MeSH term | MeSH ID | Detail |
---|---|---|
Basal Ganglia Hemorrhage | D020145 | 1 associated lipids |
Edema, Cardiac | D004489 | 1 associated lipids |
Osteoblastoma | D018215 | 1 associated lipids |
Thromboxane b2 is a lipid of Fatty Acyls (FA) class. Thromboxane b2 is associated with abnormalities such as endothelial dysfunction, Diabetes Mellitus, Non-Insulin-Dependent, Diabetes Mellitus, Ischemia and Thrombocytosis. The involved functions are known as Platelet Activation, Excretory function, Anabolism, Inflammation and mRNA Expression. Thromboxane b2 often locates in Endothelium, Hepatic and Microsomes, Liver. The associated genes with Thromboxane b2 are PTGS2 gene, prothrombin fragment 2 and CCL14 wt Allele.
To understand associated biological information of Thromboxane b2, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
Thromboxane b2 is suspected in endothelial dysfunction, Diabetes Mellitus, Non-Insulin-Dependent, Diabetes Mellitus, Ischemia, Thrombocytosis, Acute Coronary Syndrome and other diseases in descending order of the highest number of associated sentences.
Disease | Cross reference | Weighted score | Related literature |
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We collected disease MeSH terms mapped to the references associated with Thromboxane b2
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
Location | Cross reference | Weighted score | Related literatures |
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Function | Cross reference | Weighted score | Related literatures |
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There are no associated biomedical information in the current reference collection.
Gene | Cross reference | Weighted score | Related literatures |
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There are no associated biomedical information in the current reference collection.
Authors | Title | Published | Journal | PubMed Link |
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Greer IA et al. | Inhibition of thromboxane and prostacyclin production in whole blood by adrenoceptor antagonists. | 1985 | Prostaglandins Leukot Med | pmid:2865745 |
Habenicht AJ et al. | Human platelet-derived growth factor stimulates prostaglandin synthesis by activation and by rapid de novo synthesis of cyclooxygenase. | 1985 | J. Clin. Invest. | pmid:3921570 |
Carmo LG et al. | Platelet desensitization induced by arachidonic acid is not due to cyclo-oxygenase inactivation and involves the endoperoxide receptor. | 1985 | Br. J. Pharmacol. | pmid:2994786 |
Patscheke H | Thromboxane synthase inhibition potentiates washed platelet activation by endogenous and exogenous arachidonic acid. | 1985 | Biochem. Pharmacol. | pmid:3922373 |
Segarnick DJ et al. | Precursor- and pool-dependent differential effects of ethanol on human platelet prostanoid synthesis. | 1985 | Biochem. Pharmacol. | pmid:3922375 |
Kimura Y et al. | Effects of stilbenes on arachidonate metabolism in leukocytes. | 1985 | Biochim. Biophys. Acta | pmid:3922423 |
Lord A et al. | Leukotriene F4 and the release of arachidonic acid metabolites from perfused guinea pig lungs in vitro. | 1985 | Prostaglandins | pmid:3923570 |
Shorr RI et al. | In vitro effects of acetaminophen and its analogues on human platelet aggregation and thromboxane B2 synthesis. | 1985 | Thromb. Res. | pmid:3923647 |
Toivanen J et al. | Differential inhibition of platelet thromboxane and lung prostacyclin production by sulphinpyrazone, acetylsalicylic acid and indomethacin by human tissues in vitro. | 1985 | Thromb. Res. | pmid:3920778 |
Francos GC et al. | Dialysis-induced hypoxemia: membrane dependent and membrane independent causes. | 1985 | Am. J. Kidney Dis. | pmid:3919574 |
Emau P et al. | Ibuprofen prevents Pasteurella hemolytica endotoxin-induced changes in plasma prostanoids and serotonin, and fever in sheep. | 1985 | J. Vet. Pharmacol. Ther. | pmid:3867760 |
Heinz TR et al. | Radiation-induced alterations in cyclooxygenase product synthesis by isolated perfused rat lungs. | 1985 | Prog Biochem Pharmacol | pmid:3921980 |
Lauri D et al. | Amplification of primary response of human platelets to platelet-activating factor: aspirin-sensitive and aspirin-insensitive pathways. | 1985 | J. Lab. Clin. Med. | pmid:3923145 |
Johnson A and Malik AB | Pulmonary transvascular fluid and protein exchange after thrombin-induced microembolism. Differential effects of cyclooxygenase inhibitors. | 1985 | Am. Rev. Respir. Dis. | pmid:3925828 |
Packham MA et al. | Duration of the effect of aspirin on the synthesis of thromboxane by density subpopulations of rabbit platelets stimulated with thrombin. | 1985 | Blood | pmid:3926022 |
Cattaneo M et al. | Human platelet aggregation and release reaction induced by platelet activating factor (PAF-acether)--effects of acetylsalicylic acid and external ionized calcium. | 1985 | Thromb. Haemost. | pmid:3927505 |
Ouwendijk RJ et al. | Production of leukotrienes and prostaglandins by human ascites cells. | 1985 | Eur. J. Clin. Invest. | pmid:3007158 |
Mobley A and Tai HH | Synergistic stimulation of thromboxane biosynthesis by calcium ionophore and phorbol ester or thrombin in human platelets. | 1985 | Biochem. Biophys. Res. Commun. | pmid:3927908 |
Jakubowski JA et al. | Cumulative antiplatelet effect of low-dose enteric coated aspirin. | 1985 | Br. J. Haematol. | pmid:3927970 |
Mehta J et al. | Influence of selective thromboxane synthetase blocker CGS-13080 on thromboxane and prostacyclin biosynthesis in whole blood: evidence for synthesis of prostacyclin by leukocytes from platelet-derived endoperoxides. | 1985 | J. Lab. Clin. Med. | pmid:3928780 |
Brown CG and Poyser NL | Further studies on prostaglandin and thromboxane production by the rat uterus during the oestrous cycle. | 1985 | J. Reprod. Fertil. | pmid:3857345 |
Aitokallio-Tallberg A et al. | Prostacyclin and thromboxane in breast cancer: relationship between steroid receptor status and medroxyprogesterone acetate. | 1985 | Br. J. Cancer | pmid:2986666 |
Callahan KS et al. | Enhancement of the antiaggregatory activity of prostacyclin by propranolol in human platelets. | 1985 | Circulation | pmid:2986877 |
Sawada M et al. | Enzyme-immunoassay of thromboxane B2 at the picogram level. | 1985 | Prostaglandins | pmid:3929333 |
Beatty CH et al. | Metabolism of arachidonic acid by macaque platelets. Implications for studies on atherosclerosis. | 1985 | Atherosclerosis | pmid:3924062 |
Apprill P et al. | Cyclic blood flow variations induced by platelet-activating factor in stenosed canine coronary arteries despite inhibition of thromboxane synthetase, serotonin receptors, and alpha-adrenergic receptors. | 1985 | Circulation | pmid:2988822 |
Fukuda Y | [Plasma prostaglandin and thromboxane levels in asthmatic children]. | 1985 | Arerugi | pmid:2992423 |
Honda M et al. | Effects of purified hog pancreatic kallikrein on the kinin-prostaglandin system and renin-angiotensin-aldosterone system. | 1985 | Nephron | pmid:2993934 |
Baud L et al. | Lipoxygenase products mediate the attachment of rat macrophages to glomeruli in vitro. | 1985 | Kidney Int. | pmid:3927056 |
Khirabadi BS et al. | Urine immunoreactive thromboxane B2 in rat cardiac allograft rejection. | 1985 | Transplantation | pmid:3880966 |
Mehta J and Mehta P | Prostacyclin and thromboxane A2 production by human cardiac atrial tissues. | 1985 | Am. Heart J. | pmid:3880988 |
Friedrich T et al. | Follow-up of prostaglandin plasma levels after acute myocardial infarction. | 1985 | Am. Heart J. | pmid:3880994 |
Wilson TW and Tan LK | Low plasma renin activity in diabetes. Relation to urine prostaglandin excretion. | 1985 | Diabetes | pmid:3881302 |
Longenecker GL et al. | Kinetics of ibuprofen effect on platelet and endothelial prostanoid release. | 1985 | Clin. Pharmacol. Ther. | pmid:3882308 |
Mitchell JA et al. | Effects of high frequency oscillatory ventilation compared to conventional ventilation upon pulmonary vascular prostanoid production in neonatal piglets. | 1985 | Prostaglandins Leukot Med | pmid:3883366 |
Wenger H et al. | Pulmonary dysfunction secondary to soft-tissue endotoxin. | 1985 | Arch Surg | pmid:3883949 |
Shephard EG et al. | Lung function and plasma levels of thromboxane B2, 6-ketoprostaglandin F1 alpha and beta-thromboglobulin in antigen-induced asthma before and after indomethacin pretreatment. | 1985 | Br J Clin Pharmacol | pmid:2581599 |
Addonizio VP et al. | Iloprost (ZK36374), a stable analogue of prostacyclin, preserves platelets during simulated extracorporeal circulation. | 1985 | J. Thorac. Cardiovasc. Surg. | pmid:2582210 |
Schafer AI and Adelman B | Plasmin inhibition of platelet function and of arachidonic acid metabolism. | 1985 | J. Clin. Invest. | pmid:3156149 |
Granström E et al. | Monitoring thromboxane production in vivo: metabolic and analytical aspects. | 1985 | Adv. Prostaglandin Thromboxane Leukot. Res. | pmid:2936194 |
FitzGerald GA et al. | Analysis of urinary metabolites of thromboxane and prostacyclin by negative-ion chemical-ionization gas chromatography/mass spectrometry. | 1985 | Adv. Prostaglandin Thromboxane Leukot. Res. | pmid:2936207 |
Kuzuya T et al. | Determination of plasma thromboxane B2 by radioimmunoassay: methodological problems and accuracy. | 1985 | Adv. Prostaglandin Thromboxane Leukot. Res. | pmid:2936210 |
Slotman GJ et al. | Thromboxane and prostacyclin in clinical acute respiratory failure. | 1985 | J. Surg. Res. | pmid:3892164 |
Sirois P et al. | Role of cyclooxygenase products in the lung action of leukotrienes A4, B4, C4, D4 and E4. | 1985 | Pharmacology | pmid:2997811 |
Hsu CY et al. | Alteration of thromboxane and prostacyclin levels in experimental spinal cord injury. | 1985 | Neurology | pmid:3892363 |
Morita I et al. | Effect of dietary protein level on platelet aggregation in rat. | 1985 | Prostaglandins Leukot Med | pmid:3892545 |
de Lorgeril M et al. | Acute influence of cigarette smoke in platelets, catecholamines and neurophysins in the normal conditions of daily life. | 1985 | Eur. Heart J. | pmid:2937635 |
Lelcuk S et al. | Prostacyclin and thromboxane A2 moderate postischemic renal failure. | 1985 | Surgery | pmid:3895535 |
Paajanen H and Kormano M | Prostacyclin (PGI2) and thromboxane (TXA2) levels during intravenous contrast medium administration in CT. | 1985 | Eur J Radiol | pmid:3896802 |
Yui Y et al. | A new stable prostacyclin analogue OP41483 (15-cyclopentyl-omega-pentanor-5(E)-carbacyclin). | 1985 | Jpn. Circ. J. | pmid:3897597 |
Túri S et al. | [Changes in serum prostaglandin metabolites in Schönlein-Henoch purpura]. | 1985 | Orv Hetil | pmid:3897944 |
Farias LR et al. | Effect of prostaglandin blockers on ascites fluid in pancreatitis. | 1985 | Surgery | pmid:3898455 |
Kubo K and Kobayashi T | Effects of OKY-046, a selective thromboxane synthetase inhibitor, on endotoxin-induced lung injury in unanesthetized sheep. | 1985 | Am. Rev. Respir. Dis. | pmid:3898941 |
Barst RJ and Stalcup SA | Endothelial function in clinical pulmonary hypertension. | 1985 | Chest | pmid:3899537 |
Codde JP and Beilin LJ | Dietary fish oil prevents dexamethasone induced hypertension in the rat. | 1985 | Clin. Sci. | pmid:3905217 |
O'Byrne PM et al. | Leukotriene B4 induces airway hyperresponsiveness in dogs. | 1985 | J. Appl. Physiol. | pmid:3001017 |
Mayfield RK et al. | Platelet function during continuous insulin infusion treatment in insulin-dependent diabetic patients. | 1985 | Diabetes | pmid:3930325 |
Tanaka M and Shibata Y | The different response of guinea pig peritoneal macrophages to various stimulators. | 1985 | Gen. Pharmacol. | pmid:3930344 |
Mundie TG et al. | Byssinosis: Release of prostaglandins, thromboxane, and 5-hydroxytryptamine in bronchopulmonary lavage fluid after inhalation of cotton dust extracts. | 1985 | Am. J. Pathol. | pmid:3966532 |
Higashihara M et al. | A monoclonal anti-human platelet antibody: a new platelet aggregating substance. | 1985 | Blood | pmid:3967086 |
Nawroth PP et al. | Thromboxane production by perturbed bovine aortic endothelial cells in culture. | 1985 | Blut | pmid:3967102 |
Martin JL et al. | Effect of high dose aspirin on coronary hemodynamics during pacing-induced myocardial ischemia. | 1985 | J. Am. Coll. Cardiol. | pmid:3968305 |
De Caterina R et al. | Inhibition of platelet aggregation and thromboxane B2 production during aspirin treatment: dependence on the dose of the aggregating agent. | 1985 | Thromb. Res. | pmid:3975876 |
Cook JA et al. | Exchange transfusions in rats with a perfluorated blood substitute: effect on thromboxane B2 levels during endotoxemia. | 1985 | Circ. Shock | pmid:3978769 |
Reines HD et al. | Dazoxiben in human sepsis and adult respiratory distress syndrome. | 1985 | Clin. Pharmacol. Ther. | pmid:3979000 |
Wilcox CS et al. | Intrarenal prostaglandin release: effects of arachidonic acid and hyperchloremia. | 1985 | Kidney Int. | pmid:3930824 |
Westenfelder C et al. | Renal function in calves with total artificial hearts. | 1985 | Trans Am Soc Artif Intern Organs | pmid:3837477 |
Greco NJ et al. | Action of platelet-activating factor on type 1 diabetic human platelets. | 1985 | J. Lab. Clin. Med. | pmid:3981054 |
Patterson GA et al. | Effects of imidazole and indomethacin on fluid balance in isolated sheep lungs. | 1985 | J. Appl. Physiol. | pmid:3884582 |
Kelley VE et al. | A fish oil diet rich in eicosapentaenoic acid reduces cyclooxygenase metabolites, and suppresses lupus in MRL-lpr mice. | 1985 | J. Immunol. | pmid:3918111 |
Schrör K et al. | [Inhibition of platelet aggregation and thromboxane formation by the calcium antagonist nisoldipine following a single oral dose of 10 mg. A double-blind study in healthy probands]. | 1985 | Klin. Wochenschr. | pmid:3838352 |
Bult H et al. | Modification of endotoxin-induced haemodynamic and haematological changes in the rabbit by methylprednisolone, F(ab')2 fragments and rosmarinic acid. | 1985 | Br. J. Pharmacol. | pmid:3838489 |
Prosdocimi M et al. | Coronary and systemic 6-ketoprostaglandin F1 alpha and thromboxane B2 during myocardial ischemia in dog. | 1985 | Am. J. Physiol. | pmid:3838623 |
Krieger BP et al. | Mechanisms of interaction between oxygen and granulocytes in hyperoxic lung injury. | 1985 | J. Appl. Physiol. | pmid:3838744 |
Bergqvist D et al. | The effect of inhibition of thromboxane synthesis in experimental thrombosis and hemostasis. | 1985 | Thromb. Res. | pmid:3838828 |
Stuart MJ et al. | Prostanoids in hemolytic uremic syndrome. | 1985 | J. Pediatr. | pmid:3839015 |
Hamilton TA et al. | gamma-Interferon enhances the secretion of arachidonic acid metabolites from murine peritoneal macrophages stimulated with phorbol diesters. | 1985 | J. Immunol. | pmid:3919102 |
Kimura Y et al. | Effects of stilbene derivatives on arachidonate metabolism in leukocytes. | 1985 | Biochim. Biophys. Acta | pmid:3931689 |
Remuzzi G et al. | Increased glomerular thromboxane synthesis as a possible cause of proteinuria in experimental nephrosis. | 1985 | J. Clin. Invest. | pmid:4038407 |
Vinge E et al. | Single intravenous and oral doses of fenflumizole: pharmacokinetics and effects on prostanoid formation. | 1985 | Acta Pharmacol Toxicol (Copenh) | pmid:3840639 |
Mogensen F et al. | Effect of specific thromboxane-synthetase inhibition on thromboxane and prostaglandin synthesis in stable angina induced by exercise test. | 1985 | Thromb. Res. | pmid:4038824 |
Bennett A et al. | Carbenoxolone and deglycyrrhized liquorice have little or no effect on prostanoid synthesis by rat gastric mucosa ex vivo. | 1985 | Br. J. Pharmacol. | pmid:3840708 |
Tada M et al. | Augmented thromboxane A2 generation and efficacy of its blockade in acute myocardial infarction. | 1985 | Int. J. Cardiol. | pmid:4040500 |
Lorenzana RM et al. | Experimental T-2 toxicosis in swine. I. Changes in cardiac output, aortic mean pressure, catecholamines, 6-keto-PGF1 alpha, thromboxane B2, and acid-base parameters. | 1985 | Fundam Appl Toxicol | pmid:3840756 |
Wargovich T et al. | Reduction in blood flow in normal and narrowed coronary arteries of dogs by leukotriene C4. | 1985 | J. Am. Coll. Cardiol. | pmid:4045029 |
Elliott GR et al. | Arachidonic acid, an in vivo inhibitor of carrageenin induced granulomas in the rat. | 1985 | Eur. J. Pharmacol. | pmid:2988985 |
Feuerstein G et al. | Effects of nafazatrom on cardiovascular, sympathetic, and endocrine responses to hemorrhagic shock in conscious rats. | 1985 | Circ. Shock | pmid:3841032 |
Cerletti C et al. | Aspirin kinetics and inhibition of platelet thromboxane generation-relevance for a solution of the "aspirin dilemma". | 1985 | Thromb. Haemost. | pmid:4049312 |
Dejana E et al. | Differential salicylate-aspirin interaction on vascular prostacyclin and platelet thromboxane synthesis in patients undergoing saphenectomy. | 1985 | Proc. Soc. Exp. Biol. Med. | pmid:3841210 |
Hillbom M et al. | Platelet thromboxane formation and bleeding time is influenced by ethanol withdrawal but not by cigarette smoking. | 1985 | Thromb. Haemost. | pmid:4049313 |
Fiedler VB et al. | The effects of nafazatrom in an acute occlusion-reperfusion model of canine myocardial injury. | 1985 | Naunyn Schmiedebergs Arch. Pharmacol. | pmid:3841382 |
Aviram M et al. | Plasma lipoproteins affect platelet malondialdehyde and thromboxane B2 production. | 1985 | Biochem Med | pmid:4052061 |
Simmet T et al. | Modulation of eicosanoid release from anaphylactic guinea-pig heart with 5-benzoyl-a-methyl-2-thiophene acetic acid (tiaprofenic acid). | 1985 | Arch Int Pharmacodyn Ther | pmid:3841634 |
Shingu T | [Prostaglandin metabolism in ischemic brain edema]. | 1985 | Nihon Geka Hokan | pmid:3841635 |
Tobian L et al. | Prostaglandin alterations in barely hypertensive Dahl S rats. | 1985 | Trans. Assoc. Am. Physicians | pmid:3842205 |
Di Minno G et al. | Platelet dysfunction in uremia. Multifaceted defect partially corrected by dialysis. | 1985 | Am. J. Med. | pmid:3933340 |
Numano F et al. | Coronary spasm, prostaglandin and HLA factors. | 1985 | Jpn. Circ. J. | pmid:3855470 |
Mallarkey G and Smith GM | A comparative study of the involvement of the prostaglandin H2/thromboxane A2 pathway in intravascular platelet aggregation in guinea-pigs and rats. | 1985 | Br. J. Pharmacol. | pmid:3156648 |
Murphy RC et al. | Surgical delay and arachidonic acid metabolites: evidence for an inflammatory mechanism: an experimental study in rats. | 1985 | Br J Plast Surg | pmid:3921087 |
Sterk PJ et al. | Limited maximal airway narrowing in nonasthmatic subjects. Role of neural control and prostaglandin release. | 1985 | Am. Rev. Respir. Dis. | pmid:2864892 |