MeSH term | MeSH ID | Detail |
---|---|---|
Radiculopathy | D011843 | 1 associated lipids |
Erythromelalgia | D004916 | 1 associated lipids |
Oligomenorrhea | D009839 | 1 associated lipids |
Thromboxane b2 is a lipid of Fatty Acyls (FA) class. Thromboxane b2 is associated with abnormalities such as endothelial dysfunction, Diabetes Mellitus, Non-Insulin-Dependent, Diabetes Mellitus, Ischemia and Thrombocytosis. The involved functions are known as Platelet Activation, Excretory function, Anabolism, Inflammation and mRNA Expression. Thromboxane b2 often locates in Endothelium, Hepatic and Microsomes, Liver. The associated genes with Thromboxane b2 are PTGS2 gene, prothrombin fragment 2 and CCL14 wt Allele.
To understand associated biological information of Thromboxane b2, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
Thromboxane b2 is suspected in endothelial dysfunction, Diabetes Mellitus, Non-Insulin-Dependent, Diabetes Mellitus, Ischemia, Thrombocytosis, Acute Coronary Syndrome and other diseases in descending order of the highest number of associated sentences.
Disease | Cross reference | Weighted score | Related literature |
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We collected disease MeSH terms mapped to the references associated with Thromboxane b2
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
Location | Cross reference | Weighted score | Related literatures |
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Function | Cross reference | Weighted score | Related literatures |
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There are no associated biomedical information in the current reference collection.
Gene | Cross reference | Weighted score | Related literatures |
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There are no associated biomedical information in the current reference collection.
Authors | Title | Published | Journal | PubMed Link |
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DeVries A et al. | Ketoconazole in the prevention of acute respiratory distress syndrome. | 1998 May-Jun | Pharmacotherapy | pmid:9620108 |
Tsai WJ et al. | Characterization of the antiplatelet effects of (2S)-5-methoxy-6-methylflavan-7-ol from Draconis Resina. | 1998 | Eur. J. Pharmacol. | pmid:9617759 |
Agnoli GC et al. | Effects of experimental salt depletion on urinary prostanoid excretions in normal women. | 1998 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:9610848 |
Beitz A | Influence of diet-modified lipoprotein fractions from rabbits on eicosanoid production and on proliferation of rabbit skin fibroblasts. | 1998 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:9610847 |
van der Weiden RM et al. | Which prostanoid metabolites should be determined for the study of reproductive processes? | 1998 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:9610843 |
Cignarella A et al. | Platelet activation supports the development of venous thrombosis in hyperlipidemic rats. | 1998 | Blood Coagul. Fibrinolysis | pmid:9607118 |
Komarevtseva IA et al. | [Change in prostanoid metabolism in cystic kidney lesion]. | 1997 Sep-Dec | Ukr. Biokhim. Zh. | pmid:9606841 |
Heller DA et al. | Mortality and biomarkers of aging in heterogeneous stock (HS) mice. | 1998 | J. Gerontol. A Biol. Sci. Med. Sci. | pmid:9597046 |
Kalgutkar AS et al. | Aspirin-like molecules that covalently inactivate cyclooxygenase-2. | 1998 | Science | pmid:9596581 |
Inoue H et al. | Changes in endothelin-1, 6-keto-PG-F1 alpha, and TX-B2 in random pattern flaps. | 1998 | J. Cardiovasc. Pharmacol. | pmid:9595517 |
Stamler A et al. | Low-dose dopexamine's effect on lung and gut function after CPB in a sheep model. | 1998 | J. Surg. Res. | pmid:9587356 |
Fuse S et al. | Plasma thromboxane B2 concentration in patients with ventricular septal defect and pulmonary hypertension. | 1998 | Jpn. Circ. J. | pmid:9583446 |
Failli P et al. | Effect of some cyclooxygenase inhibitors on the increase in guanosine 3':5'-cyclic monophosphate induced by NO-donors in human whole platelets. | 1998 | Br. J. Pharmacol. | pmid:9579743 |
Kosugi T et al. | Glomerular thromboxane contributes to pressor response in deoxycorticosterone acetate-salt hypertension. | 1998 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:9578151 |
Davì G et al. | Increased thromboxane metabolites excretion in liver cirrhosis. | 1998 | Thromb. Haemost. | pmid:9569186 |
Muscará MN et al. | Effect of a nitric oxide-releasing naproxen derivative on hypertension and gastric damage induced by chronic nitric oxide inhibition in the rat. | 1998 | Life Sci. | pmid:9566780 |
Darien BJ et al. | Low molecular weight heparin prevents the pulmonary hemodynamic and pathomorphologic effects of endotoxin in a porcine acute lung injury model. | 1998 | Shock | pmid:9565256 |
LaNoue JL et al. | Alveolar macrophage response to remote organ injury. | 1998 | Shock | pmid:9565254 |
Yang VW et al. | Size-dependent increase in prostanoid levels in adenomas of patients with familial adenomatous polyposis. | 1998 | Cancer Res. | pmid:9563494 |
Arbogast E et al. | Intrauterine eicosanoid production in uncomplicated and hypertensive pregnancies: alterations of placental 12-hydroxyeicosatetraenoic acid. | 1997 | Adv. Exp. Med. Biol. | pmid:9561182 |
Müller M | In vivo measurement of interstitial TxB2-concentrations in skeletal muscle during ischemia and reperfusion. | 1997 | Adv. Exp. Med. Biol. | pmid:9561122 |
Yoshida T et al. | Improvement of renal function with selective thromboxane A2 synthetase inhibitor, DP-1904 in lupus nephritis. | 1997 | Adv. Exp. Med. Biol. | pmid:9561116 |
Agostoni C et al. | Plasma arachidonic acid and serum thromboxane B2 concentrations in phenylketonuric children are correlated with dietary compliance. | 1998 | Z Ernahrungswiss | pmid:9558743 |
Vormann J et al. | Pathobiochemical effects of graded magnesium deficiency in rats. | 1998 | Z Ernahrungswiss | pmid:9558736 |
van den Dorpel MA et al. | Forearm vasorelaxation in hypertensive renal transplant patients: the impact of withdrawal of cyclosporine. | 1998 | J. Hypertens. | pmid:9557926 |
Naran NH and Chetty N | The in vitro effect of ridogrel on platelet function in normocholesterolaemic and familial hypercholesterolaemic type IIa subjects. | 1997 | Thromb. Res. | pmid:9556227 |
Mayser P et al. | Omega-3 fatty acid-based lipid infusion in patients with chronic plaque psoriasis: results of a double-blind, randomized, placebo-controlled, multicenter trial. | 1998 | J. Am. Acad. Dermatol. | pmid:9555791 |
Kimura H et al. | Compensatory excretion of prostacyclin and thromboxane metabolites in obstructive sleep apnea syndrome. | 1998 | Intern. Med. | pmid:9550591 |
Suchkova V | Prostanoid and anti-thrombin III levels in premature infants. | 1997 | Adv. Exp. Med. Biol. | pmid:9547655 |
Liao CH et al. | Effect of PP1D-1, a synthetic antiplatelet compound, on rabbit platelets. | 1998 | Jpn. J. Pharmacol. | pmid:9541276 |
Herrera JA et al. | Prevention of preeclampsia by linoleic acid and calcium supplementation: a randomized controlled trial. | 1998 | Obstet Gynecol | pmid:9540946 |
Zhao Y et al. | Urinary thromboxane B2 in cardiac transplant patients as a screening method of rejection. | 1997 | Prostaglandins | pmid:9533183 |
Fukushima C et al. | Effect of synthetase inhibitors and receptor antagonists in antigen-induced contraction of human lung parenchyma. | 1998 | Ann. Allergy Asthma Immunol. | pmid:9532973 |
Diven WF et al. | Expression of acute otitis media after receptor blockade of platelet activating factor, thromboxane, and leukotrienes in the chinchilla. | 1998 | Ann. Otol. Rhinol. Laryngol. | pmid:9525240 |
Bons-Sicard C et al. | Localization and quantification of TXB2 in human healthy and inflammatory gingival mucosa. | 1998 | J. Periodont. Res. | pmid:9524318 |
Ooi BS et al. | Stimulation of endothelial cell production of vasoconstrictive substances by hypertensive sera. | 1998 | Am. J. Hypertens. | pmid:9524055 |
Bode-Böger SM et al. | Differential inhibition of human platelet aggregation and thromboxane A2 formation by L-arginine in vivo and in vitro. | 1998 | Naunyn Schmiedebergs Arch. Pharmacol. | pmid:9521487 |
Giustina A et al. | Long-term treatment with the dual antithromboxane agent picotamide decreases microalbuminuria in normotensive type 2 diabetic patients. | 1998 | Diabetes | pmid:9519749 |
Rho MC et al. | Two distinct effects of 12S-hydroxyeicosatetraenoic acid on platelet aggregation by zooxanthellatoxin-A and ionomycin. | 1998 | Jpn. J. Pharmacol. | pmid:9517414 |
Larsen LN et al. | Alpha- and beta- alkyl-substituted eicosapentaenoic acids: incorporation into phospholipids and effects on prostaglandin H synthase and 5-lipoxygenase. | 1998 | Biochem. Pharmacol. | pmid:9514074 |
Giardiello FM et al. | Prostaglandin levels in human colorectal mucosa: effects of sulindac in patients with familial adenomatous polyposis. | 1998 | Dig. Dis. Sci. | pmid:9512123 |
Schilling MK et al. | Role of thromboxane and leukotriene B4 in patients with acute respiratory distress syndrome after oesophagectomy. | 1998 | Br J Anaesth | pmid:9505775 |
Dschietzig T et al. | Coronary constriction and consequent cardiodepression in pulmonary embolism are mediated by pulmonary big endothelin and enhanced in early endothelial dysfunction. | 1998 | Crit. Care Med. | pmid:9504580 |
Bernareggi M et al. | Bronchopulmonary effects of 8-epi-PGF2A in anaesthetised guinea pigs. | 1998 | Pharmacol. Res. | pmid:9503483 |
Bagdasarian A et al. | IVIG adverse reactions: potential role of cytokines and vasoactive substances. | 1998 | Vox Sang. | pmid:9501404 |
Turner NC et al. | Elevated renal endothelin-I clearance and mRNA levels associated with albuminuria and nephropathy in non-insulin-dependent diabetes mellitus: studies in obese fa/fa Zucker rats. | 1997 | Clin. Sci. | pmid:9497794 |
Takakuwa K et al. | Immunosuppressive therapy for recurrent aborters with positive antiphospholipid antibodies and alteration of 6ketoPGF1 alpha/TXB2 ratio. | 1997 | J Perinat Med | pmid:9494925 |
Takeda H et al. | Time course study for airway inflammation and responsiveness by repeated provocation of aeroantigen in guinea pigs. | 1997 | Prostaglandins | pmid:9491210 |
Provost P et al. | Platelets, neutrophils, and vasoconstriction after arterial injury by angioplasty in pigs: effects of MK-886, a leukotriene biosynthesis inhibitor. | 1998 | Br. J. Pharmacol. | pmid:9489613 |
Nieuwenhuys CM and Hornstra G | The effects of purified eicosapentaenoic and docosahexaenoic acids on arterial thrombosis tendency and platelet function in rats. | 1998 | Biochim. Biophys. Acta | pmid:9487152 |
Yamanobe S et al. | Analysis of urinary 11-dehydrothromboxane B2 in patients with occluded retinal vein using GC/SIM. | 1998 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:9482168 |
Chang MC et al. | Antithrombotic effect of crotalin, a platelet membrane glycoprotein Ib antagonist from venom of Crotalus atrox. | 1998 | Blood | pmid:9473223 |
Fujita M et al. | Effects of a specific cysteinyl leukotriene antagonist, pranlukast, on antigen-induced cysteinyl leukotriene-mediated rhinitis in guinea pigs. | 1997 | Jpn. J. Pharmacol. | pmid:9469640 |
Fadok VA et al. | Macrophages that have ingested apoptotic cells in vitro inhibit proinflammatory cytokine production through autocrine/paracrine mechanisms involving TGF-beta, PGE2, and PAF. | 1998 | J. Clin. Invest. | pmid:9466984 |
Kruse-Elliott KT et al. | Role of lipid-derived mediators in tumor necrosis factor-induced endothelin-1 release in vivo. | 1998 | Shock | pmid:9466472 |
Liao CH et al. | Bakkenolide G, a natural PAF-receptor antagonist. | 1997 | J. Pharm. Pharmacol. | pmid:9466352 |
Keen HL et al. | Maintenance of baseline angiotensin II potentiates insulin hypertension in rats. | 1998 | Hypertension | pmid:9461234 |
Forastiero R et al. | Anti-beta2 glycoprotein I antibodies and platelet activation in patients with antiphospholipid antibodies: association with increased excretion of platelet-derived thromboxane urinary metabolites. | 1998 | Thromb. Haemost. | pmid:9459320 |
Robbins DL et al. | Effect of anticardiolipin/beta2-glycoprotein I complexes on production of thromboxane A2 by platelets from patients with the antiphospholipid syndrome. | 1998 | J. Rheumatol. | pmid:9458202 |
Hanaoka M et al. | Effect of post-treatment with granulocyte colony-stimulating factor on endotoxin-induced lung injury in sheep. | 1998 Jan-Feb | Exp. Lung Res. | pmid:9457466 |
Chiba Y et al. | Effects of depletion of leukocytes and platelets on cardiac dysfunction after cardiopulmonary bypass. | 1998 | Ann. Thorac. Surg. | pmid:9456104 |
Erez E et al. | Thromboxane production in human lung during cardiopulmonary bypass: beneficial effect of aspirin? | 1998 | Ann. Thorac. Surg. | pmid:9456103 |
Yanagisawa H et al. | Ureteral obstruction enhances eicosanoid production in cortical and medullary tubules of rat kidneys. | 1997 | Kidney Blood Press. Res. | pmid:9453451 |
Parra T et al. | Cyclosporine A nephrotoxicity: role of thromboxane and reactive oxygen species. | 1998 | J. Lab. Clin. Med. | pmid:9452128 |
Moore RM et al. | Effect of platelet-activating factor antagonist L-691,880 on low-flow ischemia-reperfusion injury of the large colon in horses. | 1998 Jan-Feb | Vet Surg | pmid:9449176 |
Dent G et al. | Protein kinase C inhibition enhances platelet-activating factor-induced eicosanoid production in human eosinophils. | 1998 | Am. J. Respir. Cell Mol. Biol. | pmid:9448055 |
Snapper JR et al. | Role of endothelin in endotoxin-induced sustained pulmonary hypertension in sheep. | 1998 | Am. J. Respir. Crit. Care Med. | pmid:9445282 |
Kurosawa M et al. | Heterogeneity of mast cells in mastocytosis and inhibitory effect of ketotifen and ranitidine on indolent systemic mastocytosis. | 1997 | J. Allergy Clin. Immunol. | pmid:9440541 |
Sorem KA and Siler-Khodr TM | Effect of IGF-I on placental thromboxane and prostacyclin release in severe intrauterine growth retardation. | 1997 Nov-Dec | J Matern Fetal Med | pmid:9438218 |
Sheu JR et al. | Triflavin inhibits platelet-induced vasoconstriction in de-endothelialized aorta. | 1997 | Arterioscler. Thromb. Vasc. Biol. | pmid:9437193 |
Qureshi MA and Gore AB | Vitamin E exposure modulates prostaglandin and thromboxane production by avian cells of the mononuclear phagocytic system. | 1997 | Immunopharmacol Immunotoxicol | pmid:9436047 |
Akarsu ES et al. | Effect of ciliary neurotrophic factor on body temperature and cerebrospinal fluid prostanoids in the cat. | 1998 | Brain Res. Bull. | pmid:9434196 |
Famaey JP | In vitro and in vivo pharmacological evidence of selective cyclooxygenase-2 inhibition by nimesulide: an overview. | 1997 | Inflamm. Res. | pmid:9427063 |
Gresele P et al. | Platelet activation markers in patients with peripheral arterial disease--a prospective comparison of different platelet function tests. | 1997 | Thromb. Haemost. | pmid:9423790 |
Moutquin JM et al. | Do prostacyclin and thromboxane contribute to the "protective effect" of pregnancies with chronic hypertension? A preliminary prospective longitudinal study. | 1997 | Am. J. Obstet. Gynecol. | pmid:9423755 |
Oosaki R et al. | Urinary excretion of leukotriene E4 and 11-dehydrothromboxane B2 in patients with spontaneous asthma attacks. | 1997 | Int. Arch. Allergy Immunol. | pmid:9414142 |
Alanko J et al. | Catechol estrogens as inhibitors of leukotriene synthesis. | 1998 | Biochem. Pharmacol. | pmid:9413936 |
Davì G et al. | Enhanced thromboxane biosynthesis in patients with chronic obstructive pulmonary disease. The Chronic Obstructive Bronchitis and Haemostasis Study Group. | 1997 | Am. J. Respir. Crit. Care Med. | pmid:9412557 |
Gerdemann R et al. | [Effect of flunixin meglumine on plasma prostanoid concentrations in horses with colic in the perioperative period]. | 1997 | DTW. Dtsch. Tierarztl. Wochenschr. | pmid:9410724 |
Davi G et al. | In vivo formation of 8-Epi-prostaglandin F2 alpha is increased in hypercholesterolemia. | 1997 | Arterioscler. Thromb. Vasc. Biol. | pmid:9409316 |
Byrne A et al. | Continued thromboxane A2 formation despite administration of a platelet glycoprotein IIb/IIIa antagonist in patients undergoing coronary angioplasty. | 1997 | Arterioscler. Thromb. Vasc. Biol. | pmid:9409315 |
Vezza R et al. | Antivasoconstrictor and antiaggregatory activities of picotamide unrelated to thromboxane A2 antagonism. | 1997 | Thromb. Haemost. | pmid:9408024 |
Knowles SO and Donaldson WE | Lead disrupts eicosanoid metabolism, macrophage function, and disease resistance in birds. | 1997 Oct-Nov | Biol Trace Elem Res | pmid:9404672 |
Wettstein M and Häussinger D | Cytoprotection by the osmolytes betaine and taurine in ischemia-reoxygenation injury in the perfused rat liver. | 1997 | Hepatology | pmid:9397998 |
Bellamy MC et al. | Changes in inflammatory mediators during orthotopic liver transplantation. | 1997 | Br J Anaesth | pmid:9389852 |
Li T et al. | [Observation on TXB2 and 6-keto-PGF1 alpha in serum of patients with cor pulmonale]. | 1996 | Hua Xi Yi Ke Da Xue Xue Bao | pmid:9389073 |
Liu Z | [Effects of acupuncture on lipid, TXB2, 6-keto-PGF, alpha in simple obese patients complicated with hyperlipidemia]. | 1996 | Zhen Ci Yan Jiu | pmid:9388312 |
Han JA and Hu WY | [Progress in the study on protective effect of saponins Panax notoginseng on ischemic brain damage]. | 1996 | Zhongguo Zhong Xi Yi Jie He Za Zhi | pmid:9387754 |
Sang Y et al. | [Effects of tangshenkang capsule on diabetic nephropathy]. | 1996 | Zhongguo Zhong Xi Yi Jie He Za Zhi | pmid:9387731 |
Xiao X et al. | Effect of captopril on renal hemodynamics and renal prostaglandins in early type II diabetic patients with normo-or microalbuminuria. | 1996 | Chin. Med. Sci. J. | pmid:9387403 |
Nygaard OP et al. | The inflammatory properties of contained and noncontained lumbar disc herniation. | 1997 | Spine | pmid:9383853 |
Kobayashi T et al. | Changes in platelet calcium concentration by thromboxane A2 stimulation in patients with nephrotic syndrome of childhood. | 1997 | Nephron | pmid:9375825 |
Savla U et al. | Cyclic stretch of airway epithelium inhibits prostanoid synthesis. | 1997 | Am. J. Physiol. | pmid:9374729 |
Farker K et al. | Measurements of urinary prostaglandins in young ovulatory women during the menstrual cycle and in postmenopausal women. | 1997 | Prostaglandins | pmid:9373880 |
Siler-Khodr TM et al. | The effect of dexamethasone on CRH and prostanoid production from human term placenta. | 1997 | Prostaglandins | pmid:9373879 |
Capponi A et al. | Indomethacin modifies the fetal hemodynamic response induced by percutaneous umbilical blood sampling. | 1997 | Am. J. Obstet. Gynecol. | pmid:9369815 |
John H and Schlegel W | Reversed-phase high-performance liquid chromatographic method for the determination of the 11-hydroxythromboxane B2 anomers equilibrium. | 1997 | J. Chromatogr. B Biomed. Sci. Appl. | pmid:9367188 |
Riendeau D et al. | Comparison of the cyclooxygenase-1 inhibitory properties of nonsteroidal anti-inflammatory drugs (NSAIDs) and selective COX-2 inhibitors, using sensitive microsomal and platelet assays. | 1997 | Can. J. Physiol. Pharmacol. | pmid:9365818 |
Walker JS et al. | Nonsteroidal antiinflammatory drugs in rheumatoid arthritis and osteoarthritis: support for the concept of "responders" and "nonresponders". | 1997 | Arthritis Rheum. | pmid:9365082 |
Bar J et al. | The regulation of platelet aggregation in vitro by interleukin-1beta and tumor necrosis factor-alpha: changes in pregnancy and in pre-eclampsia. | 1997 | Thromb. Haemost. | pmid:9364994 |