| MeSH term | MeSH ID | Detail |
|---|---|---|
| Cleft Palate | D002972 | 9 associated lipids |
| Colitis | D003092 | 69 associated lipids |
| Colonic Neoplasms | D003110 | 161 associated lipids |
| Contusions | D003288 | 3 associated lipids |
| Coronary Artery Disease | D003324 | 47 associated lipids |
| Coronary Disease | D003327 | 70 associated lipids |
| Coronary Thrombosis | D003328 | 7 associated lipids |
| Coronary Vasospasm | D003329 | 9 associated lipids |
| Cough | D003371 | 19 associated lipids |
| Death, Sudden | D003645 | 12 associated lipids |
| Dermatitis, Atopic | D003876 | 19 associated lipids |
| Diabetes Mellitus | D003920 | 90 associated lipids |
| Diabetes Mellitus, Experimental | D003921 | 85 associated lipids |
| Diabetes Mellitus, Type 1 | D003922 | 56 associated lipids |
| Diabetes Mellitus, Type 2 | D003924 | 87 associated lipids |
| Diabetic Angiopathies | D003925 | 20 associated lipids |
| Diabetic Nephropathies | D003928 | 39 associated lipids |
| Diabetic Retinopathy | D003930 | 39 associated lipids |
| Diseases in Twins | D004200 | 4 associated lipids |
| Disseminated Intravascular Coagulation | D004211 | 7 associated lipids |
Thromboxane b2
Thromboxane b2 is a lipid of Fatty Acyls (FA) class. Thromboxane b2 is associated with abnormalities such as endothelial dysfunction, Diabetes Mellitus, Non-Insulin-Dependent, Diabetes Mellitus, Ischemia and Thrombocytosis. The involved functions are known as Platelet Activation, Excretory function, Anabolism, Inflammation and mRNA Expression. Thromboxane b2 often locates in Endothelium, Hepatic and Microsomes, Liver. The associated genes with Thromboxane b2 are PTGS2 gene, prothrombin fragment 2 and CCL14 wt Allele.
Cross Reference
Introduction
To understand associated biological information of Thromboxane b2, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with Thromboxane b2?
Thromboxane b2 is suspected in endothelial dysfunction, Diabetes Mellitus, Non-Insulin-Dependent, Diabetes Mellitus, Ischemia, Thrombocytosis, Acute Coronary Syndrome and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
| Disease | Cross reference | Weighted score | Related literature |
|---|
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with Thromboxane b2
PubChem Associated disorders and diseases
What pathways are associated with Thromboxane b2
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with Thromboxane b2?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
|---|
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What functions are associated with Thromboxane b2?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
|---|
What lipids are associated with Thromboxane b2?
There are no associated biomedical information in the current reference collection.
What genes are associated with Thromboxane b2?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
|---|
What common seen animal models are associated with Thromboxane b2?
There are no associated biomedical information in the current reference collection.
NCBI Entrez Crosslinks
All references with Thromboxane b2
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Siess W et al. | Stimulated platelet aggregation, thromboxane B2 formation and platelet sensitivity to prostacyclin - a critical evaluation. | 1981 | Thromb. Haemost. | pmid:7025338 |
| Watanabe J et al. | Effect of vitamin E on platelet aggregation in diabetes mellitus. | 1984 | Thromb. Haemost. | pmid:6495252 |
| Gresele P et al. | Picotamide protects mice from death in a pulmonary embolism model by a mechanism independent from thromboxane suppression. | 1990 | Thromb. Haemost. | pmid:2274931 |
| Chen SL et al. | Chlorobutanol, a preservative of desmopressin, inhibits human platelet aggregation and release in vitro. | 1990 | Thromb. Haemost. | pmid:2096493 |
| Cattaneo M et al. | Human platelet aggregation and release reaction induced by platelet activating factor (PAF-acether)--effects of acetylsalicylic acid and external ionized calcium. | 1985 | Thromb. Haemost. | pmid:3927505 |
| Perneby C et al. | Dose- and time-dependent antiplatelet effects of aspirin. | 2006 | Thromb. Haemost. | pmid:16601836 |
| Foo LC et al. | Platelets of habitual smokers have reduced susceptibility to aggregating agent. | 1991 | Thromb. Haemost. | pmid:2048056 |
| D'Angelo A et al. | Effect of des-amino-D-arginine vasopressin (DDAVP) on plasma levels of platelet and endothelial cell release products. | 1983 | Thromb. Haemost. | pmid:6687766 |
| Michelson AD et al. | Reversible inhibition of human platelet activation by hypothermia in vivo and in vitro. | 1994 | Thromb. Haemost. | pmid:7522354 |
| Hornby EJ et al. | The inhibitory effect of GR32191, a thromboxane receptor blocking drug, on human platelet aggregation, adhesion and secretion. | 1989 | Thromb. Haemost. | pmid:2529661 |
| Halawani SH et al. | Aspirin failure in patients presenting with acute cerebrovascular ischaemia. | 2011 | Thromb. Haemost. | pmid:21544317 |
| Cortellaro M et al. | Transcoronary platelet thromboxane A2 formation without platelet trapping in patients with coronary stenosis-effect of sulphinpyrazone treatment. | 1983 | Thromb. Haemost. | pmid:6665767 |
| Szczeklik A et al. | Prolonged bleeding time, reduced platelet aggregation, altered PAF-acether sensitivity and increased platelet mass are a trait of asthma and hay fever. | 1986 | Thromb. Haemost. | pmid:3563961 |
| Falcon CR et al. | The in vitro production of thromboxane B2 by platelets of diabetic patients is normal at physiological concentrations of ionized calcium. | 1993 | Thromb. Haemost. | pmid:8259535 |
| Fruzzetti F et al. | Platelet-vessel wall interactions with third-generation oral contraceptives: no evidence of detrimental effects. | 1999 | Thromb. Haemost. | pmid:10494782 |
| Cattaneo M et al. | Conditions influencing the interaction of asialo von Willebrand factor with human platelets--the effects of external ionized calcium concentration and the role of arachidonate pathway. | 1988 | Thromb. Haemost. | pmid:3146144 |
| De Caterina R et al. | Organic nitrates: direct antiplatelet effects and synergism with prostacyclin. Antiplatelet effects of organic nitrates. | 1988 | Thromb. Haemost. | pmid:3291182 |
| Teng CM and Ko FN | Comparison of the platelet aggregation induced by three thrombin-like enzymes of snake venoms and thrombin. | 1988 | Thromb. Haemost. | pmid:3291184 |
| Davì G et al. | Demonstration of Rickettsia Conorii-induced coagulative and platelet activation in vivo in patients with Mediterranean spotted fever. | 1995 | Thromb. Haemost. | pmid:8584998 |
| Habib A et al. | Increased expression of inducible cyclooxygenase-2 in human endothelial cells by antiphospholipid antibodies. | 1995 | Thromb. Haemost. | pmid:8585020 |
| Pettinella C et al. | Cyclooxygenase-1 haplotype C50T/A-842G does not affect platelet response to aspirin. | 2009 | Thromb. Haemost. | pmid:19350112 |
| Totani L et al. | Prasugrel inhibits platelet-leukocyte interaction and reduces inflammatory markers in a model of endotoxic shock in the mouse. | 2012 | Thromb. Haemost. | pmid:22436970 |
| Spowart K et al. | Haemostatic effects of ketorolac with and without concomitant heparin in normal volunteers. | 1988 | Thromb. Haemost. | pmid:3266379 |
| Cerletti C et al. | Aspirin kinetics and inhibition of platelet thromboxane generation-relevance for a solution of the "aspirin dilemma". | 1985 | Thromb. Haemost. | pmid:4049312 |
| De Caterina R et al. | Benefit/risk profile of combined antiplatelet therapy with ticlopidine and aspirin. | 1991 | Thromb. Haemost. | pmid:1871711 |
| de Boer A et al. | Interaction study between Org 10172, a low molecular weight heparinoid, and acetylsalicylic acid in healthy male volunteers. | 1991 | Thromb. Haemost. | pmid:1722918 |
| Forastiero R et al. | Anti-beta2 glycoprotein I antibodies and platelet activation in patients with antiphospholipid antibodies: association with increased excretion of platelet-derived thromboxane urinary metabolites. | 1998 | Thromb. Haemost. | pmid:9459320 |
| Montuschi P et al. | Effects of cyclo-oxygenase inhibition on exhaled eicosanoids in patients with COPD. | 2005 | Thorax | pmid:16192367 |
| Rodwell LT et al. | Effect of inhaled frusemide and oral indomethacin on the airway response to hypertonic saline challenge in asthmatic subjects. | 1997 | Thorax | pmid:9039247 |
| Montuschi P et al. | Exhaled leukotrienes and prostaglandins in COPD. | 2003 | Thorax | pmid:12832671 |
| Picado C et al. | Effects of a fish oil enriched diet on aspirin intolerant asthmatic patients: a pilot study. | 1988 | Thorax | pmid:3353894 |
| Dapper F et al. | Effects of pulsatile and nonpulsatile perfusion mode during extracorporeal circulation--a comparative clinical study. | 1992 | Thorac Cardiovasc Surg | pmid:1290181 |
| Zhou JA et al. | The effects of dauricine and verapamil as calcium channel blockers on the plasma concentration of 6-keto-prostaglandin F1 alpha and thromboxane B2 during cardiopulmonary bypass. | 1987 | Thorac Cardiovasc Surg | pmid:2442837 |
| Kobinia GS et al. | Influence of coronary artery obstruction on cardiac prostaglandin metabolism during experimental cardioplegic arrest. | 1986 | Thorac Cardiovasc Surg | pmid:2424127 |
| Pradalier A et al. | [Measurement of plasma and serum values of PGE2, PGF2 alpha and TXB2 during aspirin induced bronchospasm in asthmatics (author's transl)]. | 1979 Jul-Aug | Therapie | pmid:531778 |
| Oelz O | [The arachidonic acid metabolites (prostaglandins, thromboxanes, prostacyclin, leucotrienes):basics and clinical implications (author's transl)]. | 1979 | Ther Umsch | pmid:119331 |
| Morris HG et al. | Effects of salsalate (nonacetylated salicylate) and aspirin on serum prostaglandins in humans. | 1985 | Ther Drug Monit | pmid:3866409 |
| Semenov AV et al. | [Soluble P-selectin - a marker of platelet activation and vessel wall injury: increase of soluble P-selectin in plasma of patients with myocardial infarction, massive atherosclerosis and primary pulmonary hypertension]. | 2000 | Ter. Arkh. | pmid:10833791 |
| Iagoda AV and Gladkikh NN | [Thromboxane-prostacyclin balance and platelet aggregability in patients with minor cardiac abnormalities]. | 2010 | Ter. Arkh. | pmid:21086621 |
| Rud'ko IA et al. | [The level of thromboxane A2 and prostacyclin in patients with chronic kidney failure undergoing hemodialysis]. | 1991 | Ter. Arkh. | pmid:1948751 |
| Chen YC et al. | Studies of platelet hyperactivity in patients with ischemic cerebrovascular diseases: IV. Determination of the optimal dosage of aspirin by measuring plasma salicylate level. | 1987 | Taiwan Yi Xue Hui Za Zhi | pmid:3694163 |
| Liu MC et al. | Studies of platelet hyperactivity in patients with ischemic cerebrovascular diseases. III. Platelet hyperactivation in the chronic phase of cerebral thromboembolism. | 1985 | Taiwan Yi Xue Hui Za Zhi | pmid:3160819 |
| Ding YA et al. | Effects of exercise and ticlopidine on platelet function and prostanoids in patients with old myocardial infarction. | 1989 | Taiwan Yi Xue Hui Za Zhi | pmid:2592938 |
| Demling RH and Lalonde C | Topical ibuprofen decreases early postburn edema. | 1987 | Surgery | pmid:3672325 |
| VanderMeer TJ et al. | Protective effects of a novel 32-amino acid C-terminal fragment of CAP18 in endotoxemic pigs. | 1995 | Surgery | pmid:7778029 |
| Slotman GJ et al. | Thromboxane A2 mediates hemodynamic and respiratory dysfunction in graded bacteremia. | 1986 | Surgery | pmid:3526603 |
| Addonizio VP et al. | Prevention of heparin-induced thrombocytopenia during open heart surgery with iloprost (ZK36374). | 1987 | Surgery | pmid:2445042 |
| Demling RH et al. | Comparison of the postburn hyperdynamic state and changes in lung function (effect of wound bacterial content). | 1986 | Surgery | pmid:3535145 |
| Demling RH et al. | The pulmonary and systemic response to recurrent endotoxemia in the adult sheep. | 1986 | Surgery | pmid:3535147 |
| Kirton OC et al. | The development of a model of subacute lung injury after intra-abdominal infection. | 1984 | Surgery | pmid:6379962 |
| Lelcuk S et al. | Nicotine stimulates pulmonary parenchymal thromboxane synthesis. | 1986 | Surgery | pmid:3775653 |
| Cooper JD et al. | Prostaglandin production associated with the pulmonary vascular response to complement activation. | 1980 | Surgery | pmid:7394704 |
| Nerlich M et al. | Effect of thermal injury on endotoxin-induced lung injury. | 1983 | Surgery | pmid:6337423 |
| Huval WV et al. | Thromboxane mediation of cardiovascular dysfunction following aspiration. | 1983 | Surgery | pmid:6308843 |
| Demling RH et al. | The immediate effect of burn wound excision on pulmonary function in sheep: the role of prostanoids, oxygen radicals, and chemoattractants. | 1987 | Surgery | pmid:3798327 |
| Paterson IS et al. | Thromboxane mediates the ischemia-induced neutrophil oxidative burst. | 1989 | Surgery | pmid:2527418 |
| Lelcuk S et al. | Prostacyclin and thromboxane A2 moderate postischemic renal failure. | 1985 | Surgery | pmid:3895535 |
| Farias LR et al. | Effect of prostaglandin blockers on ascites fluid in pancreatitis. | 1985 | Surgery | pmid:3898455 |
| Klausner JM et al. | Oxygen free radicals mediate ischemia-induced lung injury. | 1989 | Surgery | pmid:2536967 |
| Demling RH et al. | The lung inflammatory response to thermal injury: relationship between physiologic and histologic changes. | 1989 | Surgery | pmid:2500726 |
| Sell LL et al. | Hypertension during extracorporeal membrane oxygenation: cause, effect, and management. | 1987 | Surgery | pmid:2821641 |
| Klausner JM et al. | Interleukin-2-induced lung injury is mediated by oxygen free radicals. | 1991 | Surgery | pmid:1899491 |
| Goldman G et al. | Leukocytes mediate acid aspiration-induced multiorgan edema. | 1993 | Surgery | pmid:8395089 |
| Wong C et al. | Effect of hydroxyl radical scavenging on endotoxin-induced lung injury. | 1985 | Surgery | pmid:2983450 |
| Slotman GJ et al. | Interaction of prostaglandins, activated complement, and granulocytes in clinical sepsis and hypotension. | 1986 | Surgery | pmid:3520916 |
| Hanazaki K et al. | Protective effect of the thromboxane A2 receptor antagonist ONO 3708 on ischemia-reperfusion injury in the dog liver. | 1994 | Surgery | pmid:7940195 |
| Ichihara T et al. | The effects of using a leukocyte removal filter during cold blood cardioplegia. | 1994 | Surg. Today | pmid:7772907 |
| Iwata M | Pathophysiology of dogs after 84% hepatectomy with emphasis on prostaglandin metabolites and the effect of a thromboxane A2 synthesis inhibitor and a prostaglandin I2 analog. | 1994 | Surg. Today | pmid:7780227 |
| Isozaki H et al. | The protective effect of thromboxane A2 synthetase inhibitor against ischemic liver injury. | 1994 | Surg. Today | pmid:8054815 |
| Isozaki H et al. | Urinary thromboxane B2 as an indicator of acute rejection in human liver transplantation. | 1996 | Surg. Today | pmid:8727944 |
| Kitagawa M et al. | The role of the spleen, especially regarding changes in both thromboxane A2 and the remnant liver dysfunction after extensive hepatectomy. | 1999 | Surg. Today | pmid:10030738 |
| Itasaka H et al. | The mechanism of hepatic graft protection against reperfusion injury by prostaglandin E1. | 1999 | Surg. Today | pmid:10385367 |
| Onizuka M et al. | Suppression of prostanoid formation and regulation of peripheral circulation after surgery using thrombin inhibitor (MD805). | 1998 | Surg. Today | pmid:9681611 |
| Yang SY and Gao ZX | Determination and clinical significance of plasma levels of prostaglandins in patients with acute brain injury. | 1999 | Surg Neurol | pmid:10511080 |
| Seifert V et al. | Arachidonic acid metabolism following aneurysm rupture. Evaluation of cerebrospinal fluid and serum concentration of 6-keto-prostaglandin F1 alpha and thromboxane B2 in patients with subarachnoid hemorrhage. | 1987 | Surg Neurol | pmid:3810456 |
| Kaufman RP et al. | A high plasma prostaglandin to thromboxane ratio protects against renal ischemia. | 1987 | Surg Gynecol Obstet | pmid:3672299 |
| Ferraris VA and Swanson E | Aspirin usage and perioperative blood loss in patients undergoing unexpected operations. | 1983 | Surg Gynecol Obstet | pmid:6836459 |
| Utsunomiya T et al. | Treatment of pulmonary embolism with positive end-expiratory pressure and prostaglandin E1. | 1981 | Surg Gynecol Obstet | pmid:7017981 |
| Rabinovici R et al. | Hemodynamic, hematologic and eicosanoid mediated mechanisms in 7.5 percent sodium chloride treatment of uncontrolled hemorrhagic shock. | 1992 | Surg Gynecol Obstet | pmid:1411892 |
| Mathieson MA et al. | Ischemia of the limb stimulates thromboxane production and myocardial depression. | 1983 | Surg Gynecol Obstet | pmid:6648769 |
| Manny J et al. | Pulmonary and systemic consequences of localized acid aspiration. | 1986 | Surg Gynecol Obstet | pmid:3952619 |
| Reines HD et al. | Lack of effect of glucocorticoids upon plasma thromboxane in patients in a state of shock. | 1985 | Surg Gynecol Obstet | pmid:3983796 |
| Davies GC et al. | Thromboxane B2 and fibrinopeptide A levels in platelet consumption and thrombosis. | 1978 | Surg Forum | pmid:401227 |
| Hagen AA et al. | Synthesis of prostaglandins and thromboxane B2 by cerebral arteries. | 1979 May-Jun | Stroke | pmid:462519 |
| Heizer ML et al. | 14,15-Epoxyeicosatrienoic acid inhibits platelet aggregation in mouse cerebral arterioles. | 1991 | Stroke | pmid:1750047 |
| Stier CT et al. | Thromboxane A2 in severe hypertension and stroke in stroke-prone spontaneously hypertensive rats. | 1988 | Stroke | pmid:3413813 |
| Chemtob S et al. | Prostanoids determine the range of cerebral blood flow autoregulation of newborn piglets. | 1990 | Stroke | pmid:2339458 |
| Juvela S et al. | Effect of nimodipine on platelet function in patients with subarachnoid hemorrhage. | 1990 | Stroke | pmid:2396264 |
| Fisher M et al. | Selective thromboxane inhibition: a new approach to antiplatelet therapy. | 1984 Sep-Oct | Stroke | pmid:6474531 |
| Jacobs TP et al. | Deteriorating stroke model: histopathology, edema, and eicosanoid changes following spinal cord ischemia in rabbits. | 1987 Jul-Aug | Stroke | pmid:3603601 |
| Grice SC et al. | Ibuprofen improves cerebral blood flow after global cerebral ischemia in dogs. | 1987 Jul-Aug | Stroke | pmid:3603606 |
| Nagatsuka K et al. | A new approach to antithrombotic therapy--evaluation of combined therapy of thromboxane synthetase inhibitor and very low dose of aspirin. | 1985 Sep-Oct | Stroke | pmid:3931302 |
| Kempski O et al. | Postischemic production of eicosanoids in gerbil brain. | 1987 Jan-Feb | Stroke | pmid:3468670 |
| van Kooten F et al. | Increased platelet activation in the chronic phase after cerebral ischemia and intracerebral hemorrhage. | 1999 | Stroke | pmid:10066850 |
| Fujimoto T et al. | Cerebrovascular injuries induced by activation of platelets in vivo. | 1985 Mar-Apr | Stroke | pmid:3975962 |
| van Kooten F et al. | Evidence for episodic platelet activation in acute ischemic stroke. | 1994 | Stroke | pmid:8303731 |
| Lee TK et al. | Inhibitory effect of acetylsalicylic acid on platelet function in patients with completed stroke or reversible ischemic neurologic deficit. | 1988 | Stroke | pmid:3363589 |
| Vinge E et al. | Thromboxane B2 levels in serum during continuous administration of nimodipine to patients with aneurysmal subarachnoid hemorrhage. | 1988 | Stroke | pmid:3363601 |
| van Kooten F et al. | Platelet activation and lipid peroxidation in patients with acute ischemic stroke. | 1997 | Stroke | pmid:9259748 |
| Fisher M | Increased thromboxane biosynthesis in patients with acute cerebral ischemia. | 1993 | Stroke | pmid:8506568 |