MeSH term | MeSH ID | Detail |
---|---|---|
Acute Coronary Syndrome | D054058 | 11 associated lipids |
Airway Remodeling | D056151 | 3 associated lipids |
Acute Kidney Injury | D058186 | 34 associated lipids |
Thromboxane b2 is a lipid of Fatty Acyls (FA) class. Thromboxane b2 is associated with abnormalities such as endothelial dysfunction, Diabetes Mellitus, Non-Insulin-Dependent, Diabetes Mellitus, Ischemia and Thrombocytosis. The involved functions are known as Platelet Activation, Excretory function, Anabolism, Inflammation and mRNA Expression. Thromboxane b2 often locates in Endothelium, Hepatic and Microsomes, Liver. The associated genes with Thromboxane b2 are PTGS2 gene, prothrombin fragment 2 and CCL14 wt Allele.
To understand associated biological information of Thromboxane b2, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
Thromboxane b2 is suspected in endothelial dysfunction, Diabetes Mellitus, Non-Insulin-Dependent, Diabetes Mellitus, Ischemia, Thrombocytosis, Acute Coronary Syndrome and other diseases in descending order of the highest number of associated sentences.
Disease | Cross reference | Weighted score | Related literature |
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We collected disease MeSH terms mapped to the references associated with Thromboxane b2
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
Location | Cross reference | Weighted score | Related literatures |
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Function | Cross reference | Weighted score | Related literatures |
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There are no associated biomedical information in the current reference collection.
Gene | Cross reference | Weighted score | Related literatures |
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There are no associated biomedical information in the current reference collection.
Authors | Title | Published | Journal | PubMed Link |
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Taylor L et al. | Prostaglandin production by type II alveolar epithelial cells. | 1979 | Biochim. Biophys. Acta | pmid:435506 |
Powell WS | Metabolism of prostaglandins, prostaglandin analogs and thromboxane B2 by lung and liver microsomes from pregnant rabbits. | 1979 | Biochim. Biophys. Acta | pmid:518891 |
Teng CM et al. | Biphasic effect on platelet aggregation by phospholipase a purified from Vipera russellii snake venom. | 1984 | Biochim. Biophys. Acta | pmid:6426517 |
Kimura Y et al. | Effects of stilbenes on arachidonate metabolism in leukocytes. | 1985 | Biochim. Biophys. Acta | pmid:3922423 |
Bellan JA et al. | Concentration-activity profile of the modulation of cyclooxygenase product formation by reduced glutathione in microsomal fractions from the goat lung. | 1990 | Biochim. Biophys. Acta | pmid:2114178 |
Shaw JO and Lyons RM | Requirement for different Ca2+ pools in the activation of rabbit platelets II. Phospholipase activity. | 1982 | Biochim. Biophys. Acta | pmid:6800410 |
Bartolini G et al. | Regulation of thromboxane A2 biosynthesis in platelet-free human monocytes and the possible role of polypeptide growth factor(s) in the induction of cyclooxygenase system. | 1986 | Biochim. Biophys. Acta | pmid:3085720 |
Grundfest CC et al. | Acrolein: a potent modulator of lung macrophage arachidonic acid metabolism. | 1982 | Biochim. Biophys. Acta | pmid:6814492 |
Aharony D et al. | Regulation of arachidonate-induced platelet aggregation by the lipoxygenase product, 12-hydroperoxyeicosatetraenoic acid. | 1982 | Biochim. Biophys. Acta | pmid:6814496 |
Croft KD et al. | Dietary modification of fatty acid and prostaglandin synthesis in the rat. Effect of variations in the level of dietary fat. | 1984 | Biochim. Biophys. Acta | pmid:6548159 |
Geisel J et al. | Endotoxin-induced arachidonic acid metabolism requires de novo protein synthesis and protein kinase C activation. | 1991 | Biochim. Biophys. Acta | pmid:1909897 |
Du JT et al. | Sex differences in arachidonate cyclo-oxygenase products in elicited rat peritoneal macrophages. | 1984 | Biochim. Biophys. Acta | pmid:6428458 |
Cook-Johnson RJ et al. | Endothelial cell COX-2 expression and activity in hypoxia. | 2006 | Biochim. Biophys. Acta | pmid:17046322 |
Heemskerk JW et al. | Influence of dietary fatty acids on membrane fluidity and activation of rat platelets. | 1989 | Biochim. Biophys. Acta | pmid:2752022 |
Ciabattoni G et al. | Fractional conversion of thromboxane B2 to urinary 11-dehydrothromboxane B2 in man. | 1989 | Biochim. Biophys. Acta | pmid:2752040 |
Roberts LJ et al. | Prostaglandin thromboxane, and 12-hydroxy-5,8,10,14-eicosatetraenoic acid production by ionophore-stimulated rat serosal mast cells. | 1979 | Biochim. Biophys. Acta | pmid:389290 |
Fitzpatrick FA and Gorman RR | A comparison of imidazole and 9,11-azoprosta-5,13-dienoic acid. Two selective thromboxane synthetase inhibitors. | 1978 | Biochim. Biophys. Acta | pmid:629996 |
Blache D et al. | Occurrence and biological effects of cholesteryl sulfate on blood platelets. | 1995 | Biochim. Biophys. Acta | pmid:8541337 |
Orlandi M et al. | Thromboxane A2 synthase activity in platelet free human monocytes. | 1994 | Biochim. Biophys. Acta | pmid:7811713 |
Truitt A et al. | Antiplatelet effects of conjugated linoleic acid isomers. | 1999 | Biochim. Biophys. Acta | pmid:10320806 |
de Waart DR et al. | Studies on the urinary excretion of thromboxane B2 in Zellweger patients and control subjects: evidence for a major role for peroxisomes in the beta-oxidative chain-shortening of thromboxane B2. | 1994 | Biochim. Biophys. Acta | pmid:8155738 |
Sato T et al. | Inhibition of platelet aggregation by unsaturated fatty acids through interference with a thromboxane-mediated process. | 1987 | Biochim. Biophys. Acta | pmid:3663714 |
Surya II et al. | Enhancement of platelet functions by low density lipoproteins. | 1992 | Biochim. Biophys. Acta | pmid:1420343 |
Robinson C and Hoult JR | Thromboxane A2 analogues inhibit the metabolism of thromboxane B2 in perfused guinea-pig lung. | 1983 | Biochim. Biophys. Acta | pmid:6652102 |
Teng CM et al. | Antiplatelet effect of butylidenephthalide. | 1987 | Biochim. Biophys. Acta | pmid:3109495 |
Ko FN et al. | Antiplatelet effects of chelerythrine chloride isolated from Zanthoxylum simulans. | 1990 | Biochim. Biophys. Acta | pmid:2162213 |
Tsunomori M et al. | 15-Hydroperoxyeicosapentaenoic acid inhibits arachidonic acid metabolism in rabbit platelets more potently than eicosapentaenoic acid. | 1996 | Biochim. Biophys. Acta | pmid:8679681 |
Bernoud-Hubac N et al. | Low concentrations of reactive gamma-ketoaldehydes prime thromboxane-dependent human platelet aggregation via p38-MAPK activation. | 2009 | Biochim. Biophys. Acta | pmid:19233311 |
Cerletti C et al. | Non-steroidal anti-inflammatory drugs react with two sites on platelet cyclo-oxygenase. Evidence from "in vivo" drug interaction studies in rats. | 1982 | Biochim. Biophys. Acta | pmid:6799004 |
Chiabrando C et al. | Metabolism of thromboxane B2 in the isolated perfused rat kidney: mass spectrometric identification of urinary products. | 1989 | Biochim. Biophys. Acta | pmid:2597664 |
Nieuwenhuys CM and Hornstra G | The effects of purified eicosapentaenoic and docosahexaenoic acids on arterial thrombosis tendency and platelet function in rats. | 1998 | Biochim. Biophys. Acta | pmid:9487152 |
Lorenz RL et al. | A critical evaluation of urinary immunoreactive thromboxane: feasibility of its determination as a potential vascular risk indicator. | 1989 | Biochim. Biophys. Acta | pmid:2597697 |
Elliott GR et al. | Changes in resident rat peritoneal macrophage eicosanoid release, induced by altering the buffer K+/Na+ ratio, are Ca2+ dependent. | 1985 | Biochim. Biophys. Acta | pmid:3933563 |
Turk J et al. | Arachidonic acid metabolism in isolated pancreatic islets. I. Identification and quantitation of lipoxygenase and cyclooxygenase products. | 1984 | Biochim. Biophys. Acta | pmid:6329307 |
Robinson C et al. | Thromboxane B2 uptake and metabolism in isolated perfused lung. Identification and comparison with prostaglandin F2 alpha. | 1982 | Biochim. Biophys. Acta | pmid:6751406 |
Schafer AI et al. | Platelet lipoxygenase-dependent oxygen burst. Evidence for differential activation of lipoxygenase in intact and disrupted human platelets. | 1982 | Biochim. Biophys. Acta | pmid:6812645 |
Caprani A et al. | Experimental evidence of a potentially increased thrombo-embolic disease risk by domestic electromagnetic field exposure. | 2004 | Bioelectromagnetics | pmid:15114641 |
Bartolini G et al. | Possible involvement of prostaglandin H synthase-1 induction in the differentiation of U-937 cells. | 1995 | Biofactors | pmid:7546213 |
Wolfram RM et al. | Salivary isoprostanes indicate increased oxidation injury in periodontitis with additional tobacco abuse. | 2006 | Biofactors | pmid:17264390 |
Olszowski T et al. | The Effect of Cadmium on COX-1 and COX-2 Gene, Protein Expression, and Enzymatic Activity in THP-1 Macrophages. | 2015 | Biol Trace Elem Res | pmid:25645360 |
Korbecki J et al. | Cyclooxygenase-1 as the main source of proinflammatory factors after sodium orthovanadate treatment. | 2015 | Biol Trace Elem Res | pmid:25398544 |
Qu X et al. | Selenium deficiency-induced alterations in the vascular system of the rat. | 2000 | Biol Trace Elem Res | pmid:11051602 |
Knowles SO and Donaldson WE | Lead disrupts eicosanoid metabolism, macrophage function, and disease resistance in birds. | 1997 Oct-Nov | Biol Trace Elem Res | pmid:9404672 |
Tran-Thi TA et al. | Output and effects of thromboxane produced by the liver perfused with phorbol myristate acetate. | 1988 | Biol. Chem. Hoppe-Seyler | pmid:3242547 |
Redl H et al. | The elastase-inhibitor eglin has no effect in an ovine model of endotoxemia. | 1988 | Biol. Chem. Hoppe-Seyler | pmid:3060136 |
Ishibashi M et al. | Analysis of 11-dehydrothromboxane B2 in human urine improved by use of gas chromatography/high-resolution selected ion monitoring with 18O2-labelled analogue as an internal standard. | 1994 | Biol. Mass Spectrom. | pmid:7986831 |
Tanaka M et al. | Effects of a thromboxane synthetase inhibitor (OKY-046) in an ischemia-reperfusion model of intrauterine growth retardation in Sprague-Dawley rats. | 1997 | Biol. Neonate | pmid:9303217 |
Stuart MJ and Dusse J | In vitro comparison of the efficacy of cyclooxygenase inhibitors on the adult versus neonatal platelet. | 1985 | Biol. Neonate | pmid:4005330 |
Smalling WE et al. | Protective effect of pentoxifylline on volume-induced lung injury in newborn piglets. | 2004 | Biol. Neonate | pmid:14981352 |
Osiovich H et al. | Cardiopulmonary effects of tumor necrosis factor-alpha in the piglet: influence of cyclooxygenase inhibition. | 1995 | Biol. Neonate | pmid:8835089 |
Zheng NX et al. | Pharmacokinetic and pharmacodynamic studies of a thromboxane synthetase inhibitor, ozagrel, in rabbits. | 1995 | Biol. Pharm. Bull. | pmid:8787798 |
Kim YJ | Rhamnetin attenuates melanogenesis by suppressing oxidative stress and pro-inflammatory mediators. | 2013 | Biol. Pharm. Bull. | pmid:23739488 |
Bermejo BP et al. | Sesquiterpenes from Jasonia glutinosa: in vitro anti-inflammatory activity. | 2002 | Biol. Pharm. Bull. | pmid:11824534 |
Togna AR et al. | 4-Methylcoumarin derivatives with anti-inflammatory effects in activated microglial cells. | 2014 | Biol. Pharm. Bull. | pmid:24389482 |
Katoh M et al. | Inhibitory effects of TA-993 and its metabolite MB3 on platelet activation induced by collagen and U-46619 in human platelets. | 2001 | Biol. Pharm. Bull. | pmid:11379769 |
Hsiao G et al. | Antiplatelet action of 3',4'-diisovalerylkhellactone diester purified from Peucedanum japonicum Thunb. | 1998 | Biol. Pharm. Bull. | pmid:9703250 |
Akagi Y et al. | Influence of nonsteroidal anti-inflammatory drugs on the antiplatelet effects of aspirin in rats. | 2011 | Biol. Pharm. Bull. | pmid:21415533 |
Noguchi M et al. | Enzymologic and pharmacologic profile of loxoprofen sodium and its metabolites. | 2005 | Biol. Pharm. Bull. | pmid:16272692 |
Yokoyama H et al. | Theoretical investigation of aspirin dosage regimen to exhibit optimal antiplatelet effects and decrease risk of upper gastrointestinal lesions. | 2012 | Biol. Pharm. Bull. | pmid:23047244 |
Basselin M et al. | Chronic carbamazepine administration reduces N-methyl-D-aspartate receptor-initiated signaling via arachidonic acid in rat brain. | 2007 | Biol. Psychiatry | pmid:17628508 |
Evans CA et al. | Gestational changes in prostanoid concentrations in intrauterine tissues and fetal fluids from pregnant sheep, and the relation to prostanoid output in vitro. | 1982 | Biol. Reprod. | pmid:6896829 |
Wilson L et al. | Alterations in reproductive tissue prostaglandins E and F, 6-keto-prostaglandin F1 alpha and thromboxane B2 with gestational age in the rat. | 1982 | Biol. Reprod. | pmid:6897617 |
Dubin NH et al. | Thromboxane production in the pregnant rat: differential recovery by platelets and uterus following aspirin administration. | 1983 | Biol. Reprod. | pmid:6626652 |
Miller JB et al. | Alterations in plasma and tissue prostaglandin levels in rabbits during luteal regression. | 1983 | Biol. Reprod. | pmid:6688954 |
Lei ZM et al. | Expression of thromboxane A2 receptor gene and thromboxane A2 synthase in bovine corpora lutea. | 1992 | Biol. Reprod. | pmid:1391329 |
Wilson L and Huang LS | Contributions of the fetoplacental unit to augmented uterine prostaglandin levels periparturition in the rat. | 1985 | Biol. Reprod. | pmid:3840391 |
Chou YI et al. | Correlations of platelet-derived microparticles with thromboxane B2, platelet-activating factor, endothelin-1, and neutrophil to lymphocyte ratio in patients with coronary intermediate lesions. | 2014 | Biomarkers | pmid:25391885 |
Lüdicke F et al. | A Japanese cross-sectional multicentre study of biomarkers associated with cardiovascular disease in smokers and non-smokers. | 2015 | Biomarkers | pmid:26616146 |
Burhop KE et al. | Effects of intravenous infusions of diaspirin cross-linked hemoglobin (DCLHb) on sheep. | 1992 | Biomater Artif Cells Immobilization Biotechnol | pmid:1391481 |
Hubbell JA and McIntire LV | Visualization and analysis of mural thrombogenesis on collagen, polyurethane and nylon. | 1986 | Biomaterials | pmid:3778995 |
Leake DL et al. | Comparative study of the thromboresistance of Dacron combined with various polyurethanes. | 1989 | Biomaterials | pmid:2529915 |
Cenni E et al. | Platelet and coagulation factor variations induced in vitro by polyethylene terephthalate (Dacron) coated with pyrolytic carbon. | 1995 | Biomaterials | pmid:8580259 |
Cenni E et al. | Numerical and functional modifications in platelets induced by polyester coated by a hydrophilic polymer. | 1993 | Biomaterials | pmid:8399951 |
Xie P et al. | Antithrombotic Effect and Mechanism of Radix Paeoniae Rubra. | 2017 | Biomed Res Int | pmid:28299338 |
Yan H et al. | Seawater Immersion Aggravates Burn Injury Causing Severe Blood Coagulation Dysfunction. | 2016 | Biomed Res Int | pmid:26885523 |
Abbas NA et al. | Thromboxane plasma level in kappa-carrageenin-induced acronecrosis of the tail in rats. | 1991 | Biomed. Biochim. Acta | pmid:1759973 |
Becker K et al. | Influence of the specific antagonist of PAF-acether, BN 52021, and of Ginkgo extract on the rejection of murine tail skin allografts and the PAF-acether mortality in mice in particular consideration of the role of TXB2. | 1988 | Biomed. Biochim. Acta | pmid:3073760 |
Ito T et al. | Selective thromboxane synthetase inhibitor and ischemic heart disease. | 1984 | Biomed. Biochim. Acta | pmid:6542777 |
Block HU et al. | Estimation of thromboxane B2 in the clotting human whole blood by gas chromatography. | 1984 | Biomed. Biochim. Acta | pmid:6517904 |
Beitz A et al. | Thromboxane B2 (TXB2) formation in clotting whole blood of healthy and diabetic humans in vitro. | 1984 | Biomed. Biochim. Acta | pmid:6517908 |
Schaper U et al. | Inhibition of lipoxygenase (LOX) or of cyclooxygenase (COX) improves survival of rats in endotoxin shock. | 1988 | Biomed. Biochim. Acta | pmid:3150270 |
Giessler C et al. | An enzyme-linked immunoassay for thromboxane B2 and 6-oxo-PGF1 alpha using peroxidase as label. | 1988 | Biomed. Biochim. Acta | pmid:3248100 |
Heinroth-Hoffmann I et al. | Effects of trapidil and trapidil derivatives on arachidonic acid and prostaglandin endoperoxide analogue U 46619-induced blood pressure changes in rats. | 1988 | Biomed. Biochim. Acta | pmid:3248102 |
Vapaatalo H et al. | Plasma catecholamines and production of thromboxane B2 by platelets after psychological and physical tests in normotensive and mild hypertensive subjects. | 1988 | Biomed. Biochim. Acta | pmid:3248115 |
Lamers JM et al. | Dietary fish oil reduces intimal proliferation of the coronary artery caused by implantation of a constrictor in pigs. | 1988 | Biomed. Biochim. Acta | pmid:3248119 |
Shindo N et al. | Rapid quantification of 11 prostanoids by combined capillary column gas chromatography and negative ion chemical ionization mass spectrometry: application to prostanoids released from normal human embryonic lung fibroblasts WI38 in a culture medium. | 1988 | Biomed. Environ. Mass Spectrom. | pmid:3349205 |
Voyksner RD et al. | Derivatization to improve thermospray HPLC/MS sensitivity for the determination of prostaglandins and thromboxane B2. | 1987 | Biomed. Environ. Mass Spectrom. | pmid:2960399 |
Ishibashi M et al. | Dimethylisopropylsilyl ether derivative in gas chromatography/mass spectrometry of 11-dehydrothromboxane B2. | 1988 | Biomed. Environ. Mass Spectrom. | pmid:3191252 |
Li D et al. | Diet rich in saturated fat decreases the ratio of thromboxane/prostacyclin in healthy men. | 2003 | Biomed. Environ. Sci. | pmid:15011964 |
Mallen DN et al. | Structural verification of 15-oxo-13,14-dihydrothromboxane B2. | 1978 | Biomed. Mass Spectrom. | pmid:678616 |
Roselló J et al. | Quantitative profiling of the metabolic cascade of arachidonic acid by capillary gas chromatography mass spectrometry. | 1981 | Biomed. Mass Spectrom. | pmid:7236862 |
Meese CO et al. | Measurement of thromboxane B2 in human urine by isotope dilution and negative ion chemical ionization mass spectrometry. | 1985 | Biomed. Mass Spectrom. | pmid:2932184 |
Nocun M et al. | French maritime pine bark extract Pycnogenol reduces thromboxane generation in blood from diabetic male rats. | 2008 | Biomed. Pharmacother. | pmid:17698319 |
Milani M et al. | Effects of two different HMG-CoA reductase inhibitors on thromboxane production in type IIA hypercholesterolemia. | 1996 | Biomed. Pharmacother. | pmid:8952866 |
Faure P et al. | Influence of a long-term zinc-deficient diet on rat platelet function and fatty acid composition. | 1995 | Biometals | pmid:7865995 |
Sadovskaia VL et al. | [Study of prostaglandins and thromboxanes B2 using mass-spectrometry of secondary ions]. | 1986 | Bioorg. Khim. | pmid:3768052 |
Vigorita MG et al. | Chiral 3,3'-(1,2-ethanediyl)-bis[2-(3,4-dimethoxyphenyl)-4-thiazolidinones] with anti-inflammatory activity. Part 11: evaluation of COX-2 selectivity and modelling. | 2003 | Bioorg. Med. Chem. | pmid:12614885 |
Mayer AM et al. | Marine sponge Hymeniacidon sp. amphilectane metabolites potently inhibit rat brain microglia thromboxane B2 generation. | 2012 | Bioorg. Med. Chem. | pmid:22153874 |
Takeuchi K et al. | Development of dual-acting agents for thromboxane receptor antagonism and thromboxane synthase inhibition--I. Synthesis, structure-activity relationship, and evaluation of substituted omega-phenyl-omega-(3-pyridyl)alkenoic acids. | 1994 | Bioorg. Med. Chem. | pmid:7894968 |
Seno K et al. | Pyrrolidine inhibitors of human cytosolic phospholipase A2. Part 2: synthesis of potent and crystallized 4-triphenylmethylthio derivative 'pyrrophenone'. | 2001 | Bioorg. Med. Chem. Lett. | pmid:11229777 |