MeSH term | MeSH ID | Detail |
---|---|---|
Acute Coronary Syndrome | D054058 | 11 associated lipids |
Airway Remodeling | D056151 | 3 associated lipids |
Acute Kidney Injury | D058186 | 34 associated lipids |
Thromboxane b2 is a lipid of Fatty Acyls (FA) class. Thromboxane b2 is associated with abnormalities such as endothelial dysfunction, Diabetes Mellitus, Non-Insulin-Dependent, Diabetes Mellitus, Ischemia and Thrombocytosis. The involved functions are known as Platelet Activation, Excretory function, Anabolism, Inflammation and mRNA Expression. Thromboxane b2 often locates in Endothelium, Hepatic and Microsomes, Liver. The associated genes with Thromboxane b2 are PTGS2 gene, prothrombin fragment 2 and CCL14 wt Allele.
To understand associated biological information of Thromboxane b2, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
Thromboxane b2 is suspected in endothelial dysfunction, Diabetes Mellitus, Non-Insulin-Dependent, Diabetes Mellitus, Ischemia, Thrombocytosis, Acute Coronary Syndrome and other diseases in descending order of the highest number of associated sentences.
Disease | Cross reference | Weighted score | Related literature |
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We collected disease MeSH terms mapped to the references associated with Thromboxane b2
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
Location | Cross reference | Weighted score | Related literatures |
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Function | Cross reference | Weighted score | Related literatures |
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There are no associated biomedical information in the current reference collection.
Gene | Cross reference | Weighted score | Related literatures |
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There are no associated biomedical information in the current reference collection.
Authors | Title | Published | Journal | PubMed Link |
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Irvine RF et al. | One-dimensional thin-layer chromatographic separation of the lipids involved in arachidonic acid metabolism. | 1984 | J Pharmacol Methods | pmid:6443136 |
Rainsford KD et al. | Comparative effects of some non-steroidal anti-inflammatory drugs on the ultrastructural integrity and prostaglandin levels in the rat gastric mucosa: relationship to drug uptake. | 1984 | Scand. J. Gastroenterol. Suppl. | pmid:6443622 |
Teng CM et al. | Biphasic effect on platelet aggregation by phospholipase a purified from Vipera russellii snake venom. | 1984 | Biochim. Biophys. Acta | pmid:6426517 |
Hsueh W et al. | Identification of C3b as the major serum protein that stimulates prostaglandin and thromboxane synthesis by macrophages. | 1984 | Prostaglandins | pmid:6240667 |
Romero SD et al. | Measurement of prostaglandins in the cerebrospinal fluid in cat, dog, and man. | 1984 | J. Neurochem. | pmid:6593432 |
Wada H et al. | Effect of TEI-4120 (3-benzoyl-N-beta-ethoxyisopropyl-2-methlindole) on carrageenan induced disseminated intravascular coagulation (DIC) in rats. | 1984 | J. Pharmacobio-dyn. | pmid:6548260 |
Johnston C et al. | Prostacyclin and thromboxane in non-insulin dependent diabetes: the chlorpropamide alcohol flush reaction revisited. | 1984 | Clin. Sci. | pmid:6548428 |
Nicod P et al. | Acute systemic and coronary hemodynamic and serologic responses to cigarette smoking in long-term smokers with atherosclerotic coronary artery disease. | 1984 | J. Am. Coll. Cardiol. | pmid:6548482 |
Welton AF et al. | Ro 22-3747: a new antiallergic agent for the treatment of immediate hypersensitivity diseases. | 1984 | J. Pharmacol. Exp. Ther. | pmid:6198511 |
Ishii H et al. | The effect of plasma on platelet function in hypercholesterolemic rabbits and the changes in fatty acid composition of the plasma. | 1984 | Thromb. Res. | pmid:6234679 |
Ritter JM | Prostanoid synthesis by aortic rings in human blood: selective increase of prostacyclin mediated by a serum factor. | 1984 | Br. J. Pharmacol. | pmid:6386089 |
Schneidkraut MJ et al. | Thromboxane and prostacyclin synthesis following whole body irradiation in rats. | 1984 | J Appl Physiol Respir Environ Exerc Physiol | pmid:6386769 |
Puustinen T et al. | Glucocorticoids do not decrease thromboxane and prostacyclin levels in human blood. | 1984 | Prostaglandins Leukot Med | pmid:6387721 |
Uehara Y et al. | [A solid phase direct radioimmunoassay for urinary thromboxane B2 and its clinical application]. | 1984 | Nihon Jinzo Gakkai Shi | pmid:6527429 |
Wang JP et al. | Antiplatelet effect of capsaicin. | 1984 | Thromb. Res. | pmid:6528310 |
Sedor JR et al. | Effects of sulindac and indomethacin on renal prostaglandin synthesis. | 1984 | Clin. Pharmacol. Ther. | pmid:6428794 |
De Caterina R et al. | Inhibition of platelet function by injectable isosorbide dinitrate. | 1984 | Am. J. Cardiol. | pmid:6428211 |
Worthington RE and Fuller GC | Dibutyryl cyclic guanosine monophosphate elevates bovine endothelial cell thromboxane production without affecting prostacyclin metabolism. | 1984 | Thromb. Res. | pmid:6322377 |
Foegh ML et al. | Urine thromboxane as an immunologic monitor in kidney transplant patients. | 1984 | Transplant. Proc. | pmid:6390872 |
Stimler NP | Spasmogenic activity of C5adesArg anaphylatoxin on guinea pig lung parenchymal strips: sensitivity of the leukotriene-mediated component to cyclooxygenase inhibitors. | 1984 | Biochem. Biophys. Res. Commun. | pmid:6440564 |
Driss F et al. | Inhibition of platelet aggregation and thromboxane synthesis after intake of small amount of icosapentaenoic acid. | 1984 | Thromb. Res. | pmid:6098051 |
Walenga RW et al. | Recovery of megakaryocyte thromboxane production in vitro after aspirin inhibition. | 1984 | Biochem. Biophys. Res. Commun. | pmid:6712680 |
Zipser RD and Smorlesi C | Regulation of urinary thromboxane B2 in man: influence of urinary flow rate and tubular transport. | 1984 | Prostaglandins | pmid:6718753 |
Kutti J et al. | The effect of acetylsalicylic acid in 3 different formulations on in vitro and in vivo platelet function tests. An experimental study on healthy male volunteers. | 1984 | Scand J Haematol | pmid:6719042 |
Holme S et al. | The effect of albumin bound polyunsaturated fatty acids on human platelets. | 1984 | Thromb. Haemost. | pmid:6719386 |
Tremoli E et al. | Increased platelet sensitivity and thromboxane B2 formation in type-II hyperlipoproteinaemic patients. | 1984 | Eur. J. Clin. Invest. | pmid:6437830 |
Marks JG et al. | Contact urticaria and airway obstruction from carbonless copy paper. | 1984 Aug 24-31 | JAMA | pmid:6235381 |
MacNab MW et al. | The effects of a new thromboxane synthetase inhibitor, CGS-13080, in man. | 1984 Feb-Mar | J Clin Pharmacol | pmid:6371062 |
Buchanan MR and Hirsh J | Effect of aspirin and salicylate on platelet-vessel wall interactions in rabbits. | 1984 Jul-Aug | Arteriosclerosis | pmid:6380468 |
Paajanen H et al. | Modification of platelet aggregation and thromboxane synthesis by intravascular contrast media. | 1984 Jul-Aug | Invest Radiol | pmid:6434489 |
De Caterina R et al. | Thromboxane-B2 generation during ex-vivo platelet aggregation. | 1984 Jul-Sep | J. Nucl. Med. Allied Sci. | pmid:6530623 |
Egg D | Concentrations of prostaglandins D2, E2, F2 alpha, 6-keto-F1 alpha and thromboxane B2 in synovial fluid from patients with inflammatory joint disorders and osteoarthritis. | 1984 Mar-Apr | Z Rheumatol | pmid:6730731 |
Tanabe M et al. | Inhibition of coronary circulatory failure and thromboxane A2 release during coronary occlusion and reperfusion by 2-phenylaminoadenosine (CV-1808) in anesthetized dogs. | 1984 May-Jun | J. Cardiovasc. Pharmacol. | pmid:6202970 |
Laustiola K et al. | Exercise-induced increase in plasma arachidonic acid and thromboxane B2 in healthy men: effect of beta-adrenergic blockade. | 1984 May-Jun | J. Cardiovasc. Pharmacol. | pmid:6202971 |
Sturm M et al. | The measurement of plasma thromboxane B2 and the effect of smoking. | 1984 Nov-Dec | Clin. Exp. Pharmacol. Physiol. | pmid:6536421 |
Menitove JE et al. | Use of prostacyclin to inhibit activation of platelets during preparation of platelet concentrates. | 1984 Nov-Dec | Transfusion | pmid:6390814 |
Fisher M et al. | Selective thromboxane inhibition: a new approach to antiplatelet therapy. | 1984 Sep-Oct | Stroke | pmid:6474531 |
Uderman HD et al. | Thromboxane synthetase inhibitor UK38,485 lowers blood pressure in the adult spontaneously hypertensive rat. | 1984 Sep-Oct | J. Cardiovasc. Pharmacol. | pmid:6209508 |
Greer IA et al. | Inhibition of thromboxane and prostacyclin production in whole blood by adrenoceptor antagonists. | 1985 | Prostaglandins Leukot Med | pmid:2865745 |
Mikhailidis DP et al. | The effect of non-specific beta-blockade on metabolic and haemostatic variables during hypoglycaemia. | 1985 | Diabetes Res. | pmid:2866057 |
Mehta J et al. | Increase in human platelet alpha 2-adrenergic receptor affinity for agonist in unstable angina. | 1985 | J. Lab. Clin. Med. | pmid:2866219 |
Greer IA et al. | A comparative study of the effects of adrenoceptor antagonists on platelet aggregation and thromboxane generation. | 1985 | Thromb. Haemost. | pmid:2867620 |
Habenicht AJ et al. | Human platelet-derived growth factor stimulates prostaglandin synthesis by activation and by rapid de novo synthesis of cyclooxygenase. | 1985 | J. Clin. Invest. | pmid:3921570 |
Gragnoli G et al. | Effects of somatostatin on the behaviour of thromboxane B2 and beta-thromboglobulin in type I diabetes. | 1985 | Acta Endocrinol. | pmid:2408435 |
Yardumian DA et al. | Platelet hyperaggregability occurring during prolonged continuous intravenous infusions of prostacyclin analogue ZK 36374. | 1985 | Br. J. Haematol. | pmid:2408653 |
Carmo LG et al. | Platelet desensitization induced by arachidonic acid is not due to cyclo-oxygenase inactivation and involves the endoperoxide receptor. | 1985 | Br. J. Pharmacol. | pmid:2994786 |
Patscheke H | Thromboxane synthase inhibition potentiates washed platelet activation by endogenous and exogenous arachidonic acid. | 1985 | Biochem. Pharmacol. | pmid:3922373 |
Segarnick DJ et al. | Precursor- and pool-dependent differential effects of ethanol on human platelet prostanoid synthesis. | 1985 | Biochem. Pharmacol. | pmid:3922375 |
Lord A et al. | Leukotriene F4 and the release of arachidonic acid metabolites from perfused guinea pig lungs in vitro. | 1985 | Prostaglandins | pmid:3923570 |
Shorr RI et al. | In vitro effects of acetaminophen and its analogues on human platelet aggregation and thromboxane B2 synthesis. | 1985 | Thromb. Res. | pmid:3923647 |
Emau P et al. | Ibuprofen prevents Pasteurella hemolytica endotoxin-induced changes in plasma prostanoids and serotonin, and fever in sheep. | 1985 | J. Vet. Pharmacol. Ther. | pmid:3867760 |
Ouwendijk RJ et al. | Production of leukotrienes and prostaglandins by human ascites cells. | 1985 | Eur. J. Clin. Invest. | pmid:3007158 |
Mobley A and Tai HH | Synergistic stimulation of thromboxane biosynthesis by calcium ionophore and phorbol ester or thrombin in human platelets. | 1985 | Biochem. Biophys. Res. Commun. | pmid:3927908 |
Jakubowski JA et al. | Cumulative antiplatelet effect of low-dose enteric coated aspirin. | 1985 | Br. J. Haematol. | pmid:3927970 |
Mehta J et al. | Influence of selective thromboxane synthetase blocker CGS-13080 on thromboxane and prostacyclin biosynthesis in whole blood: evidence for synthesis of prostacyclin by leukocytes from platelet-derived endoperoxides. | 1985 | J. Lab. Clin. Med. | pmid:3928780 |
Brown CG and Poyser NL | Further studies on prostaglandin and thromboxane production by the rat uterus during the oestrous cycle. | 1985 | J. Reprod. Fertil. | pmid:3857345 |
Sawada M et al. | Enzyme-immunoassay of thromboxane B2 at the picogram level. | 1985 | Prostaglandins | pmid:3929333 |
De Caterina R et al. | Low-dose aspirin in patients recovering from myocardial infarction. Evidence for a selective inhibition of thromboxane-related platelet function. | 1985 | Eur. Heart J. | pmid:3930246 |
Beatty CH et al. | Metabolism of arachidonic acid by macaque platelets. Implications for studies on atherosclerosis. | 1985 | Atherosclerosis | pmid:3924062 |
Fukuda Y | [Plasma prostaglandin and thromboxane levels in asthmatic children]. | 1985 | Arerugi | pmid:2992423 |
Honda M et al. | Effects of purified hog pancreatic kallikrein on the kinin-prostaglandin system and renin-angiotensin-aldosterone system. | 1985 | Nephron | pmid:2993934 |
Mehta P et al. | Plasma concentrations of thromboxane and prostacyclin metabolites in patients with bone tumors. | 1985 | Am J Pediatr Hematol Oncol | pmid:2994511 |
Baud L et al. | Lipoxygenase products mediate the attachment of rat macrophages to glomeruli in vitro. | 1985 | Kidney Int. | pmid:3927056 |
Benigni A et al. | Inhibition of human platelet aggregation by parathyroid hormone. Is cyclic AMP implicated? | 1985 | Am. J. Nephrol. | pmid:2996352 |
Mitchell JA et al. | Effects of high frequency oscillatory ventilation compared to conventional ventilation upon pulmonary vascular prostanoid production in neonatal piglets. | 1985 | Prostaglandins Leukot Med | pmid:3883366 |
Wenger H et al. | Pulmonary dysfunction secondary to soft-tissue endotoxin. | 1985 | Arch Surg | pmid:3883949 |
Sirois P et al. | Role of cyclooxygenase products in the lung action of leukotrienes A4, B4, C4, D4 and E4. | 1985 | Pharmacology | pmid:2997811 |
Túri S et al. | [Changes in serum prostaglandin metabolites in Schönlein-Henoch purpura]. | 1985 | Orv Hetil | pmid:3897944 |
Farias LR et al. | Effect of prostaglandin blockers on ascites fluid in pancreatitis. | 1985 | Surgery | pmid:3898455 |
Kubo K and Kobayashi T | Effects of OKY-046, a selective thromboxane synthetase inhibitor, on endotoxin-induced lung injury in unanesthetized sheep. | 1985 | Am. Rev. Respir. Dis. | pmid:3898941 |
Barst RJ and Stalcup SA | Endothelial function in clinical pulmonary hypertension. | 1985 | Chest | pmid:3899537 |
Pediconi M et al. | Effects of acute and chronic ethanol administration on thromboxane and prostacyclin levels and release in rat brain cortex. | 1985 | Prostaglandins | pmid:3901122 |
Neri Serneri GG et al. | Abnormal cardiocoronary thromboxane A2 production in patients with unstable angina. | 1985 | Am. Heart J. | pmid:3984828 |
O'Byrne PM et al. | Leukotriene B4 induces airway hyperresponsiveness in dogs. | 1985 | J. Appl. Physiol. | pmid:3001017 |
Tanaka M and Shibata Y | The different response of guinea pig peritoneal macrophages to various stimulators. | 1985 | Gen. Pharmacol. | pmid:3930344 |
Zahavi J and Zahavi M | Enhanced platelet release reaction, shortened platelet survival time and increased platelet aggregation and plasma thromboxane B2 in chronic obstructive arterial disease. | 1985 | Thromb. Haemost. | pmid:3158092 |
Reines HD et al. | Dazoxiben in human sepsis and adult respiratory distress syndrome. | 1985 | Clin. Pharmacol. Ther. | pmid:3979000 |
Wilcox CS et al. | Intrarenal prostaglandin release: effects of arachidonic acid and hyperchloremia. | 1985 | Kidney Int. | pmid:3930824 |
Greco NJ et al. | Action of platelet-activating factor on type 1 diabetic human platelets. | 1985 | J. Lab. Clin. Med. | pmid:3981054 |
Patterson GA et al. | Effects of imidazole and indomethacin on fluid balance in isolated sheep lungs. | 1985 | J. Appl. Physiol. | pmid:3884582 |
Prosdocimi M et al. | Coronary and systemic 6-ketoprostaglandin F1 alpha and thromboxane B2 during myocardial ischemia in dog. | 1985 | Am. J. Physiol. | pmid:3838623 |
Krieger BP et al. | Mechanisms of interaction between oxygen and granulocytes in hyperoxic lung injury. | 1985 | J. Appl. Physiol. | pmid:3838744 |
Bergqvist D et al. | The effect of inhibition of thromboxane synthesis in experimental thrombosis and hemostasis. | 1985 | Thromb. Res. | pmid:3838828 |
Stuart MJ et al. | Prostanoids in hemolytic uremic syndrome. | 1985 | J. Pediatr. | pmid:3839015 |
Nigam S et al. | The concentrations of 6-keto-PGF1 alpha and TXB2 in plasma samples from patients with benign and malignant tumours of the breast. | 1985 | Prostaglandins | pmid:3839084 |
Hamilton TA et al. | gamma-Interferon enhances the secretion of arachidonic acid metabolites from murine peritoneal macrophages stimulated with phorbol diesters. | 1985 | J. Immunol. | pmid:3919102 |
Petroni A et al. | Differential effects of various vasoactive drugs on basal and stimulated levels of TXB2 and 6-keto-PGF1 alpha in rat brain. | 1985 | Prostaglandins | pmid:3839085 |
Kimura Y et al. | Effects of stilbene derivatives on arachidonate metabolism in leukocytes. | 1985 | Biochim. Biophys. Acta | pmid:3931689 |
Hillbom M et al. | Platelet thromboxane formation and bleeding time is influenced by ethanol withdrawal but not by cigarette smoking. | 1985 | Thromb. Haemost. | pmid:4049313 |
Aviram M et al. | Plasma lipoproteins affect platelet malondialdehyde and thromboxane B2 production. | 1985 | Biochem Med | pmid:4052061 |
Simmet T et al. | Modulation of eicosanoid release from anaphylactic guinea-pig heart with 5-benzoyl-a-methyl-2-thiophene acetic acid (tiaprofenic acid). | 1985 | Arch Int Pharmacodyn Ther | pmid:3841634 |
Rinaldo JE and Dauber JH | Effect of methylprednisolone and of ibuprofen, a nonsteroidal antiinflammatory agent, on bronchoalveolar inflammation following endotoxemia. | 1985 | Circ. Shock | pmid:4053294 |
Shingu T | [Prostaglandin metabolism in ischemic brain edema]. | 1985 | Nihon Geka Hokan | pmid:3841635 |
Leffler CW and Busija DW | Prostanoids in cortical subarachnoid cerebrospinal fluid and pial arterial diameter in newborn pigs. | 1985 | Circ. Res. | pmid:4053302 |
Tobian L et al. | Prostaglandin alterations in barely hypertensive Dahl S rats. | 1985 | Trans. Assoc. Am. Physicians | pmid:3842205 |
Numano F et al. | Coronary spasm, prostaglandin and HLA factors. | 1985 | Jpn. Circ. J. | pmid:3855470 |
Purkerson ML et al. | Inhibition of thromboxane synthesis ameliorates the progressive kidney disease of rats with subtotal renal ablation. | 1985 | Proc. Natl. Acad. Sci. U.S.A. | pmid:3855542 |
Dahl ML and Uotila P | Sodium salicylate does not prevent the inhibitory effect of indomethacin on thromboxane formation in human blood ex vivo. | 1985 | Prostaglandins Leukot Med | pmid:3856282 |
Murphy RC et al. | Surgical delay and arachidonic acid metabolites: evidence for an inflammatory mechanism: an experimental study in rats. | 1985 | Br J Plast Surg | pmid:3921087 |
Sterk PJ et al. | Limited maximal airway narrowing in nonasthmatic subjects. Role of neural control and prostaglandin release. | 1985 | Am. Rev. Respir. Dis. | pmid:2864892 |