Thromboxane b2 is a lipid of Fatty Acyls (FA) class. Thromboxane b2 is associated with abnormalities such as endothelial dysfunction, Diabetes Mellitus, Non-Insulin-Dependent, Diabetes Mellitus, Ischemia and Thrombocytosis. The involved functions are known as Platelet Activation, Excretory function, Anabolism, Inflammation and mRNA Expression. Thromboxane b2 often locates in Endothelium, Hepatic and Microsomes, Liver. The associated genes with Thromboxane b2 are PTGS2 gene, prothrombin fragment 2 and CCL14 wt Allele.
To understand associated biological information of Thromboxane b2, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
Thromboxane b2 is suspected in endothelial dysfunction, Diabetes Mellitus, Non-Insulin-Dependent, Diabetes Mellitus, Ischemia, Thrombocytosis, Acute Coronary Syndrome and other diseases in descending order of the highest number of associated sentences.
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We collected disease MeSH terms mapped to the references associated with Thromboxane b2
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
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Function | Cross reference | Weighted score | Related literatures |
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There are no associated biomedical information in the current reference collection.
Gene | Cross reference | Weighted score | Related literatures |
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There are no associated biomedical information in the current reference collection.
Authors | Title | Published | Journal | PubMed Link |
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Mistry M and Nasjletti A | Role of TXA2 in the pathogenesis of severe angiotensin II-salt hypertension. | 1989 | Adv. Prostaglandin Thromboxane Leukot. Res. | pmid:2526469 |
FitzGerald GA et al. | Thromboxane biosynthesis and antagonism in humans. | 1987 | Adv. Prostaglandin Thromboxane Leukot. Res. | pmid:2959047 |
Nowak J and FitzGerald GA | In vivo formation of prostacyclin and thromboxane A2 at the site of platelet-vascular interaction in humans. | 1987 | Adv. Prostaglandin Thromboxane Leukot. Res. | pmid:2959050 |
Pedrinelli R et al. | The influence of selective and nonselective prostaglandin inhibition on renin. | 1985 | Adv. Prostaglandin Thromboxane Leukot. Res. | pmid:3159197 |
Ezra D et al. | Effects of platelet-activating factor on coronary hemodynamics and coronary venous plasma levels of TXB2, 6-keto-PGF1 alpha, and leukotriene C4 immunoreactivity in the intact domestic pig heart. | 1985 | Adv. Prostaglandin Thromboxane Leukot. Res. | pmid:3159202 |
Gensini GF et al. | Effects of dipyridamole infusion on local platelet aggregation and local formation of thromboxane A2 in patients with pulmonary hypertension. | 1985 | Adv. Prostaglandin Thromboxane Leukot. Res. | pmid:3159209 |
De Caterina R et al. | Aspirin after acute myocardial infarction: a systematic approach to compare the hemostatic effects of three different doses. | 1985 | Adv. Prostaglandin Thromboxane Leukot. Res. | pmid:3159210 |
Trimarco B et al. | Indomethacin blunts the late phase of nitroglycerin-induced coronary vasodilatation in dogs. | 1985 | Adv. Prostaglandin Thromboxane Leukot. Res. | pmid:3159220 |
Shikano M et al. | Effects of selective thromboxane synthetase inhibitor OKY-046 on plasma prostaglandins in patients with coronary artery disease during exercise. | 1985 | Adv. Prostaglandin Thromboxane Leukot. Res. | pmid:3159226 |
Prosdocimi M et al. | Prostacyclin and thromboxane levels during cardiac ischemia in dogs. | 1985 | Adv. Prostaglandin Thromboxane Leukot. Res. | pmid:3159235 |
MacIntyre DE et al. | Role of endogenous arachidonate metabolites in phospholipid-induced human platelet activation. | 1983 | Adv. Prostaglandin Thromboxane Leukot. Res. | pmid:6221557 |
Krishnamurthi S et al. | Paradoxical effects of indomethacin and trifluoperazine on Ca2+ ionophore A23187-induced human platelet aggregation, thromboxane B2 production, and dense granule release. | 1983 | Adv. Prostaglandin Thromboxane Leukot. Res. | pmid:6221559 |
Lecompte T et al. | Interference of transmethylation inhibitors with thromboxane synthesis in rat platelets: evidence for the requirement of a methyl transfer reaction in platelet activation. | 1983 | Adv. Prostaglandin Thromboxane Leukot. Res. | pmid:6221560 |
Patrono C et al. | Evidence for a renal origin of urinary thromboxane B2 in health and disease. | 1983 | Adv. Prostaglandin Thromboxane Leukot. Res. | pmid:6221569 |
Fletcher JR et al. | Thromboxane inhibition in gram-negative sepsis fails to improve survival. | 1983 | Adv. Prostaglandin Thromboxane Leukot. Res. | pmid:6221586 |
Socini A et al. | Fish oil administration lowers prostacyclin production and the antiaggregatory activity of aortic walls more effectively than platelet aggregation and thromboxane in the rat. | 1983 | Adv. Prostaglandin Thromboxane Leukot. Res. | pmid:6221591 |
Hornstra G et al. | Dietary-fat-induced changes in the formation of prostanoids of the 2 and 3 series in relation to arterial thrombosis (rat) and atherosclerosis (rabbit). | 1983 | Adv. Prostaglandin Thromboxane Leukot. Res. | pmid:6221593 |
Tremoli E et al. | North Karelian study: changes in dietary fat reduce thromboxane B2 formation by platelets only in male subjects--preliminary report. | 1983 | Adv. Prostaglandin Thromboxane Leukot. Res. | pmid:6221594 |
Basso N et al. | Gastric mucosal prostaglandin generation in rats with stress ulcer. | 1983 | Adv. Prostaglandin Thromboxane Leukot. Res. | pmid:6221618 |
Foegh M et al. | Prostacyclin and thromboxane release from human peritoneal macrophages. | 1983 | Adv. Prostaglandin Thromboxane Leukot. Res. | pmid:6221630 |