Thromboxane b2 is a lipid of Fatty Acyls (FA) class. Thromboxane b2 is associated with abnormalities such as endothelial dysfunction, Diabetes Mellitus, Non-Insulin-Dependent, Diabetes Mellitus, Ischemia and Thrombocytosis. The involved functions are known as Platelet Activation, Excretory function, Anabolism, Inflammation and mRNA Expression. Thromboxane b2 often locates in Endothelium, Hepatic and Microsomes, Liver. The associated genes with Thromboxane b2 are PTGS2 gene, prothrombin fragment 2 and CCL14 wt Allele.
To understand associated biological information of Thromboxane b2, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
Thromboxane b2 is suspected in endothelial dysfunction, Diabetes Mellitus, Non-Insulin-Dependent, Diabetes Mellitus, Ischemia, Thrombocytosis, Acute Coronary Syndrome and other diseases in descending order of the highest number of associated sentences.
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We collected disease MeSH terms mapped to the references associated with Thromboxane b2
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
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Function | Cross reference | Weighted score | Related literatures |
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There are no associated biomedical information in the current reference collection.
Gene | Cross reference | Weighted score | Related literatures |
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There are no associated biomedical information in the current reference collection.
Authors | Title | Published | Journal | PubMed Link |
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Snapper JR et al. | Effects of platelet depletion on the unanesthetized sheep's pulmonary response to endotoxemia. | 1984 | J. Clin. Invest. | pmid:6501570 |
Deimann W et al. | Endogenous peroxidase in the nuclear envelope and endoplasmic reticulum of human monocytes in vitro: association with arachidonic acid metabolism. | 1984 | Blood | pmid:6331550 |
Kopolovic R et al. | Effects of ibuprofen on a porcine model of acute respiratory failure. | 1984 | J. Surg. Res. | pmid:6708494 |
Schenkein HA and Rutherford B | C3-mediated release of prostaglandin from human monocytes. Behaviour in short-term culture. | 1984 | Immunology | pmid:6690398 |
Stahl RA et al. | Angiotensin II stimulation of prostaglandin E2 and 6-keto-F1 alpha formation by isolated human glomeruli. | 1984 | Kidney Int. | pmid:6592393 |
Krishnamurthi S et al. | Regulation of human platelet activation--analysis of cyclooxygenase and cyclic AMP-dependent pathways. | 1984 | Biochem. Pharmacol. | pmid:6091666 |
Emau P et al. | Function of prostaglandins, thromboxane A2, and histamine in hypersensitivity reaction to experimental bluetongue disease in calves. | 1984 | Am. J. Vet. Res. | pmid:6093650 |
Bush LR et al. | Effects of the selective thromboxane synthetase inhibitor dazoxiben on variations in cyclic blood flow in stenosed canine coronary arteries. | 1984 | Circulation | pmid:6546902 |
Nagashima Y et al. | [The effects of hog pancreatic kallikrein on the plasma kinins-prostaglandins and renin-angiotensin-aldosterone systems]. | 1984 | Nihon Naibunpi Gakkai Zasshi | pmid:6097484 |
Wilson TW et al. | Determination of 6-keto-prostaglandin F1 alpha and thromboxane B2 in urine by high-performance liquid chromatography and radioimmunoassay. | 1984 | J. Chromatogr. | pmid:6546935 |
Ylikorkala O et al. | Maternal thromboxane, prostacyclin, and umbilical blood flow in humans. | 1984 | Obstet Gynecol | pmid:6546976 |
Hamasaki Y et al. | Platelet-activating factor raises airway and vascular pressures and induces edema in lungs perfused with platelet-free solution. | 1984 | Am. Rev. Respir. Dis. | pmid:6547031 |
Gallenkämper W et al. | Cardioprotective actions of pentoxifylline in an animal model of acute myocardial ischaemia. | 1984 | Br. J. Pharmacol. | pmid:6547067 |
Coker SJ and Parratt JR | The effects of timolol on arrhythmias and prostanoid release during canine myocardial ischaemia and reperfusion. | 1984 | Br. J. Pharmacol. | pmid:6547068 |
Cepa SR et al. | Positive-negative, chemical-ionization, direct exposure mass spectrometry of underivatized prostaglandins. | 1984 | Prostaglandins | pmid:6547237 |
Moodley J et al. | Amniotic fluid prostanoids in preeclampsia. | 1984 | Obstet Gynecol | pmid:6547518 |
Carter AJ et al. | Human pulmonary vessels obtained from necropsy produce less prostacyclin and thromboxane than fresh vessels obtained from operations. | 1984 | Thromb. Res. | pmid:6547546 |
Fantone JC et al. | Stimulus specificity of prostaglandin inhibition of rabbit polymorphonuclear leukocyte lysosomal enzyme release and superoxide anion production. | 1984 | Am. J. Pathol. | pmid:6324595 |
Croft KD et al. | Dietary modification of platelet and renal prostaglandins. | 1984 | Aust N Z J Med | pmid:6393931 |
Benedetto C et al. | Production of prostacyclin, 6-keto-PGF1 alpha and thromboxane B2 by incubated samples of umbilical vessels: a comparison of methods for expressing the results on dry weight, wet weight, protein or DNA bases. | 1984 | Prostaglandins | pmid:6390522 |
FitzGerald GA and Oates JA | Selective and nonselective inhibition of thromboxane formation. | 1984 | Clin. Pharmacol. Ther. | pmid:6370554 |
Cooper C et al. | Production of prostaglandins and thromboxane by isolated cells from intracranial tumours. | 1984 | J. Neurol. Neurosurg. Psychiatr. | pmid:6330309 |
Hwang DH et al. | Zinc deficiency affects neither platelet arachidonic acid metabolism nor platelet aggregation in rats. | 1984 | J. Nutr. | pmid:6582232 |
Navran SS et al. | Human platelet activation by bacterial phospholipase C is mediated by phosphatidylinositol hydrolysis but not generation of phosphatidic acid: inhibition by a selective inhibitor of phospholipase C. | 1984 | Thromb. Res. | pmid:6372157 |
Furman BL et al. | Failure of drugs that selectively inhibit thromboxane synthesis to modify endotoxin shock in conscious rats. | 1984 | Br. J. Pharmacol. | pmid:6375795 |
Du JT et al. | Sex differences in arachidonate cyclo-oxygenase products in elicited rat peritoneal macrophages. | 1984 | Biochim. Biophys. Acta | pmid:6428458 |
Merola AJ et al. | Prostaglandin response in the exercise conditioned rat. | 1984 | Prostaglandins Leukot Med | pmid:6377328 |
Cuthbert AW et al. | Mediators of the secretory response to kinins. | 1984 | Br. J. Pharmacol. | pmid:6331559 |
Carter AJ et al. | A comparison of human pulmonary arterial and venous prostacyclin and thromboxane synthesis--effect of a thromboxane synthase inhibitor. | 1984 | Thromb. Haemost. | pmid:6377567 |
Salvetti A et al. | The influence of indomethacin and sulindac on some pharmacological actions of atenolol in hypertensive patients. | 1984 | Br J Clin Pharmacol | pmid:6378233 |
Kirton OC et al. | The development of a model of subacute lung injury after intra-abdominal infection. | 1984 | Surgery | pmid:6379962 |
Wilson L and Huang LS | Temporal response of uterine prostaglandins to estradiol treatment in the ovariectomized-pregnant rat. | 1984 | Prostaglandins | pmid:6484214 |
Mackey WC et al. | Aspirin decreases platelet uptake on Dacron vascular grafts in baboons. | 1984 | Ann. Surg. | pmid:6233945 |
Walinsky P et al. | Thromboxane A2 in acute myocardial infarction. | 1984 | Am. Heart J. | pmid:6485997 |
Vicenzi E et al. | Human mononuclear phagocytes from different anatomical sites differ in their capacity to metabolize arachidonic acid. | 1984 | Clin. Exp. Immunol. | pmid:6432383 |
Schenkein HA and Rutherford RB | Effects of serum on C3b-stimulated release of prostaglandins and thromboxane B2 from human monocytes. | 1984 | Immunopharmacology | pmid:6511367 |
Fung WP et al. | Effect of ethanol on gastric secretion of thromboxane B2. | 1984 | Med. J. Malaysia | pmid:6513851 |
Watanabe J et al. | Effect of prostaglandin synthetase inhibitors on platelet aggregation and thromboxane production in diabetes mellitus. | 1984 | Tohoku J. Exp. Med. | pmid:6515648 |
Ditter H and Matthias FR | Changes in thromboxane formation by platelets during and after a continuous endotoxin infusion into rabbits. | 1984 | VASA | pmid:6516562 |
Sekiya K and Okuda H | Inhibitory action of soluble elastin on thromboxane B2 formation in blood platelets. | 1984 | Biochim. Biophys. Acta | pmid:6320905 |
Fitscha P et al. | Follow-up of in-vivo platelet function (platelet half-life, thromboxane B2) in patients with coronary heart disease. | 1984 | VASA | pmid:6516563 |
Olanoff LS et al. | Effects of oleic acid on pulmonary capillary leak and thromboxanes. | 1984 | J. Surg. Res. | pmid:6233456 |
Hartung HP et al. | Release of prostaglandin E and thromboxane from macrophages by stimulation with factor H. | 1984 | Clin. Exp. Immunol. | pmid:6234114 |
Riess H et al. | Effects of BM 13.177, a new antiplatelet drug in patients with atherosclerotic disease. | 1984 | Thromb. Res. | pmid:6237460 |
Nichols AB et al. | Effect of heparin bonding on catheter-induced fibrin formation and platelet activation. | 1984 | Circulation | pmid:6237807 |
Sicard GA et al. | Prostaglandin production and platelet reactivity of small-diameter grafts. | 1984 | J. Vasc. Surg. | pmid:6238179 |
Goodman MG and Weigle WO | Regulation of B-lymphocyte proliferative responses by arachidonate metabolites: effects on membrane-directed versus intracellular activators. | 1984 | J. Allergy Clin. Immunol. | pmid:6432883 |
Zammit M et al. | Aspirin therapy in small-caliber arterial prostheses: long-term experimental observations. | 1984 | J. Vasc. Surg. | pmid:6238183 |
Klaverkamp J and Völkl KP | Maintenance of platelet viability after platelet-labeling with fluorescein isothiocyanate. | 1984 | Haemostasis | pmid:6238881 |
De Lorgeril M et al. | [Platelet function and coronary disease: demonstration of a so-called unstable platelet syndrome]. | 1984 | Arch Mal Coeur Vaiss | pmid:6239599 |
Robson MC et al. | A new explanation for the progressive tissue loss in electrical injuries. | 1984 | Plast. Reconstr. Surg. | pmid:6422484 |
Messmore HL et al. | Molecular markers of platelet activation. | 1984 | Semin. Thromb. Hemost. | pmid:6240115 |
Hornych A et al. | [Changes in plasma prostaglandins in normal subjects in an orthostatic position. Comparison with the response of the renin-aldosterone system]. | 1984 | Presse Med | pmid:6242503 |
Lampugnani MG and de Gaetano G | Effects of metabolized and unmetabolized arachidonate on rat platelet shape change. | 1984 | Am. J. Physiol. | pmid:6433724 |
Koike K et al. | Platelet secretion defect in patients with the attention deficit disorder and easy bruising. | 1984 | Blood | pmid:6692042 |
Vesterqvist O et al. | Development of a GC-MS method for quantitation of 2,3-dinor-TxB2 and determinations of the daily urinary excretion rates in healthy humans. | 1984 | Thromb. Res. | pmid:6695361 |
Davì G et al. | Platelet function changes in acute myocardial infarction. | 1984 | Adv. Exp. Med. Biol. | pmid:6695571 |
Mehta J et al. | Thromboxane release in coronary artery disease: spontaneous versus pacing-induced angina. | 1984 | Am. Heart J. | pmid:6695662 |
Klotz TA et al. | Urinary excretion of thromboxane B2 in patients with venous thromboembolic disease. | 1984 | Chest | pmid:6697787 |
Maddox Y et al. | A routine source of human peritoneal macrophages. | 1984 | Scand. J. Immunol. | pmid:6701470 |
Schieppati A et al. | The metabolism of arachidonic acid by platelets in nephrotic syndrome. | 1984 | Kidney Int. | pmid:6434788 |
Lefkowith JB et al. | Macrophage-dependent arachidonate metabolism in hydronephrosis. | 1984 | Kidney Int. | pmid:6434790 |
Hutton RA et al. | Assessment of platelet function in patients with Raynaud's syndrome. | 1984 | J. Clin. Pathol. | pmid:6229551 |
Stuart MJ et al. | Differences in thromboxane production between neonatal and adult platelets in response to arachidonic acid and epinephrine. | 1984 | Pediatr. Res. | pmid:6435080 |
Ditter H et al. | Comparison of sympathomimetic amines with collagen, calcium ionophor and adenosine diphosphate in their effects on thromboxane formation of human platelet rich plasma. | 1984 | Folia Haematol. Int. Mag. Klin. Morphol. Blutforsch. | pmid:6083951 |
Tanganelli I et al. | Effects of somatostatin on the behavior of thromboxane B2 and B-thromboglobulin in type 1 diabetes. | 1984 | Boll. Soc. Ital. Biol. Sper. | pmid:6084513 |
Goldyne ME | Heterogeneity in leukocyte preparations: effects on defining eicosanoid metabolism by human lymphocytes and monocytes. | 1984 | J. Allergy Clin. Immunol. | pmid:6088610 |
Lewis GP and Smith JR | Prostaglandin endoperoxides and thromboxane A2 in thrombus formation in the hamster cheek pouch in vivo. | 1984 | Prostaglandins | pmid:6435186 |
Pickard JD et al. | Arterial eicosanoid production following chronic exposure to a periarterial haematoma. | 1984 | J. Neurol. Neurosurg. Psychiatr. | pmid:6589362 |
MacDermot J et al. | Synthesis of leukotriene B4, and prostanoids by human alveolar macrophages: analysis by gas chromatography/mass spectrometry. | 1984 | Prostaglandins | pmid:6326199 |
Vergani CG et al. | Bile lipid composition and haemostatic variables in a case of high density lipoprotein deficiency (Tangier disease). | 1984 | Eur. J. Clin. Invest. | pmid:6421598 |
Shohami E and Sidi A | Accumulation of prostacyclin in rat brain during haemorrhagic hypotension--possible role of PGI2 in autoregulation. | 1984 | J. Cereb. Blood Flow Metab. | pmid:6363432 |
Cifone MG et al. | [Effect of calcium ionophore (A23187) on the production of thromboxane B2 in human polymorphonuclear cells in vitro]. | 1984 | Boll. Soc. Ital. Biol. Sper. | pmid:6422962 |
Simberg N | Maternal aspirin administration inhibits pulmonary arachidonic acid metabolism in fetal rabbits. | 1984 | Prostaglandins Leukot Med | pmid:6425868 |
Rao GH et al. | Enteric-coated aspirin, platelet cyclooxygenase activity and function. | 1984 | Prostaglandins Leukot Med | pmid:6425869 |
Burghuber O et al. | Lung edema due to hydrogen peroxide is independent of cyclooxygenase products. | 1984 | J Appl Physiol Respir Environ Exerc Physiol | pmid:6427146 |
Steel LK et al. | In vitro prostaglandin release from guinea pig parenchymal lung tissues is not stimulated by thymic peptides. | 1984 | Int. J. Immunopharmacol. | pmid:6427124 |
Bommer J et al. | Plastic filing from dialysis tubing induces prostanoid release from macrophages. | 1984 | Kidney Int. | pmid:6595463 |
Roth DM et al. | Effects of lipoxygenase inhibitors in arachidonate-induced sudden death. | 1984 | J. Pharm. Pharmacol. | pmid:6144761 |
Brandt R et al. | Effect of propranolol, practolol and atenolol on human platelet thromboxane formation and plasma levels of prostaglandins 6-keto-F1 alpha and E2. | 1984 | Prostaglandins Leukot Med | pmid:6597450 |
Chiba S et al. | Sex and age-related differences in the urinary excretion of TXB2 in normal human subjects: a possible pathophysiological role of TXA2 in the aged kidney. | 1984 | Prostaglandins Leukot Med | pmid:6597456 |
Kerry R et al. | Beta-adrenoceptor antagonists and human platelets: relationship of effects to lipid solubility. | 1984 | Biochem. Pharmacol. | pmid:6147145 |
Mahmud I et al. | Thromboxane synthesizing system in rat liver. | 1984 | Prostaglandins Leukot Med | pmid:6597457 |
Seregi A et al. | Decreased levels of brain cyclo-oxygenase products as a possible cause of increased seizure susceptibility in convulsion-prone gerbils. | 1984 | Brain Res. | pmid:6430471 |
Holgate ST and Robinson C | 6,9-deepoxy-6,9-(phenylimino)-delta 6,8-Prostaglandin I1, (U-60,257) stimulates prostaglandin D2 and inhibits thromboxane B2 release from ionophore challenged human dispersed lung cells. | 1984 | Br. J. Pharmacol. | pmid:6439267 |
Burch RM and Halushka PV | Alterations in extracellular calcium concentration differentially influence prostaglandin and thromboxane synthesis in epithelial cells from the toad urinary bladder. | 1984 | Arch. Biochem. Biophys. | pmid:6422855 |
Crutchley DJ | Effects of inhibitors of arachidonic acid metabolism on thromboplastin activity in human monocytes. | 1984 | Biochem. Biophys. Res. Commun. | pmid:6422935 |
DeRubertis FR et al. | Bile salt stimulation of colonic epithelial proliferation. Evidence for involvement of lipoxygenase products. | 1984 | J. Clin. Invest. | pmid:6438153 |
Axelrod L and Cornelius P | Plasma prostaglandin levels and circulating fuel levels in rats with diabetic ketoacidosis: effects of cyclooxygenase inhibitors and of alpha and beta adrenergic blockade. | 1984 | Prostaglandins | pmid:6440213 |
Schafer AI et al. | Unidirectional transfer of prostaglandin endoperoxides between platelets and endothelial cells. | 1984 | J. Clin. Invest. | pmid:6423665 |
Coker SJ | Further evidence that thromboxane exacerbates arrhythmias: effects of UK38485 during coronary artery occlusion and reperfusion in anaesthetized greyhounds. | 1984 | J. Mol. Cell. Cardiol. | pmid:6433026 |
Krell RD and Kusner EJ | Differential effect of cyclo-oxygenase inhibition on antigen- and ionophore-induced release of slow reacting substance from fragmented guinea-pig lung. | 1984 | Br. J. Pharmacol. | pmid:6434013 |
Jouve R et al. | Thromboxane B2, 6-keto-PGF1 alpha, PGE2, PGF2 alpha, and PGA1 plasma levels in arteriosclerosis obliterans: relationship to clinical manifestations, risk factors, and arterial pathoanatomy. | 1984 | Am. Heart J. | pmid:6581715 |
Branski D et al. | Effect of cimetidine on human gastric and duodenal prostanoid synthesis. | 1984 | Scand. J. Gastroenterol. | pmid:6589742 |
Galli C et al. | Acute effects of ethanol, caffeine, or both on platelet aggregation, thromboxane formation, and plasma-free fatty acids in normal subjects. | 1984 | Drug Nutr Interact | pmid:6510241 |
Lelcuk S et al. | Inhibition of ischemia-induced thromboxane synthesis in man. | 1984 | J Trauma | pmid:6325720 |
Ylikorkala O and Tenhunen A | Follicular fluid prostaglandins in endometriosis and ovarian hyperstimulation. | 1984 | Fertil. Steril. | pmid:6363141 |
Swart SS et al. | Functional significance of the platelet alpha2-adrenoceptor: studies in patients with myeloproliferative disorders. | 1984 | Thromb. Res. | pmid:6326344 |
Lefer AM et al. | Pathophysiological mechanisms of sudden death induced by platelet activating factor. | 1984 | Br. J. Pharmacol. | pmid:6435705 |
Cremer KF et al. | Effects of diltiazem, dipyridamole, and their combination on hemostasis. | 1984 | Clin. Pharmacol. Ther. | pmid:6435926 |