MeSH term | MeSH ID | Detail |
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Acute Coronary Syndrome | D054058 | 11 associated lipids |
Airway Remodeling | D056151 | 3 associated lipids |
Acute Kidney Injury | D058186 | 34 associated lipids |
Thromboxane b2 is a lipid of Fatty Acyls (FA) class. Thromboxane b2 is associated with abnormalities such as endothelial dysfunction, Diabetes Mellitus, Non-Insulin-Dependent, Diabetes Mellitus, Ischemia and Thrombocytosis. The involved functions are known as Platelet Activation, Excretory function, Anabolism, Inflammation and mRNA Expression. Thromboxane b2 often locates in Endothelium, Hepatic and Microsomes, Liver. The associated genes with Thromboxane b2 are PTGS2 gene, prothrombin fragment 2 and CCL14 wt Allele.
To understand associated biological information of Thromboxane b2, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
Thromboxane b2 is suspected in endothelial dysfunction, Diabetes Mellitus, Non-Insulin-Dependent, Diabetes Mellitus, Ischemia, Thrombocytosis, Acute Coronary Syndrome and other diseases in descending order of the highest number of associated sentences.
Disease | Cross reference | Weighted score | Related literature |
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We collected disease MeSH terms mapped to the references associated with Thromboxane b2
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
Location | Cross reference | Weighted score | Related literatures |
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Function | Cross reference | Weighted score | Related literatures |
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There are no associated biomedical information in the current reference collection.
Gene | Cross reference | Weighted score | Related literatures |
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There are no associated biomedical information in the current reference collection.
Authors | Title | Published | Journal | PubMed Link |
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Halushka PV et al. | Insulin and arachidonic acid metabolism in diabetes mellitus. | 1985 | Metab. Clin. Exp. | pmid:3934501 |
Kimura Y et al. | Effects of stilbenes on arachidonate metabolism in leukocytes. | 1985 | Biochim. Biophys. Acta | pmid:3922423 |
Bakhle YS et al. | Differential release of eicosanoids by bradykinin, arachidonic acid and calcium ionophore A23187 in guinea-pig isolated perfused lung. | 1985 | Br. J. Pharmacol. | pmid:2996675 |
Panse M et al. | An improved malondialdehyde assay for estimation of thromboxane synthase activity in washed human blood platelets. | 1985 | Prostaglandins | pmid:3937179 |
Heinz TR et al. | Radiation-induced alterations in cyclooxygenase product synthesis by isolated perfused rat lungs. | 1985 | Prog Biochem Pharmacol | pmid:3921980 |
Lauri D et al. | Amplification of primary response of human platelets to platelet-activating factor: aspirin-sensitive and aspirin-insensitive pathways. | 1985 | J. Lab. Clin. Med. | pmid:3923145 |
Johnson A and Malik AB | Pulmonary transvascular fluid and protein exchange after thrombin-induced microembolism. Differential effects of cyclooxygenase inhibitors. | 1985 | Am. Rev. Respir. Dis. | pmid:3925828 |
Packham MA et al. | Duration of the effect of aspirin on the synthesis of thromboxane by density subpopulations of rabbit platelets stimulated with thrombin. | 1985 | Blood | pmid:3926022 |
Patrono C et al. | Functional significance of renal prostacyclin and thromboxane A2 production in patients with systemic lupus erythematosus. | 1985 | J. Clin. Invest. | pmid:3900132 |
Cattaneo M et al. | Human platelet aggregation and release reaction induced by platelet activating factor (PAF-acether)--effects of acetylsalicylic acid and external ionized calcium. | 1985 | Thromb. Haemost. | pmid:3927505 |
Aitokallio-Tallberg A et al. | Prostacyclin and thromboxane in breast cancer: relationship between steroid receptor status and medroxyprogesterone acetate. | 1985 | Br. J. Cancer | pmid:2986666 |
Callahan KS et al. | Enhancement of the antiaggregatory activity of prostacyclin by propranolol in human platelets. | 1985 | Circulation | pmid:2986877 |
Schmitz JM et al. | Vascular prostaglandin and thromboxane production in a canine model of myocardial ischemia. | 1985 | Circ. Res. | pmid:3926340 |
Apprill P et al. | Cyclic blood flow variations induced by platelet-activating factor in stenosed canine coronary arteries despite inhibition of thromboxane synthetase, serotonin receptors, and alpha-adrenergic receptors. | 1985 | Circulation | pmid:2988822 |
Mehta J and Mehta P | Prostacyclin and thromboxane A2 production by human cardiac atrial tissues. | 1985 | Am. Heart J. | pmid:3880988 |
Friedrich T et al. | Follow-up of prostaglandin plasma levels after acute myocardial infarction. | 1985 | Am. Heart J. | pmid:3880994 |
Wilson TW and Tan LK | Low plasma renin activity in diabetes. Relation to urine prostaglandin excretion. | 1985 | Diabetes | pmid:3881302 |
Longenecker GL et al. | Kinetics of ibuprofen effect on platelet and endothelial prostanoid release. | 1985 | Clin. Pharmacol. Ther. | pmid:3882308 |
Kuzuya T et al. | Determination of plasma thromboxane B2 by radioimmunoassay: methodological problems and accuracy. | 1985 | Adv. Prostaglandin Thromboxane Leukot. Res. | pmid:2936210 |
Morita I et al. | Effect of dietary protein level on platelet aggregation in rat. | 1985 | Prostaglandins Leukot Med | pmid:3892545 |
de Lorgeril M et al. | Acute influence of cigarette smoke in platelets, catecholamines and neurophysins in the normal conditions of daily life. | 1985 | Eur. Heart J. | pmid:2937635 |
Lelcuk S et al. | Prostacyclin and thromboxane A2 moderate postischemic renal failure. | 1985 | Surgery | pmid:3895535 |
Paajanen H and Kormano M | Prostacyclin (PGI2) and thromboxane (TXA2) levels during intravenous contrast medium administration in CT. | 1985 | Eur J Radiol | pmid:3896802 |
Yui Y et al. | A new stable prostacyclin analogue OP41483 (15-cyclopentyl-omega-pentanor-5(E)-carbacyclin). | 1985 | Jpn. Circ. J. | pmid:3897597 |
Codde JP and Beilin LJ | Dietary fish oil prevents dexamethasone induced hypertension in the rat. | 1985 | Clin. Sci. | pmid:3905217 |
Nawroth PP et al. | Thromboxane production by perturbed bovine aortic endothelial cells in culture. | 1985 | Blut | pmid:3967102 |
Martin JL et al. | Effect of high dose aspirin on coronary hemodynamics during pacing-induced myocardial ischemia. | 1985 | J. Am. Coll. Cardiol. | pmid:3968305 |
De Caterina R et al. | Inhibition of platelet aggregation and thromboxane B2 production during aspirin treatment: dependence on the dose of the aggregating agent. | 1985 | Thromb. Res. | pmid:3975876 |
Cook JA et al. | Exchange transfusions in rats with a perfluorated blood substitute: effect on thromboxane B2 levels during endotoxemia. | 1985 | Circ. Shock | pmid:3978769 |
Westenfelder C et al. | Renal function in calves with total artificial hearts. | 1985 | Trans Am Soc Artif Intern Organs | pmid:3837477 |
Schrör K et al. | [Inhibition of platelet aggregation and thromboxane formation by the calcium antagonist nisoldipine following a single oral dose of 10 mg. A double-blind study in healthy probands]. | 1985 | Klin. Wochenschr. | pmid:3838352 |
Bult H et al. | Modification of endotoxin-induced haemodynamic and haematological changes in the rabbit by methylprednisolone, F(ab')2 fragments and rosmarinic acid. | 1985 | Br. J. Pharmacol. | pmid:3838489 |
Remuzzi G et al. | Increased glomerular thromboxane synthesis as a possible cause of proteinuria in experimental nephrosis. | 1985 | J. Clin. Invest. | pmid:4038407 |
Mogensen F et al. | Effect of specific thromboxane-synthetase inhibition on thromboxane and prostaglandin synthesis in stable angina induced by exercise test. | 1985 | Thromb. Res. | pmid:4038824 |
Tada M et al. | Augmented thromboxane A2 generation and efficacy of its blockade in acute myocardial infarction. | 1985 | Int. J. Cardiol. | pmid:4040500 |
Lorenzana RM et al. | Experimental T-2 toxicosis in swine. I. Changes in cardiac output, aortic mean pressure, catecholamines, 6-keto-PGF1 alpha, thromboxane B2, and acid-base parameters. | 1985 | Fundam Appl Toxicol | pmid:3840756 |
Wargovich T et al. | Reduction in blood flow in normal and narrowed coronary arteries of dogs by leukotriene C4. | 1985 | J. Am. Coll. Cardiol. | pmid:4045029 |
Elliott GR et al. | Arachidonic acid, an in vivo inhibitor of carrageenin induced granulomas in the rat. | 1985 | Eur. J. Pharmacol. | pmid:2988985 |
Feuerstein G et al. | Effects of nafazatrom on cardiovascular, sympathetic, and endocrine responses to hemorrhagic shock in conscious rats. | 1985 | Circ. Shock | pmid:3841032 |
Cerletti C et al. | Aspirin kinetics and inhibition of platelet thromboxane generation-relevance for a solution of the "aspirin dilemma". | 1985 | Thromb. Haemost. | pmid:4049312 |
Dejana E et al. | Differential salicylate-aspirin interaction on vascular prostacyclin and platelet thromboxane synthesis in patients undergoing saphenectomy. | 1985 | Proc. Soc. Exp. Biol. Med. | pmid:3841210 |
Fiedler VB et al. | The effects of nafazatrom in an acute occlusion-reperfusion model of canine myocardial injury. | 1985 | Naunyn Schmiedebergs Arch. Pharmacol. | pmid:3841382 |
Palmer RM and Salmon JA | Comparison of the effects of some compounds on human neutrophil degranulation and leukotriene B4 and thromboxane B2 synthesis. | 1985 | Biochem. Pharmacol. | pmid:2986647 |
Lynch TJ et al. | Carbon tetrachloride-induced eicosanoid synthesis and enzyme release from rat peritoneal leucocytes. | 1985 | Biochem. Pharmacol. | pmid:2986650 |
Elliott GR et al. | Changes in resident rat peritoneal macrophage eicosanoid release, induced by altering the buffer K+/Na+ ratio, are Ca2+ dependent. | 1985 | Biochim. Biophys. Acta | pmid:3933563 |
Miura K et al. | Effect of SA-446, an angiotensin-converting enzyme inhibitor, on renal function in anesthetized dogs: special reference to arachidonic acid metabolites. | 1985 Jan-Feb | J. Cardiovasc. Pharmacol. | pmid:2580127 |
Olanoff LS et al. | Protective effects of trans-13-APT, a thromboxane receptor antagonist, in endotoxemia. | 1985 Jan-Feb | J. Cardiovasc. Pharmacol. | pmid:2580129 |
Hook BG et al. | Experimental coronary artery thrombosis in the absence of thromboxane A2 synthesis: evidence for alternate pathways for coronary thrombosis. | 1985 Jan-Feb | J. Cardiovasc. Pharmacol. | pmid:2580139 |
Fisher M and Zipser R | Increased excretion of immunoreactive thromboxane B2 in cerebral ischemia. | 1985 Jan-Feb | Stroke | pmid:3966251 |
Mullane KM and McGiff JC | Platelet depletion and infarct size in an occlusion-reperfusion model of myocardial ischemia in anesthetized dogs. | 1985 Jul-Aug | J. Cardiovasc. Pharmacol. | pmid:2410715 |
Uyama O et al. | The effect of a thromboxane synthetase inhibitor, OKY-046, on urinary excretion of immunoreactive thromboxane B2 and 6-keto-prostaglandin F1 alpha in patients with ischemic cerebrovascular disease. | 1985 Mar-Apr | Stroke | pmid:3883580 |
Fujimoto T et al. | Cerebrovascular injuries induced by activation of platelets in vivo. | 1985 Mar-Apr | Stroke | pmid:3975962 |
Lamy M et al. | Biochemical pathways of acute lung injury. | 1985 May-Jun | Bull Eur Physiopathol Respir | pmid:3873973 |
Jolly SR et al. | Platelet depletion in experimental myocardial infarction. | 1985 May-Jun | Basic Res. Cardiol. | pmid:4026785 |
Hillbom M et al. | Effects of ethanol on platelet function. | 1985 May-Jun | Alcohol | pmid:4026960 |
Codde JP et al. | Changes in prostanoid synthesis in response to diet and hypertension in one-kidney, one clip rats. | 1985 Nov-Dec | Hypertension | pmid:3908314 |
Nagatsuka K et al. | A new approach to antithrombotic therapy--evaluation of combined therapy of thromboxane synthetase inhibitor and very low dose of aspirin. | 1985 Sep-Oct | Stroke | pmid:3931302 |
Pfliegler G et al. | Platelet function studies in myeloproliferative disorders. | 1986 | Folia Haematol. Int. Mag. Klin. Morphol. Blutforsch. | pmid:2435631 |
Bjøro K et al. | Formation of prostanoids in human umbilical vessels perfused in vitro. | 1986 | Prostaglandins | pmid:3523623 |
Bjøro K | Prostacyclin and thromboxane formation in human umbilical arteries following stimulation with vasoactive autacoids. | 1986 | Prostaglandins | pmid:3523624 |
Schleimer RP et al. | Selective inhibition of arachidonic acid metabolite release from human lung tissue by antiinflammatory steroids. | 1986 | J. Immunol. | pmid:3082976 |
Chiricolo M et al. | Prostaglandin and thromboxane biosynthesis in resting and activated platelet-free monocytes from aged subjects. | 1986 | Gerontology | pmid:3086183 |
Perico N et al. | Effect of short-term cyclosporine administration in rats on renin-angiotensin and thromboxane A2: possible relevance to the reduction in glomerular filtration rate. | 1986 | J. Pharmacol. Exp. Ther. | pmid:3531461 |
Cunnane SC et al. | n-3 Essential fatty acids decrease weight gain in genetically obese mice. | 1986 | Br. J. Nutr. | pmid:3676212 |
Hsu CY et al. | Increased thromboxane level in experimental spinal cord injury. | 1986 | J. Neurol. Sci. | pmid:3525758 |
Slotman GJ et al. | Thromboxane A2 mediates hemodynamic and respiratory dysfunction in graded bacteremia. | 1986 | Surgery | pmid:3526603 |
Fischer S et al. | Formation of prostacyclin and thromboxane in man as measured by the main urinary metabolites. | 1986 | Biochim. Biophys. Acta | pmid:3754157 |
Schenkein HA | LPS-stimulated release of prostaglandin E and thromboxane B2 from the U937 cell line. | 1986 | Cell. Immunol. | pmid:3100058 |
Ali M and Mohammed SY | Selective suppression of platelet thromboxane formation with sparing of vascular prostacyclin synthesis by aqueous extract of garlic in rabbits. | 1986 | Prostaglandins Leukot Med | pmid:3547414 |
Simonson MS and Dunn MJ | Leukotriene C4 and D4 contract rat glomerular mesangial cells. | 1986 | Kidney Int. | pmid:3465969 |
Arai M | [Plasma thromboxane B2 levels in various liver diseases]. | 1986 | Nihon Shokakibyo Gakkai Zasshi | pmid:3735742 |
Schneidkraut MJ et al. | Regional release of cyclooxygenase products after radiation exposure of the rat. | 1986 | J. Appl. Physiol. | pmid:3096935 |
Catapano AL et al. | Bile lipids, platelet aggregability and pro-ApoAI processing in 2 cases of Tangier disease. | 1986 | Monogr Atheroscler | pmid:3736556 |
Semrad SD et al. | Hypertension in bulls and steers anesthetized with guaifenesin-thiobarbiturate-halothane combination. | 1986 | Am. J. Vet. Res. | pmid:3740628 |
Cao QL | [Dynamic analysis of plasma TXB2 determined by radioimmunoassay in 30 cases of cerebral infarction]. | 1986 | Zhonghua Shen Jing Jing Shen Ke Za Zhi | pmid:3743234 |
Knapp HR et al. | In vivo indexes of platelet and vascular function during fish-oil administration in patients with atherosclerosis. | 1986 | N. Engl. J. Med. | pmid:3007982 |
Ono N et al. | Pharmacological studies on proglumetacin maleate, a new non-steroidal anti-inflammatory drug (4). Mode of action on anti-inflammatory activity. | 1986 | Jpn. J. Pharmacol. | pmid:3102823 |
Laffi G et al. | Effects of sulindac and ibuprofen in patients with cirrhosis and ascites. An explanation for the renal-sparing effect of sulindac. | 1986 | Gastroenterology | pmid:3079594 |
Ishihara Y et al. | Effect of thromboxane synthetase inhibitors (OKY-046, OKY-1580) on experimentally induced air embolism in anesthetized dogs. | 1986 | Prostaglandins Leukot Med | pmid:3457388 |
Schenkein HA | Prostaglandin E and thromboxane B2 release by PMA-induced U937 cells in response to C3b. | 1986 | J. Leukoc. Biol. | pmid:3457882 |
Kääpä P et al. | Increased platelet thromboxane B2 production in newborn infants of diabetic mothers. | 1986 | Prostaglandins Leukot Med | pmid:3458263 |
Kudo K et al. | [Urinary excretion of thromboxane B2 in normal human subjects: sex and age differences]. | 1986 | Nippon Naika Gakkai Zasshi | pmid:3746076 |
Weiner BH et al. | Inhibition of atherosclerosis by cod-liver oil in a hyperlipidemic swine model. | 1986 | N. Engl. J. Med. | pmid:3748103 |
Catella F et al. | 11-Dehydrothromboxane B2: a quantitative index of thromboxane A2 formation in the human circulation. | 1986 | Proc. Natl. Acad. Sci. U.S.A. | pmid:3461463 |
DiMinno G et al. | Trial of repeated low-dose aspirin in diabetic angiopathy. | 1986 | Blood | pmid:3092890 |
Mueller HS et al. | Platelet hyperactivity in acute myocardial infarction in man--effects of prostacyclin. | 1986 | Herz | pmid:2939012 |
Legrand YJ et al. | Activation of platelets by microfibrils and collagen. A comparative study. | 1986 | Lab. Invest. | pmid:2939291 |
Connellan JM et al. | Investigation of alternative mechanisms of collagen-induced platelet activation by using monoclonal antibodies to glycoprotein IIb-IIIa and fibrinogen. | 1986 | Thromb. Haemost. | pmid:2940722 |
Eldrup-Jorgensen J et al. | Antiplatelet therapy and vascular grafts. Studies in a baboon ex vivo shunt. | 1986 | Arch Surg | pmid:2940991 |
Arai M et al. | Platelet dysfunction and alteration of prostaglandin metabolism after chronic alcohol consumption. | 1986 | Scand. J. Gastroenterol. | pmid:3810010 |
Chiang TM and Kang AH | The effect of platelet surface protein phosphorylation on collagen-platelet interaction. | 1986 | Thromb. Res. | pmid:3810565 |
Perkett EA et al. | Lymphocyte and granulocyte migration across the endothelial layer of bovine pulmonary artery intimal explants towards lymphocyte conditioned medium. | 1986 | Tissue Cell | pmid:3810636 |
Cerletti C et al. | Comparison of the effects of oral and intravenous aspirin administration on platelet and peripheral vascular cyclo-oxygenase activity: studies in rats and in man. | 1986 | Agents Actions Suppl. | pmid:3101444 |
Perico N et al. | Functional significance of exaggerated renal thromboxane A2 synthesis induced by cyclosporin A. | 1986 | Am. J. Physiol. | pmid:3094383 |
Gyllenhammar H et al. | Essential fatty acid deficiency in rats: effects on arachidonate metabolism, generation of cyclooxygenase products and functional responses in neutrophils. | 1986 | Immunol. Lett. | pmid:3095230 |
Tremoli E et al. | Dietary interventions in north Karelia, Finland and south Italy. Modification of thromboxane B2 formation in platelets of male subjects only. | 1986 | Atherosclerosis | pmid:3964338 |
Boukili MA et al. | Pharmacological modulation of the effects of N-formyl-L-methionyl-L-leucyl-L-phenylalanine in guinea-pigs: involvement of the arachidonic acid cascade. | 1986 | Br. J. Pharmacol. | pmid:3096407 |
Pohanka E and Sinzinger H | Effect of a single pentoxifylline administration on platelet sensitivity, plasma factor activity, plasma-6-oxo-PGF1 alpha and thromboxane B2 in healthy volunteers. | 1986 | Prostaglandins Leukot Med | pmid:3523540 |
Masi I et al. | Effects of CDP-choline on platelet aggregation and the antiaggregatory activity of arterial wall in the rat. | 1986 | Pharmacol Res Commun | pmid:3523545 |
Winn R et al. | Lung permeability and hemodynamics during endotoxemia: effect of aprotinin. | 1986 | J. Surg. Res. | pmid:2431222 |