Thromboxane b2 is a lipid of Fatty Acyls (FA) class. Thromboxane b2 is associated with abnormalities such as endothelial dysfunction, Diabetes Mellitus, Non-Insulin-Dependent, Diabetes Mellitus, Ischemia and Thrombocytosis. The involved functions are known as Platelet Activation, Excretory function, Anabolism, Inflammation and mRNA Expression. Thromboxane b2 often locates in Endothelium, Hepatic and Microsomes, Liver. The associated genes with Thromboxane b2 are PTGS2 gene, prothrombin fragment 2 and CCL14 wt Allele.
To understand associated biological information of Thromboxane b2, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
Thromboxane b2 is suspected in endothelial dysfunction, Diabetes Mellitus, Non-Insulin-Dependent, Diabetes Mellitus, Ischemia, Thrombocytosis, Acute Coronary Syndrome and other diseases in descending order of the highest number of associated sentences.
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We collected disease MeSH terms mapped to the references associated with Thromboxane b2
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
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Function | Cross reference | Weighted score | Related literatures |
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There are no associated biomedical information in the current reference collection.
Gene | Cross reference | Weighted score | Related literatures |
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There are no associated biomedical information in the current reference collection.
Authors | Title | Published | Journal | PubMed Link |
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Simmons PM et al. | The release of leukotriene B4 during experimental inflammation. | 1983 | Biochem. Pharmacol. | pmid:6305369 |
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Johnsen SA et al. | Conversion of arachidonic acid in human maternal and neonatal mononuclear leukocytes. | 1983 | Immunol. Lett. | pmid:6411611 |
Nordøy A et al. | Platelets and coagulation in patients with familial hypercholesterolemia (type IIa). | 1983 | Acta Med Scand | pmid:6188328 |
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Nerlich M et al. | Effect of thermal injury on endotoxin-induced lung injury. | 1983 | Surgery | pmid:6337423 |
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Ball HA et al. | Effect of dazoxiben, a specific inhibitor of thromboxane synthetase, on acute pulmonary responses to E. coli endotoxin in anaesthetized cats. | 1983 | Br J Clin Pharmacol | pmid:6337603 |
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Hartung HP | Acetyl glyceryl ether phosphorylcholine (platelet-activating factor) mediates heightened metabolic activity in macrophages. Studies on PGE, TXB2 and O2- production, spreading, and the influence of calmodulin-inhibitor W-7. | 1983 | FEBS Lett. | pmid:6309563 |
Sheng WY et al. | Kinetic comparison and regulation of the cascade of microsomal enzymes involved in renal arachidonate and endoperoxide metabolism. | 1983 | J. Biol. Chem. | pmid:6401732 |
Chetty N and Bradlow BA | The effects of a vegetarian diet on platelet function and fatty acids. | 1983 | Thromb. Res. | pmid:6612688 |
Ahlquist DA et al. | Factors influencing metabolism of arachidonic acid in guinea pig gastric mucosa. | 1983 | Am. J. Physiol. | pmid:6401937 |
Parry MJ | Effects of thromboxane synthetase inhibition on arachidonate metabolism and platelet behaviour. | 1983 | Br J Clin Pharmacol | pmid:6401997 |
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Kawaguchi H | Thromboxane synthesis in hypercholesterolemic platelets--on the mechanism of increased thromboxane synthesis. | 1983 | Hokkaido Igaku Zasshi | pmid:6618425 |
Jakubowski JA et al. | Arachidonic acid metabolism by platelets of differing size. | 1983 | Br. J. Haematol. | pmid:6402003 |
Dubin NH et al. | Thromboxane production in the pregnant rat: differential recovery by platelets and uterus following aspirin administration. | 1983 | Biol. Reprod. | pmid:6626652 |
Nuotto E et al. | Effect of acetylsalicylic acid on plasma thromboxane B2 and platelet aggregation in man. | 1983 | Eur. J. Clin. Pharmacol. | pmid:6628518 |
MacIntyre DE et al. | Role of endogenous arachidonate metabolites in phospholipid-induced human platelet activation. | 1983 | Adv. Prostaglandin Thromboxane Leukot. Res. | pmid:6221557 |
Krishnamurthi S et al. | Paradoxical effects of indomethacin and trifluoperazine on Ca2+ ionophore A23187-induced human platelet aggregation, thromboxane B2 production, and dense granule release. | 1983 | Adv. Prostaglandin Thromboxane Leukot. Res. | pmid:6221559 |
Lecompte T et al. | Interference of transmethylation inhibitors with thromboxane synthesis in rat platelets: evidence for the requirement of a methyl transfer reaction in platelet activation. | 1983 | Adv. Prostaglandin Thromboxane Leukot. Res. | pmid:6221560 |
Patrono C et al. | Evidence for a renal origin of urinary thromboxane B2 in health and disease. | 1983 | Adv. Prostaglandin Thromboxane Leukot. Res. | pmid:6221569 |
Fletcher JR et al. | Thromboxane inhibition in gram-negative sepsis fails to improve survival. | 1983 | Adv. Prostaglandin Thromboxane Leukot. Res. | pmid:6221586 |
Socini A et al. | Fish oil administration lowers prostacyclin production and the antiaggregatory activity of aortic walls more effectively than platelet aggregation and thromboxane in the rat. | 1983 | Adv. Prostaglandin Thromboxane Leukot. Res. | pmid:6221591 |
Hornstra G et al. | Dietary-fat-induced changes in the formation of prostanoids of the 2 and 3 series in relation to arterial thrombosis (rat) and atherosclerosis (rabbit). | 1983 | Adv. Prostaglandin Thromboxane Leukot. Res. | pmid:6221593 |
Mandrovnaia NV et al. | [Age-related changes in prostacyclin and thromboxane B2 biosynthesis under normal conditions and in arterial hypertension]. | 1983 | Kardiologiia | pmid:6366325 |
Tremoli E et al. | North Karelian study: changes in dietary fat reduce thromboxane B2 formation by platelets only in male subjects--preliminary report. | 1983 | Adv. Prostaglandin Thromboxane Leukot. Res. | pmid:6221594 |
Basso N et al. | Gastric mucosal prostaglandin generation in rats with stress ulcer. | 1983 | Adv. Prostaglandin Thromboxane Leukot. Res. | pmid:6221618 |
Abiko Y et al. | The stimulation of macrophage prostaglandin E2 and thromboxane B2 secretion by Streptococcus mutans insoluble glucans. | 1983 | FEBS Lett. | pmid:6403385 |
Foegh M et al. | Prostacyclin and thromboxane release from human peritoneal macrophages. | 1983 | Adv. Prostaglandin Thromboxane Leukot. Res. | pmid:6221630 |
Sinzinger H and Firbas W | [Cells of the vascular wall synthesize thromboxane]. | 1983 | Wien. Klin. Wochenschr. | pmid:6369802 |
Westwick J et al. | Inhibition of thromboxane formation prevents endotoxin-induced renal fibrin deposition in jaundiced rats. | 1983 | Adv. Prostaglandin Thromboxane Leukot. Res. | pmid:6221642 |
Sakamoto T | [Studies on platelet function in toxemia of pregnancy]. | 1983 | Nippon Sanka Fujinka Gakkai Zasshi | pmid:6223964 |
Mehta P et al. | Inhibitory effects of diltiazem on platelet activation caused by ionophore A23187 plus ADP or epinephrine in subthreshold concentrations. | 1983 | J. Lab. Clin. Med. | pmid:6411841 |
Gordon PR et al. | Platelet arachidonate metabolism and platelet function in zinc-deficient rats. | 1983 | J. Nutr. | pmid:6403678 |
Winchester JF et al. | Early indicators of renal allograft rejection. | 1983 | Kidney Int. Suppl. | pmid:6224041 |
Okegawa T et al. | Endotoxin induces chronic prostaglandin and thromboxane synthesis from ureter-obstructed kidneys: role of inflammatory cells. | 1983 | J. Pharmacol. Exp. Ther. | pmid:6403696 |
Ellsworth ML et al. | Pulmonary prostacyclin production with increased flow and sympathetic stimulation. | 1983 | J Appl Physiol Respir Environ Exerc Physiol | pmid:6415017 |
Dahl ML et al. | Sodium salicylate interferes with the inhibitory effects of aspirin and indomethacin on human platelets. | 1983 | Prostaglandins Leukot Med | pmid:6415666 |
Halushka PV et al. | Studies on the beneficial effects of aspirin in endotoxic shock. Relationship to inhibition of arachidonic acid metabolism. | 1983 | Am. J. Med. | pmid:6687979 |
Tsukatani E | Etiology of EPH-gestosis from the viewpoint of dynamics of vasoactive prostanoid, lipid peroxides and vitamin E. | 1983 | Nippon Sanka Fujinka Gakkai Zasshi | pmid:6688085 |
Han P et al. | Verapamil and collagen-induced platelet reactions--evidence for a role for intracellular calcium in platelet activation. | 1983 | Thromb. Haemost. | pmid:6415847 |
Fischer S et al. | In vivo and in vitro effects of nafazatrom (Bay g 6575), an antithrombotic compound, on arachidonic acid metabolism in platelets and vascular tissue. | 1983 | Biochem. Pharmacol. | pmid:6688182 |
Barnhart MI et al. | DDAVP: does the drug have a direct effect on the vessel wall? | 1983 | Thromb. Res. | pmid:6415852 |
Bailey IA et al. | Effects of vascular trauma and transient myocardial ischaemia on coronary venous prostaglandin levels in the dog. | 1983 | Cardiovasc. Res. | pmid:6688202 |
Wallis RB | Mechanisms of action of sulphinpyrazone. | 1983 | Thromb. Res. Suppl. | pmid:6415857 |
Srivastava KC and Awasthi KK | Separation and quantitative determination of radiolabeled prostaglandins, thromboxanes, 6-keto-prostaglandin F1 alpha and other arachidonic acid metabolites produced in biological material. | 1983 | J. Chromatogr. | pmid:6688256 |
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Saldeen P and Saldeen T | 6-keto-prostaglandin F1 alpha/thromboxane B2 ratio in vascular and lung tissue. | 1983 | Thromb. Res. | pmid:6688484 |
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Gurtner GH et al. | Oxidant- and lipid-induced pulmonary vasoconstriction mediated by arachidonic acid metabolites. | 1983 | J Appl Physiol Respir Environ Exerc Physiol | pmid:6688802 |
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Miller JB et al. | Alterations in plasma and tissue prostaglandin levels in rabbits during luteal regression. | 1983 | Biol. Reprod. | pmid:6688954 |
Hidaka T et al. | Thromboxane formation from arachidonic acid and prostaglandin H2 in rabbit spleen. | 1983 | J. Biochem. | pmid:6404897 |
Davì G et al. | The effect of two low doses of aspirin on whole blood thromboxane and prostacyclin generation in healthy subjects. | 1983 | Thromb. Haemost. | pmid:6417815 |
Muccitelli RM et al. | Effect of inhibition of thromboxane production on the leukotriene D4-mediated bronchoconstriction in the guinea pig. | 1983 | Prostaglandins | pmid:6689082 |
Gerozissis K and Dray F | In-vitro prostanoid production by the rat vas deferens. | 1983 | J. Reprod. Fertil. | pmid:6572721 |
Dale J et al. | The effect of a thromboxane synthetase inhibitor, dazoxiben, and acetylsalicylic acid on platelet function and prostaglandin metabolism. | 1983 | Thromb. Haemost. | pmid:6689091 |
Schleimer RP et al. | Effects of dexamethasone on mediator release from human lung fragments and purified human lung mast cells. | 1983 | J. Clin. Invest. | pmid:6134755 |
Liu J | [Effect of Paeonia obovata 801 on metabolism of thromboxane B2 and arachidonic acid and on platelet aggregation in patients with coronary heart disease and cerebral thrombosis]. | 1983 | Zhonghua Yi Xue Za Zhi | pmid:6418338 |
Moonen P et al. | An improved method for separation of thromboxane B2 by reversed phase liquid chromatography. | 1983 | Prostaglandins | pmid:6669711 |
Hartung HP et al. | Induction of thromboxane release from macrophages by anaphylatoxic peptide C3a of complement and synthetic hexapeptide C3a 72-77. | 1983 | J. Immunol. | pmid:6600482 |
Zipser RD et al. | Urinary thromboxane B2 and prostaglandin E2 in the hepatorenal syndrome: evidence for increased vasoconstrictor and decreased vasodilator factors. | 1983 | Gastroenterology | pmid:6572162 |
Okahara T et al. | Zonal heterogeneity of prostaglandin and thromboxane release in the dog kidney. | 1983 | Prostaglandins | pmid:6575405 |
Hoult JR and Robinson C | Selective inhibition of thromboxane B2 accumulation and metabolism in perfused guinea-pig lung. | 1983 | Br. J. Pharmacol. | pmid:6824820 |
Hirsh PD et al. | Effects of provocation on transcardiac thromboxane in patients with coronary artery disease. | 1983 | Am. J. Cardiol. | pmid:6829431 |
Walinsky P et al. | Beneficial effects of ibuprofen in pacing-induced myocardial ischemia. | 1983 | Am. J. Cardiol. | pmid:6829434 |
Roy L et al. | Increased plasma concentrations of prostacyclin metabolite 6-keto-PGF1 alpha in essential hypertension. Influence of therapy with labetalol. | 1983 | Am. J. Cardiol. | pmid:6823861 |
Reuben SR et al. | Effects of dazoxiben on exercise performance in chronic stable angina. | 1983 | Br J Clin Pharmacol | pmid:6402000 |
Rojas J et al. | Effects of cyclooxygenase inhibition on the response to group B streptococcal toxin in sheep. | 1983 | Pediatr. Res. | pmid:6402752 |
Gimenez T et al. | Fetal-maternal secretion of prostaglandins in the cow. | 1983 | Prostaglandins | pmid:6576447 |
Förster W and Pönicke K | Influence of sympathomimetic drugs (1-phenyl-2-amino-ethan-1-ol derivatives) on the biosynthesis of prostaglandins and thromboxane B2. | 1983 | Br. J. Pharmacol. | pmid:6403094 |
Nenci GG et al. | Platelet malondialdehyde production kinetics after cyclooxygenase block. A study performed with a modified high sensitivity assay. | 1983 | Haemostasis | pmid:6404715 |
Sharon P et al. | Prostanoid synthesis by cultured gastric and duodenal mucosa: Possible role in the pathogenesis of duodenal ulcer. | 1983 | Scand. J. Gastroenterol. | pmid:6584967 |
Lewy RI | Role of thromboxanes in vasotonic versus vaso-occlusive angina. | 1983 | Arch Mal Coeur Vaiss | pmid:6407435 |
Hayashi Y et al. | Enzyme immunoassay of thromboxane B2. | 1983 | Biochim. Biophys. Acta | pmid:6407530 |
Poyser NL and Brydon LJ | Prostaglandin release from the guinea-pig uterus superfused in vitro. Effect of stage of estrous cycle, progesterone, estradiol, oxytocin and A23187. | 1983 | Prostaglandins | pmid:6408712 |
Butler RR et al. | Gentamicin and indomethacin in the treatment of septic shock: effects on prostacyclin and thromboxane A2 production. | 1983 | J. Pharmacol. Exp. Ther. | pmid:6339712 |
Laitinen O et al. | Plasma levels and urinary excretion of prostaglandins in patients with rheumatoid arthritis. | 1983 | Clin. Rheumatol. | pmid:6589104 |
Ouwendijk RJ et al. | Raised plasma levels of thromboxane B2 in systemic mastocytosis. | 1983 | Eur. J. Clin. Invest. | pmid:6409646 |
Snapper JR et al. | Effects of cyclooxygenase inhibitors on the alterations in lung mechanics caused by endotoxemia in the unanesthetized sheep. | 1983 | J. Clin. Invest. | pmid:6409930 |
Asbóth G et al. | Conversion of arachidonic acid to prostanoids in the avian uterus. | 1983 | Biochim. Biophys. Acta | pmid:6402032 |