MeSH term | MeSH ID | Detail |
---|---|---|
Acute Coronary Syndrome | D054058 | 11 associated lipids |
Airway Remodeling | D056151 | 3 associated lipids |
Acute Kidney Injury | D058186 | 34 associated lipids |
Thromboxane b2 is a lipid of Fatty Acyls (FA) class. Thromboxane b2 is associated with abnormalities such as endothelial dysfunction, Diabetes Mellitus, Non-Insulin-Dependent, Diabetes Mellitus, Ischemia and Thrombocytosis. The involved functions are known as Platelet Activation, Excretory function, Anabolism, Inflammation and mRNA Expression. Thromboxane b2 often locates in Endothelium, Hepatic and Microsomes, Liver. The associated genes with Thromboxane b2 are PTGS2 gene, prothrombin fragment 2 and CCL14 wt Allele.
To understand associated biological information of Thromboxane b2, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
Thromboxane b2 is suspected in endothelial dysfunction, Diabetes Mellitus, Non-Insulin-Dependent, Diabetes Mellitus, Ischemia, Thrombocytosis, Acute Coronary Syndrome and other diseases in descending order of the highest number of associated sentences.
Disease | Cross reference | Weighted score | Related literature |
---|
We collected disease MeSH terms mapped to the references associated with Thromboxane b2
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
Location | Cross reference | Weighted score | Related literatures |
---|
Function | Cross reference | Weighted score | Related literatures |
---|
There are no associated biomedical information in the current reference collection.
Gene | Cross reference | Weighted score | Related literatures |
---|
There are no associated biomedical information in the current reference collection.
Authors | Title | Published | Journal | PubMed Link |
---|---|---|---|---|
Eynard AR et al. | Platelet formation of 12-hydroxyeicosatetraenoic acid and thromboxane B2 is increased in type IIA hypercholesterolemic subjects. | 1986 | Atherosclerosis | pmid:3085686 |
Pfliegler G et al. | Platelet function studies in myeloproliferative disorders. | 1986 | Folia Haematol. Int. Mag. Klin. Morphol. Blutforsch. | pmid:2435631 |
Bjøro K et al. | Formation of prostanoids in human umbilical vessels perfused in vitro. | 1986 | Prostaglandins | pmid:3523623 |
Bjøro K | Prostacyclin and thromboxane formation in human umbilical arteries following stimulation with vasoactive autacoids. | 1986 | Prostaglandins | pmid:3523624 |
Chesterman CN et al. | Substrate for endothelial prostacyclin production in the presence of platelets exposed to collagen is derived from the platelets rather than the endothelium. | 1986 | Blood | pmid:3085750 |
Hughes RD et al. | 9 beta-methylcarbacyclin, a stable prostacyclin analogue, in prevention of platelet losses during charcoal haemoperfusion. | 1986 | J. Pharm. Pharmacol. | pmid:2869131 |
Uraemic platelets. | 1986 | Lancet | pmid:2870380 | |
Roberts MS et al. | Slow-release aspirin and prostaglandin inhibition. | 1986 | Lancet | pmid:2871403 |
Schleimer RP et al. | Selective inhibition of arachidonic acid metabolite release from human lung tissue by antiinflammatory steroids. | 1986 | J. Immunol. | pmid:3082976 |
Chiricolo M et al. | Prostaglandin and thromboxane biosynthesis in resting and activated platelet-free monocytes from aged subjects. | 1986 | Gerontology | pmid:3086183 |
Tripp CS et al. | Monocyte migration explains the changes in macrophage arachidonate metabolism during the immune response. | 1986 | Proc. Natl. Acad. Sci. U.S.A. | pmid:3099288 |
Perico N et al. | Effect of short-term cyclosporine administration in rats on renin-angiotensin and thromboxane A2: possible relevance to the reduction in glomerular filtration rate. | 1986 | J. Pharmacol. Exp. Ther. | pmid:3531461 |
Cunnane SC et al. | n-3 Essential fatty acids decrease weight gain in genetically obese mice. | 1986 | Br. J. Nutr. | pmid:3676212 |
Hsu CY et al. | Increased thromboxane level in experimental spinal cord injury. | 1986 | J. Neurol. Sci. | pmid:3525758 |
Slotman GJ et al. | Thromboxane A2 mediates hemodynamic and respiratory dysfunction in graded bacteremia. | 1986 | Surgery | pmid:3526603 |
Ylikorkala O et al. | Maternal ingestion of acetylsalicylic acid inhibits fetal and neonatal prostacyclin and thromboxane in humans. | 1986 | Am. J. Obstet. Gynecol. | pmid:3526896 |
Ylikorkala O et al. | Fetal and neonatal prostacyclin and thromboxane in relation to mode of delivery. | 1986 | Arch. Dis. Child. | pmid:3527082 |
Mäkilä UM et al. | Placental thromboxane and prostacyclin in the regulation of placental blood flow. | 1986 | Obstet Gynecol | pmid:3528955 |
Fischer S et al. | Formation of prostacyclin and thromboxane in man as measured by the main urinary metabolites. | 1986 | Biochim. Biophys. Acta | pmid:3754157 |
Laekeman GM et al. | Prostacyclin and thromboxane in benign and malignant breast tumours. | 1986 | Br. J. Cancer | pmid:3530307 |
Quilley CP and Rifkind AB | Prostaglandin release by the chick embryo heart is increased by 2,3,7,8-tetrachlorodibenzo-p-dioxin and by other cytochrome P-448 inducers. | 1986 | Biochem. Biophys. Res. Commun. | pmid:3085671 |
Huijgens PC et al. | Aspirin does not inhibit human megakaryocyte thromboxane synthesis in vivo. | 1986 | Scand J Haematol | pmid:3081996 |
Henriksson P et al. | In vivo production of prostacyclin and thromboxane in patients with acute myocardial infarction. | 1986 | Br Heart J | pmid:3521690 |
Fitzgerald DJ et al. | Platelet activation in unstable coronary disease. | 1986 | N. Engl. J. Med. | pmid:3531859 |
Shimanuki T et al. | A kinetic analysis of peritoneal fluid cytology and arachidonic acid metabolism after abrasion and reabrasion of rabbit peritoneum. | 1986 | J. Surg. Res. | pmid:3463833 |
Schenkein HA | LPS-stimulated release of prostaglandin E and thromboxane B2 from the U937 cell line. | 1986 | Cell. Immunol. | pmid:3100058 |
Rogers TS et al. | Differential alteration of lipoxygenase and cyclooxygenase metabolism by rat peritoneal macrophages induced by endotoxin tolerance. | 1986 | Prostaglandins | pmid:3088676 |
Harris DN et al. | Inhibition of prostaglandin biosynthesis by SQ 28,852, a 7-oxabicyclo[2.2.1]heptane analog. | 1986 | Prostaglandins | pmid:3088677 |
Küster LJ et al. | Mechanism of PAF-induced platelet aggregation in man. | 1986 | Thromb. Res. | pmid:3764802 |
Sadovskaia VL et al. | [Study of prostaglandins and thromboxanes B2 using mass-spectrometry of secondary ions]. | 1986 | Bioorg. Khim. | pmid:3768052 |
Wang Z et al. | [Preliminary report on the application of thromboxane B2 radioimmunoassay]. | 1986 | Zhongguo Yi Xue Ke Xue Yuan Xue Bao | pmid:2953485 |
Ali M and Mohammed SY | Selective suppression of platelet thromboxane formation with sparing of vascular prostacyclin synthesis by aqueous extract of garlic in rabbits. | 1986 | Prostaglandins Leukot Med | pmid:3547414 |
Fang YX et al. | Beneficial changes in prostacyclin and thromboxane A2 induced by ginsenosides in myocardial infarction and reperfusion injury in dogs. | 1986 | Zhongguo Yao Li Xue Bao | pmid:2954367 |
Carrico CJ et al. | Multiple-organ-failure syndrome. | 1986 | Arch Surg | pmid:3484944 |
Simonson MS and Dunn MJ | Leukotriene C4 and D4 contract rat glomerular mesangial cells. | 1986 | Kidney Int. | pmid:3465969 |
Simpson PJ et al. | Reduction in the incidence of thrombosis by the thromboxane synthetase inhibitor CGS 13080 in a canine model of coronary artery injury. | 1986 | J. Pharmacol. Exp. Ther. | pmid:3735129 |
Arai M | [Plasma thromboxane B2 levels in various liver diseases]. | 1986 | Nihon Shokakibyo Gakkai Zasshi | pmid:3735742 |
Schneidkraut MJ et al. | Regional release of cyclooxygenase products after radiation exposure of the rat. | 1986 | J. Appl. Physiol. | pmid:3096935 |
Catapano AL et al. | Bile lipids, platelet aggregability and pro-ApoAI processing in 2 cases of Tangier disease. | 1986 | Monogr Atheroscler | pmid:3736556 |
Semrad SD et al. | Hypertension in bulls and steers anesthetized with guaifenesin-thiobarbiturate-halothane combination. | 1986 | Am. J. Vet. Res. | pmid:3740628 |
Cao QL | [Dynamic analysis of plasma TXB2 determined by radioimmunoassay in 30 cases of cerebral infarction]. | 1986 | Zhonghua Shen Jing Jing Shen Ke Za Zhi | pmid:3743234 |
Xie P | [Clinical significance of TXB2 level in CSF of patients with acute cerebrovascular diseases]. | 1986 | Zhonghua Shen Jing Jing Shen Ke Za Zhi | pmid:3743244 |
Yang Y | [Analysis of serum TXB2 in essential hypertension]. | 1986 | Zhonghua Xin Xue Guan Bing Za Zhi | pmid:3743385 |
Marasini B et al. | Cigarette smoking and platelet function. | 1986 | Thromb. Res. | pmid:3787563 |
Matsuo T et al. | A new thrombin inhibitor MD805 and thrombocytopenia encountered with heparin hemodialysis. | 1986 | Thromb. Res. | pmid:3787568 |
Shibamoto T and Kobayashi T | Acute effect of paraquat on lung fluid balance and prostanoid production in awake sheep. | 1986 | Am. Rev. Respir. Dis. | pmid:3789525 |
Knapp HR et al. | In vivo indexes of platelet and vascular function during fish-oil administration in patients with atherosclerosis. | 1986 | N. Engl. J. Med. | pmid:3007982 |
Ono N et al. | Pharmacological studies on proglumetacin maleate, a new non-steroidal anti-inflammatory drug (4). Mode of action on anti-inflammatory activity. | 1986 | Jpn. J. Pharmacol. | pmid:3102823 |
Bucchi F et al. | Salicylate may prevent the inhibitory effect of indomethacin on serum thromboxane formation in man. | 1986 | Prostaglandins Leukot Med | pmid:3456617 |
Laffi G et al. | Effects of sulindac and ibuprofen in patients with cirrhosis and ascites. An explanation for the renal-sparing effect of sulindac. | 1986 | Gastroenterology | pmid:3079594 |
Ishihara Y et al. | Effect of thromboxane synthetase inhibitors (OKY-046, OKY-1580) on experimentally induced air embolism in anesthetized dogs. | 1986 | Prostaglandins Leukot Med | pmid:3457388 |
Schenkein HA | Prostaglandin E and thromboxane B2 release by PMA-induced U937 cells in response to C3b. | 1986 | J. Leukoc. Biol. | pmid:3457882 |
Kääpä P et al. | Increased platelet thromboxane B2 production in newborn infants of diabetic mothers. | 1986 | Prostaglandins Leukot Med | pmid:3458263 |
Kudo K et al. | [Urinary excretion of thromboxane B2 in normal human subjects: sex and age differences]. | 1986 | Nippon Naika Gakkai Zasshi | pmid:3746076 |
Weiner BH et al. | Inhibition of atherosclerosis by cod-liver oil in a hyperlipidemic swine model. | 1986 | N. Engl. J. Med. | pmid:3748103 |
Oei HH et al. | Inhibition of thromboxane biosynthesis in splanchnic ischemia shock. | 1986 | Circ. Shock | pmid:3753907 |
Catella F et al. | 11-Dehydrothromboxane B2: a quantitative index of thromboxane A2 formation in the human circulation. | 1986 | Proc. Natl. Acad. Sci. U.S.A. | pmid:3461463 |
Carey F and Haworth D | Thromboxane synthase inhibition: implications for prostaglandin endoperoxide metabolism. II. Testing the 'redirection hypothesis' in an acute intravenous challenge model. | 1986 | Prostaglandins | pmid:3754057 |
Krishnamurthi S et al. | Synergistic potentiation of 5-hydroxytryptamine secretion by platelet agonists and phorbol myristate acetate despite inhibition of agonist-induced arachidonate/thromboxane and beta-thromboglobulin release and Ca2+ mobilization by phorbol myristate acetate. | 1986 | Biochem. J. | pmid:2948494 |
Zadoff AD et al. | Diethylcarbamazine on pulmonary vascular response to endotoxin in awake sheep. | 1986 | J. Appl. Physiol. | pmid:3754554 |
Arima T et al. | [Synthesis of prostaglandins (TXB2 and 6-keto-PGF1 alpha) during cardiopulmonary bypass]. | 1986 | Masui | pmid:3754591 |
Teitelbaum I et al. | Effect of cAMP on prostaglandin E2 production in cultured rat inner medullary collecting tubule cells. | 1986 | Am. J. Physiol. | pmid:3020997 |
DiMinno G et al. | Trial of repeated low-dose aspirin in diabetic angiopathy. | 1986 | Blood | pmid:3092890 |
Turi S et al. | Abnormalities of vascular prostaglandins in Henoch-Schönlein purpura. | 1986 | Arch. Dis. Child. | pmid:2420289 |
Traber DL et al. | The pulmonary lesion of smoke inhalation in an ovine model. | 1986 | Circ. Shock | pmid:2421939 |
Yardumian DA et al. | Platelet function studies during and after infusions of ZK 36374, a stable prostacyclin analogue, to healthy volunteers. | 1986 | Haemostasis | pmid:2422095 |
Hartung HP et al. | Substance P: binding properties and studies on cellular responses in guinea pig macrophages. | 1986 | J. Immunol. | pmid:2422264 |
Zucker ML et al. | Platelet function in hypercholesterolemics before and after hypolipidemic drug therapy. | 1986 | Haemostasis | pmid:2939008 |
Mueller HS et al. | Platelet hyperactivity in acute myocardial infarction in man--effects of prostacyclin. | 1986 | Herz | pmid:2939012 |
Legrand YJ et al. | Activation of platelets by microfibrils and collagen. A comparative study. | 1986 | Lab. Invest. | pmid:2939291 |
Connellan JM et al. | Investigation of alternative mechanisms of collagen-induced platelet activation by using monoclonal antibodies to glycoprotein IIb-IIIa and fibrinogen. | 1986 | Thromb. Haemost. | pmid:2940722 |
Eldrup-Jorgensen J et al. | Antiplatelet therapy and vascular grafts. Studies in a baboon ex vivo shunt. | 1986 | Arch Surg | pmid:2940991 |
Kirschenbaum MA and Chaudhari A | Effect of experimental diabetes on glomerular filtration rate and glomerular prostanoid production in the rat. | 1986 | Miner Electrolyte Metab | pmid:3807832 |
Arai M et al. | Platelet dysfunction and alteration of prostaglandin metabolism after chronic alcohol consumption. | 1986 | Scand. J. Gastroenterol. | pmid:3810010 |
Altieri DC et al. | von Willebrand factor contaminating porcine factor VIII concentrate (Hyate:C) causes platelet aggregation. | 1986 | Br. J. Haematol. | pmid:2942172 |
Fareed J et al. | Molecular markers of hemostatic activation in atherosclerosis: a new concept in diagnostic profiling of endogenous pathophysiologic transition. | 1986 | Semin. Thromb. Hemost. | pmid:2943019 |
Chiang TM and Kang AH | The effect of platelet surface protein phosphorylation on collagen-platelet interaction. | 1986 | Thromb. Res. | pmid:3810565 |
Schleimer RP et al. | Characterization of inflammatory mediator release from purified human lung mast cells. | 1986 | Am. Rev. Respir. Dis. | pmid:3485946 |
Perkett EA et al. | Lymphocyte and granulocyte migration across the endothelial layer of bovine pulmonary artery intimal explants towards lymphocyte conditioned medium. | 1986 | Tissue Cell | pmid:3810636 |
Gairola CG and Tai HH | Cigarette smoke-induced alterations in the release of arachidonate metabolites by pulmonary alveolar macrophage from selenium-fed and selenium-deficient rats. | 1986 | Biochem. Pharmacol. | pmid:3015150 |
Kudo K et al. | Urinary excretion of TXB2 after angiotensin converting enzyme inhibition in hypertensive patients. | 1986 | Prostaglandins Leukot Med | pmid:3006084 |
Addonizio VP et al. | Effects of verapamil and diltiazem on human platelet function. | 1986 | Am. J. Physiol. | pmid:3006516 |
Uehara S et al. | Effects of the calcium antagonist nifedipine on thromboxane B2 level and platelet aggregation in hypertensive patients. | 1986 | Arzneimittelforschung | pmid:3814228 |
Greer IA et al. | Endothelial stimulation by DDAVP in von Willebrand's disease and haemophilia. | 1986 | Haemostasis | pmid:3084364 |
Cerletti C et al. | Comparison of the effects of oral and intravenous aspirin administration on platelet and peripheral vascular cyclo-oxygenase activity: studies in rats and in man. | 1986 | Agents Actions Suppl. | pmid:3101444 |
Perico N et al. | Functional significance of exaggerated renal thromboxane A2 synthesis induced by cyclosporin A. | 1986 | Am. J. Physiol. | pmid:3094383 |
Laffi G et al. | Altered renal and platelet arachidonic acid metabolism in cirrhosis. | 1986 | Gastroenterology | pmid:3079716 |
Gyllenhammar H et al. | Essential fatty acid deficiency in rats: effects on arachidonate metabolism, generation of cyclooxygenase products and functional responses in neutrophils. | 1986 | Immunol. Lett. | pmid:3095230 |
Tremoli E et al. | Dietary interventions in north Karelia, Finland and south Italy. Modification of thromboxane B2 formation in platelets of male subjects only. | 1986 | Atherosclerosis | pmid:3964338 |
Al-Hassan JM et al. | Vasoconstrictor components in the Arabian Gulf catfish (Arius thalassinus, Ruppell) proteinaceous skin secretion. | 1986 | Toxicon | pmid:3824400 |
Hoult JR et al. | Failure of anti-inflammatory steroids to inhibit prostaglandin release from the hydronephrotic rabbit kidney. | 1986 | Agents Actions | pmid:3962772 |
Boukili MA et al. | Pharmacological modulation of the effects of N-formyl-L-methionyl-L-leucyl-L-phenylalanine in guinea-pigs: involvement of the arachidonic acid cascade. | 1986 | Br. J. Pharmacol. | pmid:3096407 |
Hsueh W et al. | Release of leukotriene C4 by isolated, perfused rat small intestine in response to platelet-activating factor. | 1986 | J. Clin. Invest. | pmid:3459734 |
Slotman GJ et al. | Interaction of prostaglandins, activated complement, and granulocytes in clinical sepsis and hypotension. | 1986 | Surgery | pmid:3520916 |
Pohanka E and Sinzinger H | Effect of a single pentoxifylline administration on platelet sensitivity, plasma factor activity, plasma-6-oxo-PGF1 alpha and thromboxane B2 in healthy volunteers. | 1986 | Prostaglandins Leukot Med | pmid:3523540 |
Küster LJ and Frölich JC | Platelet aggregation and thromboxane release induced by arachidonic acid, collagen, ADP and platelet-activating factor following low dose acetylsalicylic acid in man. | 1986 | Prostaglandins | pmid:3097760 |
Masi I et al. | Effects of CDP-choline on platelet aggregation and the antiaggregatory activity of arterial wall in the rat. | 1986 | Pharmacol Res Commun | pmid:3523545 |
Shinonaga M et al. | [Sequential measurements of TxB2 and 6-keto PGF1 alpha in cerebrospinal fluid and serum in patients with subarachnoid hemorrhage]. | 1986 | Neurol. Med. Chir. (Tokyo) | pmid:2429203 |
Villa ML et al. | Primary in vitro antibody response in humans: role of adherent cells in the development of haemolytic colonies. | 1986 | Immunology | pmid:3460964 |
Winn R et al. | Lung permeability and hemodynamics during endotoxemia: effect of aprotinin. | 1986 | J. Surg. Res. | pmid:2431222 |