aspirin in combination with stable fish oil on whole blood production of eicosanoids. 2001 Prostaglandins Leukot. Essent. Fatty Acids pmid:11427037
Isenring P et al. Eicosanoid modulation of the norepinephrine effect on blood pressure and renal hemodynamics in humans. 1996 Prostaglandins Leukot. Essent. Fatty Acids pmid:8992495
Leung S et al. Isolation and purification of anticardiolipin antibody from plasma of a patient with antiphospholipid syndrome: induced generation of platelet thromboxane A2 synthesis. 1996 Prostaglandins Leukot. Essent. Fatty Acids pmid:9014216
Vranic II et al. Adenosine cardioprotection study in clinical setting of paroxysmal supraventricular tachycardia. 2006 Prostaglandins Leukot. Essent. Fatty Acids pmid:16682179
Bell JG et al. Growth, mortality, tissue histopathology and fatty acid compositions, eicosanoid production and response to stress, in juvenile turbot fed diets rich in gamma-linolenic acid in combination with eicosapentaenoic acid or docosahexaenoic acid. 1998 Prostaglandins Leukot. Essent. Fatty Acids pmid:9690713
Agnoli GC et al. Renal synthesis of prostacyclin and thromboxane in healthy women: differential effects of a short-term saline loading. 2000 Prostaglandins Leukot. Essent. Fatty Acids pmid:10780876
Anfossi G et al. Effects of diltiazem on thromboxane B2 production from platelet-rich plasma and whole blood. 1991 Prostaglandins Leukot. Essent. Fatty Acids pmid:1808624
Lueddeckens G et al. Influence of aminophylline and ketotifen in comparison to the lipoxygenase inhibitors NDGA and esculetin and the PAF antagonists WEB 2170 [correction of 2107] and BN 52021 on endothelin-1 induced vaso- and bronchoconstriction. 1991 Prostaglandins Leukot. Essent. Fatty Acids pmid:1808625
Brose SA and Golovko MY Eicosanoid post-mortem induction in kidney tissue is prevented by microwave irradiation. 2013 Prostaglandins Leukot. Essent. Fatty Acids pmid:24113545
van der Weiden RM et al. Which prostanoid metabolites should be determined for the study of reproductive processes? 1998 Prostaglandins Leukot. Essent. Fatty Acids pmid:9610843
Beitz A Influence of diet-modified lipoprotein fractions from rabbits on eicosanoid production and on proliferation of rabbit skin fibroblasts. 1998 Prostaglandins Leukot. Essent. Fatty Acids pmid:9610847
Agnoli GC et al. Effects of experimental salt depletion on urinary prostanoid excretions in normal women. 1998 Prostaglandins Leukot. Essent. Fatty Acids pmid:9610848
Ali M and Thomson M Consumption of a garlic clove a day could be beneficial in preventing thrombosis. 1995 Prostaglandins Leukot. Essent. Fatty Acids pmid:7480084
Myers SI et al. Acute burn down regulates rabbit splanchnic and renal prostanoid release. 1995 Prostaglandins Leukot. Essent. Fatty Acids pmid:7480086
Darlametsos IE et al. Effect of nifedipine in cyclosporine-induced nephrotoxicity in rats: roles of the thromboxane and endothelin systems. 2000 Prostaglandins Leukot. Essent. Fatty Acids pmid:11090252
Anfossi G et al. Influence of propranolol on platelet aggregation and thromboxane B2 production from platelet-rich plasma and whole blood. 1989 Prostaglandins Leukot. Essent. Fatty Acids pmid:2525784
Karamouzis M et al. The response of muscle interstitial prostaglandin E(2)(PGE(2)), prostacyclin I(2)(PGI(2)) and thromboxane A(2)(TXA(2)) levels during incremental dynamic exercise in humans determined by in vivo microdialysis. 2001 Apr-May Prostaglandins Leukot. Essent. Fatty Acids pmid:11418021
Mita H et al. Generation of thromboxane A2 from highly purified human sinus mast cells after immunological stimulation. 1999 Prostaglandins Leukot. Essent. Fatty Acids pmid:10359019
Ferretti A et al. GC/MS/MS quantification of 11-dehydrothromboxane B2 in human urine. 1992 Prostaglandins Leukot. Essent. Fatty Acids pmid:1409763
Selg E et al. Effects of selective and non-selective COX inhibitors on antigen-induced release of prostanoid mediators and bronchoconstriction in the isolated perfused and ventilated guinea pig lung. 2008 Prostaglandins Leukot. Essent. Fatty Acids pmid:18294831
Chang WC and Hsu FL Inhibition of platelet activation and endothelial cell injury by flavan-3-ol and saikosaponin compounds. 1991 Prostaglandins Leukot. Essent. Fatty Acids pmid:1946562
Srivastava KC Extracts from two frequently consumed spices--cumin (Cuminum cyminum) and turmeric (Curcuma longa)--inhibit platelet aggregation and alter eicosanoid biosynthesis in human blood platelets. 1989 Prostaglandins Leukot. Essent. Fatty Acids pmid:2503839
Nagase T et al. Reduction of 15-hydroxyeicosatetraenoic acid (15-HETE) in tracheal fluid by high frequency oscillatory ventilation. 1990 Prostaglandins Leukot. Essent. Fatty Acids pmid:2402521
Peredo HA et al. Prostanoid production in hypoxic rat isolated atria: influence of acute diabetes. 1994 Prostaglandins Leukot. Essent. Fatty Acids pmid:7846089
Moon CH et al. Mechanism for antiplatelet effect of onion: AA release inhibition, thromboxane A(2)synthase inhibition and TXA(2)/PGH(2)receptor blockade. 2000 Prostaglandins Leukot. Essent. Fatty Acids pmid:10883058
Neuer A et al. The effect of zearalenone and 17 beta-estradiol on prostacyclin and thromboxane production in cell cultures from human umbilical cord veins. 1994 Prostaglandins Leukot. Essent. Fatty Acids pmid:7846091
Lasserre B et al. Modifications in the TXA(2) and PGI(2) plasma levels and some other biochemical parameters during the initiation and development of non-insulin-dependent diabetes mellitus (NIDDM) syndrome in the rabbit. 2000 Prostaglandins Leukot. Essent. Fatty Acids pmid:10883059
Norman JF and Miller CW Prostacyclin, thromboxane A2, and atherosclerosis in young hypercholesterolemic swine. 1994 Prostaglandins Leukot. Essent. Fatty Acids pmid:7846098
Bereczki C et al. The roles of platelet function, thromboxane, blood lipids and nitric oxide in hypertension of children and adolescents. 2000 Prostaglandins Leukot. Essent. Fatty Acids pmid:10883060
Rizk M and Abdel-Rahman MS Salicylamide reverses the aspirin-antagonistic effect of salicylic acid on rat platelet cyclooxygenase. 1994 Prostaglandins Leukot. Essent. Fatty Acids pmid:7846108
Brunkwall JS et al. Papaverine effects on PGI2 and TXA2 release from the canine vascular wall. 1992 Prostaglandins Leukot. Essent. Fatty Acids pmid:1508951
Arnold JH et al. Production of platelet thromboxane A2 and arterial prostacyclin I2 from hypercholesterolemic rats. 1992 Prostaglandins Leukot. Essent. Fatty Acids pmid:1508954
Jung YS et al. Antithrombotic effect of onion in streptozotocin-induced diabetic rat. 2002 Prostaglandins Leukot. Essent. Fatty Acids pmid:12054917
Sciulli MG et al. Platelet activation in patients with colorectal cancer. 2005 Prostaglandins Leukot. Essent. Fatty Acids pmid:15626589
Bordia T et al. An evaluation of garlic and onion as antithrombotic agents. 1996 Prostaglandins Leukot. Essent. Fatty Acids pmid:8860105
Gajdos M et al. Effective long-term inhibition of thromboxane production but not of serotonin release in patients with coronary heart disease by 30 mg/d acetylsalicylic acid dosage. 1998 Prostaglandins Leukot. Essent. Fatty Acids pmid:9758203
Peredo HA et al. Time-course of the alterations in prostanoid production and in contractile responses of mesenteric beds isolated from streptozotocin diabetic rats. 1999 Prostaglandins Leukot. Essent. Fatty Acids pmid:10397409
Sanigorski AJ et al. n-3 fatty acids reduce in vitro thromboxane production while having little effect on in vitro prostacyclin production in the rat. 1994 Prostaglandins Leukot. Essent. Fatty Acids pmid:8066095
Srivastava KC and Malhotra N Acetyl eugenol, a component of oil of cloves (Syzygium aromaticum L.) inhibits aggregation and alters arachidonic acid metabolism in human blood platelets. 1991 Prostaglandins Leukot. Essent. Fatty Acids pmid:2011614
Nagai H et al. The effect of three novel thromboxane A2 receptor antagonists (S-1452, AA-2414 and ONO-3708) on the increase in pulmonary pressure caused by Forssman anaphylaxis in guinea-pigs. 1992 Prostaglandins Leukot. Essent. Fatty Acids pmid:1534171
Tsuruta LR et al. Characterization of 11-dehydro-thromboxane B2 recombinant antibody obtained by phage display technology. 2003 Prostaglandins Leukot. Essent. Fatty Acids pmid:12628223
Gow JA et al. The effect of regular and enteric-coated aspirin on bleeding time, thromboxane, and prostacyclin. 1993 Prostaglandins Leukot. Essent. Fatty Acids pmid:8361987