MeSH term | MeSH ID | Detail |
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Acute Coronary Syndrome | D054058 | 11 associated lipids |
Airway Remodeling | D056151 | 3 associated lipids |
Acute Kidney Injury | D058186 | 34 associated lipids |
Thromboxane b2 is a lipid of Fatty Acyls (FA) class. Thromboxane b2 is associated with abnormalities such as endothelial dysfunction, Diabetes Mellitus, Non-Insulin-Dependent, Diabetes Mellitus, Ischemia and Thrombocytosis. The involved functions are known as Platelet Activation, Excretory function, Anabolism, Inflammation and mRNA Expression. Thromboxane b2 often locates in Endothelium, Hepatic and Microsomes, Liver. The associated genes with Thromboxane b2 are PTGS2 gene, prothrombin fragment 2 and CCL14 wt Allele.
To understand associated biological information of Thromboxane b2, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
Thromboxane b2 is suspected in endothelial dysfunction, Diabetes Mellitus, Non-Insulin-Dependent, Diabetes Mellitus, Ischemia, Thrombocytosis, Acute Coronary Syndrome and other diseases in descending order of the highest number of associated sentences.
Disease | Cross reference | Weighted score | Related literature |
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We collected disease MeSH terms mapped to the references associated with Thromboxane b2
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
Location | Cross reference | Weighted score | Related literatures |
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Function | Cross reference | Weighted score | Related literatures |
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There are no associated biomedical information in the current reference collection.
Gene | Cross reference | Weighted score | Related literatures |
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There are no associated biomedical information in the current reference collection.
Authors | Title | Published | Journal | PubMed Link |
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Hwang DH | Characteristics of the aggregation of platelets and the formation of prostaglandins (PGs) in rat. | 1981 | Prog. Lipid Res. | pmid:7342108 |
Cook JA et al. | Elevated thromboxane levels in the rat during endotoxic shock: protective effects of imidazole, 13-azaprostanoic acid, or essential fatty acid deficiency. | 1980 | J. Clin. Invest. | pmid:7350199 |
Stuart MJ et al. | Effect of cholesterol on production of thromboxane b2 by platelets in vitro. | 1980 | N. Engl. J. Med. | pmid:7350406 |
Schrör K et al. | Preservation of ischemic myocardium by pinane thromboxane A2. | 1980 | Am. J. Physiol. | pmid:7356037 |
Hassid A and Dunn MJ | Microsomal prostaglandin biosynthesis of human kidney. | 1980 | J. Biol. Chem. | pmid:7358683 |
Kadowitz PJ and Hyman AL | Comparative effects of thromboxane B2 on the canine and feline pulmonary vascular bed. | 1980 | J. Pharmacol. Exp. Ther. | pmid:7365689 |
Patrono C et al. | Low dose aspirin and inhibition of thromboxane B2 production in healthy subjects. | 1980 Feb 1-15 | Thromb. Res. | pmid:7368167 |
Koh H et al. | A radioimmunoassay of thromboxane B2 with thromboxane B2-125I-tyramide and its application to the study on the thromboxane B2 formation during platelet aggregation. | 1980 Feb 1-15 | Thromb. Res. | pmid:7368170 |
Schlondorff D and Folkert VW | Prostaglandin synthesis in glomeruli from rats with unilateral ureteral obstruction. | 1980 | Adv Prostaglandin Thromboxane Res | pmid:7369028 |
Van Praag D and Farber SJ | Prostaglandin biosynthesis in normal and ureteral obstructed rabbit kidney; formation of a novel metabolite. | 1980 | Adv Prostaglandin Thromboxane Res | pmid:7369029 |
Kot PA et al. | Modification of the cardiovascular actions of prostaglandins by thromboxane B2. | 1980 | Adv Prostaglandin Thromboxane Res | pmid:7369035 |
Friedman LS et al. | Thromboxane B2 inhibits the pulmonary metabolism of PGE2 in the anesthetized dog. | 1980 | Adv Prostaglandin Thromboxane Res | pmid:7369063 |
Garfield RE et al. | Gap junction formation in myometrium: control by estrogens, progesterone, and prostaglandins. | 1980 | Am. J. Physiol. | pmid:7369350 |
Lewy RI et al. | Thromboxane release during pacing-induced angina pectoris: possible vasoconstrictor influence on the coronary vasculature. | 1980 | Circulation | pmid:7371128 |
Lewy RI | Effect of elevated plasma-free fatty acids on thromboxane release in patients with coronary artery disease. | 1980 | Haemostasis | pmid:7372200 |
Bishai I and Coceani F | Metabolism of PGH2 in the feline brain. | 1980 | Adv Prostaglandin Thromboxane Res | pmid:7376980 |
Galli C et al. | Factors affecting brain prostaglandin formation. | 1980 | Adv Prostaglandin Thromboxane Res | pmid:7376983 |
Blotman F et al. | PGE2, PGF2 alpha, and TXB2 biosynthesis by human rheumatoid synovia. | 1980 | Adv Prostaglandin Thromboxane Res | pmid:7377017 |
Katori M et al. | Changes of prostaglandin and thromboxane levels in pleural fluid of rat carrageenin-induced pleurisy. | 1980 | Adv Prostaglandin Thromboxane Res | pmid:7377020 |
Crutchley DJ et al. | Potentiation of thromboxane B2 release from guinea pig lung during anaphylaxis following exposure to 100% O2. | 1980 | Adv Prostaglandin Thromboxane Res | pmid:7377022 |
Morris HG and Sherman NA | Prostaglandin-like substances in urine of asthmatic patients. | 1980 | Adv Prostaglandin Thromboxane Res | pmid:7377024 |
Schoene NW et al. | Effects of diets varying in fat and P/S ratio on arachidonic acid metabolism in human platelets. | 1980 | Adv Prostaglandin Thromboxane Res | pmid:7377026 |
Smith EF et al. | Influence of thromboxane inhibition on the severity of myocardial ischemia in cats. | 1980 | Can. J. Physiol. Pharmacol. | pmid:7378931 |
Kent L et al. | Differential response of articular chondrocyte populations to thromboxane B2 and analogs of prostaglandin cyclic endoperoxides. | 1980 | Prostaglandins | pmid:7384546 |
Ellwood DA et al. | Specific changes in the in vitro production of prostanoids by the ovine cervix at parturition. | 1980 | Prostaglandins | pmid:7384553 |
Lagarde M et al. | Nicergoline, an anti-aggregating agent which inhibits release of arachidonic acid from human platelet phospholipids. | 1980 | Prostaglandins | pmid:7384555 |
Patrono C et al. | Radioimmunoassay of serum thromboxane B2: a simple method of assessing pharmacologic effects on platelet function. | 1980 | Adv Prostaglandin Thromboxane Res | pmid:7386257 |
Langs DA et al. | Thromboxane molecules are not hairpin conformers. | 1980 | Adv Prostaglandin Thromboxane Res | pmid:7386281 |
Bailey JM | Essential fatty acid requirements and metabolism of cells in tissue culture. | 1980 | Adv Prostaglandin Thromboxane Res | pmid:7386288 |
Galli C et al. | Effects of 8-monochloro-3-beta-diethylaminoethyl-4-methyl-7-ethoxy carboxyl methoxy coumarin (AD6) on aggregation, arachidonic acid metabolism and thromboxane B2 formation in human platelets. | 1980 | Pharmacol Res Commun | pmid:7393988 |
Oka M and Manku MS | Spironolactone decreases the formation of prostaglandins and related substances from arachidonic acid in rat vascular rings and human platelets. | 1980 | Prostaglandins Med | pmid:7394062 |
Karmali RA et al. | Intrarenal growth of the Walker 256 tumour and renal vein concentrations of PGE2, PGF 2 alpha, and TXB2: effects of diazepam. | 1980 | Prostaglandins Med | pmid:7394064 |
Cooper JD et al. | Prostaglandin production associated with the pulmonary vascular response to complement activation. | 1980 | Surgery | pmid:7394704 |
Anhut H et al. | Release of 15-keto-13, 14-dihydro-thromboxane B2 and prostaglandin D2 during anaphylaxis as measured by radioimmunoassay. | 1978 | Naunyn Schmiedebergs Arch. Pharmacol. | pmid:740052 |
Dupont J et al. | Effects of dietary essential fatty acid concentration upon prostanoid synthesis in rats. | 1980 | J. Nutr. | pmid:7400858 |
Rao GH et al. | Influence of epinephrine on the aggregation response of aspirin-treated platelets. | 1980 | Prostaglandins Med | pmid:7403340 |
Maclouf J et al. | Interactions of prostaglandin H2 and thromboxane A2 with human serum albumin. | 1980 | Eur. J. Biochem. | pmid:7408901 |
Hwang DH | Aggregation and inhibition of rat platelets, and the formation of endoperoxide metabolites. | 1980 | Prostaglandins Med | pmid:7413850 |
Cerskus AL et al. | Thromboxane B2 and 6-keto-prostaglandin F1 alpha synthesis during infusion of collagen and arachidonic acid in rabbits: inhibition by aspirin and sulfinpyrazone. | 1980 | Thromb. Res. | pmid:7414555 |
Tada M et al. | Significance of thromboxane A2 in myocardial ischemia in patients with coronary artery disease. | 1980 | Adv Myocardiol | pmid:7423053 |
Matsumoto M et al. | Thromboxane generation in patients with essential hypertension or cerebrovascular disease and effect of oral aspirin. | 1980 | Thromb. Haemost. | pmid:7423441 |
McManus LM et al. | Thromboxane B2 (TxB2) release during IgE anaphylaxis in the rabbit. | 1980 | J. Immunol. | pmid:7430618 |
Hwang DW et al. | Species variation in serum levels of prostaglandins and their precursor acids. | 1980 | Lipids | pmid:7432104 |
McMillan RM et al. | Malonaldehyde formation in intact platelets is catalysed by thromboxane synthase. | 1978 | Biochem. J. | pmid:743261 |
Chignard M et al. | Synthesis of thromboxane B2 in incubates of dog platelet-rich plasma with arachidonic acid and its inhibition by different drugs. | 1978 | Biochem. Biophys. Res. Commun. | pmid:743319 |
Bolton HS et al. | Prostaglandin synthesis by adult heart myocytes. | 1980 | J. Mol. Cell. Cardiol. | pmid:7441771 |
Dejana E et al. | Impaired thromboxane production by newly formed platelets after aspirin administration to thrombocytopenic rats. | 1980 | Br. J. Haematol. | pmid:7448129 |
Catalano PM et al. | Platelet recovery from aspirin inhibition in vivo; differing patterns under various assay conditions. | 1981 | Blood | pmid:7448419 |
Ylikorkala O and Viinikka L | Thromboxane A2 in pregnancy and puerperium. | 1980 | Br Med J | pmid:7448530 |
Mitchell MD and Robinson JS | Concentrations of 6-oxo-prostaglandin F1 alpha and thromboxane B2 in the tracheal fluid of foetal sheep. | 1978 | J. Endocrinol. | pmid:744937 |
Bone EA et al. | The effects of strontium and calcium ions on 5-hydroxytryptamine secretion and thromboxane B2 biosynthesis in washed human platelets. | 1980 | Biochem. Soc. Trans. | pmid:7450206 |
Mitchell MD | Prostaglandins at parturition and in the neonatal infant. | 1980 | Biochem. Soc. Trans. | pmid:7450282 |
Halushka PV et al. | Increased platelet thromboxane synthesis in diabetes mellitus. | 1981 | J. Lab. Clin. Med. | pmid:7452084 |
Wise WC et al. | Ibuprofen improves survival from endotoxic shock in the rat. | 1980 | J. Pharmacol. Exp. Ther. | pmid:7452480 |
Subbiah MT et al. | Studies of aggregation and thromboxane B2 synthesis in avian thrombocytes: comparison between atherosclerosis-susceptible and resistant breeds. | 1980 | Thromb. Haemost. | pmid:7455983 |
Pace-Asciak CR and Edwards NS | Tetranor thromboxane B2 is the principal urinary catabolite formed after i.v. infusion of thromboxane B2 in the rat. | 1980 | Biochem. Biophys. Res. Commun. | pmid:7458943 |
Viinikka L and Ylikorkala O | Measurement of thromboxane B2 in human plasma or serum by radioimmunoassay. | 1980 | Prostaglandins | pmid:7465865 |
Lagarde M et al. | Increase of platelet thromboxane A2 formation and of its plasmatic half-life in diabetes mellitus. | 1980 | Thromb. Res. | pmid:7466751 |
Beck N and Shaw JO | Thromboxane B2 and prostaglandin E2 in the K+-depleted rat kidney. | 1981 | Am. J. Physiol. | pmid:7468800 |
Setty BN et al. | Sickle cell vaso-occlusive crisis is associated with abnormalities in the ratio of vasoconstrictor to vasodilator prostanoids. | 1995 | Pediatr. Res. | pmid:7478805 |
Ono Y et al. | Improvement in blood flow and diabetic neuropathy by thromboxane A2 dual blocker KDI-792. | 1995 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:7480076 |
Ali M and Thomson M | Consumption of a garlic clove a day could be beneficial in preventing thrombosis. | 1995 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:7480084 |
Myers SI et al. | Acute burn down regulates rabbit splanchnic and renal prostanoid release. | 1995 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:7480086 |
Hotta N et al. | Prevention of abnormalities in motor nerve conduction and nerve blood-flow by a prostacyclin analog, beraprost sodium, in streptozotocin-induced diabetic rats. | 1995 | Prostaglandins | pmid:7480803 |
Petroni A et al. | Inhibition of platelet aggregation and eicosanoid production by phenolic components of olive oil. | 1995 | Thromb. Res. | pmid:7482432 |
Eisenmann CJ and Miller RK | The effect of selenium compounds (selenite, selenate, ebselen) on the production of thromboxane and prostacyclin by the human term placenta in vitro. | 1995 | Toxicol. Appl. Pharmacol. | pmid:7482536 |
Hoballah JJ et al. | Lazaroid U74389G attenuates skeletal muscle reperfusion injury in a canine model. | 1995 | Transplant. Proc. | pmid:7482936 |
Huang HL and Rao MR | [Effects of neferine and its combination with taurine on platelet aggregation and experimental thrombosis in rats]. | 1995 | Yao Xue Xue Bao | pmid:7484155 |
Agradi E et al. | Influence of short term dietary supplementation of different lipids on aggregation and arachidonic acid metabolism in rabbit platelets. | 1978 | Prostaglandins | pmid:748984 |
Badalamenti S et al. | Renal effects of dietary supplementation with fish oil in cyclosporine-treated liver transplant recipients. | 1995 | Hepatology | pmid:7489976 |
Hui R et al. | Human immunodeficiency virus type 1 envelope protein does not stimulate either prostaglandin formation or the expression of prostaglandin H synthase in THP-1 human monocytes/macrophages. | 1995 | J. Virol. | pmid:7494315 |
Peaceman AM and Rehnberg KA | The effect of aspirin and indomethacin on prostacyclin and thromboxane production by placental tissue incubated with immunoglobulin G fractions from patients with lupus anticoagulant. | 1995 | Am. J. Obstet. Gynecol. | pmid:7503174 |
Wright RM et al. | Lipopolysaccharide induces interleukin-6 release from rat peritoneal macrophages in vitro: evidence for a novel mechanism. | 1993 | Circ. Shock | pmid:7505726 |
Paul-Eugene N et al. | Biochemical and functional alterations induced by CD23 ligation in the human promonocytic cell line U937. | 1993 | Immunology | pmid:7507091 |
Hay DW et al. | Relative contributions of direct and indirect mechanisms mediating endothelin-induced contraction of guinea-pig trachea. | 1993 | Br. J. Pharmacol. | pmid:7507780 |
Paul-Eugène N et al. | Beta 2-adrenoceptor agonists regulate the IL-4-induced phenotypical changes and IgE-dependent functions in normal human monocytes. | 1994 | J. Leukoc. Biol. | pmid:7509842 |
Hohlfeld T et al. | Antiplatelet effects of ticlopidine are reduced in experimental hypercholesterolemia. | 1994 | Thromb. Haemost. | pmid:7513092 |
Johnson BF et al. | Urinary thromboxane and 6-keto-prostaglandin F1 alpha are early markers of acute rejection in experimental pancreas transplantation. | 1994 | Transplantation | pmid:7518618 |
Grabarek J et al. | Human kit ligand (stem cell factor) modulates platelet activation in vitro. | 1994 | J. Biol. Chem. | pmid:7520441 |
Pan YZ et al. | [The clinical significance of platelet activation during exercise-induced myocardial ischemia]. | 1994 | Zhonghua Nei Ke Za Zhi | pmid:7520851 |
Kusner EJ et al. | The 5-lipoxygenase inhibitors ZD2138 and ZM230487 are potent and selective inhibitors of several antigen-induced guinea-pig pulmonary responses. | 1994 | Eur. J. Pharmacol. | pmid:7522174 |
Michelson AD et al. | Reversible inhibition of human platelet activation by hypothermia in vivo and in vitro. | 1994 | Thromb. Haemost. | pmid:7522354 |
Kuroda T et al. | Effects of leukocyte and platelet depletion on ischemia--reperfusion injury to dog pancreas. | 1994 | Gastroenterology | pmid:7523218 |
Meyer J et al. | Increased organ blood flow in chronic endotoxemia is reversed by nitric oxide synthase inhibition. | 1994 | J. Appl. Physiol. | pmid:7523359 |
Hohlfeld T et al. | Protection of reperfused ischemic pig myocardium by nexopamil, a new combined Ca2+ and serotonin antagonist. | 1994 | J. Cardiovasc. Pharmacol. | pmid:7523784 |
Tabuchi N et al. | Aprotinin preserves hemostasis in aspirin-treated patients undergoing cardiopulmonary bypass. | 1994 | Ann. Thorac. Surg. | pmid:7524460 |
Jörres A et al. | Urinary excretion of thromboxane and markers for renal injury in patients undergoing cardiopulmonary bypass. | 1994 | Artif Organs | pmid:7527629 |
Siegal T and Pfeffer MR | Radiation-induced changes in the profile of spinal cord serotonin, prostaglandin synthesis, and vascular permeability. | 1995 | Int. J. Radiat. Oncol. Biol. Phys. | pmid:7527800 |
Mitamura T et al. | Tacrolimus (FK506)-induced nephrotoxicity in spontaneous hypertensive rats. | 1994 | J Toxicol Sci | pmid:7533848 |
Landucci EC et al. | Inhibition of carrageenin-induced rat paw oedema by crotapotin, a polypeptide complexed with phospholipase A2. | 1995 | Br. J. Pharmacol. | pmid:7537590 |
Koch T et al. | Effects of stroma-free hemoglobin solutions on pulmonary vascular resistance and mediator release in the isolated perfused rabbit lung. | 1994 | Shock | pmid:7538430 |
Schierhorn K et al. | Gelatin sponge-supported histoculture of human nasal mucosa. | 1995 | In Vitro Cell. Dev. Biol. Anim. | pmid:7538857 |
Kawamori R et al. | Subclinical exocrine pancreatic derangement in human diabetic patients evaluated from pure pancreatic juice. | 1995 Apr-Jun | J. Diabetes Complicat. | pmid:7541259 |
Fujimoto K et al. | Neutrophil elastase inhibitor reduces asthmatic responses in allergic sheep. | 1995 | Respir Physiol | pmid:7541545 |
Horn EH et al. | Longitudinal studies of platelet cyclic AMP during healthy pregnancy and pregnancies at risk of pre-eclampsia. | 1995 | Clin. Sci. | pmid:7545563 |
Mest HJ et al. | Relevance of mediators to cardiac parameters of isolated anaphylactic guinea-pig heart. | 1995 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:7545818 |
Bartolini G et al. | Possible involvement of prostaglandin H synthase-1 induction in the differentiation of U-937 cells. | 1995 | Biofactors | pmid:7546213 |
Ko FN et al. | Inhibition on platelet activation by shikonin derivatives isolated from Arnebia euchroma. | 1995 | Biochim. Biophys. Acta | pmid:7548232 |
Cipollone F et al. | Effects of nabumetone on prostanoid biosynthesis in humans. | 1995 | Clin. Pharmacol. Ther. | pmid:7554708 |
Wong HM et al. | Role of calcium in thromboxane B2-mediated injury to rabbit gastric mucosal cells. | 1995 | Dig. Dis. Sci. | pmid:7555460 |