MeSH term | MeSH ID | Detail |
---|---|---|
Cholecystitis, Acute | D041881 | 1 associated lipids |
Gastric Dilatation | D013271 | 1 associated lipids |
Stomach Volvulus | D013277 | 1 associated lipids |
Thromboxane b2 is a lipid of Fatty Acyls (FA) class. Thromboxane b2 is associated with abnormalities such as endothelial dysfunction, Diabetes Mellitus, Non-Insulin-Dependent, Diabetes Mellitus, Ischemia and Thrombocytosis. The involved functions are known as Platelet Activation, Excretory function, Anabolism, Inflammation and mRNA Expression. Thromboxane b2 often locates in Endothelium, Hepatic and Microsomes, Liver. The associated genes with Thromboxane b2 are PTGS2 gene, prothrombin fragment 2 and CCL14 wt Allele.
To understand associated biological information of Thromboxane b2, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
Thromboxane b2 is suspected in endothelial dysfunction, Diabetes Mellitus, Non-Insulin-Dependent, Diabetes Mellitus, Ischemia, Thrombocytosis, Acute Coronary Syndrome and other diseases in descending order of the highest number of associated sentences.
Disease | Cross reference | Weighted score | Related literature |
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We collected disease MeSH terms mapped to the references associated with Thromboxane b2
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
Location | Cross reference | Weighted score | Related literatures |
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Function | Cross reference | Weighted score | Related literatures |
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There are no associated biomedical information in the current reference collection.
Gene | Cross reference | Weighted score | Related literatures |
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There are no associated biomedical information in the current reference collection.
Authors | Title | Published | Journal | PubMed Link |
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Eizayaga FX et al. | Modifications produced by selective inhibitors of cyclooxygenase and ultra low dose aspirin on platelet activity in portal hypertension. | 2007 | World J. Gastroenterol. | pmid:17876871 |
Fujiwara T et al. | Exploratory aspirin resistance trial in healthy Japanese volunteers (J-ART) using platelet aggregation as a measure of thrombogenicity. | 2007 | Pharmacogenomics J. | pmid:17245331 |
Maree AO et al. | Drug insight: aspirin resistance-fact or fashion? | 2007 | Nat Clin Pract Cardiovasc Med | pmid:17330121 |
Ciabattoni G et al. | Determinants of platelet activation in Alzheimer's disease. | 2007 | Neurobiol. Aging | pmid:16442186 |
De Candia E et al. | Defective platelet responsiveness to thrombin and protease-activated receptors agonists in a novel case of gray platelet syndrome: correlation between the platelet defect and the alpha-granule content in the patient and four relatives. | 2007 | J. Thromb. Haemost. | pmid:17137471 |
Miyamoto A et al. | Ibuprofen or ozagrel increases NO release and l-nitro arginine induces TXA(2) release from cultured porcine basilar arterial endothelial cells. | 2007 | Vascul. Pharmacol. | pmid:17113355 |
Kim YJ and Chung HY | Antioxidative and anti-inflammatory actions of docosahexaenoic acid and eicosapentaenoic acid in renal epithelial cells and macrophages. | 2007 | J Med Food | pmid:17651056 |
Rossoni G et al. | Positive interaction of the novel beta2-agonist carmoterol and tiotropium bromide in the control of airway changes induced by different challenges in guinea-pigs. | 2007 | Pulm Pharmacol Ther | pmid:16533614 |
Jeng JH et al. | Antiplatelet effect of sanguinarine is correlated to calcium mobilization, thromboxane and cAMP production. | 2007 | Atherosclerosis | pmid:16797553 |
Ansari HR et al. | Involvement of COX-1 in A3 adenosine receptor-mediated contraction through endothelium in mice aorta. | 2007 | Am. J. Physiol. Heart Circ. Physiol. | pmid:17921329 |
Ivandic BT et al. | Determination of aspirin responsiveness by use of whole blood platelet aggregometry. | 2007 | Clin. Chem. | pmid:17332149 |
Calzada C et al. | In vitro glycoxidized low-density lipoproteins and low-density lipoproteins isolated from type 2 diabetic patients activate platelets via p38 mitogen-activated protein kinase. | 2007 | J. Clin. Endocrinol. Metab. | pmid:17341567 |
Eligini S et al. | Paracrine up-regulation of monocyte cyclooxygenase-2 by platelets: role of transforming growth factor-beta1. | 2007 | Cardiovasc. Res. | pmid:17250815 |
Sood BG et al. | PGE2/TXB2 imbalance in neonatal hypoxemic respiratory failure. | 2007 | Acta Paediatr. | pmid:17376184 |
Kalaitzis C et al. | Role of eicosanoids of the contralateral kidney in maintenance of two-kidney, one-clip renovascular hypertension in rats. | 2007 | Scand. J. Urol. Nephrol. | pmid:17853043 |
Coppinger JA et al. | Moderation of the platelet releasate response by aspirin. | 2007 | Blood | pmid:17303692 |
Graff J et al. | Effects of parecoxib and dipyrone on platelet aggregation in patients undergoing meniscectomy: a double-blind, randomized, parallel-group study. | 2007 | Clin Ther | pmid:17577465 |
Crescente M et al. | Gallic acid, a dietary polyphenolic component, blunts the inhibition of platelet COX-1 by aspirin: preliminary in-vitro findings. | 2007 | Thromb. Haemost. | pmid:17549313 |
Undas A et al. | Lack of aspirin-induced decrease in thrombin formation in subjects resistant to aspirin. | 2007 | Thromb. Haemost. | pmid:17549314 |
Chakroun T et al. | Screening for aspirin resistance in stable coronary artery patients by three different tests. | 2007 | Thromb. Res. | pmid:17553552 |
Pucsok JM et al. | Effect of exercise on levels of cyclo-oxygenase mediators in exhaled breath condensate in elite athletes. | 2007 | J Sports Med Phys Fitness | pmid:17557063 |
Hohlfeld T et al. | Variable platelet response to aspirin in patients with ischemic stroke. | 2007 | Cerebrovasc. Dis. | pmid:17519543 |
Allais G et al. | Naproxen sodium in short-term prophylaxis of pure menstrual migraine: pathophysiological and clinical considerations. | 2007 | Neurol. Sci. | pmid:17508177 |
Wong PC et al. | Platelet aggregometry and receptor binding to predict the magnitude of antithrombotic and bleeding time effects of clopidogrel in rabbits. | 2007 | J. Cardiovasc. Pharmacol. | pmid:17513951 |
Hsiao G et al. | Characterization of a novel and potent collagen antagonist, caffeic acid phenethyl ester, in human platelets: in vitro and in vivo studies. | 2007 | Cardiovasc. Res. | pmid:17560560 |
Basselin M et al. | Flurbiprofen, a cyclooxygenase inhibitor, reduces the brain arachidonic acid signal in response to the cholinergic muscarinic agonist, arecoline, in awake rats. | 2007 | Neurochem. Res. | pmid:17562170 |
Aras-Lopéz R et al. | Dexamethasone decreases contraction to electrical field stimulation in mesenteric arteries from spontaneously hypertensive rats through decreases in thromboxane A2 release. | 2007 | J. Pharmacol. Exp. Ther. | pmid:17562850 |
Zheng BH et al. | [The effect of inhaled nitric oxide on endothelium-derived angiokinetic factors in patients with acute high altitude disease]. | 2007 | Zhonghua Jie He He Hu Xi Za Zhi | pmid:17445476 |
Suzuki A et al. | Ferulic acid restores endothelium-dependent vasodilation in aortas of spontaneously hypertensive rats. | 2007 | Am. J. Hypertens. | pmid:17485012 |
Basselin M et al. | Chronic lithium administration attenuates up-regulated brain arachidonic acid metabolism in a rat model of neuroinflammation. | 2007 | J. Neurochem. | pmid:17488274 |
Gracia-Sancho J et al. | Enhanced vasoconstrictor prostanoid production by sinusoidal endothelial cells increases portal perfusion pressure in cirrhotic rat livers. | 2007 | J. Hepatol. | pmid:17459512 |
Yu XM et al. | [Relations of platelet phospholipid fatty acids to thrombotic risk factors in middle-aged and geriatric patients with hyperlipidemia]. | 2007 | Zhonghua Yi Xue Za Zhi | pmid:17418017 |
Maree AO and Fitzgerald DJ | Variable platelet response to aspirin and clopidogrel in atherothrombotic disease. | 2007 | Circulation | pmid:17452618 |
Aïd S and Bosetti F | Gene expression of cyclooxygenase-1 and Ca(2+)-independent phospholipase A(2) is altered in rat hippocampus during normal aging. | 2007 | Brain Res. Bull. | pmid:17499644 |
Faraday N et al. | Heritability of platelet responsiveness to aspirin in activation pathways directly and indirectly related to cyclooxygenase-1. | 2007 | Circulation | pmid:17470694 |
Luceri C et al. | p-Coumaric acid, a common dietary phenol, inhibits platelet activity in vitro and in vivo. | 2007 | Br. J. Nutr. | pmid:17313706 |
Basselin M et al. | Chronic carbamazepine administration reduces N-methyl-D-aspartate receptor-initiated signaling via arachidonic acid in rat brain. | 2007 | Biol. Psychiatry | pmid:17628508 |
Bray PF et al. | Heritability of platelet function in families with premature coronary artery disease. | 2007 | J. Thromb. Haemost. | pmid:17663734 |
Saeed SA et al. | Dual inhibition of cyclooxygenase and lipoxygenase by human haptoglobin: its polymorphism and relation to hemoglobin binding. | 2007 | Biochem. Biophys. Res. Commun. | pmid:17198677 |
Chang MC et al. | Hydroxychavicol, a novel betel leaf component, inhibits platelet aggregation by suppression of cyclooxygenase, thromboxane production and calcium mobilization. | 2007 | Br. J. Pharmacol. | pmid:17641677 |
Liu J et al. | FcRgamma-chain signals in the absence of glycoprotein VI. | 2007 | J. Thromb. Haemost. | pmid:17010148 |
Li XM et al. | [Physiological effects of cold and cool Chinese herbal medicine of channel tropism of stomach on rats with stomach-heat syndrome]. | 2007 | Zhongguo Zhong Yao Za Zhi | pmid:17672345 |
Park JB | Caffedymine from cocoa has COX inhibitory activity suppressing the expression of a platelet activation marker, P-selectin. | 2007 | J. Agric. Food Chem. | pmid:17319684 |
Guthikonda S et al. | Reticulated platelets and uninhibited COX-1 and COX-2 decrease the antiplatelet effects of aspirin. | 2007 | J. Thromb. Haemost. | pmid:17319904 |
Rohatagi S et al. | Predictive population pharmacokinetic/pharmacodynamic model for a novel COX-2 inhibitor. | 2007 | J Clin Pharmacol | pmid:17322148 |
González-Correa JA et al. | Differences in the influence of the interaction between acetylsalicylic acid and salicylic acid on platelet function in whole blood and isolated platelets: influence of neutrophils. | 2007 | Pharmacol. Res. | pmid:17644353 |
Gendron ME and Thorin E | A change in the redox environment and thromboxane A2 production precede endothelial dysfunction in mice. | 2007 | Am. J. Physiol. Heart Circ. Physiol. | pmid:17644574 |
Weber AA et al. | Effects of selective cyclooxygenase isoform inhibition on systemic prostacyclin synthesis and on platelet function at rest and after exercise in healthy volunteers. | 2007 | Platelets | pmid:17654308 |
Sun LQ et al. | [Relationship between syndrome differentiation of traditional Chinese medicine and vascular endothelial function in patients with diabetic arterial occlusion of lower extremities]. | 2007 | Zhong Xi Yi Jie He Xue Bao | pmid:17997934 |
Marvin CC et al. | Synthesis of thromboxane B2 via ketalization/ring-closing metathesis. | 2007 | Org. Lett. | pmid:18047355 |
Wang Z et al. | Changes of vasoactive polypeptides during postoperative hypertensive crisis in patients with hypertensive intracerebral hemorrhage. | 2007 | Chin. Med. J. | pmid:18167188 |
Silvanto M et al. | Effect of 3 g of intravenous paracetamol on post-operative analgesia, platelet function and liver enzymes in patients undergoing tonsillectomy under local anaesthesia. | 2007 | Acta Anaesthesiol Scand | pmid:17711562 |
Xing X and Li H | Isolated liver perfusion for regional chemotherapy in rats. | 2007 | HBPD INT | pmid:17690035 |
Schwartz JI et al. | Effects of etoricoxib and comparator nonsteroidal anti-inflammatory drugs on urinary sodium excretion, blood pressure, and other renal function indicators in elderly subjects consuming a controlled sodium diet. | 2007 | J Clin Pharmacol | pmid:17925592 |
Capone ML et al. | Human pharmacology of naproxen sodium. | 2007 | J. Pharmacol. Exp. Ther. | pmid:17473175 |
Maksimova MIu et al. | [Hemorheology and homeostasis in the most acute stage of lacunar stroke]. | 2007 | Zh Nevrol Psikhiatr Im S S Korsakova | pmid:18427452 |
Yousefipour Z et al. | Ciglitazone, a peroxisome proliferator-activated receptor gamma inducer, ameliorates renal preglomerular production and activity of angiotensin II and thromboxane A2 in glycerol-induced acute renal failure. | 2007 | J. Pharmacol. Exp. Ther. | pmid:17494862 |
Holma R et al. | Prophylactic potential of montelukast against mild colitis induced by dextran sulphate sodium in rats. | 2007 | J. Physiol. Pharmacol. | pmid:17928642 |
Bogani P et al. | Postprandial anti-inflammatory and antioxidant effects of extra virgin olive oil. | 2007 | Atherosclerosis | pmid:16488419 |
Vidal C et al. | Licofelone, a balanced inhibitor of cyclooxygenase and 5-lipoxygenase, reduces inflammation in a rabbit model of atherosclerosis. | 2007 | J. Pharmacol. Exp. Ther. | pmid:17015640 |
Sekine S et al. | Lowering systolic blood pressure and increases in vasodilator levels in SHR with oral alpha-linolenic acid administration. | 2007 | J Oleo Sci | pmid:17898500 |
Dawood MY and Khan-Dawood FS | Differential suppression of menstrual fluid prostaglandin F2a, prostaglandin E2, 6-keto prostaglandin F1a and thromboxane B2 by suprofen in women with primary dysmenorrhea. | 2007 | Prostaglandins Other Lipid Mediat. | pmid:17259081 |
Jin UH et al. | Inhibitory effect of Panax notoginseng on nitric oxide synthase, cyclo-oxygenase-2 and neutrophil functions. | 2007 | Phytother Res | pmid:17128437 |
Yang YY et al. | Effect of chronic CB1 cannabinoid receptor antagonism on livers of rats with biliary cirrhosis. | 2007 | Clin. Sci. | pmid:17176248 |
Shemesh E et al. | Symptoms of posttraumatic stress disorder in patients who have had a myocardial infarction. | 2006 May-Jun | Psychosomatics | pmid:16684940 |
Tuominen OM et al. | Effects of bisphosphonates on prostaglandin E2 and thromboxane B2 production in human whole blood and monocytes stimulated by lipopolysaccharide and A23187. | 2006 Jul-Aug | Methods Find Exp Clin Pharmacol | pmid:16894405 |
Wang LH et al. | Effect of heparin on activation of platelet function in patients during radiofrequency catheter ablation. | 2006 Jan-Feb | Clin. Exp. Pharmacol. Physiol. | pmid:16445701 |
Wynn RL and Cook J | Does ibuprofen block the cardioprotective effects of aspirin in dental patients? | 2006 Jan-Feb | Gen Dent | pmid:16494111 |
Sciulli MG et al. | Heterogeneity in the suppression of platelet cyclooxygenase-1 activity by aspirin in coronary heart disease. | 2006 | Clin. Pharmacol. Ther. | pmid:16890573 |
Shi T et al. | Anti-beta2-glycoprotein I antibodies in complex with beta2-glycoprotein I can activate platelets in a dysregulated manner via glycoprotein Ib-IX-V. | 2006 | Arthritis Rheum. | pmid:16868978 |
Ramamurthy S et al. | Characterization of thromboxane A2 receptor signaling in developing rat oligodendrocytes: nuclear receptor localization and stimulation of myelin basic protein expression. | 2006 | J. Neurosci. Res. | pmid:16998891 |
Zhou Y et al. | Increased expression of cyclooxygenase-2 mediates enhanced contraction to endothelin ETA receptor stimulation in endothelial nitric oxide synthase knockout mice. | 2006 | Circ. Res. | pmid:16645140 |
Karkabounas S et al. | Anticarcinogenic and antiplatelet effects of carvacrol. | 2006 | Exp. Oncol. | pmid:16837902 |
Wilder-Smith CH et al. | Dose-effect comparisons of the CINOD AZD3582 and naproxen on upper gastrointestinal tract mucosal injury in healthy subjects. | 2006 | Scand. J. Gastroenterol. | pmid:16497612 |
Brenneis C et al. | Inhibition of prostaglandin E2 synthesis by SC-560 is independent of cyclooxygenase 1 inhibition. | 2006 | FASEB J. | pmid:16816110 |
Baltzer WI et al. | Measurement of urinary 11-dehydro-thromboxane B2 excretion in dogs with gastric dilatation-volvulus. | 2006 | Am. J. Vet. Res. | pmid:16426215 |
Chiu HF et al. | Mechanisms involved in the antiplatelet effect of C-phycocyanin. | 2006 | Br. J. Nutr. | pmid:16469164 |
Rossoni G et al. | Nitric oxide and prostacyclin pathways: an integrated mechanism that limits myocardial infarction progression in anaesthetized rats. | 2006 | Pharmacol. Res. | pmid:16488624 |
Lepäntalo A et al. | Polymorphisms of COX-1 and GPVI associate with the antiplatelet effect of aspirin in coronary artery disease patients. | 2006 | Thromb. Haemost. | pmid:16493486 |
Kurosawa S et al. | Effects of ulinastatin on pulmonary artery pressure during abdominal aortic aneurysmectomy. | 2006 | J Clin Anesth | pmid:16517327 |
Ibrahim S et al. | Transfer of very low density lipoprotein-associated phospholipids to activated human platelets. | 2006 | J. Lipid Res. | pmid:16293890 |
Yin M et al. | [Experimental study of effects of cyclooxygenase-2 inhibitor on apoptosis of hypoxic myocardial cells in vitro]. | 2006 | Zhongguo Wei Zhong Bing Ji Jiu Yi Xue | pmid:16647015 |
Ahmad S et al. | Cardamonin, inhibits pro-inflammatory mediators in activated RAW 264.7 cells and whole blood. | 2006 | Eur. J. Pharmacol. | pmid:16650843 |
Fontana P et al. | Biological effects of aspirin and clopidogrel in a randomized cross-over study in 96 healthy volunteers. | 2006 | J. Thromb. Haemost. | pmid:16634751 |
Markuszewski L et al. | Reduced blood platelet sensitivity to aspirin in coronary artery disease: are dyslipidaemia and inflammatory states possible factors predisposing to sub-optimal platelet response to aspirin? | 2006 | Basic Clin. Pharmacol. Toxicol. | pmid:16635110 |
Cheung PY et al. | Platelet dysfunction in asphyxiated newborn piglets resuscitated with 21% and 100% oxygen. | 2006 | Pediatr. Res. | pmid:16627873 |
Laleman W et al. | A stable model of cirrhotic portal hypertension in the rat: thioacetamide revisited. | 2006 | Eur. J. Clin. Invest. | pmid:16620286 |
Zhao Y et al. | Effect of a Chinese herbal formula, Shi-Bi-Lin, on an experimental model of allergic rhinitis. | 2006 | Ann. Allergy Asthma Immunol. | pmid:16802773 |
Lee KS et al. | Antiplatelet activity of [5-(2-methoxy-5-chlorophenyl)furan-2-ylcarbonyl]guanidine (KR-32570), a novel sodium/hydrogen exchanger-1 and its mechanism of action. | 2006 | Arch. Pharm. Res. | pmid:16756082 |
Peck OM et al. | The phosphatidylinositol 3 kinase pathway regulates tolerance to lipopolysaccharide and priming responses to Staphylococcus aureus and lipopolysaccharide. | 2006 | Shock | pmid:16783195 |
Frelinger AL et al. | Residual arachidonic acid-induced platelet activation via an adenosine diphosphate-dependent but cyclooxygenase-1- and cyclooxygenase-2-independent pathway: a 700-patient study of aspirin resistance. | 2006 | Circulation | pmid:16785341 |
Cox D et al. | Effect of enteric coating on antiplatelet activity of low-dose aspirin in healthy volunteers. | 2006 | Stroke | pmid:16794200 |
Munsterhjelm E et al. | Influence on platelet aggregation of i.v. parecoxib and acetaminophen in healthy volunteers. | 2006 | Br J Anaesth | pmid:16698862 |
Zhang JY et al. | [Study on therapeutic effects of series of muskone on myocardial infarction canines]. | 2006 | Zhongguo Zhong Yao Za Zhi | pmid:17225541 |
Basili S et al. | Insulin resistance as a determinant of platelet activation in obese women. | 2006 | J. Am. Coll. Cardiol. | pmid:17174194 |
Hrushka NH et al. | [Effect of thromboxane B2 on morphological features of apoptosis in cultured rat hepatocytes exposed to hepatotropic substances]. | 2006 | Fiziol Zh | pmid:17176837 |
Niemi TT et al. | The effect of N-acetylcysteine on blood coagulation and platelet function in patients undergoing open repair of abdominal aortic aneurysm. | 2006 | Blood Coagul. Fibrinolysis | pmid:16607076 |
Chiang N and Serhan CN | New mechanism for an old drug: aspirin triggers anti-inflammatory lipid mediators with gender implications. | 2006 | Compr Ther | pmid:17435267 |
Chiang N et al. | Aspirin has a gender-dependent impact on antiinflammatory 15-epi-lipoxin A4 formation: a randomized human trial. | 2006 | Arterioscler. Thromb. Vasc. Biol. | pmid:16293793 |
Wolfram RM et al. | Salivary isoprostanes indicate increased oxidation injury in periodontitis with additional tobacco abuse. | 2006 | Biofactors | pmid:17264390 |