Thromboxane b2
Thromboxane b2 is a lipid of Fatty Acyls (FA) class. Thromboxane b2 is associated with abnormalities such as endothelial dysfunction, Diabetes Mellitus, Non-Insulin-Dependent, Diabetes Mellitus, Ischemia and Thrombocytosis. The involved functions are known as Platelet Activation, Excretory function, Anabolism, Inflammation and mRNA Expression. Thromboxane b2 often locates in Endothelium, Hepatic and Microsomes, Liver. The associated genes with Thromboxane b2 are PTGS2 gene, prothrombin fragment 2 and CCL14 wt Allele.
Cross Reference
Introduction
To understand associated biological information of Thromboxane b2, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with Thromboxane b2?
Thromboxane b2 is suspected in endothelial dysfunction, Diabetes Mellitus, Non-Insulin-Dependent, Diabetes Mellitus, Ischemia, Thrombocytosis, Acute Coronary Syndrome and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
| Disease | Cross reference | Weighted score | Related literature |
|---|
Loading... please refresh the page if content is not showing up.
Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with Thromboxane b2
PubChem Associated disorders and diseases
What pathways are associated with Thromboxane b2
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with Thromboxane b2?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
|---|
Loading... please refresh the page if content is not showing up.
What functions are associated with Thromboxane b2?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
|---|
What lipids are associated with Thromboxane b2?
There are no associated biomedical information in the current reference collection.
What genes are associated with Thromboxane b2?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
|---|
What common seen animal models are associated with Thromboxane b2?
There are no associated biomedical information in the current reference collection.
NCBI Entrez Crosslinks
All references with Thromboxane b2
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Pampolina C and McNicol A | Streptococcus sanguis-induced platelet activation involves two waves of tyrosine phosphorylation mediated by FcgammaRIIA and alphaIIbbeta3. | 2005 | Thromb. Haemost. | pmid:15886812 |
| Hansen JB et al. | The effect of lipopolysaccharides (LPS) on generation of thromboxane A2 and thromboplastin activity in whole blood of males, females and females on oral contraceptives. | 1989 | Thromb. Haemost. | pmid:2799762 |
| Lepäntalo A et al. | Polymorphisms of COX-1 and GPVI associate with the antiplatelet effect of aspirin in coronary artery disease patients. | 2006 | Thromb. Haemost. | pmid:16493486 |
| Matsumoto M et al. | Thromboxane generation in patients with essential hypertension or cerebrovascular disease and effect of oral aspirin. | 1980 | Thromb. Haemost. | pmid:7423441 |
| Kyrle PA et al. | Thromboxane A2 and prostacyclin generation in the microvasculature of patients with atherosclerosis--effect of low-dose aspirin. | 1989 | Thromb. Haemost. | pmid:2508252 |
| Scharf RE | In vitro thromboxane synthesis of depleted blood platelets following renal transplantation. | 1990 | Thromb. Haemost. | pmid:2148845 |
| Hoet B et al. | Ridogrel, a combined thromboxane synthase inhibitor and receptor blocker, decreases elevated plasma beta-thromboglobulin levels in patients with documented peripheral arterial disease. | 1990 | Thromb. Haemost. | pmid:2148849 |
| Wang WJ and Huang TF | A novel tetrameric venom protein, agglucetin from Agkistrodon acutus, acts as a glycoprotein Ib agonist. | 2001 | Thromb. Haemost. | pmid:11686327 |
| Jackson C et al. | DN 9693: a phosphodiesterase inhibitor with a platelet membrane effect. | 1989 | Thromb. Haemost. | pmid:2546286 |
| Lessiani G et al. | Inflammation, oxidative stress and platelet activation in aspirin-treated critical limb ischaemia: beneficial effects of iloprost. | 2011 | Thromb. Haemost. | pmid:21103664 |
| Hohlfeld T et al. | Antiplatelet effects of ticlopidine are reduced in experimental hypercholesterolemia. | 1994 | Thromb. Haemost. | pmid:7513092 |
| Han P et al. | Verapamil and collagen-induced platelet reactions--evidence for a role for intracellular calcium in platelet activation. | 1983 | Thromb. Haemost. | pmid:6415847 |
| Turpeinen AM et al. | Replacement of dietary saturated by unsaturated fatty acids: effects of platelet protein kinase C activity, urinary content of 2,3-dinor-TXB2 and in vitro platelet aggregation in healthy man. | 1998 | Thromb. Haemost. | pmid:9798986 |
| Gresele P et al. | Platelet activation markers in patients with peripheral arterial disease--a prospective comparison of different platelet function tests. | 1997 | Thromb. Haemost. | pmid:9423790 |
| Davì G et al. | The effect of two low doses of aspirin on whole blood thromboxane and prostacyclin generation in healthy subjects. | 1983 | Thromb. Haemost. | pmid:6417815 |
| Dale J et al. | The effect of a thromboxane synthetase inhibitor, dazoxiben, and acetylsalicylic acid on platelet function and prostaglandin metabolism. | 1983 | Thromb. Haemost. | pmid:6689091 |
| Falcon CR et al. | The in vitro production of thromboxane B2 by platelets of diabetic patients is normal at physiological concentrations of ionized calcium. | 1993 | Thromb. Haemost. | pmid:8259535 |
| Larsen SB et al. | Increased platelet aggregation and serum thromboxane levels in aspirin-treated patients with prior myocardial infarction. | 2012 | Thromb. Haemost. | pmid:22534977 |
| de Castellarnau C et al. | Prostacyclin and thromboxane production by autogenous femoral veins grafted into the arterial circulation of the dog. | 1989 | Thromb. Haemost. | pmid:2665174 |
| Davì G et al. | Demonstration of Rickettsia Conorii-induced coagulative and platelet activation in vivo in patients with Mediterranean spotted fever. | 1995 | Thromb. Haemost. | pmid:8584998 |
| Habib A et al. | Increased expression of inducible cyclooxygenase-2 in human endothelial cells by antiphospholipid antibodies. | 1995 | Thromb. Haemost. | pmid:8585020 |
| Evangelista V et al. | Defibrotide inhibits platelet activation by cathepsin G released from stimulated polymorphonuclear leukocytes. | 1992 | Thromb. Haemost. | pmid:1509406 |
| Huang TF et al. | Mechanism of action of a potent antiplatelet peptide, triflavin from Trimeresurus flavoviridis snake venom. | 1991 | Thromb. Haemost. | pmid:1665595 |
| Dotevall A et al. | Cigarette smoking increases thromboxane A2 formation without affecting platelet survival in young healthy females. | 1992 | Thromb. Haemost. | pmid:1455405 |
| Davì G et al. | Influence of metabolic control on thromboxane biosynthesis and plasma plasminogen activator inhibitor type-1 in non-insulin-dependent diabetes mellitus. | 1996 | Thromb. Haemost. | pmid:8819248 |
| Ding YA et al. | Potentiation of adrenaline-induced platelet aggregation by angiotensin II. | 1985 | Thromb. Haemost. | pmid:4089801 |
| Butler KD et al. | The effects of modulation of prostanoid metabolism on the thoracic platelet accumulation induced by intravenous administration of collagen in the guinea-pig. | 1986 | Thromb. Haemost. | pmid:3105104 |
| Montuschi P et al. | Effects of cyclo-oxygenase inhibition on exhaled eicosanoids in patients with COPD. | 2005 | Thorax | pmid:16192367 |
| Rodwell LT et al. | Effect of inhaled frusemide and oral indomethacin on the airway response to hypertonic saline challenge in asthmatic subjects. | 1997 | Thorax | pmid:9039247 |
| Montuschi P et al. | Exhaled leukotrienes and prostaglandins in COPD. | 2003 | Thorax | pmid:12832671 |
| Picado C et al. | Effects of a fish oil enriched diet on aspirin intolerant asthmatic patients: a pilot study. | 1988 | Thorax | pmid:3353894 |
| Dapper F et al. | Effects of pulsatile and nonpulsatile perfusion mode during extracorporeal circulation--a comparative clinical study. | 1992 | Thorac Cardiovasc Surg | pmid:1290181 |
| Zhou JA et al. | The effects of dauricine and verapamil as calcium channel blockers on the plasma concentration of 6-keto-prostaglandin F1 alpha and thromboxane B2 during cardiopulmonary bypass. | 1987 | Thorac Cardiovasc Surg | pmid:2442837 |
| Kobinia GS et al. | Influence of coronary artery obstruction on cardiac prostaglandin metabolism during experimental cardioplegic arrest. | 1986 | Thorac Cardiovasc Surg | pmid:2424127 |
| Pradalier A et al. | [Measurement of plasma and serum values of PGE2, PGF2 alpha and TXB2 during aspirin induced bronchospasm in asthmatics (author's transl)]. | 1979 Jul-Aug | Therapie | pmid:531778 |
| Oelz O | [The arachidonic acid metabolites (prostaglandins, thromboxanes, prostacyclin, leucotrienes):basics and clinical implications (author's transl)]. | 1979 | Ther Umsch | pmid:119331 |
| Morris HG et al. | Effects of salsalate (nonacetylated salicylate) and aspirin on serum prostaglandins in humans. | 1985 | Ther Drug Monit | pmid:3866409 |
| Semenov AV et al. | [Soluble P-selectin - a marker of platelet activation and vessel wall injury: increase of soluble P-selectin in plasma of patients with myocardial infarction, massive atherosclerosis and primary pulmonary hypertension]. | 2000 | Ter. Arkh. | pmid:10833791 |
| Iagoda AV and Gladkikh NN | [Thromboxane-prostacyclin balance and platelet aggregability in patients with minor cardiac abnormalities]. | 2010 | Ter. Arkh. | pmid:21086621 |
| Rud'ko IA et al. | [The level of thromboxane A2 and prostacyclin in patients with chronic kidney failure undergoing hemodialysis]. | 1991 | Ter. Arkh. | pmid:1948751 |
| Chen YC et al. | Studies of platelet hyperactivity in patients with ischemic cerebrovascular diseases: IV. Determination of the optimal dosage of aspirin by measuring plasma salicylate level. | 1987 | Taiwan Yi Xue Hui Za Zhi | pmid:3694163 |
| Liu MC et al. | Studies of platelet hyperactivity in patients with ischemic cerebrovascular diseases. III. Platelet hyperactivation in the chronic phase of cerebral thromboembolism. | 1985 | Taiwan Yi Xue Hui Za Zhi | pmid:3160819 |
| Ding YA et al. | Effects of exercise and ticlopidine on platelet function and prostanoids in patients with old myocardial infarction. | 1989 | Taiwan Yi Xue Hui Za Zhi | pmid:2592938 |
| Demling RH and Lalonde C | Topical ibuprofen decreases early postburn edema. | 1987 | Surgery | pmid:3672325 |
| VanderMeer TJ et al. | Protective effects of a novel 32-amino acid C-terminal fragment of CAP18 in endotoxemic pigs. | 1995 | Surgery | pmid:7778029 |
| Slotman GJ et al. | Thromboxane A2 mediates hemodynamic and respiratory dysfunction in graded bacteremia. | 1986 | Surgery | pmid:3526603 |
| Addonizio VP et al. | Prevention of heparin-induced thrombocytopenia during open heart surgery with iloprost (ZK36374). | 1987 | Surgery | pmid:2445042 |
| Demling RH et al. | Comparison of the postburn hyperdynamic state and changes in lung function (effect of wound bacterial content). | 1986 | Surgery | pmid:3535145 |
| Demling RH et al. | The pulmonary and systemic response to recurrent endotoxemia in the adult sheep. | 1986 | Surgery | pmid:3535147 |
| Kirton OC et al. | The development of a model of subacute lung injury after intra-abdominal infection. | 1984 | Surgery | pmid:6379962 |
| Lelcuk S et al. | Nicotine stimulates pulmonary parenchymal thromboxane synthesis. | 1986 | Surgery | pmid:3775653 |
| Cooper JD et al. | Prostaglandin production associated with the pulmonary vascular response to complement activation. | 1980 | Surgery | pmid:7394704 |
| Nerlich M et al. | Effect of thermal injury on endotoxin-induced lung injury. | 1983 | Surgery | pmid:6337423 |
| Huval WV et al. | Thromboxane mediation of cardiovascular dysfunction following aspiration. | 1983 | Surgery | pmid:6308843 |
| Demling RH et al. | The immediate effect of burn wound excision on pulmonary function in sheep: the role of prostanoids, oxygen radicals, and chemoattractants. | 1987 | Surgery | pmid:3798327 |
| Paterson IS et al. | Thromboxane mediates the ischemia-induced neutrophil oxidative burst. | 1989 | Surgery | pmid:2527418 |
| Lelcuk S et al. | Prostacyclin and thromboxane A2 moderate postischemic renal failure. | 1985 | Surgery | pmid:3895535 |
| Farias LR et al. | Effect of prostaglandin blockers on ascites fluid in pancreatitis. | 1985 | Surgery | pmid:3898455 |
| Klausner JM et al. | Oxygen free radicals mediate ischemia-induced lung injury. | 1989 | Surgery | pmid:2536967 |
| Demling RH et al. | The lung inflammatory response to thermal injury: relationship between physiologic and histologic changes. | 1989 | Surgery | pmid:2500726 |
| Sell LL et al. | Hypertension during extracorporeal membrane oxygenation: cause, effect, and management. | 1987 | Surgery | pmid:2821641 |
| Klausner JM et al. | Interleukin-2-induced lung injury is mediated by oxygen free radicals. | 1991 | Surgery | pmid:1899491 |
| Goldman G et al. | Leukocytes mediate acid aspiration-induced multiorgan edema. | 1993 | Surgery | pmid:8395089 |
| Wong C et al. | Effect of hydroxyl radical scavenging on endotoxin-induced lung injury. | 1985 | Surgery | pmid:2983450 |
| Slotman GJ et al. | Interaction of prostaglandins, activated complement, and granulocytes in clinical sepsis and hypotension. | 1986 | Surgery | pmid:3520916 |
| Hanazaki K et al. | Protective effect of the thromboxane A2 receptor antagonist ONO 3708 on ischemia-reperfusion injury in the dog liver. | 1994 | Surgery | pmid:7940195 |
| Ichihara T et al. | The effects of using a leukocyte removal filter during cold blood cardioplegia. | 1994 | Surg. Today | pmid:7772907 |
| Iwata M | Pathophysiology of dogs after 84% hepatectomy with emphasis on prostaglandin metabolites and the effect of a thromboxane A2 synthesis inhibitor and a prostaglandin I2 analog. | 1994 | Surg. Today | pmid:7780227 |
| Isozaki H et al. | The protective effect of thromboxane A2 synthetase inhibitor against ischemic liver injury. | 1994 | Surg. Today | pmid:8054815 |
| Isozaki H et al. | Urinary thromboxane B2 as an indicator of acute rejection in human liver transplantation. | 1996 | Surg. Today | pmid:8727944 |
| Kitagawa M et al. | The role of the spleen, especially regarding changes in both thromboxane A2 and the remnant liver dysfunction after extensive hepatectomy. | 1999 | Surg. Today | pmid:10030738 |
| Itasaka H et al. | The mechanism of hepatic graft protection against reperfusion injury by prostaglandin E1. | 1999 | Surg. Today | pmid:10385367 |
| Onizuka M et al. | Suppression of prostanoid formation and regulation of peripheral circulation after surgery using thrombin inhibitor (MD805). | 1998 | Surg. Today | pmid:9681611 |
| Yang SY and Gao ZX | Determination and clinical significance of plasma levels of prostaglandins in patients with acute brain injury. | 1999 | Surg Neurol | pmid:10511080 |
| Seifert V et al. | Arachidonic acid metabolism following aneurysm rupture. Evaluation of cerebrospinal fluid and serum concentration of 6-keto-prostaglandin F1 alpha and thromboxane B2 in patients with subarachnoid hemorrhage. | 1987 | Surg Neurol | pmid:3810456 |
| Kaufman RP et al. | A high plasma prostaglandin to thromboxane ratio protects against renal ischemia. | 1987 | Surg Gynecol Obstet | pmid:3672299 |
| Ferraris VA and Swanson E | Aspirin usage and perioperative blood loss in patients undergoing unexpected operations. | 1983 | Surg Gynecol Obstet | pmid:6836459 |
| Utsunomiya T et al. | Treatment of pulmonary embolism with positive end-expiratory pressure and prostaglandin E1. | 1981 | Surg Gynecol Obstet | pmid:7017981 |
| Rabinovici R et al. | Hemodynamic, hematologic and eicosanoid mediated mechanisms in 7.5 percent sodium chloride treatment of uncontrolled hemorrhagic shock. | 1992 | Surg Gynecol Obstet | pmid:1411892 |
| Mathieson MA et al. | Ischemia of the limb stimulates thromboxane production and myocardial depression. | 1983 | Surg Gynecol Obstet | pmid:6648769 |
| Manny J et al. | Pulmonary and systemic consequences of localized acid aspiration. | 1986 | Surg Gynecol Obstet | pmid:3952619 |
| Reines HD et al. | Lack of effect of glucocorticoids upon plasma thromboxane in patients in a state of shock. | 1985 | Surg Gynecol Obstet | pmid:3983796 |
| Davies GC et al. | Thromboxane B2 and fibrinopeptide A levels in platelet consumption and thrombosis. | 1978 | Surg Forum | pmid:401227 |
| Heizer ML et al. | 14,15-Epoxyeicosatrienoic acid inhibits platelet aggregation in mouse cerebral arterioles. | 1991 | Stroke | pmid:1750047 |
| Juvela S et al. | Platelet thromboxane release after subarachnoid hemorrhage and surgery. | 1990 | Stroke | pmid:2326838 |
| Feinberg WM and Bruck DC | Effect of oral nimodipine on platelet function. | 1993 | Stroke | pmid:8418530 |
| Minamisawa H et al. | Brain eicosanoid levels in spontaneously hypertensive rats after ischemia with reperfusion: leukotriene C4 as a possible cause of cerebral edema. | 1988 | Stroke | pmid:3354024 |
| Ohkuma H et al. | Role of platelet function in symptomatic cerebral vasospasm following aneurysmal subarachnoid hemorrhage. | 1991 | Stroke | pmid:1830180 |
| Bruno A et al. | Serial urinary 11-dehydrothromboxane B2, aspirin dose, and vascular events in blacks after recent cerebral infarction. | 2004 | Stroke | pmid:14963281 |
| Sirén AL et al. | Release of proinflammatory and prothrombotic mediators in the brain and peripheral circulation in spontaneously hypertensive and normotensive Wistar-Kyoto rats. | 1992 | Stroke | pmid:1440713 |
| Uyama O et al. | The effect of a thromboxane synthetase inhibitor, OKY-046, on urinary excretion of immunoreactive thromboxane B2 and 6-keto-prostaglandin F1 alpha in patients with ischemic cerebrovascular disease. | 1985 Mar-Apr | Stroke | pmid:3883580 |
| Kempski O et al. | Postischemic production of eicosanoids in gerbil brain. | 1987 Jan-Feb | Stroke | pmid:3468670 |
| van Kooten F et al. | Evidence for episodic platelet activation in acute ischemic stroke. | 1994 | Stroke | pmid:8303731 |
| Fisher M and Zipser R | Increased excretion of immunoreactive thromboxane B2 in cerebral ischemia. | 1985 Jan-Feb | Stroke | pmid:3966251 |
| Stummer W et al. | Cerebral protection against ischemia by locomotor activity in gerbils. Underlying mechanisms. | 1995 | Stroke | pmid:7631348 |
| Juvela S et al. | Angiographic vasospasm and release of platelet thromboxane after subarachnoid hemorrhage. | 1991 | Stroke | pmid:2024274 |
| van Kooten F et al. | Increased thromboxane biosynthesis is associated with poststroke dementia. | 1999 | Stroke | pmid:10436098 |
| Gonzalez-Conejero R et al. | Biological assessment of aspirin efficacy on healthy individuals: heterogeneous response or aspirin failure? | 2005 | Stroke | pmid:15604423 |
| Fisher M | Increased thromboxane biosynthesis in patients with acute cerebral ischemia. | 1993 | Stroke | pmid:8506568 |
| Kaplan S et al. | A new combination therapy for selective and prolonged antiplatelet effect: results in the dog. | 1986 May-Jun | Stroke | pmid:3520978 |