MeSH term | MeSH ID | Detail |
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Adenocarcinoma | D000230 | 166 associated lipids |
Lung Neoplasms | D008175 | 171 associated lipids |
Body Weight | D001835 | 333 associated lipids |
Thromboxane b2 is a lipid of Fatty Acyls (FA) class. Thromboxane b2 is associated with abnormalities such as endothelial dysfunction, Diabetes Mellitus, Non-Insulin-Dependent, Diabetes Mellitus, Ischemia and Thrombocytosis. The involved functions are known as Platelet Activation, Excretory function, Anabolism, Inflammation and mRNA Expression. Thromboxane b2 often locates in Endothelium, Hepatic and Microsomes, Liver. The associated genes with Thromboxane b2 are PTGS2 gene, prothrombin fragment 2 and CCL14 wt Allele.
To understand associated biological information of Thromboxane b2, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
Thromboxane b2 is suspected in endothelial dysfunction, Diabetes Mellitus, Non-Insulin-Dependent, Diabetes Mellitus, Ischemia, Thrombocytosis, Acute Coronary Syndrome and other diseases in descending order of the highest number of associated sentences.
Disease | Cross reference | Weighted score | Related literature |
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We collected disease MeSH terms mapped to the references associated with Thromboxane b2
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
Location | Cross reference | Weighted score | Related literatures |
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Function | Cross reference | Weighted score | Related literatures |
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There are no associated biomedical information in the current reference collection.
Gene | Cross reference | Weighted score | Related literatures |
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There are no associated biomedical information in the current reference collection.
Authors | Title | Published | Journal | PubMed Link |
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Pfliegler G et al. | Platelet function studies in myeloproliferative disorders. | 1986 | Folia Haematol. Int. Mag. Klin. Morphol. Blutforsch. | pmid:2435631 |
Bjøro K et al. | Formation of prostanoids in human umbilical vessels perfused in vitro. | 1986 | Prostaglandins | pmid:3523623 |
Bjøro K | Prostacyclin and thromboxane formation in human umbilical arteries following stimulation with vasoactive autacoids. | 1986 | Prostaglandins | pmid:3523624 |
Schleimer RP et al. | Selective inhibition of arachidonic acid metabolite release from human lung tissue by antiinflammatory steroids. | 1986 | J. Immunol. | pmid:3082976 |
Chiricolo M et al. | Prostaglandin and thromboxane biosynthesis in resting and activated platelet-free monocytes from aged subjects. | 1986 | Gerontology | pmid:3086183 |
Tripp CS et al. | Monocyte migration explains the changes in macrophage arachidonate metabolism during the immune response. | 1986 | Proc. Natl. Acad. Sci. U.S.A. | pmid:3099288 |
Perico N et al. | Effect of short-term cyclosporine administration in rats on renin-angiotensin and thromboxane A2: possible relevance to the reduction in glomerular filtration rate. | 1986 | J. Pharmacol. Exp. Ther. | pmid:3531461 |
Cunnane SC et al. | n-3 Essential fatty acids decrease weight gain in genetically obese mice. | 1986 | Br. J. Nutr. | pmid:3676212 |
Hsu CY et al. | Increased thromboxane level in experimental spinal cord injury. | 1986 | J. Neurol. Sci. | pmid:3525758 |
Slotman GJ et al. | Thromboxane A2 mediates hemodynamic and respiratory dysfunction in graded bacteremia. | 1986 | Surgery | pmid:3526603 |
Ylikorkala O et al. | Maternal ingestion of acetylsalicylic acid inhibits fetal and neonatal prostacyclin and thromboxane in humans. | 1986 | Am. J. Obstet. Gynecol. | pmid:3526896 |
Fischer S et al. | Formation of prostacyclin and thromboxane in man as measured by the main urinary metabolites. | 1986 | Biochim. Biophys. Acta | pmid:3754157 |
Quilley CP and Rifkind AB | Prostaglandin release by the chick embryo heart is increased by 2,3,7,8-tetrachlorodibenzo-p-dioxin and by other cytochrome P-448 inducers. | 1986 | Biochem. Biophys. Res. Commun. | pmid:3085671 |
Czer GT et al. | Low-dose PGI2 prevents monocrotaline-induced thromboxane production and lung injury. | 1986 | J. Appl. Physiol. | pmid:3081477 |
Cross PE et al. | Selective thromboxane synthetase inhibitors. 2. 3-(1H-imidazol-1-ylmethyl)-2-methyl-1H-indole-1-propanoic acid and analogues. | 1986 | J. Med. Chem. | pmid:3081722 |
Huijgens PC et al. | Aspirin does not inhibit human megakaryocyte thromboxane synthesis in vivo. | 1986 | Scand J Haematol | pmid:3081996 |
Fitzgerald DJ et al. | Platelet activation in unstable coronary disease. | 1986 | N. Engl. J. Med. | pmid:3531859 |
Schenkein HA | LPS-stimulated release of prostaglandin E and thromboxane B2 from the U937 cell line. | 1986 | Cell. Immunol. | pmid:3100058 |
Fuller RW et al. | Immunoglobulin E-dependent stimulation of human alveolar macrophages: significance in type 1 hypersensitivity. | 1986 | Clin. Exp. Immunol. | pmid:2947765 |
Strobl-Jäger E et al. | Platelet half-life in comparison to other in-vivo platelet function parameters such as thromboxane B2, beta-thromboglobulin and platelet factor 4 in patients with atherosclerotic lesions with and without hyperlipoproteinemia. | 1986 | VASA | pmid:2948337 |
Foegh ML et al. | Eicosanoids, gamma-interferon and inflammatory cells in kidney transplant patients. | 1986 | Adv. Prostaglandin Thromboxane Leukot. Res. | pmid:2949550 |
Davì G et al. | Enhanced platelet sensitivity to prostacyclin after isosorbide-5-mononitrate in patients with stable angina pectoris. | 1986 | Z Kardiol | pmid:3541421 |
Säynävälammi P | Effects of captopril on the urinary excretion of prostanoids and kallikrein in spontaneously hypertensive rats. | 1986 | Acta Pharmacol Toxicol (Copenh) | pmid:3541494 |
Morris DD et al. | Endotoxin-induced changes in plasma concentrations of thromboxane and prostacyclin in neonatal calves given antiserum to a mutant Escherichia coli (J-5). | 1986 | Am. J. Vet. Res. | pmid:3541703 |
Wang Z et al. | [Preliminary report on the application of thromboxane B2 radioimmunoassay]. | 1986 | Zhongguo Yi Xue Ke Xue Yuan Xue Bao | pmid:2953485 |
Ali M and Mohammed SY | Selective suppression of platelet thromboxane formation with sparing of vascular prostacyclin synthesis by aqueous extract of garlic in rabbits. | 1986 | Prostaglandins Leukot Med | pmid:3547414 |
Simonson MS and Dunn MJ | Leukotriene C4 and D4 contract rat glomerular mesangial cells. | 1986 | Kidney Int. | pmid:3465969 |
Endean ED et al. | Effect of thromboxane synthetase inhibition on canine autogenous vein grafts. | 1986 | J. Surg. Res. | pmid:3702387 |
Croft KD et al. | Dietary fish oils reduce plasma levels of platelet activating factor precursor (lyso-PAF) in rats. | 1986 | Life Sci. | pmid:3702610 |
Handley DA et al. | Vascular responses of platelet-activating factor in the Cebus apella primate and inhibitory profiles of antagonists SRI 63-072 and SRI 63-119. | 1986 | Immunopharmacology | pmid:3733419 |
Houston DS et al. | Aggregating human platelets cause direct contraction and endothelium-dependent relaxation of isolated canine coronary arteries. Role of serotonin, thromboxane A2, and adenine nucleotides. | 1986 | J. Clin. Invest. | pmid:3734103 |
Simpson PJ et al. | Reduction in the incidence of thrombosis by the thromboxane synthetase inhibitor CGS 13080 in a canine model of coronary artery injury. | 1986 | J. Pharmacol. Exp. Ther. | pmid:3735129 |
Arai M | [Plasma thromboxane B2 levels in various liver diseases]. | 1986 | Nihon Shokakibyo Gakkai Zasshi | pmid:3735742 |
Schneidkraut MJ et al. | Regional release of cyclooxygenase products after radiation exposure of the rat. | 1986 | J. Appl. Physiol. | pmid:3096935 |
Catapano AL et al. | Bile lipids, platelet aggregability and pro-ApoAI processing in 2 cases of Tangier disease. | 1986 | Monogr Atheroscler | pmid:3736556 |
Semrad SD et al. | Hypertension in bulls and steers anesthetized with guaifenesin-thiobarbiturate-halothane combination. | 1986 | Am. J. Vet. Res. | pmid:3740628 |
Cao QL | [Dynamic analysis of plasma TXB2 determined by radioimmunoassay in 30 cases of cerebral infarction]. | 1986 | Zhonghua Shen Jing Jing Shen Ke Za Zhi | pmid:3743234 |
Xie P | [Clinical significance of TXB2 level in CSF of patients with acute cerebrovascular diseases]. | 1986 | Zhonghua Shen Jing Jing Shen Ke Za Zhi | pmid:3743244 |
Knapp HR et al. | In vivo indexes of platelet and vascular function during fish-oil administration in patients with atherosclerosis. | 1986 | N. Engl. J. Med. | pmid:3007982 |
Ono N et al. | Pharmacological studies on proglumetacin maleate, a new non-steroidal anti-inflammatory drug (4). Mode of action on anti-inflammatory activity. | 1986 | Jpn. J. Pharmacol. | pmid:3102823 |
Bucchi F et al. | Salicylate may prevent the inhibitory effect of indomethacin on serum thromboxane formation in man. | 1986 | Prostaglandins Leukot Med | pmid:3456617 |
Laffi G et al. | Effects of sulindac and ibuprofen in patients with cirrhosis and ascites. An explanation for the renal-sparing effect of sulindac. | 1986 | Gastroenterology | pmid:3079594 |
Ishihara Y et al. | Effect of thromboxane synthetase inhibitors (OKY-046, OKY-1580) on experimentally induced air embolism in anesthetized dogs. | 1986 | Prostaglandins Leukot Med | pmid:3457388 |
Schenkein HA | Prostaglandin E and thromboxane B2 release by PMA-induced U937 cells in response to C3b. | 1986 | J. Leukoc. Biol. | pmid:3457882 |
Kääpä P et al. | Increased platelet thromboxane B2 production in newborn infants of diabetic mothers. | 1986 | Prostaglandins Leukot Med | pmid:3458263 |
Hawkey CJ | Synthesis of prostaglandin E2, thromboxane B2 and prostaglandin catabolism in gastritis and gastric ulcer. | 1986 | Gut | pmid:3468053 |
Schaub RG and Yamashita A | Leukocyte mediated vein injury and thrombosis is reduced by a lipoxygenase inhibitor. | 1986 | Exp. Mol. Pathol. | pmid:3025012 |
Kudo K et al. | [Urinary excretion of thromboxane B2 in normal human subjects: sex and age differences]. | 1986 | Nippon Naika Gakkai Zasshi | pmid:3746076 |
Ahmed T et al. | Endotoxin-induced changes in pulmonary hemodynamics and respiratory mechanics. Role of lipoxygenase and cyclooxygenase products. | 1986 | Am. Rev. Respir. Dis. | pmid:3098146 |
Weiner BH et al. | Inhibition of atherosclerosis by cod-liver oil in a hyperlipidemic swine model. | 1986 | N. Engl. J. Med. | pmid:3748103 |
Oei HH et al. | Inhibition of thromboxane biosynthesis in splanchnic ischemia shock. | 1986 | Circ. Shock | pmid:3753907 |
Catella F et al. | 11-Dehydrothromboxane B2: a quantitative index of thromboxane A2 formation in the human circulation. | 1986 | Proc. Natl. Acad. Sci. U.S.A. | pmid:3461463 |
Krishnamurthi S et al. | Synergistic potentiation of 5-hydroxytryptamine secretion by platelet agonists and phorbol myristate acetate despite inhibition of agonist-induced arachidonate/thromboxane and beta-thromboglobulin release and Ca2+ mobilization by phorbol myristate acetate. | 1986 | Biochem. J. | pmid:2948494 |
Teitelbaum I et al. | Effect of cAMP on prostaglandin E2 production in cultured rat inner medullary collecting tubule cells. | 1986 | Am. J. Physiol. | pmid:3020997 |
DiMinno G et al. | Trial of repeated low-dose aspirin in diabetic angiopathy. | 1986 | Blood | pmid:3092890 |
Shohami E and Gross J | Effects of hypoxia and anoxia on the ex vivo release of prostaglandins from mouse cortical slices. | 1986 | J. Neurochem. | pmid:3464697 |
Ekblad U | The effect of oxytocin and betamimetic stimulation on prostaglandin release in perfused human fetal placenta. | 1986 | Eur. J. Obstet. Gynecol. Reprod. Biol. | pmid:3469120 |
Turi S et al. | Abnormalities of vascular prostaglandins in Henoch-Schönlein purpura. | 1986 | Arch. Dis. Child. | pmid:2420289 |
Kutti J et al. | Evaluation of platelet reactivity in diabetes mellitus. | 1986 | Acta Med Scand | pmid:2938425 |
Zucker ML et al. | Platelet function in hypercholesterolemics before and after hypolipidemic drug therapy. | 1986 | Haemostasis | pmid:2939008 |
Mueller HS et al. | Platelet hyperactivity in acute myocardial infarction in man--effects of prostacyclin. | 1986 | Herz | pmid:2939012 |
Legrand YJ et al. | Activation of platelets by microfibrils and collagen. A comparative study. | 1986 | Lab. Invest. | pmid:2939291 |
Komatsu H et al. | Beneficial effect of OKY-046, a selective thromboxane A2 synthetase inhibitor, on experimental cerebral vasospasm. | 1986 | Jpn. J. Pharmacol. | pmid:3761754 |
Fiore S et al. | Endotoxin-induced TxB2 release by polymorphonuclears and macrophages. | 1986 | Boll. Soc. Ital. Biol. Sper. | pmid:3098261 |
Burhop KE et al. | Platelet-activating factor increases lung vascular permeability to protein. | 1986 | J. Appl. Physiol. | pmid:3804927 |
Connellan JM et al. | Investigation of alternative mechanisms of collagen-induced platelet activation by using monoclonal antibodies to glycoprotein IIb-IIIa and fibrinogen. | 1986 | Thromb. Haemost. | pmid:2940722 |
Fuller RW and MacDermot J | Stimulation of IgE sensitized human alveolar macrophages by anti-IgE is unaffected by sodium cromoglycate. | 1986 | Clin. Allergy | pmid:3098449 |
Lokesh BR et al. | Peritoneal macrophages from mice fed dietary (n-3) polyunsaturated fatty acids secrete low levels of prostaglandins. | 1986 | J. Nutr. | pmid:3806247 |
Eldrup-Jorgensen J et al. | Antiplatelet therapy and vascular grafts. Studies in a baboon ex vivo shunt. | 1986 | Arch Surg | pmid:2940991 |
Kirschenbaum MA and Chaudhari A | Effect of experimental diabetes on glomerular filtration rate and glomerular prostanoid production in the rat. | 1986 | Miner Electrolyte Metab | pmid:3807832 |
Arai M et al. | Platelet dysfunction and alteration of prostaglandin metabolism after chronic alcohol consumption. | 1986 | Scand. J. Gastroenterol. | pmid:3810010 |
Chiang TM and Kang AH | The effect of platelet surface protein phosphorylation on collagen-platelet interaction. | 1986 | Thromb. Res. | pmid:3810565 |
Szczeklik A et al. | Prolonged bleeding time, reduced platelet aggregation, altered PAF-acether sensitivity and increased platelet mass are a trait of asthma and hay fever. | 1986 | Thromb. Haemost. | pmid:3563961 |
Schleimer RP et al. | Characterization of inflammatory mediator release from purified human lung mast cells. | 1986 | Am. Rev. Respir. Dis. | pmid:3485946 |
Perkett EA et al. | Lymphocyte and granulocyte migration across the endothelial layer of bovine pulmonary artery intimal explants towards lymphocyte conditioned medium. | 1986 | Tissue Cell | pmid:3810636 |
Michael LH et al. | Myocardial ischemia: platelet and thromboxane concentrations in cardiac lymph and the effects of ibuprofen and prostacyclin. | 1986 | Circ. Res. | pmid:3524894 |
Gairola CG and Tai HH | Cigarette smoke-induced alterations in the release of arachidonate metabolites by pulmonary alveolar macrophage from selenium-fed and selenium-deficient rats. | 1986 | Biochem. Pharmacol. | pmid:3015150 |
Geoffroy J et al. | [Urinary excretion of thromboxane B2 in the genetically hypertensive rat of the Lyons strain]. | 1986 | Arch Mal Coeur Vaiss | pmid:3099702 |
Greer IA et al. | Endothelial stimulation by DDAVP in von Willebrand's disease and haemophilia. | 1986 | Haemostasis | pmid:3084364 |
Hatmi M et al. | Modulation by cyclic AMP of arachidonic acid-induced platelet desensitization. | 1986 | Eur. J. Pharmacol. | pmid:3028837 |
Cerletti C et al. | Comparison of the effects of oral and intravenous aspirin administration on platelet and peripheral vascular cyclo-oxygenase activity: studies in rats and in man. | 1986 | Agents Actions Suppl. | pmid:3101444 |
Perico N et al. | Functional significance of exaggerated renal thromboxane A2 synthesis induced by cyclosporin A. | 1986 | Am. J. Physiol. | pmid:3094383 |
Podjarny E et al. | Effect of angiotensin II on prostanoid synthesis in isolated rat glomeruli. | 1986 | Clin. Sci. | pmid:3457671 |
Laffi G et al. | Altered renal and platelet arachidonic acid metabolism in cirrhosis. | 1986 | Gastroenterology | pmid:3079716 |
Gyllenhammar H et al. | Essential fatty acid deficiency in rats: effects on arachidonate metabolism, generation of cyclooxygenase products and functional responses in neutrophils. | 1986 | Immunol. Lett. | pmid:3095230 |
Tremoli E et al. | Dietary interventions in north Karelia, Finland and south Italy. Modification of thromboxane B2 formation in platelets of male subjects only. | 1986 | Atherosclerosis | pmid:3964338 |
Boukili MA et al. | Pharmacological modulation of the effects of N-formyl-L-methionyl-L-leucyl-L-phenylalanine in guinea-pigs: involvement of the arachidonic acid cascade. | 1986 | Br. J. Pharmacol. | pmid:3096407 |
Singer P et al. | Long-term effect of mackerel diet on blood pressure, serum lipids and thromboxane formation in patients with mild essential hypertension. | 1986 | Atherosclerosis | pmid:3026412 |
Guarner C et al. | Renal prostaglandins in cirrhosis of the liver. | 1986 | Clin. Sci. | pmid:3516533 |
Burghuber OC et al. | Hydrogen peroxide induced pulmonary vasoconstriction in isolated rat lungs is attenuated by U60,257, a leucotriene synthesis blocker. | 1986 | Wien. Klin. Wochenschr. | pmid:3518246 |
Mest HJ and Beitz J | [Significance of eicosanoids for arteriosclerosis and the effect of lipoproteins on prostanoid formation]. | 1986 | Z Gesamte Inn Med | pmid:3518258 |
Seeger W et al. | Pulmonary microvascular injury induced by Pseudomonas aeruginosa cytotoxin in isolated rabbit lungs. | 1986 | Infect. Immun. | pmid:3519462 |
Westlund P et al. | Circulating and urinary thromboxane B2 metabolites in the rabbit: 11-dehydro-thromboxane B2 as parameter of thromboxane production. | 1986 | Prostaglandins | pmid:3520685 |
Slotman GJ et al. | Interaction of prostaglandins, activated complement, and granulocytes in clinical sepsis and hypotension. | 1986 | Surgery | pmid:3520916 |
Bales CW et al. | The effect of zinc deficiency and food restriction on prostaglandin E2 and thromboxane B2 in saliva and plasma of rats. | 1986 | Prostaglandins | pmid:3460117 |
Pohanka E and Sinzinger H | Effect of a single pentoxifylline administration on platelet sensitivity, plasma factor activity, plasma-6-oxo-PGF1 alpha and thromboxane B2 in healthy volunteers. | 1986 | Prostaglandins Leukot Med | pmid:3523540 |
Masi I et al. | Effects of CDP-choline on platelet aggregation and the antiaggregatory activity of arterial wall in the rat. | 1986 | Pharmacol Res Commun | pmid:3523545 |
Kobinia GS et al. | Influence of coronary artery obstruction on cardiac prostaglandin metabolism during experimental cardioplegic arrest. | 1986 | Thorac Cardiovasc Surg | pmid:2424127 |
Shinonaga M et al. | [Sequential measurements of TxB2 and 6-keto PGF1 alpha in cerebrospinal fluid and serum in patients with subarachnoid hemorrhage]. | 1986 | Neurol. Med. Chir. (Tokyo) | pmid:2429203 |
Winn R et al. | Lung permeability and hemodynamics during endotoxemia: effect of aprotinin. | 1986 | J. Surg. Res. | pmid:2431222 |