MeSH term | MeSH ID | Detail |
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Adenocarcinoma | D000230 | 166 associated lipids |
Lung Neoplasms | D008175 | 171 associated lipids |
Body Weight | D001835 | 333 associated lipids |
Thromboxane b2 is a lipid of Fatty Acyls (FA) class. Thromboxane b2 is associated with abnormalities such as endothelial dysfunction, Diabetes Mellitus, Non-Insulin-Dependent, Diabetes Mellitus, Ischemia and Thrombocytosis. The involved functions are known as Platelet Activation, Excretory function, Anabolism, Inflammation and mRNA Expression. Thromboxane b2 often locates in Endothelium, Hepatic and Microsomes, Liver. The associated genes with Thromboxane b2 are PTGS2 gene, prothrombin fragment 2 and CCL14 wt Allele.
To understand associated biological information of Thromboxane b2, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
Thromboxane b2 is suspected in endothelial dysfunction, Diabetes Mellitus, Non-Insulin-Dependent, Diabetes Mellitus, Ischemia, Thrombocytosis, Acute Coronary Syndrome and other diseases in descending order of the highest number of associated sentences.
Disease | Cross reference | Weighted score | Related literature |
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We collected disease MeSH terms mapped to the references associated with Thromboxane b2
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
Location | Cross reference | Weighted score | Related literatures |
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Function | Cross reference | Weighted score | Related literatures |
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There are no associated biomedical information in the current reference collection.
Gene | Cross reference | Weighted score | Related literatures |
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There are no associated biomedical information in the current reference collection.
Authors | Title | Published | Journal | PubMed Link |
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Düsing R et al. | Dietary linoleic acid deprivation: effects on blood pressure and PGI2 synthesis. | 1983 | Am. J. Physiol. | pmid:6337507 |
McManus LM et al. | Thromboxane B2 (TxB2) release following acetyl glyceryl ether phosphorylcholine (AGEPC) infusion in the rabbit. | 1983 | Immunopharmacology | pmid:6832960 |
Martin JL et al. | Effect of atrial pacing on intracoronary thromboxane production in coronary artery disease. | 1983 | J. Am. Coll. Cardiol. | pmid:6833660 |
Ferraris VA and Swanson E | Aspirin usage and perioperative blood loss in patients undergoing unexpected operations. | 1983 | Surg Gynecol Obstet | pmid:6836459 |
Menys VC and Davies JA | Inhibitory effects of ZK 36374, a stable prostacyclin analogue, on adhesion of rabbit platelets to damaged aorta and serotonin release by adherent platelets. | 1983 | Clin. Sci. | pmid:6190604 |
Kangasaho M et al. | Formation of thromboxane B2 by platelets and concentrations of thromboxane B2 and 6-keto-prostaglandin F1 alpha in plasma after acute ethanol ingestion. | 1983 | Adv. Prostaglandin Thromboxane Leukot. Res. | pmid:6303086 |
Ylikorkala O and Viinikka L | Prostaglandins and endometriosis. | 1983 | Acta Obstet Gynecol Scand Suppl | pmid:6344540 |
Ylikorkala O | Prostacyclin and thromboxane during human pregnancy. | 1983 | Acta Obstet Gynecol Scand Suppl | pmid:6344543 |
Qvist R and Larkins RG | Diminished production of thromboxane B2 and prostaglandin E by stimulated polymorphonuclear leukocytes from insulin-treated diabetic subjects. | 1983 | Diabetes | pmid:6345241 |
Newman JH et al. | Effects of 100% oxygen on lung vascular function in awake sheep. | 1983 | J Appl Physiol Respir Environ Exerc Physiol | pmid:6345493 |
Eldor A et al. | Effects of dipyrone on prostaglandin production by human platelets and cultured bovine aortic endothelial cells. | 1983 | Thromb. Haemost. | pmid:6346571 |
Kiff PS et al. | Haemodynamic and metabolic effects of dazoxiben at rest and during atrial pacing. | 1983 | Br J Clin Pharmacol | pmid:6681708 |
Winchester JF et al. | Early indicators of renal allograft rejection. | 1983 | Kidney Int. Suppl. | pmid:6224041 |
Westwick J et al. | Platelet activation during steady state sickle cell disease. | 1983 | J Med | pmid:6224876 |
Dale J et al. | The effect of a thromboxane synthetase inhibitor, dazoxiben, and acetylsalicylic acid on platelet function and prostaglandin metabolism. | 1983 | Thromb. Haemost. | pmid:6689091 |
Liu J | [Effect of Paeonia obovata 801 on metabolism of thromboxane B2 and arachidonic acid and on platelet aggregation in patients with coronary heart disease and cerebral thrombosis]. | 1983 | Zhonghua Yi Xue Za Zhi | pmid:6418338 |
Aehringhaus U et al. | Effect of inhibition of synthesis and receptor antagonism of SRS-A in cardiac anaphylaxis. | 1983 | Br. J. Pharmacol. | pmid:6689134 |
Kurata M | [Relation between mouse peritoneal macrophage functions and prostaglandins]. | 1983 | Rinsho Byori | pmid:6689184 |
Maguire ED and Wallis RB | In vivo redirection of prostaglandin endoperoxides into 6-keto PGF1 alpha formation by thromboxane synthetase inhibitors in the rat. | 1983 | Thromb. Res. | pmid:6689221 |
McDonald JW and Ali M | Recovery of cyclooxygenase activity after aspirin in populations of platelets separated on stractan density gradients. | 1983 | Prostaglandins Leukot Med | pmid:6419234 |
Zijlstra FJ and Vincent JE | Comparison of the determination of thromboxane A2 by bioassay on the rabbit mesenteric artery and in the form of TxB2 by radioimmunoassay. | 1983 | J Pharmacol Methods | pmid:6632924 |
Bryant RW and Hwang DH | Development of a radioimmunoassay for 15-HETE and its application to 15-HETE production by reticulocytes. | 1983 | Prostaglandins | pmid:6419285 |
Wilson L | Effects of estradiol and progesterone on uterine prostaglandin levels in the pregnant rat. | 1983 | Prostaglandins | pmid:6635211 |
Schenkelaars EJ and Bonta IL | Effect of leukotriene C4 on the release of secretory products by elicited populations of rat peritoneal macrophages. | 1983 | Eur. J. Pharmacol. | pmid:6572592 |
Rocklin RE et al. | Augmentation of prostaglandin and thromboxane production in vitro by monocytes exposed to histamine-induced suppressor factor (HSF). | 1983 | Cell. Immunol. | pmid:6573232 |
Ouwendijk RJ et al. | Raised plasma thromboxane B2 levels in alcoholic liver disease. | 1983 | Prostaglandins Leukot Med | pmid:6573682 |
Hornych A et al. | Thromboxane B2 in borderline and essential hypertensive patients. | 1983 | Prostaglandins Leukot Med | pmid:6573683 |
Flynn JT et al. | Effects of anesthesia and surgery on prostanoid concentrations in plasma and pulmonary lymph. | 1983 | Prostaglandins Leukot Med | pmid:6573688 |
Mest HJ et al. | [Effect of stress on blood level of prostaglandins in students during exams]. | 1982 May-Jun | Farmakol Toksikol | pmid:7095121 |
Shohami E et al. | The effect of incomplete cerebral ischemia on prostaglandin levels in rat brain. | 1982 Jul-Aug | Stroke | pmid:6896589 |
Giannessi D et al. | Methodological assessment and applications of a radioimmunoassay for thromboxane (TxB2) to measurement of TxB2 release by platelets. | 1982 Jan-Mar | J. Nucl. Med. Allied Sci. | pmid:7108634 |
Sakai K et al. | Roles of endogenous prostacyclin and thromboxane A2 in the ischemic canine heart. | 1982 Jan-Feb | J. Cardiovasc. Pharmacol. | pmid:6176788 |
Uyama O et al. | Plasma concentrations of 6-keto-prostaglandin F1 alpha in patients with hypertension, cerebrovascular disease or Takayasu's arteritis. | 1982 Jan 1-15 | Thromb. Res. | pmid:6121391 |
Clark KE et al. | Effect of bisenoic prostaglandins and arachidonic acid on the uterine vasculature of pregnant sheep. | 1982 | Am. J. Obstet. Gynecol. | pmid:7065014 |
Schuette AH et al. | Effect of lung thromboxane generation on regional blood flow during sheep bypass. | 1982 | Am. J. Physiol. | pmid:7065206 |
Mäkilä UM et al. | Regulation of prostacyclin and thromboxane production by human umbilical vessels: the effect of estradiol and progesterone in a superfusion model. | 1982 | Prostaglandins Leukot Med | pmid:7043492 |
Han P et al. | Inhibition of platelet function of antiarrhythmic drugs, verapamil and disopyramide. | 1982 | Thromb. Haemost. | pmid:7101234 |
Krausz MM et al. | Adverse effects of prostacyclin used to perfuse isolated lung lobes. | 1982 | Am. J. Physiol. | pmid:7044149 |
Hirsh PD et al. | Influence of blood sampling site and technique on thromboxane concentrations in patients with ischemic heart disease. | 1982 | Am. Heart J. | pmid:7102506 |
Siess W et al. | Plasma catecholamines, platelet aggregation and associated thromboxane formation after physical exercise, smoking or norepinephrine infusion. | 1982 | Circulation | pmid:7044612 |
Chierchia S et al. | Failure of thromboxane A2 blockade to prevent attacks of vasospastic angina. | 1982 | Circulation | pmid:7116586 |
Sasagawa S et al. | Effects of thromboxane A2 injection on the rabbit coronary artery. I. Physiologic effects in healthy animals. | 1982 | Exp. Mol. Pathol. | pmid:7117494 |
Socini A et al. | Effects of the coumarin derivative AD6 on platelet aggregation, platelet vessel wall interactions and 6 keto PGF1 alpha production in perfused aortas, in experimentally hypercholesterolaemic rabbits. | 1982 | Pharmacol Res Commun | pmid:7048340 |
Simpson RM et al. | Generation of thromboxane A2 and aorta-contracting activity from platelets stimulated with modified C-reactive protein. | 1982 | Immunology | pmid:7118160 |
Leach CM and Thorburn GD | A comparative study of collagen induced thromboxane release from platelets of different species: implications for human atherosclerosis models. | 1982 | Prostaglandins | pmid:7122912 |
Bottoms GD et al. | Thromboxane, prostaglandin I2 (epoprostenol), and the hemodynamic changes in equine endotoxin shock. | 1982 | Am. J. Vet. Res. | pmid:7049018 |
Poubelle P et al. | [Mononucleated phagocytes from rheumatoid synovial fluid. Synthesis of prostanoids and first pharmacological applications]. | 1982 | Rev Rhum Mal Osteoartic | pmid:7123126 |
Homma T and Malik KU | Effect of prostaglandins on pancreatic circulation in anesthetized dogs. | 1982 | J. Pharmacol. Exp. Ther. | pmid:7050343 |
Bradlow BA and Chetty N | Dosage frequency for suppression of platelet function by low dose aspirin therapy. | 1982 | Thromb. Res. | pmid:7123514 |
Buchanan MR et al. | Aspirin inhibits platelet function independent of the acetylation of cyclo-oxygenase. | 1982 | Thromb. Res. | pmid:7071811 |
Tremoli E et al. | Metformin reduces platelet hypersensitivity in hypercholesterolemic rabbits. | 1982 | Atherosclerosis | pmid:7073794 |
Peterson MB et al. | Thromboxane mediates acute pulmonary hypertension in sheep extracorporeal perfusion. | 1982 | Am. J. Physiol. | pmid:7051860 |
Martin JF et al. | Effect of acetylsalicylic acid on platelet aggregation and thromboxane B2 production in flowing aortic blood in the rat studied with a filter loop technique. | 1982 | Thromb. Res. | pmid:6814004 |
Fletcher MS et al. | Endotoxin, prostaglandins and renal fibrin deposition in obstructive jaundice. | 1982 | Br J Surg | pmid:6751458 |
Dejana E et al. | Bleeding time in rats: a comparison of different experimental conditions. | 1982 | Thromb. Haemost. | pmid:6753230 |
Axelrod L and Levine L | Plasma prostaglandin levels in rats with diabetes mellitus and diabetic ketoacidosis. | 1982 | Diabetes | pmid:6816644 |
Strano A et al. | Platelet sensitivity to prostacyclin and thromboxane production in hyperlipidemic patients. | 1982 | Thromb. Haemost. | pmid:6753232 |
Numano F et al. | Effects of thromboxane A2 injection on the rabbit coronary artery. II. The production of infarcts in cholesterol-fed animals. | 1982 | Exp. Mol. Pathol. | pmid:6956517 |
Flynn JT and Demling RH | Inhibition of endogenous thromboxane synthesis by exogenous prostacyclin during endotoxemia in conscious sheep. | 1982 | Adv Shock Res | pmid:6753534 |
Grundfest CC et al. | Acrolein: a potent modulator of lung macrophage arachidonic acid metabolism. | 1982 | Biochim. Biophys. Acta | pmid:6814492 |
Smith MC et al. | Prostacyclin substitution for heparin in long-term hemodialysis. | 1982 | Am. J. Med. | pmid:6753575 |
Aharony D et al. | Regulation of arachidonate-induced platelet aggregation by the lipoxygenase product, 12-hydroperoxyeicosatetraenoic acid. | 1982 | Biochim. Biophys. Acta | pmid:6814496 |
Ylikorkala O et al. | Prostacyclin and thromboxane in chronic uremia: effect of hemodialysis. | 1982 | Clin. Nephrol. | pmid:6754193 |
Shohami E et al. | [Thromboxane in rat brain following incomplete ischemia]. | 1982 | Harefuah | pmid:7182317 |
Ylikorkala O et al. | Production of prostacyclin and thromboxane during cesarean section. | 1982 | Obstet Gynecol | pmid:6755324 |
Hamasaki Y et al. | Hypoxia stimulates prostacyclin generation by dog lung in vitro. | 1982 | Prostaglandins Leukot Med | pmid:7051045 |
Goldsmith JC and Needleman SW | A comparative study of thromboxane and prostacyclin release from ex vivo and cultured bovine vascular endothelium. | 1982 | Prostaglandins | pmid:6815717 |
Numano F et al. | Changes in the plasma levels of thromboxane B2 and cyclic nucleotides in patients with Takayasu disease. | 1982 | Jpn. Circ. J. | pmid:6119373 |
Davì G et al. | [Effects of flurbiprofen on the platelet function in patients with ischemic cardiopathy]. | 1982 | Cardiologia | pmid:6892383 |
De Caterina R et al. | [Effects of isosorbide dinitrate on platelet aggregation and production of thromboxane B2]. | 1982 | Cardiologia | pmid:6892461 |
Ody C et al. | 6-Ketoprostaglandin F1 alpha, prostaglandins E2, F2 alpha and thromboxane B2 production by endothelial cells, smooth muscle cells and fibroblasts cultured from piglet aorta. | 1982 | Biochim. Biophys. Acta | pmid:6214281 |
de Boer AC et al. | Platelet release and thromboxane synthesis in symptomatic coronary artery disease. | 1982 | Circulation | pmid:6212161 |
Mari D et al. | Coagulation and platelet activation after retinal vein occlusions. | 1982 | Haemostasis | pmid:6215293 |
de Clerck F et al. | Inhibition of 5-hydroxytryptamine-induced and -amplified human platelet aggregation by ketanserin (R 41 468), a selective 5-HT2-receptor antagonist. | 1982 | Agents Actions | pmid:6215842 |
Mehta J and Mehta P | Effects of propranolol therapy on platelet release and prostaglandin generation in patients with coronary heart disease. | 1982 | Circulation | pmid:6216027 |
Mehta P et al. | Thromboxane and prostacyclin generation by intact human vessels in response to balloon catheter trauma. | 1982 | Prostaglandins Leukot Med | pmid:6217465 |
Koyama I et al. | [Production of 6-keto-prostaglandin F1 alpha and thromboxane B2 in mouse peritoneal macrophages during preparation of the cells]. | 1982 | Yakugaku Zasshi | pmid:6897423 |
Wilson L et al. | Alterations in reproductive tissue prostaglandins E and F, 6-keto-prostaglandin F1 alpha and thromboxane B2 with gestational age in the rat. | 1982 | Biol. Reprod. | pmid:6897617 |
Randall MJ and Wilding RI | Acute arterial thrombosis in rabbits: reduced platelet accumulation after treatment with thromboxane synthetase inhibitor dazoxiben hydrochloride, (UK-37, 248-01). | 1982 | Thromb. Res. | pmid:6897751 |
De Caterina R et al. | [Effect of isosorbide dinitrate on platelet aggregation and production of thromboxane B2]. | 1982 | Cardiologia | pmid:6927441 |
Davì G et al. | [Effects of flurbiprofen on platelet function in patients with ischemic cardiomyopathy]. | 1982 | Cardiologia | pmid:6927457 |
Whinnery MA et al. | Thromboxane B2 and prostaglandin E2 in the rat kidney with unilateral ureteral obstruction. | 1982 | Am. J. Physiol. | pmid:6950670 |
Hornych A et al. | [Urinary thromboxane B2 in hypertensive patients]. | 1982 | Arch Mal Coeur Vaiss | pmid:6810812 |
Worthington RE and Nakeff A | Aspirin inhibits rat megakaryocyte thromboxane synthesis. | 1982 | Prostaglandins | pmid:6812167 |
Havill AM et al. | alpha-Naphthylthiourea produces dose-dependent lung vascular injury in sheep. | 1982 | Am. J. Physiol. | pmid:6812437 |
Meydani SN and Dupont J | Effect of zinc deficiency on prostaglandin synthesis in different organs of the rat. | 1982 | J. Nutr. | pmid:7045297 |
Jackson CA et al. | Relationship between platelet aggregation, thromboxane synthesis and albumin concentration in nephrotic syndrome. | 1982 | Br. J. Haematol. | pmid:6810912 |
Rettkowski W et al. | Studies of the influence of nitroglycerin on the synthesis of prostaglandins and thromboxane A2 and on platelet aggregation. | 1982 | Arzneimittelforschung | pmid:6805480 |
Michelassi F et al. | Leukotriene D4: a potent coronary artery vasoconstrictor associated with impaired ventricular contraction. | 1982 | Science | pmid:6808665 |
Landgraf-Leurs MM et al. | Aggregation and thromboxane formation by platelets and vascular prostacyclin production from BB rats. An animal model for type I diabetes. | 1982 | Prostaglandins | pmid:6812171 |
Nugent WC et al. | Prostaglandin response to intravenous nitroglycerin. | 1982 | J. Surg. Res. | pmid:6810023 |
Miller JL et al. | Arachidonic acid metabolism in guinea pig megakaryocytes. | 1982 | Biochem. Biophys. Res. Commun. | pmid:6812584 |
Tai HH | Assay of thromboxane A synthase inhibitors. | 1982 | Meth. Enzymol. | pmid:6890139 |
Rothberg KG and Hitchcock M | In vitro biosynthesis of cyclooxygenase metabolites in ovalbumin-sensitized and control lungs of guinea pigs. | 1982 | Biochem. Pharmacol. | pmid:6812589 |
Watkins WD et al. | Thromboxane and prostacyclin changes during cardiopulmonary bypass with and without pulsatile flow. | 1982 | J. Thorac. Cardiovasc. Surg. | pmid:6980332 |
Robinson C et al. | Thromboxane B2 uptake and metabolism in isolated perfused lung. Identification and comparison with prostaglandin F2 alpha. | 1982 | Biochim. Biophys. Acta | pmid:6751406 |
Schafer AI et al. | Platelet lipoxygenase-dependent oxygen burst. Evidence for differential activation of lipoxygenase in intact and disrupted human platelets. | 1982 | Biochim. Biophys. Acta | pmid:6812645 |
Xiu RJ et al. | Anisodamine inhibits thromboxane synthesis, granulocyte aggregation, and platelet aggregation. A possible mechanism for its efficacy in bacteremic shock. | 1982 | JAMA | pmid:7057538 |
Kelton JG et al. | Sex related differences in platelet function: the effect of aspirin. | 1982 | Blood | pmid:7059670 |
Ylikorkala O et al. | The effect of oral contraceptives on antiaggregatory prostacyclin and proaggregatory thromboxane A2 in humans. | 1982 | Am. J. Obstet. Gynecol. | pmid:7036746 |