MeSH term | MeSH ID | Detail |
---|---|---|
Cholecystitis, Acute | D041881 | 1 associated lipids |
Gastric Dilatation | D013271 | 1 associated lipids |
Stomach Volvulus | D013277 | 1 associated lipids |
Thromboxane b2 is a lipid of Fatty Acyls (FA) class. Thromboxane b2 is associated with abnormalities such as endothelial dysfunction, Diabetes Mellitus, Non-Insulin-Dependent, Diabetes Mellitus, Ischemia and Thrombocytosis. The involved functions are known as Platelet Activation, Excretory function, Anabolism, Inflammation and mRNA Expression. Thromboxane b2 often locates in Endothelium, Hepatic and Microsomes, Liver. The associated genes with Thromboxane b2 are PTGS2 gene, prothrombin fragment 2 and CCL14 wt Allele.
To understand associated biological information of Thromboxane b2, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
Thromboxane b2 is suspected in endothelial dysfunction, Diabetes Mellitus, Non-Insulin-Dependent, Diabetes Mellitus, Ischemia, Thrombocytosis, Acute Coronary Syndrome and other diseases in descending order of the highest number of associated sentences.
Disease | Cross reference | Weighted score | Related literature |
---|
We collected disease MeSH terms mapped to the references associated with Thromboxane b2
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
Location | Cross reference | Weighted score | Related literatures |
---|
Function | Cross reference | Weighted score | Related literatures |
---|
There are no associated biomedical information in the current reference collection.
Gene | Cross reference | Weighted score | Related literatures |
---|
There are no associated biomedical information in the current reference collection.
Authors | Title | Published | Journal | PubMed Link |
---|---|---|---|---|
Kallmann R et al. | Effects of low doses of aspirin, 10 mg and 30 mg daily, on bleeding time, thromboxane production and 6-keto-PGF1 alpha excretion in healthy subjects. | 1987 | Thromb. Res. | pmid:3576521 |
Ersöz G et al. | Effect of submaximal and incremental upper extremity exercise on platelet function and the role of blood shear stress. | 2002 | Thromb. Res. | pmid:12676189 |
Filep J and Rosenkranz B | Mechanism of vasopressin-induced platelet aggregation. | 1987 | Thromb. Res. | pmid:3105115 |
Ushiyama S et al. | RS-5186, a novel thromboxane synthetase inhibitor with a potent and extended duration of action. | 1988 | Thromb. Res. | pmid:3175990 |
Rogasi PG et al. | Radioimmunoassay of thromboxane B2 in plasma: methodological modifications. | 1988 | Thromb. Res. | pmid:3175991 |
Saldeen P et al. | Increased synthesis of thromboxane B2 and 6-keto-PGF1 alpha in hand veins from patients with deep venous thrombosis. | 1983 | Thromb. Res. | pmid:6658723 |
Bradlow BA and Chetty N | Dosage frequency for suppression of platelet function by low dose aspirin therapy. | 1982 | Thromb. Res. | pmid:7123514 |
Buchanan MR et al. | Aspirin inhibits platelet function independent of the acetylation of cyclo-oxygenase. | 1982 | Thromb. Res. | pmid:7071811 |
Butler KD et al. | Prolongation of platelet survival in hypercholesterolaemic rabbits by CGS 12970 (3-methyl-2-(3-pyridyl)-1 indoleoctanoic acid) and dazoxiben. | 1987 | Thromb. Res. | pmid:3109067 |
Anfossi G et al. | Studies on in vitro effect of picotamide on human platelet aggregation in platelet-rich plasma and whole blood. | 1995 | Thromb. Res. | pmid:7778055 |
Lee GY et al. | Antiplatelet activity of BRX-018, (6aS,cis)-malonic acid 3-acetoxy-6a9-bis-(2-methoxycarbonyl-acetoxy)-6,6a,7,11b-tetrahydro-indeno[2,1-c]chromen-10-yl ester methylester. | 2005 | Thromb. Res. | pmid:15668191 |
Ljungberg B et al. | Immediate effects of heparin and LMW heparin on some platelet and endothelial derived factors. | 1988 | Thromb. Res. | pmid:2847353 |
Winter M et al. | Synthesis of thromboxane B2 in uraemia and the effects of dialysis. | 1983 | Thromb. Res. | pmid:6868024 |
Pedersen AK et al. | Inhibition of thromboxane biosynthesis in serum: limitations of the measurement of immunoreactive 6-keto-PGF1 alpha. | 1984 | Thromb. Res. | pmid:6546456 |
Huang CG et al. | Effect of berberine on arachidonic acid metabolism in rabbit platelets and endothelial cells. | 2002 | Thromb. Res. | pmid:12297129 |
Pekonen F et al. | Platelet function and coagulation in normal and preeclamptic pregnancy. | 1986 | Thromb. Res. | pmid:2944245 |
Grauso F et al. | Effects of iloprost (ZK 36374), a prostacyclin derivative, on platelet function after ischaemic exercise in patients with stable angina pectoris. | 1987 | Thromb. Res. | pmid:2447664 |
Chou TC and Li CY | Inhibitory mechanisms of dantrolene on platelet aggregation. | 1999 | Thromb. Res. | pmid:10593433 |
Cerskus AL et al. | Effects of indomethacin and sulfinpyrazone on in vivo formation of thromboxane B2 and prostaglandin D2 during arachidonate infusion in rabbits. | 1978 | Thromb. Res. | pmid:653641 |
Hernández R et al. | Influence of co-incubation and cell number of platelets and polymorphonuclear leukocytes in cellular inhibition and activation phenomena. | 1994 | Thromb. Res. | pmid:8042192 |
Tsuboi T et al. | Effect of gliclazide on prostaglandin and thromboxane synthesis in guinea-pig platelets. | 1981 Jan 1-15 | Thromb. Res. | pmid:7233394 |
Vanags D et al. | The antiplatelet effect of daily low dose enteric-coated aspirin in man: a time course of onset and recovery. | 1990 | Thromb. Res. | pmid:2264023 |
Rostagno C et al. | In vitro effects of two novel calcium antagonists (nitrendipine and nisoldipine) on intraplatelet calcium redistribution, platelet aggregation and thromboxane A2 formation. Comparison with diltiazem, nifedipine and verapamil. | 1991 | Thromb. Res. | pmid:1754998 |
Gachályi B et al. | In vitro effect of cimetidine on ADP induced platelet aggregation and thromboxane A2 synthesis in man. | 1984 | Thromb. Res. | pmid:6474407 |
Stegmeier K et al. | The pharmacological profile of the thromboxane A2 antagonist BM 13.177. A new anti-platelet and anti-thrombotic drug. | 1984 | Thromb. Res. | pmid:6385334 |
Davis RB et al. | Evaluation of platelet function in pregnancy. Comparative studies in non-smokers and smokers. | 1987 | Thromb. Res. | pmid:2955542 |
Di Minno G et al. | Arachidonic acid induces human platelet-fibrin retraction: the role of platelet cyclic endoperoxides. | 1982 | Thromb. Res. | pmid:6803385 |
Catella F and FitzGerald GA | Paired analysis of urinary thromboxane B2 metabolites in humans. | 1987 | Thromb. Res. | pmid:3686481 |
Suehiro A et al. | The role of platelet hyperfunction in thrombus formation in hyperlipidemia. | 1982 | Thromb. Res. | pmid:6803387 |
Vericel E et al. | Platelets and aging. I--Aggregation, arachidonate metabolism and antioxidant status. | 1988 | Thromb. Res. | pmid:3129819 |
Wang JP et al. | Antiplatelet effect of capsaicin. | 1984 | Thromb. Res. | pmid:6528310 |
Riess H et al. | Effects of BM 13.177, a new antiplatelet drug in patients with atherosclerotic disease. | 1984 | Thromb. Res. | pmid:6237460 |
Cattaneo M et al. | In vitro effects of picotamide on human platelet aggregation, the release reaction and thromboxane B2 production. | 1991 | Thromb. Res. | pmid:1926062 |
Weide I et al. | Effects of cyclooxygenase inhibitors on ex vivo cysteinyl-leukotriene production by whole human blood allowed to clot spontaneously. Comparison to stimulated blood. | 1992 | Thromb. Res. | pmid:1440511 |
Tindall H et al. | Thrombin generation precedes platelet activation in native blood taken from the hand during multiple blood sampling following cold challenge. | 1987 | Thromb. Res. | pmid:3617016 |
Simmet T and Luck W | Clotting of whole human blood induces cysteinyl-leukotriene formation. | 1989 | Thromb. Res. | pmid:2549655 |
Winther K et al. | Platelet function and fibrinolytic activity in cervical spinal cord injured patients. | 1992 | Thromb. Res. | pmid:1321515 |
Randall MJ and Wilding RI | Acute arterial thrombosis in rabbits: reduced platelet accumulation after treatment with thromboxane synthetase inhibitor dazoxiben hydrochloride, (UK-37, 248-01). | 1982 | Thromb. Res. | pmid:6897751 |
Di Minno G and Violi F | Aspirin resistance and diabetic angiopathy: back to the future. | 2004 | Thromb. Res. | pmid:15115664 |
Lee TK et al. | Comparison of the effect of acetylsalicylic acid on platelet function in male and female patients with ischemic stroke. | 1987 | Thromb. Res. | pmid:3629557 |
Jørgensen KA et al. | The survival of pig to rabbit renal xenografts during inhibition of thromboxane synthesis. | 1983 | Thromb. Res. | pmid:6364449 |
Tanoue K et al. | A new variant of thrombasthenia with abnormally glycosylated GP IIb/IIIa. | 1987 | Thromb. Res. | pmid:3629560 |
Naran NH and Chetty N | The in vitro effect of ridogrel on platelet function in normocholesterolaemic and familial hypercholesterolaemic type IIa subjects. | 1997 | Thromb. Res. | pmid:9556227 |
Altman R and Scazziota A | Synergistic actions of paf-acether and sodium arachidonate in human platelet aggregation. 2. Unexpected results after aspirin intake. | 1986 | Thromb. Res. | pmid:3088757 |
Kudolo GB et al. | Effect of the ingestion of Ginkgo biloba extract on platelet aggregation and urinary prostanoid excretion in healthy and Type 2 diabetic subjects. | 2002 | Thromb. Res. | pmid:12590952 |
Todd MH et al. | The involvement of prostaglandins and thromboxanes in the response to pulmonary embolism in anaesthetized rabbits and isolated perfused lungs. | 1983 | Thromb. Res. | pmid:6687961 |
Davì G et al. | Inhibition of platelet function by ticlopidine in arteriosclerosis obliterans of the lower limbs. | 1985 | Thromb. Res. | pmid:2933846 |
Sandler H et al. | Studies on the role of thromboxane in thrombin-induced pulmonary insufficiency in the rat. | 1986 | Thromb. Res. | pmid:3754987 |
Pattison A et al. | The in vitro effect of amrinone on thromboxane B2 synthesis in human whole blood. | 1986 | Thromb. Res. | pmid:3755259 |
Hashimoto Y et al. | Characteristics of protein kinase C-independent exocytosis in human platelets. | 1997 | Thromb. Res. | pmid:9336873 |
Igawa T et al. | Potentiation of anti-platelet aggregating activity of cilostazol with vascular endothelial cells. | 1990 | Thromb. Res. | pmid:2158154 |
Thorwest M et al. | Dietary fish oil reduces microvascular thrombosis in a porcine experimental model. | 2000 | Thromb. Res. | pmid:10946095 |
Di Minno MN et al. | Genotype-independent in vivo oxidative stress following a methionine loading test: maximal platelet activation in subjects with early-onset thrombosis. | 2011 | Thromb. Res. | pmid:21669453 |
Dupin JP et al. | In vitro antiaggregant activity of paracetamol and derivatives. | 1988 | Thromb. Res. | pmid:3134743 |
McGill D et al. | Platelet function and exercise-induced myocardial ischaemia in coronary heart disease patients. | 1989 | Thromb. Res. | pmid:2533414 |
Martin JF et al. | The biological significance of platelet volume: its relationship to bleeding time, platelet thromboxane B2 production and megakaryocyte nuclear DNA concentration. | 1983 | Thromb. Res. | pmid:6658722 |
Togna GI et al. | Cisplatin triggers platelet activation. | 2000 | Thromb. Res. | pmid:10973681 |
Li C et al. | Aspirin response variability after major orthopedic surgery. | 2012 | Thromb. Res. | pmid:22575418 |
Serebruany VL and Gurbel PA | Assessment of platelet activity by measuring platelet-derived substances in plasma from patients with acute myocardial infarction: surprising lessons from the GUSTO-III Platelet Study. | 1999 | Thromb. Res. | pmid:10030832 |
Kelton JG et al. | A study of the bioavailability and platelet inhibitory effects of a new enteric-coated acetylsalicylic acid preparation. | 1984 | Thromb. Res. | pmid:6740573 |
Weide I et al. | Intravascular cysteinyl-leukotriene formation by clotting whole human blood. Evidence from clamped umbilical vein segments and thrombus specimens. | 1993 | Thromb. Res. | pmid:8122190 |
Grimm LJ et al. | Inhibition of platelet thromboxane synthesis by 7-(1-imidazolyl) heptanoic acid: dissociation from inhibition of aggregation. | 1981 | Thromb. Res. | pmid:6801806 |
Uyama O et al. | Plasma concentrations of 6-keto-prostaglandin F1 alpha in patients with hypertension, cerebrovascular disease or Takayasu's arteritis. | 1982 Jan 1-15 | Thromb. Res. | pmid:6121391 |
Voss R et al. | In vitro and ex vivo effects of aspirin in patients on a low-dose aspirin therapy. | 1993 | Thromb. Res. | pmid:8122187 |
Hashizume T et al. | Vinblastine inhibits platelet aggregation by a microtubule-independent mechanism, probably by its perturbing action on the plasma membrane. | 1988 | Thromb. Res. | pmid:3135636 |
Croft KD and Beilin LJ | Platelet and neutrophil function and eicosanoid release in a subject with abetalipoproteinaemia. | 1993 | Thromb. Res. | pmid:8385810 |
Chou TC et al. | The inhibitory effect of 2-thienyl 2'-hydroxyphenyl ketone (C85) on platelet thromboxane formation. | 1996 | Thromb. Res. | pmid:8897698 |
Teng CM et al. | Antiplatelet actions of some coumarin compounds isolated from plant sources. | 1992 | Thromb. Res. | pmid:1523611 |
Takasaki W et al. | Enzyme immunoassay of human plasma 11-dehydrothromboxane B2. | 1991 | Thromb. Res. | pmid:1957275 |
Korth R et al. | Unsaturated platelet-activating factor: influence on aggregation, serotonin release and thromboxane synthesis of human thrombocytes. | 1986 | Thromb. Res. | pmid:3961742 |
Preston FE et al. | Low-dose aspirin inhibits platelet and venous cyclo-oxygenase in man. | 1982 | Thromb. Res. | pmid:6815823 |
Sinzinger H et al. | Response of thromboxane B2, malondialdehyde and platelet sensitivity to 3 weeks low-dose aspirin (ASA) in healthy volunteers. | 1989 | Thromb. Res. | pmid:2497545 |
Riess H et al. | Thromboxane receptor blockade versus cyclooxigenase inhibition: antiplatelet effects in patients. | 1986 | Thromb. Res. | pmid:3012819 |
Pirich C et al. | Effects of fish oil supplementation on platelet survival and ex vivo platelet function in hypercholesterolemic patients. | 1999 | Thromb. Res. | pmid:10588465 |
Altman R et al. | Synergistic actions of PAF-acether and sodium arachidonate in human platelet aggregation. 1. Studies in normal human platelet rich plasma. | 1986 | Thromb. Res. | pmid:3014677 |
Worthington RE and Fuller GC | Dibutyryl cyclic guanosine monophosphate elevates bovine endothelial cell thromboxane production without affecting prostacyclin metabolism. | 1984 | Thromb. Res. | pmid:6322377 |
Teng CM et al. | Platelet aggregation induced by equinatoxin. | 1988 | Thromb. Res. | pmid:2906181 |
Kelton JG et al. | Sex-related differences in the efficacy of acetylsalicylic acid (ASA) : the absorption of ASA and its effect on collagen-induced thromboxane B2 generation. | 1981 Oct 1-15 | Thromb. Res. | pmid:7330835 |
Yamaguchi A et al. | Effect of cetiedil on platelet aggregation and thromboxane synthesis. | 1985 | Thromb. Res. | pmid:2986312 |
De La Cruz JP et al. | Effect of DT-TX 30, a combined thromboxane synthase inhibitor and thromboxane receptor antagonist, on retinal vascularity in experimental diabetes mellitus. | 2000 | Thromb. Res. | pmid:10680643 |
Lai LJ et al. | Trilinolein inhibits epinephrine-induced human platelet aggregation. | 1994 | Thromb. Res. | pmid:7863478 |
Weber AA et al. | 40 mg of aspirin are not sufficient to inhibit platelet function under conditions of limited compliance. | 2000 | Thromb. Res. | pmid:10709913 |
Ding YA et al. | Antiplatelet actions of 2-(4-[1-(2-chlorophenyl) piperazinyl]) methyl-2,3-dihydroimidazo[1,2-c]quinazolin-5(6H)-one compound. | 1995 | Thromb. Res. | pmid:7740521 |
Shatoor AS et al. | Effect of Hawthorn (Crataegus aronia syn. Azarolus (L)) on platelet function in albino Wistar rats. | 2012 | Thromb. Res. | pmid:22261477 |
Prosdocimi M et al. | Inhibition by AD6 (8-monochloro-3-beta-diethylaminoethyl-4-methyl-7-ethoxycarbonyl methoxy coumarin) of platelet aggregation in dog stenosed coronary artery. | 1985 | Thromb. Res. | pmid:3840290 |
Schorer AE and White JG | Interleukin 1 enhances arterial thrombogenicity in vitro. | 1989 | Thromb. Res. | pmid:2609290 |
Vila V et al. | Fibrinopeptide A release from intraplatelet fibrinogen is related to thrombin platelet activation. | 1997 | Thromb. Res. | pmid:9175247 |
Tzeng SH et al. | Inhibition of platelet aggregation by some flavonoids. | 1991 | Thromb. Res. | pmid:1776142 |
Neiman J et al. | Platelet responses to platelet-activating factor are inhibited in alcoholics undergoing alcohol withdrawal. | 1989 | Thromb. Res. | pmid:2617478 |
Udvardy M et al. | Altered primary haemostasis in Conn's syndrome. | 1992 | Thromb. Res. | pmid:1448795 |
Zahavi M et al. | Enhanced platelet release reaction and increased thromboxane generation in esophageal achalasia and selective in vitro inhibition of arachidonic acid induced platelet aggregation by vasoactive intestinal peptide. | 1990 | Thromb. Res. | pmid:2146767 |
Simmet T and Weide I | Thromboxane and cysteinyl-leukotriene formation are differentially activated in spontaneously clotting whole human blood in vitro. | 1991 | Thromb. Res. | pmid:1866709 |
Lukaszyk A et al. | Does acute experimental pancreatitis affect blood platelet function? | 1989 | Thromb. Res. | pmid:2524119 |
Delvos U et al. | Direct radioimmunological measurement of thromboxane B2 in plasma. | 1985 | Thromb. Res. | pmid:4082109 |
Ito T et al. | Role of activated platelets in endotoxin-induced DIC in rats. | 1990 | Thromb. Res. | pmid:2080492 |
Alessandrini P et al. | Physiologic variables affecting thromboxane B2 production in human whole blood. | 1985 | Thromb. Res. | pmid:3983893 |
Lukaszyk A et al. | Blood platelet function in canine acute pancreatitis with reference to treatment with Nafamostat mesilate (FUT-175). | 1992 | Thromb. Res. | pmid:1579898 |
Grignani G et al. | Activation of platelet prostaglandin biosynthesis pathway during neoplastic cell-induced platelet aggregation. | 1984 | Thromb. Res. | pmid:6729776 |
Patterson WR et al. | Aggregation of killer whale platelets. | 1993 | Thromb. Res. | pmid:8327987 |
Barbieri B et al. | p-Aminobenzoic acid, but not its metabolite p-acetamidobenzoic acid, inhibits thrombin induced thromboxane formation in human platelets in a non NSAID like manner. | 1997 | Thromb. Res. | pmid:9175234 |