MeSH term | MeSH ID | Detail |
---|---|---|
Adenocarcinoma | D000230 | 166 associated lipids |
Acidosis | D000138 | 13 associated lipids |
Abortion, Habitual | D000026 | 5 associated lipids |
Thromboxane b2 is a lipid of Fatty Acyls (FA) class. Thromboxane b2 is associated with abnormalities such as endothelial dysfunction, Diabetes Mellitus, Non-Insulin-Dependent, Diabetes Mellitus, Ischemia and Thrombocytosis. The involved functions are known as Platelet Activation, Excretory function, Anabolism, Inflammation and mRNA Expression. Thromboxane b2 often locates in Endothelium, Hepatic and Microsomes, Liver. The associated genes with Thromboxane b2 are PTGS2 gene, prothrombin fragment 2 and CCL14 wt Allele.
To understand associated biological information of Thromboxane b2, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
Thromboxane b2 is suspected in endothelial dysfunction, Diabetes Mellitus, Non-Insulin-Dependent, Diabetes Mellitus, Ischemia, Thrombocytosis, Acute Coronary Syndrome and other diseases in descending order of the highest number of associated sentences.
Disease | Cross reference | Weighted score | Related literature |
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We collected disease MeSH terms mapped to the references associated with Thromboxane b2
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
Location | Cross reference | Weighted score | Related literatures |
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Function | Cross reference | Weighted score | Related literatures |
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There are no associated biomedical information in the current reference collection.
Gene | Cross reference | Weighted score | Related literatures |
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There are no associated biomedical information in the current reference collection.
Authors | Title | Published | Journal | PubMed Link |
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Snapper JR et al. | Effects of platelet depletion on the unanesthetized sheep's pulmonary response to endotoxemia. | 1984 | J. Clin. Invest. | pmid:6501570 |
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Saldeen P et al. | Thromboxane production in umbilical vein grafts. | 1984 | Thromb. Res. | pmid:6546814 |
Emau P et al. | Function of prostaglandins, thromboxane A2, and histamine in hypersensitivity reaction to experimental bluetongue disease in calves. | 1984 | Am. J. Vet. Res. | pmid:6093650 |
Bush LR et al. | Effects of the selective thromboxane synthetase inhibitor dazoxiben on variations in cyclic blood flow in stenosed canine coronary arteries. | 1984 | Circulation | pmid:6546902 |
Wilson TW et al. | Determination of 6-keto-prostaglandin F1 alpha and thromboxane B2 in urine by high-performance liquid chromatography and radioimmunoassay. | 1984 | J. Chromatogr. | pmid:6546935 |
Benedetto C et al. | Production of prostacyclin, 6-keto-PGF1 alpha and thromboxane B2 by incubated samples of umbilical vessels: a comparison of methods for expressing the results on dry weight, wet weight, protein or DNA bases. | 1984 | Prostaglandins | pmid:6390522 |
FitzGerald GA and Oates JA | Selective and nonselective inhibition of thromboxane formation. | 1984 | Clin. Pharmacol. Ther. | pmid:6370554 |
Wilson L and Huang LS | Temporal response of uterine prostaglandins to estradiol treatment in the ovariectomized-pregnant rat. | 1984 | Prostaglandins | pmid:6484214 |
Walinsky P et al. | Thromboxane A2 in acute myocardial infarction. | 1984 | Am. Heart J. | pmid:6485997 |
Sekiya K and Okuda H | Inhibitory action of soluble elastin on thromboxane B2 formation in blood platelets. | 1984 | Biochim. Biophys. Acta | pmid:6320905 |
Olanoff LS et al. | Effects of oleic acid on pulmonary capillary leak and thromboxanes. | 1984 | J. Surg. Res. | pmid:6233456 |
Hartung HP et al. | Release of prostaglandin E and thromboxane from macrophages by stimulation with factor H. | 1984 | Clin. Exp. Immunol. | pmid:6234114 |
Riess H et al. | Effects of BM 13.177, a new antiplatelet drug in patients with atherosclerotic disease. | 1984 | Thromb. Res. | pmid:6237460 |
Robson MC et al. | A new explanation for the progressive tissue loss in electrical injuries. | 1984 | Plast. Reconstr. Surg. | pmid:6422484 |
Lampugnani MG and de Gaetano G | Effects of metabolized and unmetabolized arachidonate on rat platelet shape change. | 1984 | Am. J. Physiol. | pmid:6433724 |
Stuart MJ et al. | Differences in thromboxane production between neonatal and adult platelets in response to arachidonic acid and epinephrine. | 1984 | Pediatr. Res. | pmid:6435080 |
Shohami E and Sidi A | Accumulation of prostacyclin in rat brain during haemorrhagic hypotension--possible role of PGI2 in autoregulation. | 1984 | J. Cereb. Blood Flow Metab. | pmid:6363432 |
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Brandt R et al. | Effect of propranolol, practolol and atenolol on human platelet thromboxane formation and plasma levels of prostaglandins 6-keto-F1 alpha and E2. | 1984 | Prostaglandins Leukot Med | pmid:6597450 |
Chiba S et al. | Sex and age-related differences in the urinary excretion of TXB2 in normal human subjects: a possible pathophysiological role of TXA2 in the aged kidney. | 1984 | Prostaglandins Leukot Med | pmid:6597456 |
Holgate ST and Robinson C | 6,9-deepoxy-6,9-(phenylimino)-delta 6,8-Prostaglandin I1, (U-60,257) stimulates prostaglandin D2 and inhibits thromboxane B2 release from ionophore challenged human dispersed lung cells. | 1984 | Br. J. Pharmacol. | pmid:6439267 |
DeRubertis FR et al. | Bile salt stimulation of colonic epithelial proliferation. Evidence for involvement of lipoxygenase products. | 1984 | J. Clin. Invest. | pmid:6438153 |
Axelrod L and Cornelius P | Plasma prostaglandin levels and circulating fuel levels in rats with diabetic ketoacidosis: effects of cyclooxygenase inhibitors and of alpha and beta adrenergic blockade. | 1984 | Prostaglandins | pmid:6440213 |
Meydani M et al. | Effects of dietary methionine, methylmercury, and atrazine on ex-vivo synthesis of prostaglandin E1 and thromboxane B2. | 1984 | Prostaglandins Leukot Med | pmid:6588393 |
Branski D et al. | Effect of cimetidine on human gastric and duodenal prostanoid synthesis. | 1984 | Scand. J. Gastroenterol. | pmid:6589742 |
Marks JG et al. | Contact urticaria and airway obstruction from carbonless copy paper. | 1984 Aug 24-31 | JAMA | pmid:6235381 |
MacNab MW et al. | The effects of a new thromboxane synthetase inhibitor, CGS-13080, in man. | 1984 Feb-Mar | J Clin Pharmacol | pmid:6371062 |
Buchanan MR and Hirsh J | Effect of aspirin and salicylate on platelet-vessel wall interactions in rabbits. | 1984 Jul-Aug | Arteriosclerosis | pmid:6380468 |
Paajanen H et al. | Modification of platelet aggregation and thromboxane synthesis by intravascular contrast media. | 1984 Jul-Aug | Invest Radiol | pmid:6434489 |
De Caterina R et al. | Thromboxane-B2 generation during ex-vivo platelet aggregation. | 1984 Jul-Sep | J. Nucl. Med. Allied Sci. | pmid:6530623 |
Egg D | Concentrations of prostaglandins D2, E2, F2 alpha, 6-keto-F1 alpha and thromboxane B2 in synovial fluid from patients with inflammatory joint disorders and osteoarthritis. | 1984 Mar-Apr | Z Rheumatol | pmid:6730731 |
Tanabe M et al. | Inhibition of coronary circulatory failure and thromboxane A2 release during coronary occlusion and reperfusion by 2-phenylaminoadenosine (CV-1808) in anesthetized dogs. | 1984 May-Jun | J. Cardiovasc. Pharmacol. | pmid:6202970 |
Laustiola K et al. | Exercise-induced increase in plasma arachidonic acid and thromboxane B2 in healthy men: effect of beta-adrenergic blockade. | 1984 May-Jun | J. Cardiovasc. Pharmacol. | pmid:6202971 |
Sturm M et al. | The measurement of plasma thromboxane B2 and the effect of smoking. | 1984 Nov-Dec | Clin. Exp. Pharmacol. Physiol. | pmid:6536421 |
Menitove JE et al. | Use of prostacyclin to inhibit activation of platelets during preparation of platelet concentrates. | 1984 Nov-Dec | Transfusion | pmid:6390814 |
Fisher M et al. | Selective thromboxane inhibition: a new approach to antiplatelet therapy. | 1984 Sep-Oct | Stroke | pmid:6474531 |
Uderman HD et al. | Thromboxane synthetase inhibitor UK38,485 lowers blood pressure in the adult spontaneously hypertensive rat. | 1984 Sep-Oct | J. Cardiovasc. Pharmacol. | pmid:6209508 |
Hänsch GM et al. | Induction of prostanoid synthesis in human platelets by the late complement components C5b-9 and channel forming antibiotic nystatin: inhibition of the reacylation of liberated arachidonic acid. | 1985 | J. Immunol. | pmid:2409145 |
Fiedler VB et al. | Leukotrienes on porcine hemodynamics and prostanoid release. | 1985 | Int. J. Cardiol. | pmid:2993176 |
Boraschi D et al. | Regulation of arachidonic acid metabolism in macrophages by immune and nonimmune interferons. | 1985 | J. Immunol. | pmid:3923110 |
Ment LR et al. | Randomized indomethacin trial for prevention of intraventricular hemorrhage in very low birth weight infants. | 1985 | J. Pediatr. | pmid:3906073 |
Slotman GJ et al. | Thromboxane, prostacyclin, and the hemodynamic effects of graded bacteremic shock. | 1985 | Circ. Shock | pmid:3915237 |
De Caterina R et al. | Nitrates and endothelial prostacyclin production: studies in vitro. | 1985 | Circulation | pmid:3917245 |
Walenga RW et al. | Megakaryocyte thromboxane production induced by platelet stimuli during in vitro culture. | 1985 | Exp. Hematol. | pmid:3918879 |
Stenmark KR et al. | Alveolar inflammation and arachidonate metabolism in monocrotaline-induced pulmonary hypertension. | 1985 | Am. J. Physiol. | pmid:3923843 |
Quilley J and McGiff JC | Arachidonic acid metabolism and urinary excretion of prostaglandins and thromboxane in rats with experimental diabetes mellitus. | 1985 | J. Pharmacol. Exp. Ther. | pmid:3925127 |
Numano F et al. | Prostacyclin and variant angina. | 1985 | Ann. N. Y. Acad. Sci. | pmid:3865605 |
Strano A et al. | [Formation of platelet thromboxane in a patient with type I glycogenosis]. | 1985 | Recenti Prog Med | pmid:3868788 |
Jensen W et al. | Hemodynamic measurements in a sheep model with a hollow fiber artificial kidney containing modified cellulose. | 1985 | Life Support Syst | pmid:3870598 |
Wang JP et al. | Antiplatelet effect of hsien-ho-t'sao (Agrimonia pilosa). | 1985 | Am. J. Chin. Med. | pmid:3927704 |
Hashimoto Y et al. | Time-dependent inhibition of the cyclooxygenase pathway by 12-hydroperoxy-5,8,10,14-eicosatetraenoic acid. | 1985 | Biochem. Biophys. Res. Commun. | pmid:3927909 |
Mueller HS et al. | Systemic and transcardiac platelet activity in acute myocardial infarction in man: resistance to prostacyclin. | 1985 | Circulation | pmid:2933181 |
Howes EL et al. | Lipopolysaccharide tolerance inhibits eye inflammation. I. Reduced immune complex or lipopolysaccharide effects. | 1985 | Arch. Ophthalmol. | pmid:3156578 |
Jouppila P et al. | Ritodrine infusion during late pregnancy: effects on fetal and placental blood flow, prostacyclin, and thromboxane. | 1985 | Am. J. Obstet. Gynecol. | pmid:3885740 |
Davì G et al. | Inhibition of platelet function by ticlopidine in arteriosclerosis obliterans of the lower limbs. | 1985 | Thromb. Res. | pmid:2933846 |
Bloom A et al. | Hemolytic-uremic syndrome: demonstration of abnormalities of platelet reactivity and insensitivity to prostaglandin I2. | 1985 | Clin. Nephrol. | pmid:3886228 |
Meyrick B et al. | Endothelial prostacyclin production is a late event in granulocyte migration into bovine pulmonary artery intimal explants. | 1985 | Blood | pmid:3904871 |
Janka HU | Platelet and endothelial function tests during metformin treatment in diabetes mellitus (short communication). | 1985 | Horm. Metab. Res. Suppl. | pmid:2934311 |
Hayashi C | [Thromboxane B2 in surgery]. | 1985 | Nihon Geka Gakkai Zasshi | pmid:2935731 |
Steinhauer HB et al. | Thromboxane B2 and beta 2-microglobulin as early indicators of renal allograft rejection. | 1985 | Proc Eur Dial Transplant Assoc Eur Ren Assoc | pmid:3887370 |
Lenhard V et al. | Transfusion-induced enhancement of prostaglandin and thromboxane release in prospective kidney graft recipients. | 1985 | Proc Eur Dial Transplant Assoc Eur Ren Assoc | pmid:3887386 |
Naesh O et al. | Platelet function in surgical stress. | 1985 | Thromb. Haemost. | pmid:2935969 |
Takahata K et al. | [Effect of PSK on prostaglandin metabolism (I)]. | 1985 | Gan To Kagaku Ryoho | pmid:3888117 |
Miyazaki H et al. | Microdetermination of prostaglandins and thromboxane B2 by gas chromatography/high-resolution selected-ion monitoring. | 1985 | Adv. Prostaglandin Thromboxane Leukot. Res. | pmid:2936139 |
Hutchison AA et al. | Effect of endotoxemia on hypoxic pulmonary vasoconstriction in unanesthetized sheep. | 1985 | J. Appl. Physiol. | pmid:3888946 |
Ogawa K et al. | Effects of orally administered glandular kallikrein on urinary kallikrein and prostaglandin excretion, plasma immunoreactive prostanoids and platelet aggregation in essential hypertension. | 1985 | Klin. Wochenschr. | pmid:3889484 |
Pedersen AK and FitzGerald GA | Cyclooxygenase inhibition, platelet function, and metabolite formation during chronic sulfinpyrazone dosing. | 1985 | Clin. Pharmacol. Ther. | pmid:3917387 |
Barst RJ et al. | Relation of arachidonate metabolites to abnormal control of the pulmonary circulation in a child. | 1985 | Am. Rev. Respir. Dis. | pmid:3917630 |
Stuart MJ and Dusse J | In vitro comparison of the efficacy of cyclooxygenase inhibitors on the adult versus neonatal platelet. | 1985 | Biol. Neonate | pmid:4005330 |
Amado JA et al. | Influence of acetylsalicylic acid on bleeding time and serum thromboxane B2 in diabetes mellitus type I. | 1985 | Diabete Metab | pmid:4007228 |
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McGinley S et al. | The effect of inhibiting brain thromboxane biosynthesis on pentylenetetrazole-induced seizure threshold. | 1985 | J. Neurosci. Res. | pmid:4009745 |
Halenda SP et al. | Phorbol esters and oleoyl acetoyl glycerol enhance release of arachidonic acid in platelets stimulated by Ca2+ ionophore A23187. | 1985 | J. Biol. Chem. | pmid:3930496 |
Yamaguchi A et al. | Effect of cetiedil on platelet aggregation and thromboxane synthesis. | 1985 | Thromb. Res. | pmid:2986312 |
Utsunomiya T et al. | [Circulating negative inotropic substance produced by the lung, affected by prostaglandin and thromboxane]. | 1985 | Nihon Geka Gakkai Zasshi | pmid:3160927 |
Wang CB and Chang AM | [Plasma thromboxane B2 changes in severe icteric hepatitis treated by traditional Chinese medicine--dispelling the pathogenic heat from blood, promoting blood circulation and administrating large doses of radix Paeoniae--a report of 6 cases]. | 1985 | Zhong Xi Yi Jie He Za Zhi | pmid:3161645 |
Mendieta CF et al. | Biosynthesis of prostaglandins in gingiva of patients with chronic periodontitis. | 1985 | J. Periodontol. | pmid:3919173 |
Giani E et al. | Platelets from aged rats aggregate more, but are more sensitive to prostacyclin. | 1985 | Prostaglandins Leukot Med | pmid:3003760 |
Ikkala E et al. | Haemostatic parameters in Cushing's syndrome. | 1985 | Acta Med Scand | pmid:4025006 |
Sylvester JT et al. | Prostaglandins and estradiol-induced attenuation of hypoxic pulmonary vasoconstriction. | 1985 | Chest | pmid:3840073 |
Seitz M and Hunstein W | Enhanced prostanoid release from monocytes of patients with rheumatoid arthritis and active systemic lupus erythematosus. | 1985 | Ann. Rheum. Dis. | pmid:4026405 |
Nomura S | [Plasma levels of thromboxane B2 and 6-keto PGF1 alpha in patients with variant angina]. | 1985 | Nippon Naika Gakkai Zasshi | pmid:3840191 |
Freund HR et al. | Muscle prostaglandin production in the rat. Effect of abdominal sepsis and different amino acid formulations. | 1985 | Arch Surg | pmid:4026556 |
Haurand M and Ullrich V | Isolation and characterization of thromboxane synthase from human platelets as a cytochrome P-450 enzyme. | 1985 | J. Biol. Chem. | pmid:2999104 |
Prosdocimi M et al. | Inhibition by AD6 (8-monochloro-3-beta-diethylaminoethyl-4-methyl-7-ethoxycarbonyl methoxy coumarin) of platelet aggregation in dog stenosed coronary artery. | 1985 | Thromb. Res. | pmid:3840290 |
Lelcuk S et al. | Thromboxane A2 moderates permeability after limb ischemia. | 1985 | Ann. Surg. | pmid:3840349 |
Wilson L and Huang LS | Contributions of the fetoplacental unit to augmented uterine prostaglandin levels periparturition in the rat. | 1985 | Biol. Reprod. | pmid:3840391 |
Levine RF et al. | Megakaryocyte interaction with subendothelial extracellular matrix is associated with adhesion, platelet-like shape change, and thromboxane A2 production. | 1985 | Blood | pmid:4027379 |
Templeton CB et al. | Effects of repeated endotoxin injections on prostanoids, hemodynamics, endothelial cells, and survival in ponies. | 1985 | Circ. Shock | pmid:3840414 |
Roberts DG et al. | Sulindac is not renal sparing in man. | 1985 | Clin. Pharmacol. Ther. | pmid:4028619 |
Fink MP et al. | Plasma levels of 6-keto PGF1 alpha but not TxB2 increase in rats with peritonitis due to cecal ligation. | 1985 | Circ. Shock | pmid:3840415 |
Chang J et al. | Modulation by hydroxyeicosatetraenoic acids (HETEs) of arachidonic acid metabolism in mouse resident peritoneal macrophages. | 1985 | Eur. J. Pharmacol. | pmid:3920057 |
Shohami E and Gross J | An ex vivo method for evaluating prostaglandin synthetase activity in cortical slices of mouse brain. | 1985 | J. Neurochem. | pmid:3923156 |
Reines HD et al. | Lack of effect of glucocorticoids upon plasma thromboxane in patients in a state of shock. | 1985 | Surg Gynecol Obstet | pmid:3983796 |
Alessandrini P et al. | Physiologic variables affecting thromboxane B2 production in human whole blood. | 1985 | Thromb. Res. | pmid:3983893 |
Fukushima M et al. | [Role of thromboxane A2 in pulmonary air embolism in conscious sheep]. | 1985 | Kokyu To Junkan | pmid:4023449 |
Conti P et al. | Effect of supernatants from PHA-stimulated and non-stimulated lymphocyte cultures on thromboxane B2 release by polymorphonuclear leukocytes in vitro. | 1985 | Agents Actions | pmid:4003201 |
Carter AJ and Hanley SP | The effect of platelet number and haematocrit on whole blood thromboxane synthesis. | 1985 | Thromb. Haemost. | pmid:4024033 |
Kawaguchi A et al. | Increase in urinary thromboxane B2 in rats caused by cyclosporine. | 1985 | Transplantation | pmid:4024243 |