MeSH term | MeSH ID | Detail |
---|---|---|
Cholecystitis, Acute | D041881 | 1 associated lipids |
Gastric Dilatation | D013271 | 1 associated lipids |
Stomach Volvulus | D013277 | 1 associated lipids |
Thromboxane b2 is a lipid of Fatty Acyls (FA) class. Thromboxane b2 is associated with abnormalities such as endothelial dysfunction, Diabetes Mellitus, Non-Insulin-Dependent, Diabetes Mellitus, Ischemia and Thrombocytosis. The involved functions are known as Platelet Activation, Excretory function, Anabolism, Inflammation and mRNA Expression. Thromboxane b2 often locates in Endothelium, Hepatic and Microsomes, Liver. The associated genes with Thromboxane b2 are PTGS2 gene, prothrombin fragment 2 and CCL14 wt Allele.
To understand associated biological information of Thromboxane b2, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
Thromboxane b2 is suspected in endothelial dysfunction, Diabetes Mellitus, Non-Insulin-Dependent, Diabetes Mellitus, Ischemia, Thrombocytosis, Acute Coronary Syndrome and other diseases in descending order of the highest number of associated sentences.
Disease | Cross reference | Weighted score | Related literature |
---|
We collected disease MeSH terms mapped to the references associated with Thromboxane b2
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
Location | Cross reference | Weighted score | Related literatures |
---|
Function | Cross reference | Weighted score | Related literatures |
---|
There are no associated biomedical information in the current reference collection.
Gene | Cross reference | Weighted score | Related literatures |
---|
There are no associated biomedical information in the current reference collection.
Authors | Title | Published | Journal | PubMed Link |
---|---|---|---|---|
Ward PS et al. | Excretion of metabolites of prostacyclin and thromboxane by rats with nephrotoxic nephritis: effects of interleukin-1. | 1991 | Br. J. Pharmacol. | pmid:1933130 |
Esser R et al. | Preclinical pharmacology of lumiracoxib: a novel selective inhibitor of cyclooxygenase-2. | 2005 | Br. J. Pharmacol. | pmid:15655513 |
Carmo LG et al. | Platelet desensitization induced by arachidonic acid is not due to cyclo-oxygenase inactivation and involves the endoperoxide receptor. | 1985 | Br. J. Pharmacol. | pmid:2994786 |
Fitzpatrick TM et al. | Tromboxane B2 inhibits the pulmonary inactivation of prostaglandin E2 in the dog. | 1980 | Br. J. Pharmacol. | pmid:7000216 |
Goel RK et al. | Effect of ethanol on eicosanoid synthesis by human gastric and colonic mucosal pieces. | 1990 | Br. J. Pharmacol. | pmid:2328396 |
Anhut H et al. | Prostaglandin D2 is the prevailing prostaglandin in the acute inflammatory exudate of urate arthritis in the chicken. | 1979 | Br. J. Pharmacol. | pmid:570865 |
Giembycz MA et al. | Leukotriene D4 receptors are not negatively coupled to adenylyl cyclase in guinea-pig lung parenchyma. | 1993 | Br. J. Pharmacol. | pmid:8385538 |
Yin K et al. | Blood pressure and vascular reactivity changes in spontaneously hypertensive rats fed fish oil. | 1991 | Br. J. Pharmacol. | pmid:1855129 |
Renesto P et al. | Interference of anti-inflammatory and anti-asthmatic drugs with neutrophil-mediated platelet activation: singularity of azelastine. | 1991 | Br. J. Pharmacol. | pmid:1653073 |
Zhang BL and Sassard J | Eicosanoid-dependence of responses of pre- but not postglomerular vessels to noradrenaline in rat isolated kidneys. | 1993 | Br. J. Pharmacol. | pmid:8220883 |
De La Cruz JP et al. | Antiplatelet effect of the anaesthetic drug propofol: influence of red blood cells and leucocytes. | 1999 | Br. J. Pharmacol. | pmid:10602334 |
Okamura T et al. | Neuroeffector actions of thromboxane B2 in dog isolated mesenteric arteries. | 1988 | Br. J. Pharmacol. | pmid:3359109 |
Ciabattoni G et al. | Effects of vasoactive intestinal polypeptide on antigen-induced bronchoconstriction and thromboxane release in guinea-pig lung. | 1993 | Br. J. Pharmacol. | pmid:8495242 |
Ochi T and Goto T | Differential effect of FR122047, a selective cyclo-oxygenase-1 inhibitor, in rat chronic models of arthritis. | 2002 | Br. J. Pharmacol. | pmid:11834626 |
Zingarelli B et al. | The inhibitory effects of mercaptoalkylguanidines on cyclo-oxygenase activity. | 1997 | Br. J. Pharmacol. | pmid:9031736 |
Sheu JR et al. | Expression of matrix metalloproteinase-9 in human platelets: regulation of platelet activation in in vitro and in vivo studies. | 2004 | Br. J. Pharmacol. | pmid:15289295 |
Tateson JE et al. | Selective inhibition of arachidonate 5-lipoxygenase by novel acetohydroxamic acids: biochemical assessment in vitro and ex vivo. | 1988 | Br. J. Pharmacol. | pmid:2840160 |
Gao YJ and Lee RM | Hydrogen peroxide induces a greater contraction in mesenteric arteries of spontaneously hypertensive rats through thromboxane A(2) production. | 2001 | Br. J. Pharmacol. | pmid:11739239 |
Feuerstein N et al. | Leukotrienes C4 and D4 induce prostaglandin and thromboxane release from rat peritoneal macrophages. | 1981 | Br. J. Pharmacol. | pmid:6894882 |
Bombardieri S et al. | The synovial prostaglandin system in chronic inflammatory arthritis: differential effects of steroidal and nonsteroidal anti-inflammatory drugs. | 1981 | Br. J. Pharmacol. | pmid:6895043 |
Henrion D et al. | Alteration of flow-induced dilatation in mesenteric resistance arteries of L-NAME treated rats and its partial association with induction of cyclo-oxygenase-2. | 1997 | Br. J. Pharmacol. | pmid:9146891 |
Failli P et al. | Effect of some cyclooxygenase inhibitors on the increase in guanosine 3':5'-cyclic monophosphate induced by NO-donors in human whole platelets. | 1998 | Br. J. Pharmacol. | pmid:9579743 |
Alster P and Wennmalm A | Effect of nicotine on the formation of prostacyclin-like activity and thromboxane in rabbit aorta and platelets. | 1984 | Br. J. Pharmacol. | pmid:6367870 |
Burka JF and Garland LG | A possible modulatory role for prostacyclin (PGI2) INIgGa-induced release of slow-reacting substance of anaphylaxis in rats. | 1977 | Br. J. Pharmacol. | pmid:339980 |
Anderegg K et al. | Effects of a pyridine derivative thromboxane synthetase inhibitor and its inactive isomer in endotoxic shock in the rat. | 1983 | Br. J. Pharmacol. | pmid:6687819 |
Ziyyat A et al. | Interactions between nitric oxide and prostanoids in isolated perfused kidneys of the rat. | 1996 | Br. J. Pharmacol. | pmid:8886425 |
Booth RF et al. | Inhibitory effect of a selective thromboxane A2 receptor antagonist, EP 092, on platelet aggregation in whole blood ex vivo and in vivo. | 1989 | Br. J. Pharmacol. | pmid:2522336 |
Frazer CE and Ritter JM | Recovery of prostacyclin synthesis by rabbit aortic endothelium and other tissues after inhibition by aspirin. | 1987 | Br. J. Pharmacol. | pmid:3297227 |
Bult H et al. | Modification of endotoxin-induced haemodynamic and haematological changes in the rabbit by methylprednisolone, F(ab')2 fragments and rosmarinic acid. | 1985 | Br. J. Pharmacol. | pmid:3838489 |
Gray PA et al. | Effects of non-steroidal anti-inflammatory drugs on cyclo-oxygenase and lipoxygenase activity in whole blood from aspirin-sensitive asthmatics vs healthy donors. | 2002 | Br. J. Pharmacol. | pmid:12429575 |
Sheu JR et al. | The antiplatelet activity of PMC, a potent alpha-tocopherol analogue, is mediated through inhibition of cyclo-oxygenase. | 1999 | Br. J. Pharmacol. | pmid:10455267 |
Jiménez R et al. | Involvement of thromboxane A2 in the endothelium-dependent contractions induced by myricetin in rat isolated aorta. | 1999 | Br. J. Pharmacol. | pmid:10455307 |
Boukili MA et al. | Pharmacological modulation of the effects of N-formyl-L-methionyl-L-leucyl-L-phenylalanine in guinea-pigs: involvement of the arachidonic acid cascade. | 1986 | Br. J. Pharmacol. | pmid:3096407 |
Förster W and Pönicke K | Influence of sympathomimetic drugs (1-phenyl-2-amino-ethan-1-ol derivatives) on the biosynthesis of prostaglandins and thromboxane B2. | 1983 | Br. J. Pharmacol. | pmid:6403094 |
Mallarkey G and Smith GM | A comparative study of the involvement of the prostaglandin H2/thromboxane A2 pathway in intravascular platelet aggregation in guinea-pigs and rats. | 1985 | Br. J. Pharmacol. | pmid:3156648 |
Riendeau D et al. | Biochemical and pharmacological profile of a tetrasubstituted furanone as a highly selective COX-2 inhibitor. | 1997 | Br. J. Pharmacol. | pmid:9146894 |
Lees P et al. | Serum thromboxane in the horse and its inhibition by aspirin, phenylbutazone and flunixin. | 1987 Sep-Oct | Br. Vet. J. | pmid:3119142 |
Delatour P et al. | Pharmacodynamics and chiral pharmacokinetics of carprofen in calves. | 1996 | Br. Vet. J. | pmid:8680841 |
McKellar QA et al. | Serum thromboxane generation by platelets in several domestic animal species. | 1990 Sep-Oct | Br. Vet. J. | pmid:2224484 |
Taylor PM et al. | Flunixin in the cat: a pharmacodynamic, pharmacokinetic and toxicological study. | 1994 May-Jun | Br. Vet. J. | pmid:8044665 |
Lees P and Taylor PM | Pharmacodynamics and pharmacokinetics of flunixin in the cat. | 1991 Jul-Aug | Br. Vet. J. | pmid:1913126 |
Nobutoki T et al. | Fluctuating hearing loss, episodic headache, and stroke with platelet hyperaggregability: coexistence of auditory neuropathy and cochlear hearing loss. | 2006 | Brain Dev. | pmid:16168600 |
Patel PM et al. | Differential temperature sensitivity of ischemia-induced glutamate release and eicosanoid production in rats. | 1994 | Brain Res. | pmid:7953685 |
Cach R et al. | Microvascular spasm is mediated by vasopressin fibers in the rat hippocampal slice. | 1989 | Brain Res. | pmid:2706515 |
Busija DW et al. | Acetylcholine dramatically increases prostanoid synthesis in piglet parietal cortex. | 1988 | Brain Res. | pmid:3359178 |
Petroni A et al. | Effects of hypoxia and recovery on brain eicosanoids and carbohydrate metabolites in rat brain cortex. | 1987 | Brain Res. | pmid:3607494 |
Hynes N et al. | Leukotrienes in brain: natural occurrence and induced changes. | 1991 | Brain Res. | pmid:1933275 |
Cach R et al. | Blood-borne factors regulating microvascular constriction in the rat hippocampal slice. | 1987 | Brain Res. | pmid:3620912 |
Hartung HP et al. | Recombinant interleukin-1 beta stimulates eicosanoid production in rat primary culture astrocytes. | 1989 | Brain Res. | pmid:2501001 |
Faden AI et al. | Effects of BW755C, a mixed cyclo-oxygenase-lipoxygenase inhibitor, following traumatic spinal cord injury in rats. | 1988 | Brain Res. | pmid:3143469 |
Seregi A et al. | Decreased levels of brain cyclo-oxygenase products as a possible cause of increased seizure susceptibility in convulsion-prone gerbils. | 1984 | Brain Res. | pmid:6430471 |
Pettigrew LC et al. | Delayed elevation of platelet activating factor in ischemic hippocampus. | 1995 | Brain Res. | pmid:8590061 |
Constable AL et al. | Production of prostanoids by Lewis rat Schwann cells in vitro. | 1994 | Brain Res. | pmid:8173981 |
Andrus PK et al. | Effects of the lipid peroxidation inhibitor tirilazad mesylate (U-74006F) on gerbil brain eicosanoid levels following ischemia and reperfusion. | 1994 | Brain Res. | pmid:7820653 |
Ahmad M et al. | Prolonged opportunity for neuroprotection in experimental stroke with selective blockade of cyclooxygenase-2 activity. | 2009 | Brain Res. | pmid:19446533 |
Aïd S and Bosetti F | Gene expression of cyclooxygenase-1 and Ca(2+)-independent phospholipase A(2) is altered in rat hippocampus during normal aging. | 2007 | Brain Res. Bull. | pmid:17499644 |
Tuppo EE et al. | Sign of lipid peroxidation as measured in the urine of patients with probable Alzheimer's disease. | 2001 | Brain Res. Bull. | pmid:11397549 |
Akarsu ES et al. | Effect of ciliary neurotrophic factor on body temperature and cerebrospinal fluid prostanoids in the cat. | 1998 | Brain Res. Bull. | pmid:9434196 |
Petroni A et al. | Eicosanoid and inositol phosphate response to platelet-activating factor (PAF) and to a PAF antagonist in rat astroglial cells. | 1994 | Brain Res. Dev. Brain Res. | pmid:8026072 |
Petrikova M et al. | Carvedilol--a beta-blocker with considerable antiaggregatory effect on human blood platelets. | 2005 | Bratisl Lek Listy | pmid:15869009 |
Gajdos M et al. | [The effect of monotherapy with ciprofibrate and in combination with acetylsalicylic acid on the spectrum of lipids, thromboxane and fibrinogen in patients with atherosclerosis and hyperlipoproteinemia]. | 1999 | Bratisl Lek Listy | pmid:10645034 |
Kasjanovová D and Baláz V | [Functional status of thrombocytes in men of various age groups]. | 1990 | Bratisl Lek Listy | pmid:2224554 |
Rajec J et al. | Biochemical evaluation of the antiplatelet effect of aspirin in patients at different levels of cardiovascular risk. | 2008 | Bratisl Lek Listy | pmid:18814431 |
Kasjanovová D | [Functional status of thrombocytes in men and women in younger age groups]. | 1993 | Bratisl Lek Listy | pmid:8004501 |
Röth E | Effect of Ca-antagonists, beta-blockers and antioxidant during reperfusion period. | 1991 Mar-Apr | Bratisl Lek Listy | pmid:2029661 |
Lamy M et al. | Biochemical pathways of acute lung injury. | 1985 May-Jun | Bull Eur Physiopathol Respir | pmid:3873973 |
Sakanishi N et al. | Thromboxane A2 and hemodynamic-biochemical parameters in canine endotoxin shock. | 1983 | Bull. Tokyo Med. Dent. Univ. | pmid:6580966 |
Huang YS et al. | Roles of thromboxane and its inhibitor anisodamine in burn shock. | 1990 | Burns | pmid:2257065 |
Yregård L et al. | Influence of local anaesthetics on inflammatory activity postburn. | 2003 | Burns | pmid:12781610 |
Huang YS et al. | Serial experimental and clinical studies on the pathogenesis of multiple organ dysfunction syndrome (MODS) in severe burns. | 1998 | Burns | pmid:9915670 |
Huang YS et al. | Effect of smoke inhalation injury on thromboxane levels and platelet counts. | 1988 | Burns Incl Therm Inj | pmid:3250716 |
Girotti MJ et al. | Comparison of regional pulmonary perfusion in lobar pneumonia during high frequency and conventional mechanical ventilation in sheep. | 1987 | Can J Anaesth | pmid:3581395 |
Licker M et al. | Chronic angiotensin converting inhibition does not influence renal hemodynamic and function during cardiac surgery. | 1999 | Can J Anaesth | pmid:10442956 |
Byrick RJ et al. | Corticosteroids do not inhibit acute pulmonary response to fat embolism. | 1990 | Can J Anaesth | pmid:2193732 |
Byrick RJ et al. | Prostanoid production and pulmonary hypertension after fat embolism are not modified by methylprednisolone. | 1991 | Can J Anaesth | pmid:1934222 |
Landymore RW et al. | Correlation between the effects of aspirin and dipyridamole on platelet function and prevention of intimal hyperplasia in autologous vein grafts. | 1988 Jan-Feb | Can J Cardiol | pmid:3359354 |
Gerrard JM et al. | The structured interview elicits a differential prostacyclin response in A and B behaviour types. | 1991 | Can J Cardiol | pmid:2070285 |
Klein RC et al. | Absence of differential inhibition of thromboxane A2 and prostacyclin by low and high dose aspirin in coronary artery disease. | 1987 | Can J Cardiol | pmid:3322532 |
Shizukuda Y et al. | Effect of prednisolone on myocardial infarct healing: characteristics and comparison with indomethacin. | 1991 | Can J Cardiol | pmid:1768984 |
Chou TZ et al. | Effect of felodipine-ER on blood pressure, platelet function, and rheological properties in hypertension. | 1993 | Can J Cardiol | pmid:8394193 |
Moreno A et al. | Prostacyclin-thromboxane balance and retinal vascular pattern in rats with experimentally induced diabetes. | 1995 | Can. J. Ophthalmol. | pmid:7627895 |
Tosaki A et al. | Effect of cicletanine on reperfusion-induced arrhythmias and its relation to 6-keto-PGF1 alpha and thromboxane B2 release. | 1991 | Can. J. Physiol. Pharmacol. | pmid:2059911 |
Datar S et al. | Effect of cyclooxygenase and thromboxane synthetase inhibition on furosemide-stimulated plasma renin activity. | 1987 | Can. J. Physiol. Pharmacol. | pmid:3105853 |
Rodrigue ME et al. | Cyclooxygenase inhibition with acetylsalicylic acid unmasks a role for prostacyclin in erythropoietin-induced hypertension in uremic rats. | 2005 | Can. J. Physiol. Pharmacol. | pmid:16049546 |
Gerrard JM | Measurements of 6-keto-prostaglandin F1 alpha and thromboxane B2 in bleeding time blood: relation to bleeding and vascular disorders? | 1989 | Can. J. Physiol. Pharmacol. | pmid:2688855 |
Kitamura R et al. | Thiopental enhances human platelet aggregation by increasing arachidonic acid release. | 2001 | Can. J. Physiol. Pharmacol. | pmid:11697744 |
Kaushal RD and Wilson TW | Effect of furegrelate on renal plasma flow after angiotensin II infusion. | 1990 | Can. J. Physiol. Pharmacol. | pmid:2328452 |
Liao CH et al. | Antiplatelet effect of demethyldiisoeugenol. | 1996 | Can. J. Physiol. Pharmacol. | pmid:9022830 |
Jancar S et al. | Mechanism of action of platelet-activating factor on guinea-pig lung parenchyma strips. | 1988 | Can. J. Physiol. Pharmacol. | pmid:3146431 |
Smith EF et al. | Influence of thromboxane inhibition on the severity of myocardial ischemia in cats. | 1980 | Can. J. Physiol. Pharmacol. | pmid:7378931 |
Jiang J et al. | Endothelin-1 blockade prevents COX2 induction and TXA2 production in the fructose hypertensive rat. | 2007 Mar-Apr | Can. J. Physiol. Pharmacol. | pmid:17612651 |
Carvalho C et al. | Inhibition of airway hyperreactivity, edema, and lung cell infiltration by compound U-83836E in sensitized guinea pigs. | 1998 Jul-Aug | Can. J. Physiol. Pharmacol. | pmid:10030451 |
Lewis K et al. | Effect of neuropeptide Y on bradykinin-induced release of prostacyclin and thromboxane from guinea pig perfused lung. | 1997 | Can. J. Physiol. Pharmacol. | pmid:9276148 |
Jenkins DK et al. | Effects of albumin on fatty acid, protein, and eicosanoid levels in rat mesenteric arterial bed perfusions. | 1988 | Can. J. Physiol. Pharmacol. | pmid:3167681 |
Gibb W et al. | Cyclooxygenase products formed by primary cultures of cells from human chorion laeve: influence of steroids. | 1988 | Can. J. Physiol. Pharmacol. | pmid:3167693 |
Riendeau D et al. | Comparison of the cyclooxygenase-1 inhibitory properties of nonsteroidal anti-inflammatory drugs (NSAIDs) and selective COX-2 inhibitors, using sensitive microsomal and platelet assays. | 1997 | Can. J. Physiol. Pharmacol. | pmid:9365818 |
Jackman BR et al. | Comparison of the effects of ketoprofen and flunixin meglumine on the in vitro response of equine peripheral blood monocytes to bacterial endotoxin. | 1994 | Can. J. Vet. Res. | pmid:8004539 |
King JN | The use of intradermal carrageenan in calves to estimate the dose of oxindanac, a nonsteroidal anti-inflammatory drug. | 1993 | Can. J. Vet. Res. | pmid:8269358 |
Yamamura S et al. | Prostaglandin levels of primary bone tumor tissues correlate with peritumoral edema demonstrated by magnetic resonance imaging. | 1997 | Cancer | pmid:9010098 |
Klausner JM et al. | Interleukin-2-induced lung permeability is mediated by leukotriene B4. | 1990 | Cancer | pmid:2173970 |