Thromboxane b2 is a lipid of Fatty Acyls (FA) class. Thromboxane b2 is associated with abnormalities such as endothelial dysfunction, Diabetes Mellitus, Non-Insulin-Dependent, Diabetes Mellitus, Ischemia and Thrombocytosis. The involved functions are known as Platelet Activation, Excretory function, Anabolism, Inflammation and mRNA Expression. Thromboxane b2 often locates in Endothelium, Hepatic and Microsomes, Liver. The associated genes with Thromboxane b2 are PTGS2 gene, prothrombin fragment 2 and CCL14 wt Allele.
To understand associated biological information of Thromboxane b2, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
Thromboxane b2 is suspected in endothelial dysfunction, Diabetes Mellitus, Non-Insulin-Dependent, Diabetes Mellitus, Ischemia, Thrombocytosis, Acute Coronary Syndrome and other diseases in descending order of the highest number of associated sentences.
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We collected disease MeSH terms mapped to the references associated with Thromboxane b2
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
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Function | Cross reference | Weighted score | Related literatures |
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There are no associated biomedical information in the current reference collection.
Gene | Cross reference | Weighted score | Related literatures |
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There are no associated biomedical information in the current reference collection.
Authors | Title | Published | Journal | PubMed Link |
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Burch RM and Halushka PV | Thromboxane and stable prostaglandin endoperoxide analogs stimulate water permeability in the toad urinary bladder. | 1980 | J. Clin. Invest. | pmid:6777398 |
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Best LC et al. | Studies on the role of calcium in the control of thromboxane B2 production. | 1980 | Artery | pmid:6783015 |
Fitzpatrick TM et al. | Tromboxane B2 inhibits the pulmonary inactivation of prostaglandin E2 in the dog. | 1980 | Br. J. Pharmacol. | pmid:7000216 |
Poyser NL and Scott FM | Prostaglandin and thromboxane production by the rat uterus and ovary in vitro during the oestrous cycle. | 1980 | J. Reprod. Fertil. | pmid:7001011 |
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Giri SN and Krishna GA | Development of a dual isotopes techniques and two-stage column chromatography to characterize the prostaglandin F2alpha, E2 and Thromboxane B2 formed by the guinea pig lung. | 1980 | J Pharmacol Methods | pmid:7009992 |
Mathé AA et al. | Increased content of immunoreactive prostaglandin E in cerebrospinal fluid of patients with schizophrenia. | 1980 | Lancet | pmid:6101355 |
Harris RH et al. | Relationship of TXB2 and 6-keto PGF1 alpha to the hemodynamic changes during baboon endotoxic shock. | 1980 | Adv Prostaglandin Thromboxane Res | pmid:6768234 |
Jécsai G and Bagdány S | Quantitative determination of thromboxane synthesis in blood samples by video-densitometry. | 1980 | Acta Biochim. Biophys. Acad. Sci. Hung. | pmid:7282294 |
Hwang DH | Aggregation and inhibition of rat platelets, and the formation of endoperoxide metabolites. | 1980 | Prostaglandins Med | pmid:7413850 |
Cerskus AL et al. | Thromboxane B2 and 6-keto-prostaglandin F1 alpha synthesis during infusion of collagen and arachidonic acid in rabbits: inhibition by aspirin and sulfinpyrazone. | 1980 | Thromb. Res. | pmid:7414555 |
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Hassid A and Dunn MJ | Microsomal prostaglandin biosynthesis of human kidney. | 1980 | J. Biol. Chem. | pmid:7358683 |
Kadowitz PJ and Hyman AL | Comparative effects of thromboxane B2 on the canine and feline pulmonary vascular bed. | 1980 | J. Pharmacol. Exp. Ther. | pmid:7365689 |
Schlondorff D and Folkert VW | Prostaglandin synthesis in glomeruli from rats with unilateral ureteral obstruction. | 1980 | Adv Prostaglandin Thromboxane Res | pmid:7369028 |
Powell WS | Rapid extraction of oxygenated metabolites of arachidonic acid from biological samples using octadecylsilyl silica. | 1980 | Prostaglandins | pmid:6258197 |
Kent L et al. | Differential response of articular chondrocyte populations to thromboxane B2 and analogs of prostaglandin cyclic endoperoxides. | 1980 | Prostaglandins | pmid:7384546 |
Subbiah MT et al. | Studies of aggregation and thromboxane B2 synthesis in avian thrombocytes: comparison between atherosclerosis-susceptible and resistant breeds. | 1980 | Thromb. Haemost. | pmid:7455983 |
Pace-Asciak CR and Edwards NS | Tetranor thromboxane B2 is the principal urinary catabolite formed after i.v. infusion of thromboxane B2 in the rat. | 1980 | Biochem. Biophys. Res. Commun. | pmid:7458943 |
Viinikka L and Ylikorkala O | Measurement of thromboxane B2 in human plasma or serum by radioimmunoassay. | 1980 | Prostaglandins | pmid:7465865 |
Lagarde M et al. | Increase of platelet thromboxane A2 formation and of its plasmatic half-life in diabetes mellitus. | 1980 | Thromb. Res. | pmid:7466751 |
Kosaki G et al. | The mechanism of the inhibitory effect of protease inhibitors on platelet aggregation and cellular synthesis of prostaglandins. I. The effect on the release of arachidonic acid from phospholipids. | 1980 Dec 1-15 | Thromb. Res. | pmid:6785893 |
Patrono C et al. | Low dose aspirin and inhibition of thromboxane B2 production in healthy subjects. | 1980 Feb 1-15 | Thromb. Res. | pmid:7368167 |
Koh H et al. | A radioimmunoassay of thromboxane B2 with thromboxane B2-125I-tyramide and its application to the study on the thromboxane B2 formation during platelet aggregation. | 1980 Feb 1-15 | Thromb. Res. | pmid:7368170 |
Boyd JA and Eling TE | Prostaglandin release and the interaction of platelets with the pulmonary vasculature of rat and guinea pig. | 1980 Jul 1-15 | Thromb. Res. | pmid:7003800 |
Singh D et al. | Evidence for the generation of hydroxyl radical during arachidonic acid metabolism by human platelets. | 1981 | Am. J. Hematol. | pmid:6274189 |
Strand JC et al. | Effect of imidazole on renal function in unilateral ureteral-obstructed rat kidneys. | 1981 | Am. J. Physiol. | pmid:6787931 |
Stuart MJ et al. | Abnormal platelet function and arachidonate metabolism in chronic idiopathic thrombocytopenic purpura. | 1981 | Blood | pmid:6788109 |
Handin RI and Alexander RW | Humoral heartache -- do platelets have a role? | 1981 | N. Engl. J. Med. | pmid:7010170 |
Robertson RM et al. | Thromboxane A2 in vasotonic angina pectoris: evidence from direct measurements and inhibitor trials. | 1981 | N. Engl. J. Med. | pmid:7010173 |
Hladovec J | Prostaglandins and endothelial stability. | 1981 | Arzneimittelforschung | pmid:7011332 |
Sananès N et al. | A role for prostaglandins in decidualization of the rat uterus. | 1981 | J. Endocrinol. | pmid:7012263 |
Kadowitz PJ et al. | Pulmonary vascular responses to prostaglandins. | 1981 | Fed. Proc. | pmid:7014258 |
Ingerman-Wojenski C et al. | Bovine endothelial cells in culture produce thromboxane as well as prostacyclin. | 1981 | J. Clin. Invest. | pmid:7014633 |
Takasu N et al. | Augmentation of prostacyclin and depression of PGE2, PGF2 alpha and thromboxane A2 by TSH in cultured porcine thyroid cells: an important role of prostacyclin in maintaining thyroid cell function. | 1981 | FEBS Lett. | pmid:7016591 |
Utsunomiya T et al. | Treatment of pulmonary embolism with positive end-expiratory pressure and prostaglandin E1. | 1981 | Surg Gynecol Obstet | pmid:7017981 |
Nordøy A | Lipids and thrombogenesis. | 1981 | Ann. Clin. Res. | pmid:7018362 |
Moncada S and Vane JR | Prostacyclin and blood coagulation. | 1981 | Drugs | pmid:7018874 |
Ylikorkala O et al. | Increased prostacyclin and thromboxane production in man during cardiopulmonary bypass. | 1981 | J. Thorac. Cardiovasc. Surg. | pmid:7019583 |
Baroody RA and Bito LZ | The impermeability of the basic cell membrane to thromboxane-B2' prostacyclin and 6-keto-PGF 1 alpha. | 1981 | Prostaglandins | pmid:7010455 |
Rosenfeld J et al. | Extractive alkylation of prostaglandins. | 1981 | Prostaglandins | pmid:7010456 |
Tanaka M et al. | Increased prostacyclin synthesizing activity in human ripening uterine cervix. | 1981 | Prostaglandins | pmid:7010458 |
Dembélé-Duchesne MJ et al. | Some new prospects in the mechanism of control of arachidonate metabolism in human placenta and amnion. | 1981 | Prostaglandins | pmid:6801732 |
Tyler HM et al. | Administration to man of UK-37,248-01, a selective inhibitor of thromboxane synthetase. | 1981 | Lancet | pmid:6110861 |
Vermylen J et al. | Thromboxane synthetase inhibition as antithrombotic strategy. | 1981 | Lancet | pmid:6112447 |
Fasce L et al. | [Effects of glucocorticoids on the gastrointestinal tract of normal rats and rats deficient in endogenous prostaglandins]. | 1981 | Boll. Soc. Ital. Biol. Sper. | pmid:7295403 |
Tada M et al. | Elevation of thromboxane B2 levels in patients with classic and variant angina Pectoris. | 1981 | Circulation | pmid:7296786 |
McManus LM et al. | Acetyl glyceryl ether phosphorylcholine. Intravascular alterations following intravenous infusion into the baboon. | 1981 | Lab. Invest. | pmid:7300244 |
Uyama O et al. | Plasma concentrations of thromboxane B2 in patients with hypertension or cerebrovascular disease. | 1981 | Prostaglandins Med | pmid:7302001 |
Smith JB and Jubiz W | OKY-1581: a selective inhibitor of thromboxane synthesis in vivo and in vitro. | 1981 | Prostaglandins | pmid:7302264 |
Spector SL et al. | Clinical response and serum prostaglandin levels in aspirin idiosyncrasy. Effect of aspirin and a new nonsteroidal anti-inflammatory agent. | 1981 | Chest | pmid:7307588 |
Meyers KM et al. | Evaluation of the platelet storage pool deficiency in the feline counterpart of the Chediak-Higashi syndrome. | 1981 | Am. J. Hematol. | pmid:7315839 |
Mehta J and Mehta P | Significance of platelet function and thromboxane B2 levels across the human myocardial vascular bed. | 1981 | Acta Med. Scand. Suppl. | pmid:6948499 |
Chong BH et al. | Heparin-induced thrombocytopenia: effect of heparin platelet antibody on platelets. | 1981 | Br. J. Haematol. | pmid:7317283 |
Gordon D et al. | Selective inhibition of thromboxane biosynthesis in human blood mononuclear cells and the effects of mitogen-stimulated lymphocyte proliferation. | 1981 | Br. J. Pharmacol. | pmid:7317694 |
Bray MA et al. | Prostaglandin generation by separated human blood mononuclear cell fractions. | 1981 | Int. J. Immunopharmacol. | pmid:6949878 |
Satoh K et al. | Augmented malondialdehyde production by platelets from patients with cerebrovascular disorders. | 1981 | Jpn. Circ. J. | pmid:7321143 |
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Matsumoto M et al. | Platelet aggregation induced by arachidonic acid and thromboxane generation in patients with hypertension or cerebrovascular disease. | 1981 | Prostaglandins Med | pmid:7323212 |
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Hirsh PD et al. | Release of prostaglandins and thromboxane into the coronary circulation in patients with ischemic heart disease. | 1981 | N. Engl. J. Med. | pmid:6894016 |
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Defreyn G et al. | Familial bleeding tendency with partial platelet thromboxane synthetase deficiency: reorientation of cyclic endoperoxide metabolism. | 1981 | Br. J. Haematol. | pmid:6268139 |
Catalano PM et al. | Platelet recovery from aspirin inhibition in vivo; differing patterns under various assay conditions. | 1981 | Blood | pmid:7448419 |
Agradi E et al. | In vitro effects of synthetic antioxidants and vitamin E on arachidonic acid metabolism and thromboxane formation in human platelets and on platelet aggregation. | 1981 | Prostaglandins | pmid:6794104 |
Laviolette M et al. | Human alveolar macrophages: a lesion in arachidonic acid metabolism in cigarette smokers. | 1981 | Am. Rev. Respir. Dis. | pmid:6794395 |
Grimm LJ et al. | Inhibition of platelet thromboxane synthesis by 7-(1-imidazolyl) heptanoic acid: dissociation from inhibition of aggregation. | 1981 | Thromb. Res. | pmid:6801806 |
Worthington RE and Nakeff A | Thromboxane synthesis in megakaryocytes isolated by centrifugal elutriation. | 1981 | Blood | pmid:6786393 |
Corby DG and O'Barr TP | Neonatal platelet function: a membrane-related phenomenon? | 1981 | Haemostasis | pmid:7250785 |
Wonders TR et al. | Reduced plasma thromboxane elevation during partial cardiopulmonary bypass in thrombocytopenic sheep. | 1981 | Trans Am Soc Artif Intern Organs | pmid:7331082 |
Mezzano D et al. | Evidence that platelet buoyant density, but not size, correlates with platelet age in man. | 1981 | Am. J. Hematol. | pmid:7270546 |
Williamson EM et al. | Studies on the mechanism of action of 12-deoxyphorbolphenylacetate, a potent platelet aggregating tigliane ester. | 1981 | Biochem. Pharmacol. | pmid:6794576 |
Ylikorkala O et al. | Prostacyclin and thromboxane in diabetes. | 1981 | Br Med J (Clin Res Ed) | pmid:6794795 |
Lee SH et al. | Prostacyclin and thromboxane A2 in thrombotic thrombocytopenic purpura. | 1981 | Br Med J (Clin Res Ed) | pmid:6797537 |
Igarashi K et al. | Effect of polyamines on prostaglandin synthesis in various cell-free systems. | 1981 | Biochem. Biophys. Res. Commun. | pmid:6800368 |
Morris HG et al. | Variables associated with radioimmunoassay of prostaglandins in plasma. | 1981 | Prostaglandins | pmid:6803306 |
Landgraf-Leurs MM et al. | Aggregation and thromboxane B2 formation in platelets and vascular prostacyclin production from genetically obese rats. | 1981 | Prostaglandins | pmid:6798637 |
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Satoh H et al. | Influence of angiotensins (I, II & III) on prostaglandin production by minced rat renal medulla. | 1981 | Prostaglandins | pmid:7197382 |
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Robson MC and Heggers JP | Evaluation of hand frostbite blister fluid as a clue to pathogenesis. | 1981 | J Hand Surg Am | pmid:7204918 |
Subbiah MT et al. | Effect of specific estrogens on prostaglandin synthesis in aorta and thrombocytes of female pigeons. | 1981 | Proc. Soc. Exp. Biol. Med. | pmid:7208490 |
Brox JH et al. | The effect of cod liver oil and corn oil on platelets and vessel wall in man. | 1981 | Thromb. Haemost. | pmid:7031981 |
Hirsh PD et al. | Prostaglandins and ischemic heart disease. | 1981 | Am. J. Med. | pmid:7032286 |
Dunham BM et al. | Role of prostaglandins in positive end-expiratory pressure-induced negative inotropism. | 1981 | Am. J. Physiol. | pmid:7034549 |
Strano A et al. | Thromboxane formation by platelets and platelet sensitivity to prostacyclin in patients with acute myocardial infarction. | 1981 | Thromb. Haemost. | pmid:7036402 |