| MeSH term | MeSH ID | Detail |
|---|---|---|
| Drowning | D004332 | 2 associated lipids |
| Ductus Arteriosus, Patent | D004374 | 5 associated lipids |
| Edema | D004487 | 152 associated lipids |
| Edema, Cardiac | D004489 | 1 associated lipids |
| Embolism, Fat | D004620 | 4 associated lipids |
| Endometriosis | D004715 | 29 associated lipids |
| Enteritis | D004751 | 8 associated lipids |
| Erythromelalgia | D004916 | 1 associated lipids |
| Escherichia coli Infections | D004927 | 17 associated lipids |
| Eye Burns | D005126 | 13 associated lipids |
| Facial Pain | D005157 | 5 associated lipids |
| Fatty Liver | D005234 | 48 associated lipids |
| Femoral Fractures | D005264 | 7 associated lipids |
| Fetal Diseases | D005315 | 8 associated lipids |
| Fever | D005334 | 35 associated lipids |
| Fibromuscular Dysplasia | D005352 | 2 associated lipids |
| Fibrosis | D005355 | 23 associated lipids |
| Fistula | D005402 | 8 associated lipids |
| Foot Rot | D005535 | 1 associated lipids |
| Frostbite | D005627 | 1 associated lipids |
Thromboxane b2
Thromboxane b2 is a lipid of Fatty Acyls (FA) class. Thromboxane b2 is associated with abnormalities such as endothelial dysfunction, Diabetes Mellitus, Non-Insulin-Dependent, Diabetes Mellitus, Ischemia and Thrombocytosis. The involved functions are known as Platelet Activation, Excretory function, Anabolism, Inflammation and mRNA Expression. Thromboxane b2 often locates in Endothelium, Hepatic and Microsomes, Liver. The associated genes with Thromboxane b2 are PTGS2 gene, prothrombin fragment 2 and CCL14 wt Allele.
Cross Reference
Introduction
To understand associated biological information of Thromboxane b2, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with Thromboxane b2?
Thromboxane b2 is suspected in endothelial dysfunction, Diabetes Mellitus, Non-Insulin-Dependent, Diabetes Mellitus, Ischemia, Thrombocytosis, Acute Coronary Syndrome and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
| Disease | Cross reference | Weighted score | Related literature |
|---|
Loading... please refresh the page if content is not showing up.
Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with Thromboxane b2
PubChem Associated disorders and diseases
What pathways are associated with Thromboxane b2
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with Thromboxane b2?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
|---|
Loading... please refresh the page if content is not showing up.
What functions are associated with Thromboxane b2?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
|---|
What lipids are associated with Thromboxane b2?
There are no associated biomedical information in the current reference collection.
What genes are associated with Thromboxane b2?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
|---|
What common seen animal models are associated with Thromboxane b2?
There are no associated biomedical information in the current reference collection.
NCBI Entrez Crosslinks
All references with Thromboxane b2
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Ersöz G et al. | The effect of submaximal exercise on platelet aggregation during late follicular and midluteal phases in women. | 2002 | Thromb. Res. | pmid:12590951 |
| Mikashima H and Muramoto Y | Protective effect of Y-20811, a long-lasting thromboxane synthetase inhibitor, on endotoxin shock in rabbits. | 1990 | Thromb. Res. | pmid:2326771 |
| Carter AJ et al. | Human pulmonary vessels obtained from necropsy produce less prostacyclin and thromboxane than fresh vessels obtained from operations. | 1984 | Thromb. Res. | pmid:6547546 |
| Mercer JB et al. | The effect of short-term cold exposure on risk factors for cardiovascular disease. | 1999 | Thromb. Res. | pmid:10418798 |
| Hall ER et al. | The reduction of platelet thrombi on damaged vessel wall by a thromboxane synthetase inhibitor in rabbits. | 1982 | Thromb. Res. | pmid:6891109 |
| Mannucci L et al. | Indobufen is a potent inhibitor of whole blood aggregation in patients with a high atherosclerotic risk. | 1987 | Thromb. Res. | pmid:3445229 |
| Nosál' R et al. | Chloroquine: a multipotent inhibitor of human platelets in vitro. | 2000 | Thromb. Res. | pmid:10828481 |
| Zijlstra FJ et al. | Thrombotic thrombocytopenic purpura and plasma thromboxane B2 levels. | 1983 | Thromb. Res. | pmid:6684333 |
| Kudolo GB et al. | Effect of the ingestion of Ginkgo biloba extract on platelet aggregation and urinary prostanoid excretion in healthy and Type 2 diabetic subjects. | 2002 | Thromb. Res. | pmid:12590952 |
| Grimm LJ et al. | Inhibition of platelet thromboxane synthesis by 7-(1-imidazolyl) heptanoic acid: dissociation from inhibition of aggregation. | 1981 | Thromb. Res. | pmid:6801806 |
| Hashizume T et al. | Vinblastine inhibits platelet aggregation by a microtubule-independent mechanism, probably by its perturbing action on the plasma membrane. | 1988 | Thromb. Res. | pmid:3135636 |
| Pinto S et al. | No signs of increased thrombin generation in menopause. | 1990 | Thromb. Res. | pmid:2201101 |
| Shatoor AS et al. | Effect of Hawthorn (Crataegus aronia syn. Azarolus (L)) on platelet function in albino Wistar rats. | 2012 | Thromb. Res. | pmid:22261477 |
| Carter AJ and Jones EW | The effect of the degree of diabetic control on thromboxane synthesis in clotted whole blood. | 1986 | Thromb. Res. | pmid:3515613 |
| Best LC et al. | The interrelationship between thromboxane biosynthesis, aggregation and 5-hydroxytryptamine secretion in human platelets in vitro. | 1980 | Thromb. Haemost. | pmid:6773171 |
| Han P et al. | Inhibition of platelet function of antiarrhythmic drugs, verapamil and disopyramide. | 1982 | Thromb. Haemost. | pmid:7101234 |
| Greer IA et al. | A comparative study of the effects of adrenoceptor antagonists on platelet aggregation and thromboxane generation. | 1985 | Thromb. Haemost. | pmid:2867620 |
| Miller KW and Keith JC | Effect of thromboxane synthetase inhibition on platelet function and morphology during ovine pregnancy-induced hypertension. | 1988 | Thromb. Haemost. | pmid:3238644 |
| Santilli F et al. | Effects of high-amount-high-intensity exercise on in vivo platelet activation: modulation by lipid peroxidation and AGE/RAGE axis. | 2013 | Thromb. Haemost. | pmid:24030807 |
| di Minno G et al. | Effects of any epoxymethano stable analogue of prostaglandin endoperoxides (U-46619) on human platelets. | 1981 | Thromb. Haemost. | pmid:6266066 |
| Jilma-Stohlawetz P et al. | Impaired platelet function among platelet donors. | 2001 | Thromb. Haemost. | pmid:11583322 |
| Dejana E et al. | Bleeding time in rats: a comparison of different experimental conditions. | 1982 | Thromb. Haemost. | pmid:6753230 |
| Strano A et al. | Platelet sensitivity to prostacyclin and thromboxane production in hyperlipidemic patients. | 1982 | Thromb. Haemost. | pmid:6753232 |
| Hansen JB et al. | The effect of lipopolysaccharides (LPS) on generation of thromboxane A2 and thromboplastin activity in whole blood of males, females and females on oral contraceptives. | 1989 | Thromb. Haemost. | pmid:2799762 |
| Swartz SL and Moore TJ | Effect of angiotensin II on collagen-induced platelet activation in normotensive subjects. | 1990 | Thromb. Haemost. | pmid:2339363 |
| Siess W et al. | Stimulated platelet aggregation, thromboxane B2 formation and platelet sensitivity to prostacyclin - a critical evaluation. | 1981 | Thromb. Haemost. | pmid:7025338 |
| Watanabe J et al. | Effect of vitamin E on platelet aggregation in diabetes mellitus. | 1984 | Thromb. Haemost. | pmid:6495252 |
| Lepäntalo A et al. | Polymorphisms of COX-1 and GPVI associate with the antiplatelet effect of aspirin in coronary artery disease patients. | 2006 | Thromb. Haemost. | pmid:16493486 |
| Matsumoto M et al. | Thromboxane generation in patients with essential hypertension or cerebrovascular disease and effect of oral aspirin. | 1980 | Thromb. Haemost. | pmid:7423441 |
| Spectre G et al. | Twice daily dosing of aspirin improves platelet inhibition in whole blood in patients with type 2 diabetes mellitus and micro- or macrovascular complications. | 2011 | Thromb. Haemost. | pmid:21800009 |
| Honey AC et al. | Effect of indomethacin and dazoxiben on intravascular platelet aggregation in the anaesthetized rabbit. | 1986 | Thromb. Haemost. | pmid:3775692 |
| Kyrle PA et al. | Investigation of the interaction of blood platelets with the coagulation system at the site of plug formation in vivo in man--effect of low-dose aspirin. | 1987 | Thromb. Haemost. | pmid:2954260 |
| Gresele P et al. | Picotamide protects mice from death in a pulmonary embolism model by a mechanism independent from thromboxane suppression. | 1990 | Thromb. Haemost. | pmid:2274931 |
| Essien EM et al. | Blood changes and enhanced thromboxane and 6-keto prostaglandin F1 alpha production in experimental acute Plasmodium bergei infection in hamsters. | 1984 | Thromb. Haemost. | pmid:6388013 |
| Chen SL et al. | Chlorobutanol, a preservative of desmopressin, inhibits human platelet aggregation and release in vitro. | 1990 | Thromb. Haemost. | pmid:2096493 |
| Kyrle PA et al. | Thromboxane A2 and prostacyclin generation in the microvasculature of patients with atherosclerosis--effect of low-dose aspirin. | 1989 | Thromb. Haemost. | pmid:2508252 |
| Stratta P et al. | Warning: platelet factor 4, beta-thromboglobulin and thromboxane in donor's plasma units. | 1983 | Thromb. Haemost. | pmid:6189235 |
| Larson MK et al. | Effects of omega-3 acid ethyl esters and aspirin, alone and in combination, on platelet function in healthy subjects. | 2008 | Thromb. Haemost. | pmid:18841286 |
| Scharf RE | In vitro thromboxane synthesis of depleted blood platelets following renal transplantation. | 1990 | Thromb. Haemost. | pmid:2148845 |
| Cattaneo M et al. | Human platelet aggregation and release reaction induced by platelet activating factor (PAF-acether)--effects of acetylsalicylic acid and external ionized calcium. | 1985 | Thromb. Haemost. | pmid:3927505 |
| Jackson C et al. | DN 9693: a phosphodiesterase inhibitor with a platelet membrane effect. | 1989 | Thromb. Haemost. | pmid:2546286 |
| Crescente M et al. | Gallic acid, a dietary polyphenolic component, blunts the inhibition of platelet COX-1 by aspirin: preliminary in-vitro findings. | 2007 | Thromb. Haemost. | pmid:17549313 |
| Landolfi R et al. | Effects of unfractionated and low molecular weight heparins on platelet thromboxane biosynthesis "in vivo". | 1994 | Thromb. Haemost. | pmid:7740468 |
| Undas A et al. | Lack of aspirin-induced decrease in thrombin formation in subjects resistant to aspirin. | 2007 | Thromb. Haemost. | pmid:17549314 |
| Homoncik M et al. | Monitoring of aspirin (ASA) pharmacodynamics with the platelet function analyzer PFA-100. | 2000 | Thromb. Haemost. | pmid:10739392 |
| Vejar M et al. | Dissociation of platelet activation and spontaneous myocardial ischemia in unstable angina. | 1990 | Thromb. Haemost. | pmid:2363117 |
| Foo LC et al. | Platelets of habitual smokers have reduced susceptibility to aggregating agent. | 1991 | Thromb. Haemost. | pmid:2048056 |
| Dragani A et al. | Oxidative stress and platelet activation in subjects with moderate hyperhomocysteinaemia due to MTHFR 677 C→T polymorphism. | 2012 | Thromb. Haemost. | pmid:22782530 |
| D'Angelo A et al. | Effect of des-amino-D-arginine vasopressin (DDAVP) on plasma levels of platelet and endothelial cell release products. | 1983 | Thromb. Haemost. | pmid:6687766 |
| Vezza R et al. | Antivasoconstrictor and antiaggregatory activities of picotamide unrelated to thromboxane A2 antagonism. | 1997 | Thromb. Haemost. | pmid:9408024 |
| Greer IA et al. | Platelet activation in allergic asthma. | 1985 | Thromb. Haemost. | pmid:2931855 |
| Han P et al. | Verapamil and collagen-induced platelet reactions--evidence for a role for intracellular calcium in platelet activation. | 1983 | Thromb. Haemost. | pmid:6415847 |
| Turpeinen AM et al. | Replacement of dietary saturated by unsaturated fatty acids: effects of platelet protein kinase C activity, urinary content of 2,3-dinor-TXB2 and in vitro platelet aggregation in healthy man. | 1998 | Thromb. Haemost. | pmid:9798986 |
| Guthikonda S et al. | Increased platelet sensitivity among individuals with aspirin resistance - platelet aggregation to submaximal concentration of arachidonic acid predicts response to antiplatelet therapy. | 2008 | Thromb. Haemost. | pmid:18612542 |
| Gresele P et al. | Platelet activation markers in patients with peripheral arterial disease--a prospective comparison of different platelet function tests. | 1997 | Thromb. Haemost. | pmid:9423790 |
| Davì G et al. | The effect of two low doses of aspirin on whole blood thromboxane and prostacyclin generation in healthy subjects. | 1983 | Thromb. Haemost. | pmid:6417815 |
| Michelson AD et al. | Reversible inhibition of human platelet activation by hypothermia in vivo and in vitro. | 1994 | Thromb. Haemost. | pmid:7522354 |
| Hornby EJ et al. | The inhibitory effect of GR32191, a thromboxane receptor blocking drug, on human platelet aggregation, adhesion and secretion. | 1989 | Thromb. Haemost. | pmid:2529661 |
| Husted SE et al. | Intravenous acetylsalicylic acid--dose-related effects on platelet function and fibrinolysis in healthy males. | 1992 | Thromb. Haemost. | pmid:1412171 |
| Wang JS et al. | Effect of strenuous arm exercise on oxidized-LDL-potentiated platelet activation in individuals with spinal cord injury. | 2000 | Thromb. Haemost. | pmid:10928481 |
| Subbiah MT et al. | Studies of aggregation and thromboxane B2 synthesis in avian thrombocytes: comparison between atherosclerosis-susceptible and resistant breeds. | 1980 | Thromb. Haemost. | pmid:7455983 |
| Zahavi M et al. | Abnormal typical pattern of platelet function and thromboxane generation in unstable angina. | 1989 | Thromb. Haemost. | pmid:2531938 |
| Barrett PA and Butler KD | Shortening of platelet survival by induced hypercholesterolaemia in rabbits and its prolongation by anagrelide. | 1983 | Thromb. Haemost. | pmid:6648889 |
| Halawani SH et al. | Aspirin failure in patients presenting with acute cerebrovascular ischaemia. | 2011 | Thromb. Haemost. | pmid:21544317 |
| Connellan JM et al. | Investigation of alternative mechanisms of collagen-induced platelet activation by using monoclonal antibodies to glycoprotein IIb-IIIa and fibrinogen. | 1986 | Thromb. Haemost. | pmid:2940722 |
| Patrono C et al. | Characterization of biochemical and functional effects of antiplatelet drugs as a key to their clinical development. | 1995 | Thromb. Haemost. | pmid:8578493 |
| Cortellaro M et al. | Transcoronary platelet thromboxane A2 formation without platelet trapping in patients with coronary stenosis-effect of sulphinpyrazone treatment. | 1983 | Thromb. Haemost. | pmid:6665767 |
| Szczeklik A et al. | Prolonged bleeding time, reduced platelet aggregation, altered PAF-acether sensitivity and increased platelet mass are a trait of asthma and hay fever. | 1986 | Thromb. Haemost. | pmid:3563961 |
| Falcon CR et al. | The in vitro production of thromboxane B2 by platelets of diabetic patients is normal at physiological concentrations of ionized calcium. | 1993 | Thromb. Haemost. | pmid:8259535 |
| Fruzzetti F et al. | Platelet-vessel wall interactions with third-generation oral contraceptives: no evidence of detrimental effects. | 1999 | Thromb. Haemost. | pmid:10494782 |
| Cattaneo M et al. | Conditions influencing the interaction of asialo von Willebrand factor with human platelets--the effects of external ionized calcium concentration and the role of arachidonate pathway. | 1988 | Thromb. Haemost. | pmid:3146144 |
| Fimognari FL et al. | Nocturnal rise of urinary thromboxane B 2 in patients with coronary artery disease. | 2005 | Thromb. Haemost. | pmid:15735822 |
| De Caterina R et al. | Organic nitrates: direct antiplatelet effects and synergism with prostacyclin. Antiplatelet effects of organic nitrates. | 1988 | Thromb. Haemost. | pmid:3291182 |
| Teng CM and Ko FN | Comparison of the platelet aggregation induced by three thrombin-like enzymes of snake venoms and thrombin. | 1988 | Thromb. Haemost. | pmid:3291184 |
| Davì G et al. | Demonstration of Rickettsia Conorii-induced coagulative and platelet activation in vivo in patients with Mediterranean spotted fever. | 1995 | Thromb. Haemost. | pmid:8584998 |
| Habib A et al. | Increased expression of inducible cyclooxygenase-2 in human endothelial cells by antiphospholipid antibodies. | 1995 | Thromb. Haemost. | pmid:8585020 |
| Zahavi J and Zahavi M | Enhanced platelet release reaction, shortened platelet survival time and increased platelet aggregation and plasma thromboxane B2 in chronic obstructive arterial disease. | 1985 | Thromb. Haemost. | pmid:3158092 |
| Evangelista V et al. | Defibrotide inhibits platelet activation by cathepsin G released from stimulated polymorphonuclear leukocytes. | 1992 | Thromb. Haemost. | pmid:1509406 |
| Etulain J et al. | Acidosis downregulates platelet haemostatic functions and promotes neutrophil proinflammatory responses mediated by platelets. | 2012 | Thromb. Haemost. | pmid:22159527 |
| Pettinella C et al. | Cyclooxygenase-1 haplotype C50T/A-842G does not affect platelet response to aspirin. | 2009 | Thromb. Haemost. | pmid:19350112 |
| Korbut R et al. | On the mechanism of thrombolytic action of thromboxane synthetase inhibitors. | 1987 | Thromb. Haemost. | pmid:3324381 |
| Huang TF et al. | Mechanism of action of a potent antiplatelet peptide, triflavin from Trimeresurus flavoviridis snake venom. | 1991 | Thromb. Haemost. | pmid:1665595 |
| Véricel E et al. | Moderate oral supplementation with docosahexaenoic acid improves platelet function and oxidative stress in type 2 diabetic patients. | 2015 | Thromb. Haemost. | pmid:25832443 |
| Kyrle PA et al. | Evidence for an increased generation of prostacyclin in the microvasculature and an impairment of the platelet alpha-granule release in chronic renal failure. | 1988 | Thromb. Haemost. | pmid:2975407 |
| Spowart K et al. | Haemostatic effects of ketorolac with and without concomitant heparin in normal volunteers. | 1988 | Thromb. Haemost. | pmid:3266379 |
| Cerletti C et al. | Aspirin kinetics and inhibition of platelet thromboxane generation-relevance for a solution of the "aspirin dilemma". | 1985 | Thromb. Haemost. | pmid:4049312 |
| Hillbom M et al. | Platelet thromboxane formation and bleeding time is influenced by ethanol withdrawal but not by cigarette smoking. | 1985 | Thromb. Haemost. | pmid:4049313 |
| McMahon GS et al. | Transient heparin-induced platelet activation linked to generation of platelet 12-lipoxygenase. Findings from a randomised controlled trial. | 2013 | Thromb. Haemost. | pmid:23494053 |
| Larsen SB et al. | Reduced antiplatelet effect of aspirin is associated with low-grade inflammation in patients with coronary artery disease. | 2013 | Thromb. Haemost. | pmid:23407706 |
| De Caterina R et al. | Benefit/risk profile of combined antiplatelet therapy with ticlopidine and aspirin. | 1991 | Thromb. Haemost. | pmid:1871711 |
| de Boer A et al. | Interaction study between Org 10172, a low molecular weight heparinoid, and acetylsalicylic acid in healthy male volunteers. | 1991 | Thromb. Haemost. | pmid:1722918 |
| De Caterina R et al. | Equal antiplatelet effects of aspirin 50 or 324 mg/day in patients after acute myocardial infarction. | 1985 | Thromb. Haemost. | pmid:4082090 |
| Davì G et al. | Influence of metabolic control on thromboxane biosynthesis and plasma plasminogen activator inhibitor type-1 in non-insulin-dependent diabetes mellitus. | 1996 | Thromb. Haemost. | pmid:8819248 |
| Ding YA et al. | Potentiation of adrenaline-induced platelet aggregation by angiotensin II. | 1985 | Thromb. Haemost. | pmid:4089801 |
| Blais N et al. | Response to aspirin in healthy individuals. Cross-comparison of light transmission aggregometry, VerifyNow system, platelet count drop, thromboelastography (TEG) and urinary 11-dehydrothromboxane B(2). | 2009 | Thromb. Haemost. | pmid:19652893 |
| Forastiero R et al. | Anti-beta2 glycoprotein I antibodies and platelet activation in patients with antiphospholipid antibodies: association with increased excretion of platelet-derived thromboxane urinary metabolites. | 1998 | Thromb. Haemost. | pmid:9459320 |
| Holme S et al. | The effect of albumin bound polyunsaturated fatty acids on human platelets. | 1984 | Thromb. Haemost. | pmid:6719386 |
| Brox JH et al. | The effect of cod liver oil and corn oil on platelets and vessel wall in man. | 1981 | Thromb. Haemost. | pmid:7031981 |
| Strano A et al. | Thromboxane formation by platelets and platelet sensitivity to prostacyclin in patients with acute myocardial infarction. | 1981 | Thromb. Haemost. | pmid:7036402 |
| Butler KD et al. | The effects of modulation of prostanoid metabolism on the thoracic platelet accumulation induced by intravenous administration of collagen in the guinea-pig. | 1986 | Thromb. Haemost. | pmid:3105104 |