Thromboxane b2 is a lipid of Fatty Acyls (FA) class. Thromboxane b2 is associated with abnormalities such as endothelial dysfunction, Diabetes Mellitus, Non-Insulin-Dependent, Diabetes Mellitus, Ischemia and Thrombocytosis. The involved functions are known as Platelet Activation, Excretory function, Anabolism, Inflammation and mRNA Expression. Thromboxane b2 often locates in Endothelium, Hepatic and Microsomes, Liver. The associated genes with Thromboxane b2 are PTGS2 gene, prothrombin fragment 2 and CCL14 wt Allele.
To understand associated biological information of Thromboxane b2, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
Thromboxane b2 is suspected in endothelial dysfunction, Diabetes Mellitus, Non-Insulin-Dependent, Diabetes Mellitus, Ischemia, Thrombocytosis, Acute Coronary Syndrome and other diseases in descending order of the highest number of associated sentences.
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We collected disease MeSH terms mapped to the references associated with Thromboxane b2
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
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Function | Cross reference | Weighted score | Related literatures |
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There are no associated biomedical information in the current reference collection.
Gene | Cross reference | Weighted score | Related literatures |
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There are no associated biomedical information in the current reference collection.
Authors | Title | Published | Journal | PubMed Link |
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Simmons PM et al. | The release of leukotriene B4 during experimental inflammation. | 1983 | Biochem. Pharmacol. | pmid:6305369 |
Düsing R et al. | Dietary linoleic acid deprivation: effects on blood pressure and PGI2 synthesis. | 1983 | Am. J. Physiol. | pmid:6337507 |
Ferraris VA and Swanson E | Aspirin usage and perioperative blood loss in patients undergoing unexpected operations. | 1983 | Surg Gynecol Obstet | pmid:6836459 |
Margotat A et al. | A rapid and simple assay for the study of thromboxane B2 synthesis by intact human platelets. | 1983 | J Pharmacol Methods | pmid:6843139 |
Johnsen SA et al. | Conversion of arachidonic acid in human maternal and neonatal mononuclear leukocytes. | 1983 | Immunol. Lett. | pmid:6411611 |
Rotmensch HH et al. | Plasma platelet products and exercise-induced myocardial ischemia. | 1983 | J. Lab. Clin. Med. | pmid:6854135 |
Hamelin SS and Chan AC | Modulation of platelet thromboxane and malonaldehyde by dietary vitamin E and linoleate. | 1983 | Lipids | pmid:6855486 |
De Clerck F et al. | Platelet activation by endogenous 5-hydroxytryptamine and histamine released by mast cell degranulation with compound 48/80 in the rat. | 1983 | Agents Actions | pmid:6858790 |
Preston FE | Aspirin, prostaglandins, and peripheral gangrene. | 1983 | Am. J. Med. | pmid:6859070 |
Winter M et al. | Synthesis of thromboxane B2 in uraemia and the effects of dialysis. | 1983 | Thromb. Res. | pmid:6868024 |
Nordøy A et al. | Platelets and coagulation in patients with familial hypercholesterolemia (type IIa). | 1983 | Acta Med Scand | pmid:6188328 |
Roth DM et al. | Protective actions of ibuprofen in arachidonate-induced sudden death. | 1983 | Pharmacology | pmid:6413987 |
Salmon JA et al. | Synthesis of arachidonate cyclo-oxygenase products by rheumatoid and nonrheumatoid synovial lining in nonproliferative organ culture. | 1983 | Ann. Rheum. Dis. | pmid:6402992 |
Horellou MH et al. | Familial and constitutional bleeding disorder due to platelet cyclo-oxygenase deficiency. | 1983 | Am. J. Hematol. | pmid:6404162 |
Stratta P et al. | Warning: platelet factor 4, beta-thromboglobulin and thromboxane in donor's plasma units. | 1983 | Thromb. Haemost. | pmid:6189235 |
Di Minno G et al. | Exposure of platelet fibrinogen-binding sites by collagen, arachidonic acid, and ADP: inhibition by a monoclonal antibody to the glycoprotein IIb-IIIa complex. | 1983 | Blood | pmid:6216929 |
de Kergommeaux BD et al. | Effects of ASA on thromboxane and prostacyclin synthesis by rabbit aorta and pulmonary artery. | 1983 | Prostaglandins Leukot Med | pmid:6410417 |
Eldor A et al. | Effects of dipyrone on prostaglandin production by human platelets and cultured bovine aortic endothelial cells. | 1983 | Thromb. Haemost. | pmid:6346571 |
Sheng WY et al. | Kinetic comparison and regulation of the cascade of microsomal enzymes involved in renal arachidonate and endoperoxide metabolism. | 1983 | J. Biol. Chem. | pmid:6401732 |
Menys VC and Davies JA | Selective inhibition of thromboxane synthetase with dazoxiben - basis of its inhibitory effect on platelet adhesion. | 1983 | Thromb. Haemost. | pmid:6346575 |
Reeves WC et al. | The release of thromboxane A2 and prostacyclin following experimental acute pulmonary embolism. | 1983 | Prostaglandins Leukot Med | pmid:6348800 |
Aznavoorian SA et al. | Prostacyclin inhibits 5-hydroxytryptamine release but stimulates thromboxane synthesis during cardiopulmonary bypass. | 1983 | Prostaglandins | pmid:6348886 |
Ahlquist DA et al. | Factors influencing metabolism of arachidonic acid in guinea pig gastric mucosa. | 1983 | Am. J. Physiol. | pmid:6401937 |
Kaar ML et al. | Prostacyclin and thromboxane in diabetic children. | 1983 | Prostaglandins Leukot Med | pmid:6351104 |
Parry MJ | Effects of thromboxane synthetase inhibition on arachidonate metabolism and platelet behaviour. | 1983 | Br J Clin Pharmacol | pmid:6401997 |
Fischer S et al. | The influence of selective thromboxane synthetase inhibition with a novel imidazole derivative, UK-38,485, on prostanoid formation in man. | 1983 | Circulation | pmid:6352080 |
Davi' G et al. | Platelet activation after adrenergic stimulation in hypertensive patients: effects of acebutolol. | 1983 | Eur. Heart J. | pmid:6352266 |
Jakubowski JA et al. | Arachidonic acid metabolism by platelets of differing size. | 1983 | Br. J. Haematol. | pmid:6402003 |
FitzGerald GA et al. | Endogenous prostacyclin biosynthesis and platelet function during selective inhibition of thromboxane synthase in man. | 1983 | J. Clin. Invest. | pmid:6355181 |
Jouve R et al. | [Plasma thromboxane B2 and capacity of the aorta to produce prostacyclin in arteriopathies of the lower extremities]. | 1983 | J Mal Vasc | pmid:6355348 |
Bach MK et al. | In vivo and in vitro actions of a new selective inhibitor of leukotriene C and D synthesis. | 1983 | Adv. Prostaglandin Thromboxane Leukot. Res. | pmid:6221551 |
Mehta J et al. | Stimulation of vessel wall prostacyclin by selective thromboxane synthetase inhibitor OKY 1581. | 1983 | Prostaglandins Leukot Med | pmid:6356153 |
Grose JH et al. | Imbalanced prostacyclin and thromboxane A2 production in essential hypertension. | 1983 | Adv. Prostaglandin Thromboxane Leukot. Res. | pmid:6221555 |
Henriksen RA and Brotherton AF | Evidence that activation of platelets and endothelium by thrombin involves distinct sites of interaction. Studies with the dysthrombin, Thrombin Quick I. | 1983 | J. Biol. Chem. | pmid:6358210 |
Hornych A et al. | Thromboxane B2 in borderline and essential hypertension. | 1983 | Adv. Prostaglandin Thromboxane Leukot. Res. | pmid:6221556 |
Kaliman J et al. | [Venous prostacycline synthesis and plasma thromboxane B2 after low-dose aspirin]. | 1983 | Wien. Klin. Wochenschr. | pmid:6359724 |
MacIntyre DE et al. | Role of endogenous arachidonate metabolites in phospholipid-induced human platelet activation. | 1983 | Adv. Prostaglandin Thromboxane Leukot. Res. | pmid:6221557 |
Ylikorkala O et al. | Prostacyclin and thromboxane in ovarian cancer: effect of cytostatics and prostaglandin synthesis inhibitors. | 1983 | Gynecol. Oncol. | pmid:6360817 |
Krishnamurthi S et al. | Paradoxical effects of indomethacin and trifluoperazine on Ca2+ ionophore A23187-induced human platelet aggregation, thromboxane B2 production, and dense granule release. | 1983 | Adv. Prostaglandin Thromboxane Leukot. Res. | pmid:6221559 |
Hardisty RM et al. | A new congenital defect of platelet secretion: impaired responsiveness of the platelets to cytoplasmic free calcium. | 1983 | Br. J. Haematol. | pmid:6830700 |
Lecompte T et al. | Interference of transmethylation inhibitors with thromboxane synthesis in rat platelets: evidence for the requirement of a methyl transfer reaction in platelet activation. | 1983 | Adv. Prostaglandin Thromboxane Leukot. Res. | pmid:6221560 |
Patrono C et al. | Evidence for a renal origin of urinary thromboxane B2 in health and disease. | 1983 | Adv. Prostaglandin Thromboxane Leukot. Res. | pmid:6221569 |
Kiff PS et al. | Haemodynamic and metabolic effects of dazoxiben at rest and during atrial pacing. | 1983 | Br J Clin Pharmacol | pmid:6681708 |
Hutton I et al. | Effects of dazoxiben on transcardiac thromboxane levels and haemodynamics in coronary heart disease. | 1983 | Br J Clin Pharmacol | pmid:6681709 |
Fletcher JR et al. | Thromboxane inhibition in gram-negative sepsis fails to improve survival. | 1983 | Adv. Prostaglandin Thromboxane Leukot. Res. | pmid:6221586 |
Socini A et al. | Fish oil administration lowers prostacyclin production and the antiaggregatory activity of aortic walls more effectively than platelet aggregation and thromboxane in the rat. | 1983 | Adv. Prostaglandin Thromboxane Leukot. Res. | pmid:6221591 |
Zijlstra FJ et al. | Thrombotic thrombocytopenic purpura and plasma thromboxane B2 levels. | 1983 | Thromb. Res. | pmid:6684333 |
Hornstra G et al. | Dietary-fat-induced changes in the formation of prostanoids of the 2 and 3 series in relation to arterial thrombosis (rat) and atherosclerosis (rabbit). | 1983 | Adv. Prostaglandin Thromboxane Leukot. Res. | pmid:6221593 |
Lianos EA et al. | Glomerular prostaglandin and thromboxane synthesis in rat nephrotoxic serum nephritis. Effects on renal hemodynamics. | 1983 | J. Clin. Invest. | pmid:6685136 |
Tremoli E et al. | North Karelian study: changes in dietary fat reduce thromboxane B2 formation by platelets only in male subjects--preliminary report. | 1983 | Adv. Prostaglandin Thromboxane Leukot. Res. | pmid:6221594 |
Wynalda MA et al. | Sodium 5-(3'-pyridinylmethyl)benzofuran-2-carboxylate (U-63557A), a new, selective thromboxane synthase inhibitor: intravenous and oral pharmacokinetics in dogs and correlations with ex situ thromboxane B2 production. | 1983 | Prostaglandins | pmid:6685888 |
Basso N et al. | Gastric mucosal prostaglandin generation in rats with stress ulcer. | 1983 | Adv. Prostaglandin Thromboxane Leukot. Res. | pmid:6221618 |
McDonald JW et al. | Thromboxane synthesis by sources other than platelets in association with complement-induced pulmonary leukostasis and pulmonary hypertension in sheep. | 1983 | Circ. Res. | pmid:6687354 |
Randall MJ and Wilding RI | Acute arterial thrombosis in rabbits: reduced platelet accumulation after treatment with dazoxiben hydrochloride (UK 37,248-01). | 1983 | Br J Clin Pharmacol | pmid:6687429 |
Foegh M et al. | Prostacyclin and thromboxane release from human peritoneal macrophages. | 1983 | Adv. Prostaglandin Thromboxane Leukot. Res. | pmid:6221630 |
Bruckner G et al. | Dietary trilinoelaidate: effects on hematological parameters, serum eicosanoids and tissue fatty acid composition in rats. | 1983 | J. Nutr. | pmid:6687476 |
Westwick J et al. | Inhibition of thromboxane formation prevents endotoxin-induced renal fibrin deposition in jaundiced rats. | 1983 | Adv. Prostaglandin Thromboxane Leukot. Res. | pmid:6221642 |
Bessin P et al. | Acute circulatory collapse caused by platelet-activating factor (PAF-acether) in dogs. | 1983 | Eur. J. Pharmacol. | pmid:6687572 |
Ingerman-Wojenski CM et al. | Early morphological changes in the endothelium of a peripheral artery of rabbits fed an atherogenic diet. | 1983 | Exp. Mol. Pathol. | pmid:6687574 |
Sakamoto T | [Studies on platelet function in toxemia of pregnancy]. | 1983 | Nippon Sanka Fujinka Gakkai Zasshi | pmid:6223964 |
Hartung HP and Toyka KV | Tuftsin stimulates the release of oxygen radicals and thromboxane from macrophages. | 1983 | Immunol. Lett. | pmid:6687720 |
Gordon PR et al. | Platelet arachidonate metabolism and platelet function in zinc-deficient rats. | 1983 | J. Nutr. | pmid:6403678 |
D'Angelo A et al. | Effect of des-amino-D-arginine vasopressin (DDAVP) on plasma levels of platelet and endothelial cell release products. | 1983 | Thromb. Haemost. | pmid:6687766 |
Ku EC et al. | Characterization of imidazo[1,5-a]pyridine-5-hexanoic acid (CGS 13080) as a selective thromboxane synthetase inhibitor using in vitro and in vivo biochemical models. | 1983 | Biochem. Biophys. Res. Commun. | pmid:6687803 |
Hidaka T et al. | Thromboxane formation from arachidonic acid and prostaglandin H2 in rabbit spleen. | 1983 | J. Biochem. | pmid:6404897 |
Zijlstra FJ and Vincent JE | Comparison of the determination of thromboxane A2 by bioassay on the rabbit mesenteric artery and in the form of TxB2 by radioimmunoassay. | 1983 | J Pharmacol Methods | pmid:6632924 |
Wilson L | Effects of estradiol and progesterone on uterine prostaglandin levels in the pregnant rat. | 1983 | Prostaglandins | pmid:6635211 |
Sanders TA and Hochland MC | A comparison of the influence on plasma lipids and platelet function of supplements of omega 3 and omega 6 polyunsaturated fatty acids. | 1983 | Br. J. Nutr. | pmid:6639916 |
Mehta JL | Prostaglandins: regulatory role in cardiovascular system and implications in ischemic heart disease. | 1983 | Int. J. Cardiol. | pmid:6642760 |
Mathieson MA et al. | Ischemia of the limb stimulates thromboxane production and myocardial depression. | 1983 | Surg Gynecol Obstet | pmid:6648769 |
Barrett PA and Butler KD | Shortening of platelet survival by induced hypercholesterolaemia in rabbits and its prolongation by anagrelide. | 1983 | Thromb. Haemost. | pmid:6648889 |
Robinson C and Hoult JR | Thromboxane A2 analogues inhibit the metabolism of thromboxane B2 in perfused guinea-pig lung. | 1983 | Biochim. Biophys. Acta | pmid:6652102 |
Higgs GA et al. | The source of thromboxane and prostaglandins in experimental inflammation. | 1983 | Br. J. Pharmacol. | pmid:6652359 |
Anton RF et al. | In vivo regional levels of PGE and thromboxane in mouse brain: effect of decapitation, focused microwave fixation, and indomethacin. | 1983 | Prostaglandins | pmid:6658001 |
Mahoney D et al. | Influence of dietary polyunsaturated fatty acids on renal & aortic prostaglandin synthesis in 1 kidney 1 clip Goldblatt hypertensive rats. | 1983 | Prostaglandins | pmid:6658002 |
Martin JF et al. | The biological significance of platelet volume: its relationship to bleeding time, platelet thromboxane B2 production and megakaryocyte nuclear DNA concentration. | 1983 | Thromb. Res. | pmid:6658722 |
Cohen RA et al. | 5-Hydroxytryptamine can mediate endothelium-dependent relaxation of coronary arteries. | 1983 | Am. J. Physiol. | pmid:6660308 |
Cortellaro M et al. | Transcoronary platelet thromboxane A2 formation without platelet trapping in patients with coronary stenosis-effect of sulphinpyrazone treatment. | 1983 | Thromb. Haemost. | pmid:6665767 |
De Caterina R et al. | Antiplatelet effects of isosorbide dinitrate in man. | 1983 | Z Kardiol | pmid:6666233 |
Smith EF et al. | RCS from human platelets: is it only thromboxane? | 1983 | Eur. J. Pharmacol. | pmid:6667711 |
Socini A et al. | Fish oil administration as a supplement to a corn oil containing diet affects arterial prostacyclin production more than platelet thromboxane formation in the rat. | 1983 | Prostaglandins | pmid:6310702 |
Gethmann U et al. | Effect of catecholestrogens on prostaglandin release by rat pituitaries superfused in vitro. | 1983 | Arch. Gynecol. | pmid:6320749 |
Flynn JT et al. | Effects of anesthesia and surgery on prostanoid concentrations in plasma and pulmonary lymph. | 1983 | Prostaglandins Leukot Med | pmid:6573688 |
Patel K and Bakhle YS | Thromboxane B2 (TxB2) metabolism in rat isolated lung and its inhibition by drugs. | 1983 | Prostaglandins Leukot Med | pmid:6573689 |
Davì G et al. | Plasmatic TXB2 and 6-keto-PGF1 alpha levels during charcoal hemoperfusion in chronic renal failure patients. | 1983 | Prostaglandins Leukot Med | pmid:6573692 |
Lieb J et al. | Elevated levels of prostaglandin E2 and thromboxane B2 in depression. | 1983 | Prostaglandins Leukot Med | pmid:6574523 |
Okahara T et al. | Zonal heterogeneity of prostaglandin and thromboxane release in the dog kidney. | 1983 | Prostaglandins | pmid:6575405 |
Coceani F et al. | Prostaglandin E2 and thromboxane B2 in cerebrospinal fluid of afebrile and febrile cat. | 1983 | Am. J. Physiol. | pmid:6574712 |
Viinikka L et al. | Effect of prolonged treatment with acetylsalicylic acid and dipyridamole on platelet thromboxane A2 production in atherosclerotic subjects. | 1983 | Prostaglandins Leukot Med | pmid:6576385 |
Fukumoto S and Tanaka K | Protective effects of thromboxane A2 synthetase inhibitors on endotoxin shock. | 1983 | Prostaglandins Leukot Med | pmid:6576388 |
Kinney EL et al. | Mechanism of action of amrinone: role of thromboxane synthetase inhibition. | 1983 | Prostaglandins Leukot Med | pmid:6576389 |
Hawkey CJ et al. | Imbalance of prostacyclin and thromboxane synthesis in Crohn's disease. | 1983 | Gut | pmid:6578172 |
Zijlstra FJ et al. | Separation of the two components of the contractile activity of leukotriene C4 on the guinea pig lung parenchymal strip. | 1983 | Prostaglandins Leukot Med | pmid:6578519 |
Roy L et al. | Increased plasma concentrations of prostacyclin metabolite 6-keto-PGF1 alpha in essential hypertension. Influence of therapy with labetalol. | 1983 | Am. J. Cardiol. | pmid:6823861 |
Mahoney DP et al. | Radioimmunoassay of prostaglandins and thromboxane B2 in extracted and unextracted urine and serum using an iodinated ligand. | 1983 | Prostaglandins Leukot Med | pmid:6579570 |
Güllner HG et al. | Renal thromboxane excretion in Brattleboro rats with hereditary hypothalamic diabetes insipidus. Effect of vasopressin treatment. | 1983 | Prostaglandins Leukot Med | pmid:6580653 |
Sakanishi N et al. | Thromboxane A2 and hemodynamic-biochemical parameters in canine endotoxin shock. | 1983 | Bull. Tokyo Med. Dent. Univ. | pmid:6580966 |
Orlandi M et al. | Normal plasma thromboxane B2 (TXB2) and 6-keto-PGF1 alpha levels in childhood diabetes. | 1983 | Prostaglandins Leukot Med | pmid:6583712 |
Butler RR et al. | Gentamicin and indomethacin in the treatment of septic shock: effects on prostacyclin and thromboxane A2 production. | 1983 | J. Pharmacol. Exp. Ther. | pmid:6339712 |
Asbóth G et al. | Conversion of arachidonic acid to prostanoids in the avian uterus. | 1983 | Biochim. Biophys. Acta | pmid:6402032 |