Thromboxane b2

Thromboxane b2 is a lipid of Fatty Acyls (FA) class. Thromboxane b2 is associated with abnormalities such as endothelial dysfunction, Diabetes Mellitus, Non-Insulin-Dependent, Diabetes Mellitus, Ischemia and Thrombocytosis. The involved functions are known as Platelet Activation, Excretory function, Anabolism, Inflammation and mRNA Expression. Thromboxane b2 often locates in Endothelium, Hepatic and Microsomes, Liver. The associated genes with Thromboxane b2 are PTGS2 gene, prothrombin fragment 2 and CCL14 wt Allele.

Cross Reference

Introduction

To understand associated biological information of Thromboxane b2, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.

What diseases are associated with Thromboxane b2?

Thromboxane b2 is suspected in endothelial dysfunction, Diabetes Mellitus, Non-Insulin-Dependent, Diabetes Mellitus, Ischemia, Thrombocytosis, Acute Coronary Syndrome and other diseases in descending order of the highest number of associated sentences.

Related references are mostly published in these journals:

Disease Cross reference Weighted score Related literature
Loading... please refresh the page if content is not showing up.

Possible diseases from mapped MeSH terms on references

We collected disease MeSH terms mapped to the references associated with Thromboxane b2

MeSH term MeSH ID Detail
Cholecystitis, Acute D041881 1 associated lipids
Gastric Dilatation D013271 1 associated lipids
Stomach Volvulus D013277 1 associated lipids
Per page 10 20 50 100 | Total 293

PubChem Associated disorders and diseases

What pathways are associated with Thromboxane b2

There are no associated biomedical information in the current reference collection.

PubChem Biomolecular Interactions and Pathways

Link to PubChem Biomolecular Interactions and Pathways

What cellular locations are associated with Thromboxane b2?

Related references are published most in these journals:

Location Cross reference Weighted score Related literatures
Loading... please refresh the page if content is not showing up.

What functions are associated with Thromboxane b2?


Related references are published most in these journals:

Function Cross reference Weighted score Related literatures

What lipids are associated with Thromboxane b2?

There are no associated biomedical information in the current reference collection.

What genes are associated with Thromboxane b2?

Related references are published most in these journals:


Gene Cross reference Weighted score Related literatures

What common seen animal models are associated with Thromboxane b2?

There are no associated biomedical information in the current reference collection.

NCBI Entrez Crosslinks

All references with Thromboxane b2

Download all related citations
Per page 10 20 50 100 | Total 6367
Authors Title Published Journal PubMed Link
Hayashi N et al. Effect of intravenous omega-6 and omega-3 fat emulsions on nitrogen retention and protein kinetics in burned rats. 1999 Nutrition pmid:9990578
Bode AP et al. Activation and adherence of lyophilized human platelets on canine vessel strips in the Baumgartner perfusion chamber. 1999 J. Lab. Clin. Med. pmid:9989772
Montuschi P et al. Anaphylaxis increases 8-iso-prostaglandin F2alpha release from guinea-pig lung in vitro. 1999 Eur. J. Pharmacol. pmid:9988124
Gust R et al. Response to inhaled nitric oxide in acute lung injury depends on distribution of pulmonary blood flow prior to its administration. 1999 Am. J. Respir. Crit. Care Med. pmid:9927374
Fredenrich A et al. Effects of low density and high density lipoproteins isolated from non-insulin dependent diabetic patients on prostaglandin secretion by mouse macrophage cell line P388D1. 1999 Atherosclerosis pmid:9920525
MacKay RJ et al. Effect of a conjugate of polymyxin B-dextran 70 in horses with experimentally induced endotoxemia. 1999 Am. J. Vet. Res. pmid:9918150
Huang YS et al. Serial experimental and clinical studies on the pathogenesis of multiple organ dysfunction syndrome (MODS) in severe burns. 1998 Burns pmid:9915670
Holt S et al. Acute cholestasis-induced renal failure: effects of antioxidants and ligands for the thromboxane A2 receptor. 1999 Kidney Int. pmid:9893136
Davì G et al. In vivo formation of 8-iso-prostaglandin f2alpha and platelet activation in diabetes mellitus: effects of improved metabolic control and vitamin E supplementation. 1999 Circulation pmid:9892587
González E et al. Nitric oxide modulates placental prostanoid production from late pregnant non-insulin-dependent diabetic rat. 1998 Prostaglandins Leukot. Essent. Fatty Acids pmid:9888203
Hoffmann MW et al. [Long term effects of 50 mg acetylsalicylic acid alone and in combination with dipyridamole on platelet function after coronary bypass surgery]. 1998 Z Kardiol pmid:9885179
Shen ZQ et al. Effects of copper-aspirin complex on platelet aggregation and thrombosis in rabbits and mice. 1998 J. Pharm. Pharmacol. pmid:9877314
Guimarães PC et al. Variations in white blood count, thromboxane B2 levels and hematocrit in chronic venous hypertension. 1998 May-Jun Sao Paulo Med J pmid:9876450
Takeuchi K et al. Development of dual-acting agents for thromboxane receptor antagonism and thromboxane synthase inhibition. 3. Synthesis and biological activities of oxazolecarboxamide-substituted omega-phenyl-omega-(3-pyridyl)alkenoic acid derivatives and related compounds. 1998 J. Med. Chem. pmid:9876106
McAdam BF et al. Systemic biosynthesis of prostacyclin by cyclooxygenase (COX)-2: the human pharmacology of a selective inhibitor of COX-2. 1999 Proc. Natl. Acad. Sci. U.S.A. pmid:9874808
Hwang GS et al. Effects of Brazilin on the phospholipase A2 activity and changes of intracellular free calcium concentration in rat platelets. 1998 Arch. Pharm. Res. pmid:9868555
Li HP et al. [The relationship between the activity of phospholipase A2 and acute hypoxic pulmonary arterial pressure]. 1997 Sheng Li Xue Bao pmid:9863193
Hu DH et al. [Effects of hypoxia and anisodamine on products of TXA2 and PGI2 in cultured intra-pulmonary arteriolar smooth muscle cells]. 1997 Sheng Li Xue Bao pmid:9863190
Wu JX et al. [Effects and mechanism of emodin and sandostatin on pancreatic ischemia in acute haemorrhagic necrotizing pancreatitis]. 1997 Zhongguo Zhong Xi Yi Jie He Za Zhi pmid:9863132
Zhang XY and Qian XM [Clinical study of sudden deafness treated with method of integrated traditional Chinese and Western medicine]. 1997 Zhongguo Zhong Xi Yi Jie He Za Zhi pmid:9863112
Sun ZT et al. [Clinical and experimental study on treating bronchial asthma with xingbei granule]. 1997 Zhongguo Zhong Xi Yi Jie He Za Zhi pmid:9863090
Paarlberg KM et al. Vasoactive mediators in pregnancy-induced hypertensive disorders: a longitudinal study. 1998 Am. J. Obstet. Gynecol. pmid:9855596
Praticò D et al. Chronic obstructive pulmonary disease is associated with an increase in urinary levels of isoprostane F2alpha-III, an index of oxidant stress. 1998 Am. J. Respir. Crit. Care Med. pmid:9847257
Stadelmann WK et al. Aprotinin in ischemia-reperfusion injury: flap survival and neutrophil response in a rat skin flap model. 1998 Microsurgery pmid:9846997
de la Cruz JP et al. Effect of WEB 2086-BS, an antagonist of platelet-activating factor receptors, on retinal vascularity in diabetic rats. 1998 Eur. J. Pharmacol. pmid:9845270
Hayashi N et al. Effects of intravenous omega-3 and omega-6 fat emulsion on cytokine production and delayed type hypersensitivity in burned rats receiving total parenteral nutrition. 1998 Nov-Dec JPEN J Parenter Enteral Nutr pmid:9829609
Ricketts AP et al. Evaluation of selective inhibition of canine cyclooxygenase 1 and 2 by carprofen and other nonsteroidal anti-inflammatory drugs. 1998 Am. J. Vet. Res. pmid:9829404
Henry A et al. Inhibition of platelet activation by the Alzheimer's disease amyloid precursor protein. 1998 Br. J. Haematol. pmid:9827912
Schmeck J et al. Endothelin-1 and thromboxane A2 increase pulmonary vascular resistance in granulocyte-mediated lung injury. 1998 Crit. Care Med. pmid:9824081
Kalgutkar AS et al. Covalent modification of cyclooxygenase-2 (COX-2) by 2-acetoxyphenyl alkyl sulfides, a new class of selective COX-2 inactivators. 1998 J. Med. Chem. pmid:9822550
Hauth J et al. Maternal serum thromboxane B2 concentrations do not predict improved outcomes in high-risk pregnancies in a low-dose aspirin trial. The National Institute of Child Health and Human Development Network of Maternal-Fetal Medical Units. 1998 Am. J. Obstet. Gynecol. pmid:9822499
Saitta A et al. Effects of picotamide on release of endothelin-1, thromboxane and prostacycline after treadmill stress in patients with peripheral artery disease. 1998 Angiology pmid:9822043
Menè P et al. Eicosanoid synthesis in peripheral blood monocytes: a marker of disease activity in lupus nephritis. 1998 Am. J. Kidney Dis. pmid:9820447
Jiang XW et al. Effects of low-dose Beraprost sodium, a stable prostaglandin I2 analogue, on reperfusion injury to rabbit lungs. 1998 Am. J. Respir. Crit. Care Med. pmid:9817723
Dobner P and Engelmann B Low-density lipoproteins supply phospholipid-bound arachidonic acid for platelet eicosanoid production. 1998 Am. J. Physiol. pmid:9814996
Hellyer PW et al. The effects of hyperoxia on the biosynthesis of cyclooxygenase products and haemodynamic response to nitric oxide synthase inhibition with L-NAME in endotoxaemic pigs. 1998 J. Vet. Pharmacol. Ther. pmid:9811434
Cullen L et al. Selective cyclooxygenase-2 inhibition by nimesulide in man. 1998 J. Pharmacol. Exp. Ther. pmid:9808683
Huszár E et al. Elevated circulating adenosine level potentiates antigen-induced immediate bronchospasm and bronchoconstrictor mediator release in sensitized guinea pigs. 1998 J. Allergy Clin. Immunol. pmid:9802380
Turpeinen AM et al. Replacement of dietary saturated by unsaturated fatty acids: effects of platelet protein kinase C activity, urinary content of 2,3-dinor-TXB2 and in vitro platelet aggregation in healthy man. 1998 Thromb. Haemost. pmid:9798986
Obase Y et al. Effects of cysteinyl-leukotriene receptor antagonist, thromboxane A2 receptor antagonist, and thromboxane A2 synthetase inhibitor on antigen-induced bronchoconstriction in patients with asthma. 1998 Chest pmid:9792572
Sheu JR et al. Mechanisms involved in the antiplatelet activity of Escherichia coli lipopolysaccharide in human platelets. 1998 Br. J. Haematol. pmid:9792285
Smith CJ et al. Pharmacological analysis of cyclooxygenase-1 in inflammation. 1998 Proc. Natl. Acad. Sci. U.S.A. pmid:9789085
Thomson M et al. Prostanoid synthesis in whole blood cells from fish of the Arabian Gulf. 1998 Comp. Biochem. Physiol. B, Biochem. Mol. Biol. pmid:9787758
John H et al. Development and review of radioimmunoassay of 12-S-hydroxyheptadecatrienoic acid. 1998 Prostaglandins Other Lipid Mediat. pmid:9785378
Lindström T et al. The effect of unreamed and reamed intramedullary nailing on the urinary excretion of prostacyclin and thromboxane A2 metabolites in patients with tibial shaft fractures. 1998 J Trauma pmid:9783614
Chen MF et al. Vitamin E supplementation attenuates myointimal proliferation of the abdominal aorta after balloon injury in diet-induced hypercholesterolemic rabbits. 1998 Prostaglandins Other Lipid Mediat. pmid:9777654
Chavali SR et al. Increased production of TNF-alpha and decreased levels of dienoic eicosanoids, IL-6 and IL-10 in mice fed menhaden oil and juniper oil diets in response to an intraperitoneal lethal dose of LPS. 1998 Prostaglandins Leukot. Essent. Fatty Acids pmid:9774171
Power I et al. Effects of ketorolac and dextran-70 alone and in combination on haemostasis. 1998 Acta Anaesthesiol Scand pmid:9773144
Brinkmann A et al. Vasopressor hormone response following mesenteric traction during major abdominal surgery. 1998 Acta Anaesthesiol Scand pmid:9773140
Yan DH et al. [Study on experimental parameters for diagnosing ganyang huafeng syndrome of cerebral infarction]. 1996 Zhongguo Zhong Xi Yi Jie He Za Zhi pmid:9772617
van Dijk AP et al. Transdermal nicotine inhibits interleukin 2 synthesis by mononuclear cells derived from healthy volunteers. 1998 Eur. J. Clin. Invest. pmid:9767362
Oosaki R et al. Correlation among urinary eosinophil protein X, leukotriene E4, and 11-dehydrothromboxane B2 in patients with spontaneous asthmatic attack. 1998 Clin. Exp. Allergy pmid:9761018
Gajdos M et al. Effective long-term inhibition of thromboxane production but not of serotonin release in patients with coronary heart disease by 30 mg/d acetylsalicylic acid dosage. 1998 Prostaglandins Leukot. Essent. Fatty Acids pmid:9758203
Simon LS et al. Preliminary study of the safety and efficacy of SC-58635, a novel cyclooxygenase 2 inhibitor: efficacy and safety in two placebo-controlled trials in osteoarthritis and rheumatoid arthritis, and studies of gastrointestinal and platelet effects. 1998 Arthritis Rheum. pmid:9751091
Gonchar MV et al. Lack of direct connection between arachidonic acid release and prostanoid synthesis upon differentiation of U937 cell. 1998 Biochem. Biophys. Res. Commun. pmid:9731221
Roberts LJ et al. Metabolism of thromboxane B2 in the monkey. 1978 J. Biol. Chem. pmid:97291
Jain SK et al. Relationship of blood thromboxane-B2 (TxB2) with lipid peroxides and effect of vitamin E and placebo supplementation on TxB2 and lipid peroxide levels in type 1 diabetic patients. 1998 Diabetes Care pmid:9727900
Takami M and Tsukada W In vitro effect of DP-1904, a novel anti-asthma agent, against antigen-induced constriction and TXB2 release from the isolated guinea-pig lung parenchymal tissue. 1998 Pharmacol. Res. pmid:9721602
Takami M and Tsukada W Correlative alteration of thromboxane A2 with antigen-induced bronchoconstriction and the role of platelets as a source of TXA2 synthesis in guinea pigs: effect of DP-1904, an inhibitor of thromboxane synthetase. 1998 Pharmacol. Res. pmid:9721601
Saareks V et al. Nicotine stereoisomers and cotinine stimulate prostaglandin E2 but inhibit thromboxane B2 and leukotriene E4 synthesis in whole blood. 1998 Eur. J. Pharmacol. pmid:9721044
Durando MM et al. Endotoxin activation of mitogen-activated protein kinase in THP-1 cells; diminished activation following endotoxin desensitization. 1998 J. Leukoc. Biol. pmid:9715266
Hsiao G et al. Antiplatelet action of 3',4'-diisovalerylkhellactone diester purified from Peucedanum japonicum Thunb. 1998 Biol. Pharm. Bull. pmid:9703250
Ingster LM and Feinleib M Salicylate intake and cardiovascular disease: Ingster and Feinleib respond to Hu and Willett. 1998 Am J Public Health pmid:9702172
Iida T et al. The effects of a thromboxane A2 synthesis inhibitor and a prostaglandin I2 analogue on experimental acute necrotizing pancreatitis in rats. 1998 Pancreas pmid:9700944
Fagugli RM et al. Reduction of renal functional reserve in kidney transplant recipients: a possible role of arachidonic acid metabolism alterations. 1998 Clin. Nephrol. pmid:9696430
Levy M et al. Cerebrospinal fluid prostaglandins after systemic dipyrone intake. 1998 Clin. Pharmacol. Ther. pmid:9695726
Murphy NP et al. Functional relevance of the expression of ligand-induced binding sites in the response to platelet GP IIb/IIIa antagonists in vivo. 1998 J. Pharmacol. Exp. Ther. pmid:9694954
Ali M et al. Urothelial synthesis of prostanoids in the ovine ureter. 1998 Urol. Res. pmid:9694598
Lebel B et al. Inhibition of mediator release from dispersed nasal polyp cells by cyclosporin A. 1998 Int. Arch. Allergy Immunol. pmid:9693278
Napoli E and Franco N [Thromboxane A2 production in the pathogenesis of diabetic complications]. 1998 Minerva Endocrinol. pmid:9691631
Bell JG et al. Growth, mortality, tissue histopathology and fatty acid compositions, eicosanoid production and response to stress, in juvenile turbot fed diets rich in gamma-linolenic acid in combination with eicosapentaenoic acid or docosahexaenoic acid. 1998 Prostaglandins Leukot. Essent. Fatty Acids pmid:9690713
Stephenson AH et al. 5,6-Epoxyeicosatrienoic acid reduces increases in pulmonary vascular resistance in the dog. 1998 Am. J. Physiol. pmid:9688901
Tewes KS et al. Measurement of thromboxane B2 in platelet-rich human plasma by gas chromatography-mass spectrometry and gas chromatography-tandem mass spectrometry following extractive pentafluorobenzyl esterification. 1998 Anal. Biochem. pmid:9683522
De La Cruz JP et al. Effect of camonagrel, a selective thromboxane synthase inhibitor, on retinal vascularization in experimental diabetes. 1998 Eur. J. Pharmacol. pmid:9683018
Onizuka M et al. Suppression of prostanoid formation and regulation of peripheral circulation after surgery using thrombin inhibitor (MD805). 1998 Surg. Today pmid:9681611
Cheng Z et al. Measurement of cyclooxygenase inhibition in vivo: a study of two non-steroidal anti-inflammatory drugs in sheep. 1998 Inflammation pmid:9675607
Miyamoto A et al. The role of thromboxane A2 in regulating porcine basilar arterial tone. 1998 J. Vet. Pharmacol. Ther. pmid:9673964
Sheu JR et al. Inhibitory mechanisms of naloxone on human platelets. 1998 Jul-Aug Clin. Exp. Pharmacol. Physiol. pmid:9673433
Kunitoh H et al. A double-blind, placebo-controlled trial of the thromboxane synthetase blocker OKY-046 on bronchial hypersensitivity in bronchial asthma patients. 1998 J Asthma pmid:9669829
Geertsen PF et al. Renal haemodynamics, sodium and water reabsorption during continuous intravenous infusion of recombinant interleukin-2. 1998 Clin. Sci. pmid:9662488
Adler S and Bollu R Glomerular endothelial cell injury mediated by shiga-like toxin-1. 1998 Kidney Blood Press. Res. pmid:9661132
Bode-Böger SM et al. Chronic dietary supplementation with L-arginine inhibits platelet aggregation and thromboxane A2 synthesis in hypercholesterolaemic rabbits in vivo. 1998 Cardiovasc. Res. pmid:9659460
Aoki T et al. Difference of (Ca2+)i movements in platelets stimulated by thrombin and TRAP: the involvement of alpha(IIb)beta3-mediated TXA2 synthesis. 1998 Thromb. Haemost. pmid:9657446
Schuligoi R et al. Effects of the cyclooxygenase-2 inhibitor NS-398 on thromboxane and leukotriene synthesis in rat peritoneal cells. 1998 Inflamm. Res. pmid:9657255
Bordia A et al. Effect of garlic (Allium sativum) on blood lipids, blood sugar, fibrinogen and fibrinolytic activity in patients with coronary artery disease. 1998 Prostaglandins Leukot. Essent. Fatty Acids pmid:9654398
Harada Y et al. Differing profiles of prostaglandin formation inhibition between selective prostaglandin H synthase-2 inhibitors and conventional NSAIDs in inflammatory and non-inflammatory sites of the rat. 1998 Prostaglandins Other Lipid Mediat. pmid:9653772
Nagao T et al. Effect of lipo-prostaglandin E1 on crescentic-type anti-glomerular basement membrane nephritis in rats. 1998 Eur. J. Pharmacol. pmid:9650829
Assaley J et al. Effects of magnesium sulfate infusion upon clotting parameters in patients with pre-eclampsia. 1998 J Perinat Med pmid:9650132
Mainwaring RD et al. Complement activation and cytokine generation after modified Fontan procedure. 1998 Ann. Thorac. Surg. pmid:9647087
Whiteford M et al. Effect of liposome-encapsulated hemoglobin on the development of endotoxin-induced shock in the rat. 1998 Shock pmid:9645495
RogovyÄ­ IuE [Beta 2-microglobulin as a criterion of dysfunction in the regulation of proximal tubular activity in mercuric chloride-induced nephropathy]. 1998 May-Jun Urol Nefrol (Mosk) pmid:9644989
Li S and Tian H [Oral low-dose magnesium gluconate preventing pregnancy induced hypertension]. 1997 Zhonghua Fu Chan Ke Za Zhi pmid:9642379
Bereczki C et al. Increased platelet thromboxane release in focal segmental glomerulosclerosis. 1998 Nephrol. Dial. Transplant. pmid:9641208
Tu Y et al. Effect of intra-arachnoid space perfusion on thromboxane A and prostacycline in experimental spinal cord injury. 1997 J. Tongji Med. Univ. pmid:9639784
Lees P et al. Pharmacodynamics and pharmacokinetics of tolfenamic acid in ruminating calves: evaluation in models of acute inflammation. 1998 Vet. J. pmid:9638074
Cadroy Y et al. Arachidonic acid enhances the tissue factor expression of mononuclear cells by the cyclo-oxygenase-1 pathway: beneficial effect of n-3 fatty acids. 1998 J. Immunol. pmid:9637532
Franconi F et al. Further insights into the anti-aggregating activity of NMDA in human platelets. 1998 Br. J. Pharmacol. pmid:9630340
Ozyazgan I et al. Eicosanoids and inflammatory cells in frostbitten tissue: prostacyclin, thromboxane, polymorphonuclear leukocytes, and mast cells. 1998 Plast. Reconstr. Surg. pmid:9623831
Gust R et al. Synergistic hemodynamic effects of low-dose endotoxin and acute lung injury. 1998 Am. J. Respir. Crit. Care Med. pmid:9620928
Bassiouny HS et al. Low flow enhances platelet activation after acute experimental arterial injury. 1998 J. Vasc. Surg. pmid:9620144