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Preclinical pharmacology of lumiracoxib: a novel selective inhibitor of cyclooxygenase-2. |
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Br. J. Pharmacol. |
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Sexual dimorphism in renal production of prostanoids in spontaneously hypertensive rats. |
2005 |
Hypertension |
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Inhibition of cyclooxygenase activity, platelet aggregation and thromboxane B2 production by two environmental toxicants: m- and o-cresol. |
2005 |
Toxicology |
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In vitro assessment of renal toxicity and inflammatory events of two protein phosphatase inhibitors cantharidin and nor-cantharidin. |
2005 |
Basic Clin. Pharmacol. Toxicol. |
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Antiplatelet activity of BRX-018, (6aS,cis)-malonic acid 3-acetoxy-6a9-bis-(2-methoxycarbonyl-acetoxy)-6,6a,7,11b-tetrahydro-indeno[2,1-c]chromen-10-yl ester methylester. |
2005 |
Thromb. Res. |
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Vaporized perfluorohexane attenuates ventilator-induced lung injury in isolated, perfused rabbit lungs. |
2005 |
Anesthesiology |
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[Insulin resistance and effects of intravenous acute saline load on renal production of prostaglandin I2 and thromboxane A2 in salt-sensitive hypertensive patients]. |
2005 |
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Bradykinin B2 receptor antagonist FR173657 ameliorates small bowel ischemia-reperfusion injury in dogs. |
2005 |
Dig. Dis. Sci. |
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Streptococcus sanguis-induced platelet activation involves two waves of tyrosine phosphorylation mediated by FcgammaRIIA and alphaIIbbeta3. |
2005 |
Thromb. Haemost. |
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Cigarette smoking is associated with increased circulating proinflammatory and procoagulant markers in patients with chronic coronary artery disease: effects of aspirin treatment. |
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Am. Heart J. |
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Carvedilol--a beta-blocker with considerable antiaggregatory effect on human blood platelets. |
2005 |
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Kidney Int. |
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The influence of acetylsalicylic acid intake by healthy volunteers on duplicate PFA-100 measurements. |
2005 |
Blood Coagul. Fibrinolysis |
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A long-acting prostacyclin agonist with thromboxane inhibitory activity for pulmonary hypertension. |
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Am. J. Respir. Crit. Care Med. |
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Dose-dependent inhibition of platelet function by acetaminophen in healthy volunteers. |
2005 |
Anesthesiology |
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Inhibitory effects of lycopene on in vitro platelet activation and in vivo prevention of thrombus formation. |
2005 |
J. Lab. Clin. Med. |
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Effects of medicinal cake-separated moxibustion on plasma 6-keto-PGF1alpha and TXB2 contents in the rabbit of hyperlipemia. |
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J Tradit Chin Med |
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Effects of salt loading on blood pressure in mice lacking the prostanoid receptor gene. |
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Circ. J. |
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Thromboxane-dependent portopulmonary hypertension. |
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Am. J. Med. |
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Platelet activation in patients with colorectal cancer. |
2005 |
Prostaglandins Leukot. Essent. Fatty Acids |
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Biological assessment of aspirin efficacy on healthy individuals: heterogeneous response or aspirin failure? |
2005 |
Stroke |
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Effects of compounds in leaves of Salix matsudana on arachidonic acid metabolism. |
2005 |
Yakugaku Zasshi |
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Inhibition of thromboxane biosynthesis by triflusal in type 2 diabetes mellitus. |
2005 |
Atherosclerosis |
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Enzymologic and pharmacologic profile of loxoprofen sodium and its metabolites. |
2005 |
Biol. Pharm. Bull. |
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[Synthesis of 2-, 4- and 5-(2-alkylcarbamoyl-1-methylvinyl)-7-alkyloxybenzo[b]furans and their leukotriene B4 receptor antagonistic activity]. |
2005 |
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Improvement of age-related endothelial dysfunction by simvastatin: effect on NO and COX pathways. |
2005 |
Br. J. Pharmacol. |
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Captopril effect on prostaglandin E2, thromboxane B2 and proteinuria in lupus nephritis patients. |
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Prostaglandins Other Lipid Mediat. |
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Plasma, serum, and platelet expression of CD40 ligand in adults with cardiovascular disease. |
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Am. J. Cardiol. |
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Serum deprivation and re-addition: effects on cyclooxygenase inhibitor sensitivity in cultured glia. |
2005 |
Inflammopharmacology |
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Comparative study of anti-inflammatory and ulcerogenic activities of different cyclo-oxygenase inhibitors. |
2005 |
Inflammopharmacology |
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Mechanisms involved in the antiplatelet activity of ketamine in human platelets. |
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Transdermal hormone replacement therapy and Doppler findings in normal and overweight postmenopausal patients. |
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Gynecol. Endocrinol. |
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Effect of COX-1/COX-2 inhibition versus selective COX-2 inhibition on coronary vasodilator responses to arachidonic acid and acetylcholine. |
2004 |
Pharmacology |
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Quantitative liquid chromatography-tandem mass spectrometric analysis of 11-dehydro TXB2 in urine. |
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Prostaglandins Other Lipid Mediat. |
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The ingestion of Ginkgo biloba extract (EGb 761) inhibits arachidonic acid-mediated platelet aggregation and thromboxane B2 production in healthy volunteers. |
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J Herb Pharmacother |
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Antithrombotic effects of FK419, a novel nonpeptide platelet GPIIb/IIIa antagonist, in a guinea pig photochemically induced middle cerebral artery thrombosis model: comparison with ozagrel and argatroban. |
2004 |
J. Pharmacol. Exp. Ther. |
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[Clinical study on relationship between sluggishness of lung-defensive qi and levels of vasoactive intestinal polypeptide and thromboxane B2]. |
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Co-administration of nitric oxide-aspirin (NCX-4016) and aspirin prevents platelet and monocyte activation and protects against gastric damage induced by aspirin in humans. |
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J. Am. Coll. Cardiol. |
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[Influence of single leaf Asarum himalaicum on renal function of rabbits]. |
2004 |
Zhong Xi Yi Jie He Xue Bao |
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Altered kidney CYP2C and cyclooxygenase-2 levels are associated with obesity-related albuminuria. |
2004 |
Obes. Res. |
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Expression of matrix metalloproteinase-9 in human platelets: regulation of platelet activation in in vitro and in vivo studies. |
2004 |
Br. J. Pharmacol. |
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Insights into the role of interleukin-6 in the induction of hepatic injury after trauma-hemorrhagic shock. |
2004 |
J. Appl. Physiol. |
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Increased platelet-derived microparticles in the coronary circulation of percutaneous transluminal coronary angioplasty patients. |
2004 |
Blood Coagul. Fibrinolysis |
pmid:15311156
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Devi MM and Das UN |
Effect of prostaglandins against alloxan-induced cytotoxicity to insulin secreting insulinoma RIN cells in vitro. |
2004 |
Prostaglandins Leukot. Essent. Fatty Acids |
pmid:15380818
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Platelet activation in type 2 diabetes mellitus. |
2004 |
J. Thromb. Haemost. |
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Novel synthesis of 3,4-diarylisoxazole analogues of valdecoxib: reversal cyclooxygenase-2 selectivity by sulfonamide group removal. |
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J. Med. Chem. |
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Cardiac pathologic effects of azidothymidine (AZT) in Mg-deficient mice. |
2004 |
Cardiovasc. Toxicol. |
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In vitro effects of poly-N-acetyl glucosamine on the activation of platelets in platelet-rich plasma with and without red blood cells. |
2004 |
J Trauma |
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Can n-3 PUFA reduce cardiac arrhythmias? Results of a clinical trial. |
2004 |
Prostaglandins Leukot. Essent. Fatty Acids |
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Apocynin prevents cyclooxygenase 2 expression in human monocytes through NADPH oxidase and glutathione redox-dependent mechanisms. |
2004 |
Free Radic. Biol. Med. |
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Membrane-associated prostaglandin E synthase-1 is upregulated by proinflammatory cytokines in chondrocytes from patients with osteoarthritis. |
2004 |
Arthritis Res. Ther. |
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Effects of thiol antioxidant on reduced nicotinamide adenine dinucleotide phosphate oxidase in hypertensive Dahl salt-sensitive rats. |
2004 |
Free Radic. Biol. Med. |
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Endotoxin-induced digital vasoconstriction in horses: associated changes in plasma concentrations of vasoconstrictor mediators. |
2004 |
Equine Vet. J. |
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Effect of BM-573 [N-terbutyl-N'-[2-(4'-methylphenylamino)-5-nitro-benzenesulfonyl]urea], a dual thromboxane synthase inhibitor and thromboxane receptor antagonist, in a porcine model of acute pulmonary embolism. |
2004 |
J. Pharmacol. Exp. Ther. |
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Experimental evidence of a potentially increased thrombo-embolic disease risk by domestic electromagnetic field exposure. |
2004 |
Bioelectromagnetics |
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Aspirin resistance and diabetic angiopathy: back to the future. |
2004 |
Thromb. Res. |
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Thrombosis and neointima formation in vein grafts are inhibited by locally applied aspirin through endothelial protection. |
2004 |
Circ. Res. |
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Inhibition of platelet aggregation by polyaspartoyl L-arginine and its mechanism. |
2004 |
Acta Pharmacol. Sin. |
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Inhibition of IL-6, TNF-alpha, and cyclooxygenase-2 protein expression by prostaglandin E2-induced IL-10 in bone marrow-derived dendritic cells. |
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Cell. Immunol. |
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Dietary conjugated linoleic acid increases the mRNA ratio of Bax/Bcl-2 in the colonic mucosa of rats. |
2004 |
J. Nutr. Biochem. |
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Inhibition of inflammation contributes to organ protection of atenolol in sinoaortic-denervated rats. |
2004 |
J. Cardiovasc. Pharmacol. |
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Serial urinary 11-dehydrothromboxane B2, aspirin dose, and vascular events in blacks after recent cerebral infarction. |
2004 |
Stroke |
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Effects of propofol on endotoxin-induced acute lung injury in rabbit. |
2004 |
J. Korean Med. Sci. |
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Lumiracoxib: pharmacokinetic and pharmacodynamic profile when coadministered with fluconazole in healthy subjects. |
2004 |
J Clin Pharmacol |
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In vitro effects of clopidogrel on the platelet-subendothelium interaction, platelet thromboxane and endothelial prostacyclin production, and nitric oxide synthesis. |
2004 |
J. Cardiovasc. Pharmacol. |
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Effects of different dietary oils on inflammatory mediator generation and fatty acid composition in rat neutrophils. |
2004 |
Metab. Clin. Exp. |
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Role of endothelin-1 and thromboxane A2 in the pulmonary hypertension induced by heparin-protamine interaction in anesthetized dogs. |
2004 |
J. Cardiovasc. Pharmacol. |
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Lack of aspirin effect: aspirin resistance or resistance to taking aspirin? |
2004 |
Am. Heart J. |
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Granulocyte colony-stimulating factor (filgrastim) treatment primes for increased ex vivo inducible prostanoid release. |
2004 |
J. Pharmacol. Exp. Ther. |
pmid:14610236
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Determinants of platelet activation in human essential hypertension. |
2004 |
Hypertension |
pmid:14656953
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Anti-inflammatory effects of a traditional Korean herbal formulation, Silsosangami, consisting of seven medicinal herbs: effect on hemolysis, neutrophil function, and gene expressions of iNOS and COX-2. |
2004 |
Vascul. Pharmacol. |
pmid:15664882
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Prostacyclin, thromboxane A and the effect of low-dose ASA in pregnancies at high risk for hypertensive disorders. |
2004 |
Acta Obstet Gynecol Scand |
pmid:15548142
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Clinical pharmacology of platelet, monocyte, and vascular cyclooxygenase inhibition by naproxen and low-dose aspirin in healthy subjects. |
2004 |
Circulation |
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[Effects of the extracts from decoction for resuscitation and its component herbs on PGI2, TXA2 and NO release from rat vascular endothelial cells under hypoxia in vitro]. |
2004 |
Zhongguo Zhong Yao Za Zhi |
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[Changes of the platelet function and serum anticardiolipin antibody in patients with pulmonary thromboembolism]. |
2004 |
Zhonghua Jie He He Hu Xi Za Zhi |
pmid:15634381
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[The effects of lupus anticoagulant on pulmonary thromboembolism]. |
2004 |
Zhonghua Jie He He Hu Xi Za Zhi |
pmid:15634384
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Franz KB |
A functional biological marker is needed for diagnosing magnesium deficiency. |
2004 |
J Am Coll Nutr |
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Amlodipine attenuates oxidative stress-induced hypertension. |
2004 |
Am. J. Hypertens. |
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Phenylpropanoid glycosides from Scrophularia scorodonia: in vitro anti-inflammatory activity. |
2004 |
Life Sci. |
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Proinflammatory cytokines enhance COX-1 gene expression in cultured rat glomerular mesangial cells. |
2004 |
Int. Immunopharmacol. |
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Protective effect of pentoxifylline on volume-induced lung injury in newborn piglets. |
2004 |
Biol. Neonate |
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Ikonomidis I et al. |
Reduction of daily life ischaemia by aspirin in patients with angina: underlying link between thromboxane A2 and macrophage colony stimulating factor. |
2004 |
Heart |
pmid:15020512
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What is the lowest dose of aspirin for maximum suppression of in vivo thromboxane production after a transient ischemic attack or ischemic stroke? |
2004 |
Cerebrovasc. Dis. |
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Licofelone, an inhibitor of cyclooxygenase and 5-lipoxygenase, specifically inhibits cyclooxygenase-1-dependent platelet activation. |
2004 |
Eur. J. Pharmacol. |
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Carrageenan-induced paw edema in rat elicits a predominant prostaglandin E2 (PGE2) response in the central nervous system associated with the induction of microsomal PGE2 synthase-1. |
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J. Biol. Chem. |
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Diabetic patients without vascular complications display enhanced basal platelet activation and decreased antioxidant status. |
2004 |
Diabetes |
pmid:15047620
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Uncontrolled hypertension, uncompensated type II diabetes, and smoking have different patterns of vascular dysfunction. |
2004 |
Chest |
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Human bone marrow megakaryocytes and platelets express PPARgamma, and PPARgamma agonists blunt platelet release of CD40 ligand and thromboxanes. |
2004 |
Blood |
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Anti-inflammatory effect of two isoforms of COX in H. pylori-induced gastritis in mice: possible involvement of PGE2. |
2004 |
Am. J. Physiol. Gastrointest. Liver Physiol. |
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Modulation of the expression and activity of cyclooxygenases in normal and accelerated erythropoiesis. |
2004 |
Exp. Hematol. |
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Low concentration of oxidized low density lipoprotein suppresses platelet reactivity in vitro: an intracellular study. |
2004 |
Lipids |
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Effects of the Chinese drugs for activating blood circulation on plasma TXB2 and 6-keto-PGF1alpha contents in rabbits with glucocorticoid-induced femoral head necrosis. |
2004 |
J Tradit Chin Med |
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Aspirin triggers antiinflammatory 15-epi-lipoxin A4 and inhibits thromboxane in a randomized human trial. |
2004 |
Proc. Natl. Acad. Sci. U.S.A. |
pmid:15471991
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Park WH et al. |
Inhibitory effect of GBH on platelet aggregation through inhibition of intracellular Ca2+ mobilization in activated human platelets. |
2004 |
Life Sci. |
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[Characteristic changes of vascular tension factors in diabetic arterial occlusion of lower extremities]. |
2004 |
Zhongguo Zhong Xi Yi Jie He Za Zhi |
pmid:15495823
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Cyclooxygenase inhibition is associated with downregulation of apolipoprotein AI promoter activity in cultured hepatoma cell line HepG2. |
2004 |
Metab. Clin. Exp. |
pmid:14767868
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TP receptors regulate renal hemodynamics during angiotensin II slow pressor response. |
2004 |
Am. J. Physiol. Renal Physiol. |
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Peck OM et al. |
Staphylococcus aureus and lipopolysaccharide induce homologous tolerance but heterologous priming: role of interferon-gamma. |
2004 |
Shock |
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