| MeSH term | MeSH ID | Detail |
|---|---|---|
| Adenocarcinoma | D000230 | 166 associated lipids |
| Lung Neoplasms | D008175 | 171 associated lipids |
| Body Weight | D001835 | 333 associated lipids |
Thromboxane b2
Thromboxane b2 is a lipid of Fatty Acyls (FA) class. Thromboxane b2 is associated with abnormalities such as endothelial dysfunction, Diabetes Mellitus, Non-Insulin-Dependent, Diabetes Mellitus, Ischemia and Thrombocytosis. The involved functions are known as Platelet Activation, Excretory function, Anabolism, Inflammation and mRNA Expression. Thromboxane b2 often locates in Endothelium, Hepatic and Microsomes, Liver. The associated genes with Thromboxane b2 are PTGS2 gene, prothrombin fragment 2 and CCL14 wt Allele.
Cross Reference
Introduction
To understand associated biological information of Thromboxane b2, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with Thromboxane b2?
Thromboxane b2 is suspected in endothelial dysfunction, Diabetes Mellitus, Non-Insulin-Dependent, Diabetes Mellitus, Ischemia, Thrombocytosis, Acute Coronary Syndrome and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
| Disease | Cross reference | Weighted score | Related literature |
|---|
Loading... please refresh the page if content is not showing up.
Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with Thromboxane b2
PubChem Associated disorders and diseases
What pathways are associated with Thromboxane b2
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with Thromboxane b2?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
|---|
Loading... please refresh the page if content is not showing up.
What functions are associated with Thromboxane b2?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
|---|
What lipids are associated with Thromboxane b2?
There are no associated biomedical information in the current reference collection.
What genes are associated with Thromboxane b2?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
|---|
What common seen animal models are associated with Thromboxane b2?
There are no associated biomedical information in the current reference collection.
NCBI Entrez Crosslinks
All references with Thromboxane b2
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Jiménez-Romero C et al. | Dactyloditerpenol acetate, a new prenylbisabolane-type diterpene from Aplysia dactylomela with significant in vitro anti-neuroinflammatory activity. | 2014 | Bioorg. Med. Chem. Lett. | pmid:24279991 |
| Seno K et al. | Pyrrolidine inhibitors of human cytosolic phospholipase A2. Part 2: synthesis of potent and crystallized 4-triphenylmethylthio derivative 'pyrrophenone'. | 2001 | Bioorg. Med. Chem. Lett. | pmid:11229777 |
| Bell DN et al. | Adenosine diphosphate-induced aggregation of human platelets in flow through tubes. II. Effect of shear rate, donor sex, and ADP concentration. | 1989 | Biophys. J. | pmid:2605299 |
| Samuelsson B | From studies of biochemical mechanism to novel biological mediators: prostaglandin endoperoxides, thromboxanes, and leukotrienes. Nobel Lecture, 8 December 1982. | 1983 | Biosci. Rep. | pmid:6315101 |
| Maslov LN et al. | [Participation of the prostacyclin-thromboxane system in the mechanisms of prevention of arrhythmia caused by occlusion of the coronary artery in adapted rats]. | 1991 | Biull Eksp Biol Med | pmid:1711383 |
| Sergeev PV et al. | [Human thrombocytes as a test system for the study of nongenomic effects of glucocorticoid hormones]. | 1996 | Biull Eksp Biol Med | pmid:8974481 |
| MikhaÄlevskaia LL et al. | [Dynamics of binding of various prostanoids in mouse serum with spontaneous metastatic Lewis lung carcinoma; effect of exogenous prostaglandins on dissemination of the tumor]. | 1994 | Biull Eksp Biol Med | pmid:8204857 |
| Viktorov AV et al. | [Phosphoinositide breakdown and diacyl glycerin formation in human thrombocytes as affected by a lipopolysaccharide toxin]. | 1988 | Biull Eksp Biol Med | pmid:2832017 |
| Panchenko EP et al. | [Thromboxane and prostacyclin in patients with stenocardia in induced and spontaneous ischemia of the myocardium]. | 1986 | Biull Vsesoiuznogo Kardiol Nauchn Tsentra AMN SSSR | pmid:3754753 |
| Stuart MJ et al. | The influence of albumin and calcium on human platelet arachidonic acid metabolism. | 1980 | Blood | pmid:6766753 |
| Dragani A et al. | The contribution of cyclooxygenase-1 and -2 to persistent thromboxane biosynthesis in aspirin-treated essential thrombocythemia: implications for antiplatelet therapy. | 2010 | Blood | pmid:19887674 |
| Chesterman CN et al. | Substrate for endothelial prostacyclin production in the presence of platelets exposed to collagen is derived from the platelets rather than the endothelium. | 1986 | Blood | pmid:3085750 |
| Sugiyama T et al. | A novel platelet aggregating factor found in a patient with defective collagen-induced platelet aggregation and autoimmune thrombocytopenia. | 1987 | Blood | pmid:3580576 |
| Deimann W et al. | Endogenous peroxidase in the nuclear envelope and endoplasmic reticulum of human monocytes in vitro: association with arachidonic acid metabolism. | 1984 | Blood | pmid:6331550 |
| Valles J et al. | Erythrocytes metabolically enhance collagen-induced platelet responsiveness via increased thromboxane production, adenosine diphosphate release, and recruitment. | 1991 | Blood | pmid:1712639 |
| Weiss HJ and Lages B | The response of platelets to epinephrine in storage pool deficiency--evidence pertaining to the role of adenosine diphosphate in mediating primary and secondary aggregation. | 1988 | Blood | pmid:2846091 |
| Stuart MJ et al. | Abnormal platelet function and arachidonate metabolism in chronic idiopathic thrombocytopenic purpura. | 1981 | Blood | pmid:6788109 |
| Patel YM et al. | Evidence for a role for Galphai1 in mediating weak agonist-induced platelet aggregation in human platelets: reduced Galphai1 expression and defective Gi signaling in the platelets of a patient with a chronic bleeding disorder. | 2003 | Blood | pmid:12609843 |
| Miller JL et al. | Characterization of a platelet membrane protein of low molecular weight associated with platelet activation following binding by monoclonal antibody AG-1. | 1986 | Blood | pmid:2943333 |
| DiMinno G et al. | Stored human platelets retain full aggregation potential in response to pairs of aggregating agents. | 1982 | Blood | pmid:6800418 |
| Hato T et al. | Exposure of platelet fibrinogen receptors by a monoclonal antibody to CD9 antigen. | 1988 | Blood | pmid:2455569 |
| Miller JL et al. | Unique interactions of asialo von Willebrand factor with platelets in platelet-type von Willebrand disease. | 1987 | Blood | pmid:3118988 |
| Landolfi R et al. | Increased thromboxane biosynthesis in patients with polycythemia vera: evidence for aspirin-suppressible platelet activation in vivo. | 1992 | Blood | pmid:1327286 |
| Weiss HJ and Lages B | Evidence for tissue factor-dependent activation of the classic extrinsic coagulation mechanism in blood obtained from bleeding time wounds. | 1988 | Blood | pmid:3345342 |
| Schafer AI et al. | Synergistic inhibition of platelet activation by plasmin and prostaglandin I2. | 1987 | Blood | pmid:3032310 |
| Lu H et al. | Temperature dependence of plasmin-induced activation or inhibition of human platelets. | 1991 | Blood | pmid:1825290 |
| Chong BH et al. | Heparin-induced thrombocytopenia: studies with a new low molecular weight heparinoid, Org 10172. | 1989 | Blood | pmid:2713496 |
| White JG and Rao GH | Effects of a microtubule stabilizing agent on the response of platelets to vincristine. | 1982 | Blood | pmid:6124288 |
| Hato T et al. | Induction of platelet Ca2+ influx and mobilization by a monoclonal antibody to CD9 antigen. | 1990 | Blood | pmid:2306515 |
| Praticò D et al. | Endogenous biosynthesis of thromboxane and prostacyclin in 2 distinct murine models of atherosclerosis. | 2000 | Blood | pmid:11090066 |
| Lin L et al. | Use of 8-methoxypsoralen and long-wavelength ultraviolet radiation for decontamination of platelet concentrates. | 1989 | Blood | pmid:2752129 |
| Santilli F et al. | Circulating endothelial progenitor cells and residual in vivo thromboxane biosynthesis in low-dose aspirin-treated polycythemia vera patients. | 2008 | Blood | pmid:18541722 |
| Di Minno G et al. | Exposure of platelet fibrinogen-binding sites by collagen, arachidonic acid, and ADP: inhibition by a monoclonal antibody to the glycoprotein IIb-IIIa complex. | 1983 | Blood | pmid:6216929 |
| Packham MA et al. | Duration of the effect of aspirin on the synthesis of thromboxane by density subpopulations of rabbit platelets stimulated with thrombin. | 1985 | Blood | pmid:3926022 |
| Okuma M and Uchino H | Altered arachidonate metabolism by platelets in patients with myeloproliferative disorders. | 1979 | Blood | pmid:116695 |
| Coppinger JA et al. | Moderation of the platelet releasate response by aspirin. | 2007 | Blood | pmid:17303692 |
| Packham MA et al. | Thromboxane A2 causes feedback amplification involving extensive thromboxane A2 formation on close contact of human platelets in media with a low concentration of ionized calcium. | 1987 | Blood | pmid:3620698 |
| Reilly IA and FitzGerald GA | Inhibition of thromboxane formation in vivo and ex vivo: implications for therapy with platelet inhibitory drugs. | 1987 | Blood | pmid:3790723 |
| Hoet B et al. | R68070, a combined thromboxane/endoperoxide receptor antagonist and thromboxane synthase inhibitor, inhibits human platelet activation in vitro and in vivo: a comparison with aspirin. | 1990 | Blood | pmid:2153424 |
| Evangelista V et al. | Platelet activation by fMLP-stimulated polymorphonuclear leukocytes: the activity of cathepsin G is not prevented by antiproteinases. | 1991 | Blood | pmid:1645603 |
| Koike K et al. | Platelet secretion defect in patients with the attention deficit disorder and easy bruising. | 1984 | Blood | pmid:6692042 |
| Chang MC et al. | Antithrombotic effect of crotalin, a platelet membrane glycoprotein Ib antagonist from venom of Crotalus atrox. | 1998 | Blood | pmid:9473223 |
| Lin YL and Wang CT | Activation of human platelets by the rabbit anticardiolipin antibodies. | 1992 | Blood | pmid:1467520 |
| Meyrick B et al. | Endothelial prostacyclin production is a late event in granulocyte migration into bovine pulmonary artery intimal explants. | 1985 | Blood | pmid:3904871 |
| Di Minno G et al. | Monitoring the entry of new platelets into the circulation after ingestion of aspirin. | 1983 | Blood | pmid:6404326 |
| Catalano PM et al. | Platelet recovery from aspirin inhibition in vivo; differing patterns under various assay conditions. | 1981 | Blood | pmid:7448419 |
| DiMinno G et al. | Trial of repeated low-dose aspirin in diabetic angiopathy. | 1986 | Blood | pmid:3092890 |
| Grabowski EF | Platelet aggregation in flowing blood at a site of injury to an endothelial cell monolayer: quantitation and real-time imaging with the TAB monoclonal antibody. | 1990 | Blood | pmid:2104767 |
| Eldor A et al. | Platelet interaction with subendothelial extracellular matrix: platelet-fibrinogen interactions are essential for platelet aggregation but not for the matrix-induced release reaction. | 1985 | Blood | pmid:3995180 |
| Maugeri N et al. | Transcellular metabolism of arachidonic acid: increased platelet thromboxane generation in the presence of activated polymorphonuclear leukocytes. | 1992 | Blood | pmid:1627802 |
| Higashihara M et al. | A monoclonal anti-human platelet antibody: a new platelet aggregating substance. | 1985 | Blood | pmid:3967086 |
| Kowalska MA et al. | Stromal cell-derived factor-1 and macrophage-derived chemokine: 2 chemokines that activate platelets. | 2000 | Blood | pmid:10891429 |
| Worthington RE and Nakeff A | Thromboxane synthesis in megakaryocytes isolated by centrifugal elutriation. | 1981 | Blood | pmid:6786393 |
| Rao GH et al. | Influence of the calcium-sensitive fluorophore, Quin 2, on platelet function. | 1986 | Blood | pmid:3510678 |
| Levine RF et al. | Megakaryocyte interaction with subendothelial extracellular matrix is associated with adhesion, platelet-like shape change, and thromboxane A2 production. | 1985 | Blood | pmid:4027379 |
| DiMinno G et al. | Increased binding of fibrinogen to platelets in diabetes: the role of prostaglandins and thromboxane. | 1985 | Blood | pmid:2981130 |
| Eldor A et al. | In vivo platelet activation in beta-thalassemia major reflected by increased platelet-thromboxane urinary metabolites. | 1991 | Blood | pmid:2015401 |
| Lages B and Weiss HJ | Evidence for a role of glycoprotein IIb-IIIa, distinct from its ability to support aggregation, in platelet activation by ionophores in the presence of extracellular divalent cations. | 1994 | Blood | pmid:8167340 |
| Levy-Toledano S et al. | Human platelet activation in the absence of aggregation: a calcium-dependent phenomenon independent of thromboxane formation. | 1982 | Blood | pmid:6803854 |
| Akbiyik F et al. | Human bone marrow megakaryocytes and platelets express PPARgamma, and PPARgamma agonists blunt platelet release of CD40 ligand and thromboxanes. | 2004 | Blood | pmid:15130939 |
| Weiss HJ and Lages B | Studies of thromboxane B2, platelet factor 4, and fibrinopeptide A in bleeding-time blood of patients deficient in von Willebrand factor, platelet glycoproteins Ib and IIb-IIIa, and storage granules. | 1993 | Blood | pmid:8329704 |
| Kelton JG et al. | Sex related differences in platelet function: the effect of aspirin. | 1982 | Blood | pmid:7059670 |
| Corash L et al. | Use of 8-methoxypsoralen and long wavelength ultraviolet radiation for decontamination of platelet concentrates. | 1992 | Blood Cells | pmid:1617193 |
| Jastrzębska M et al. | Factors influencing multiplate whole blood impedance platelet aggregometry measurements, during aspirin treatment in acute ischemic stroke: a pilot study. | 2013 | Blood Coagul. Fibrinolysis | pmid:24071649 |
| Jancinová V et al. | Inhibition of blood platelet functions by cationic amphiphilic drugs in relation to their physico-chemical properties. | 1996 | Blood Coagul. Fibrinolysis | pmid:8735816 |
| Ravn HB et al. | Magnesium inhibits human platelets. | 1996 | Blood Coagul. Fibrinolysis | pmid:8735829 |
| Klein Gunnewiek JM et al. | The influence of acetylsalicylic acid intake by healthy volunteers on duplicate PFA-100 measurements. | 2005 | Blood Coagul. Fibrinolysis | pmid:15970717 |
| Craft JA et al. | Increased platelet-derived microparticles in the coronary circulation of percutaneous transluminal coronary angioplasty patients. | 2004 | Blood Coagul. Fibrinolysis | pmid:15311156 |
| Wang ZY et al. | Comparative study of platelet activation markers in diabetes mellitus patients complicated by cerebrovascular disease. | 2001 | Blood Coagul. Fibrinolysis | pmid:11685040 |
| Smith IL and Smith EA | Inhibition of PAF-induced activation of human platelets by verapamil. | 1992 | Blood Coagul. Fibrinolysis | pmid:1336985 |
| Prieto MA et al. | Influence of triflusal on platelet activation after coronary artery bypass graft. | 2000 | Blood Coagul. Fibrinolysis | pmid:10759013 |
| Cignarella A et al. | Platelet activation supports the development of venous thrombosis in hyperlipidemic rats. | 1998 | Blood Coagul. Fibrinolysis | pmid:9607118 |
| Dharmasaroja PA and Sae-Lim S | Effects of different doses, enteric-coated preparation of aspirin, and sex on urinary 11-dehydrothromboxane B2 in healthy volunteers. | 2010 | Blood Coagul. Fibrinolysis | pmid:20689403 |
| Niemi TT et al. | The effect of N-acetylcysteine on blood coagulation and platelet function in patients undergoing open repair of abdominal aortic aneurysm. | 2006 | Blood Coagul. Fibrinolysis | pmid:16607076 |
| Dobaczewski M et al. | Targeting the urine and plasma determinants of thromboxane A2 metabolism in detection of aspirin effectiveness. | 2008 | Blood Coagul. Fibrinolysis | pmid:18600093 |
| Lechi C et al. | In vitro study of the anti-aggregating activity of two nitroderivatives of acetylsalicylic acid. | 1996 | Blood Coagul. Fibrinolysis | pmid:8735820 |
| Fuglsang J et al. | Intravenous acetylsalicylic acid, magnesium and their combination in experimental arterial thrombosis in rats. | 1999 | Blood Coagul. Fibrinolysis | pmid:10493216 |
| Osterud B et al. | Increased lipopolysaccharide-induced tissue factor activity and tumour necrosis factor production in monocytes after intake of aspirin: possible role of prostaglandin E2. | 1992 | Blood Coagul. Fibrinolysis | pmid:1643209 |
| Bridges AB et al. | Circadian variation of endothelial cell function, red blood cell deformability and dehydro-thromboxane B2 in healthy volunteers. | 1991 | Blood Coagul. Fibrinolysis | pmid:1932530 |
| Weber C et al. | Production of thromboxane and prostaglandins in human blood in the presence of thromboxane synthase inhibitors: a comparison of RIA and GC/MS determinations. | 1991 | Blood Coagul. Fibrinolysis | pmid:1773000 |
| Dharmasaroja PA et al. | Aspirin nonresponders in patients with ischaemic stroke. | 2013 | Blood Coagul. Fibrinolysis | pmid:23429255 |
| Vaskonen T et al. | Interrelationships between salt and fish oil in stroke-prone spontaneously hypertensive rat. | 1996 | Blood Press. | pmid:8790929 |
| Magagna A et al. | Hemodynamic and humoral effects of low-dose aspirin in treated and untreated essential hypertensive patients. | 1994 | Blood Press. | pmid:7994448 |
| Johnson RJ et al. | A modification of cellulose that facilitates the control of complement activation. | 1990 | Blood Purif. | pmid:2151203 |
| Nawroth PP et al. | Thromboxane production by perturbed bovine aortic endothelial cells in culture. | 1985 | Blut | pmid:3967102 |
| Lee JJ et al. | Antithrombotic and antiplatelet activities of Soshiho-tang extract. | 2013 | BMC Complement Altern Med | pmid:23773779 |
| Wang Y et al. | DanQi Pill protects against heart failure through the arachidonic acid metabolism pathway by attenuating different cyclooxygenases and leukotrienes B4. | 2014 | BMC Complement Altern Med | pmid:24555740 |
| Wang J et al. | Prevention of atherosclerosis by Yindan Xinnaotong capsule combined with swimming in rats. | 2015 | BMC Complement Altern Med | pmid:25886942 |
| Celik I et al. | Effects of ibuprofen on the physiology and outcome of rabbit endotoxic shock. | 2002 | BMC Infect. Dis. | pmid:12445332 |
| Warner JH et al. | Adaptive regression modeling of biomarkers of potential harm in a population of U.S. adult cigarette smokers and nonsmokers. | 2010 | BMC Med Res Methodol | pmid:20233412 |
| Mayer AM et al. | Differential modulation of microglia superoxide anion and thromboxane B2 generation by the marine manzamines. | 2005 | BMC Pharmacol. | pmid:15762999 |
| Lassila R et al. | Vasoactive and atherogenic effects of cigarette smoking: a study of monozygotic twins discordant for smoking. | 1988 | BMJ | pmid:3142565 |
| Orosz L et al. | Blood glucose and diabetic retinopathy. | 1992 | BMJ | pmid:1515807 |
| Fatimi J et al. | Synthesis and inhibitory effects of 1,4,5-trialkyl-2-thioimidazole derivatives on platelet aggregation. | 1994 | Boll Chim Farm | pmid:8011274 |
| Tanganelli I et al. | [Thromboxane, beta-thromboglobulin and the degree of blood sugar control in type 1 diabetes mellitus]. | 1983 | Boll. Soc. Ital. Biol. Sper. | pmid:6194801 |
| Fasce L et al. | [Effects of glucocorticoids on the gastrointestinal tract of normal rats and rats deficient in endogenous prostaglandins]. | 1981 | Boll. Soc. Ital. Biol. Sper. | pmid:7295403 |
| Tanganelli I et al. | Effects of somatostatin on the behavior of thromboxane B2 and B-thromboglobulin in type 1 diabetes. | 1984 | Boll. Soc. Ital. Biol. Sper. | pmid:6084513 |
| Fiore S et al. | Endotoxin-induced TxB2 release by polymorphonuclears and macrophages. | 1986 | Boll. Soc. Ital. Biol. Sper. | pmid:3098261 |
| Cifone MG et al. | [Effect of calcium ionophore (A23187) on the production of thromboxane B2 in human polymorphonuclear cells in vitro]. | 1984 | Boll. Soc. Ital. Biol. Sper. | pmid:6422962 |
| Yosipovitch G et al. | Diurnal rhythm of prostanoid secretion from bone/marrow organ in the rat. | 1995 | Bone | pmid:7577162 |