Thromboxane b2 is a lipid of Fatty Acyls (FA) class. Thromboxane b2 is associated with abnormalities such as endothelial dysfunction, Diabetes Mellitus, Non-Insulin-Dependent, Diabetes Mellitus, Ischemia and Thrombocytosis. The involved functions are known as Platelet Activation, Excretory function, Anabolism, Inflammation and mRNA Expression. Thromboxane b2 often locates in Endothelium, Hepatic and Microsomes, Liver. The associated genes with Thromboxane b2 are PTGS2 gene, prothrombin fragment 2 and CCL14 wt Allele.
To understand associated biological information of Thromboxane b2, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
Thromboxane b2 is suspected in endothelial dysfunction, Diabetes Mellitus, Non-Insulin-Dependent, Diabetes Mellitus, Ischemia, Thrombocytosis, Acute Coronary Syndrome and other diseases in descending order of the highest number of associated sentences.
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We collected disease MeSH terms mapped to the references associated with Thromboxane b2
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
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Function | Cross reference | Weighted score | Related literatures |
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There are no associated biomedical information in the current reference collection.
Gene | Cross reference | Weighted score | Related literatures |
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There are no associated biomedical information in the current reference collection.
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Ylikorkala O et al. | Production of prostacyclin and thromboxane during cesarean section. | 1982 | Obstet Gynecol | pmid:6755324 |
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Hamasaki Y et al. | Hypoxia stimulates prostacyclin generation by dog lung in vitro. | 1982 | Prostaglandins Leukot Med | pmid:7051045 |
Panganamala RV and Cornwell DG | The effects of vitamin E on arachidonic acid metabolism. | 1982 | Ann. N. Y. Acad. Sci. | pmid:6816121 |
Mitrovic D et al. | The in vitro production of prostanoids by cultured bovine articular chondrocytes. | 1982 | Prostaglandins | pmid:6801735 |
Watanabe T et al. | Characterization of the biosynthetic pathway of prostaglandin D2 in human platelet-rich plasma. | 1982 | J. Biol. Chem. | pmid:6816798 |
Numano F et al. | Changes in the plasma levels of thromboxane B2 and cyclic nucleotides in patients with Takayasu disease. | 1982 | Jpn. Circ. J. | pmid:6119373 |
Foegh ML et al. | Aspirin inhibition of thromboxane release in thrombosis and renal transplant rejection. | 1982 | Lancet | pmid:6119441 |
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Di Minno G et al. | Arachidonic acid induces human platelet-fibrin retraction: the role of platelet cyclic endoperoxides. | 1982 | Thromb. Res. | pmid:6803385 |
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Needleman SW et al. | Enrichment of human platelet phospholipids with linoleic acid diminishes thromboxane release. | 1982 | Prostaglandins | pmid:6819602 |
Goldyne ME and Stobo JD | Human monocytes synthesize eicosanoids from T lymphocyte-derived arachidonic acid. | 1982 | Prostaglandins | pmid:6819603 |
de Boer AC et al. | Platelet release and thromboxane synthesis in symptomatic coronary artery disease. | 1982 | Circulation | pmid:6212161 |
Mari D et al. | Coagulation and platelet activation after retinal vein occlusions. | 1982 | Haemostasis | pmid:6215293 |
de Clerck F et al. | Inhibition of 5-hydroxytryptamine-induced and -amplified human platelet aggregation by ketanserin (R 41 468), a selective 5-HT2-receptor antagonist. | 1982 | Agents Actions | pmid:6215842 |
Mehta P et al. | Comparison of umbilical vein models for measurement of relative prostacyclin and thromboxane production. | 1982 | Prostaglandins | pmid:6820165 |
Mehta J and Mehta P | Effects of propranolol therapy on platelet release and prostaglandin generation in patients with coronary heart disease. | 1982 | Circulation | pmid:6216027 |
Stuart MJ and Allen JB | Arachidonic acid metabolism in the neonatal platelet. | 1982 | Pediatrics | pmid:6804924 |
Nolan RD et al. | The pericardium as a source of prostacyclin in the dog, ox and rat. | 1982 | Prostaglandins | pmid:6820168 |
Mehta P et al. | Thromboxane and prostacyclin generation by intact human vessels in response to balloon catheter trauma. | 1982 | Prostaglandins Leukot Med | pmid:6217465 |
Wilson L et al. | Alterations in reproductive tissue prostaglandins E and F, 6-keto-prostaglandin F1 alpha and thromboxane B2 with gestational age in the rat. | 1982 | Biol. Reprod. | pmid:6897617 |
Randall MJ and Wilding RI | Acute arterial thrombosis in rabbits: reduced platelet accumulation after treatment with thromboxane synthetase inhibitor dazoxiben hydrochloride, (UK-37, 248-01). | 1982 | Thromb. Res. | pmid:6897751 |
De Caterina R et al. | [Effect of isosorbide dinitrate on platelet aggregation and production of thromboxane B2]. | 1982 | Cardiologia | pmid:6927441 |
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Whinnery MA et al. | Thromboxane B2 and prostaglandin E2 in the rat kidney with unilateral ureteral obstruction. | 1982 | Am. J. Physiol. | pmid:6950670 |
McNamara DB et al. | Prostaglandin endoperoxide metabolism by microsomes of whole kidneys from normal, congenital unilateral hydronephrotic and unilateral ureteral obstructed rats. | 1982 | Prostaglandins | pmid:6962465 |
Hornych A et al. | [Urinary thromboxane B2 in hypertensive patients]. | 1982 | Arch Mal Coeur Vaiss | pmid:6810812 |
Worthington RE and Nakeff A | Aspirin inhibits rat megakaryocyte thromboxane synthesis. | 1982 | Prostaglandins | pmid:6812167 |
Havill AM et al. | alpha-Naphthylthiourea produces dose-dependent lung vascular injury in sheep. | 1982 | Am. J. Physiol. | pmid:6812437 |
Lecompte T et al. | Interference of transmethylation inhibitors with thromboxane synthesis in rat platelets. | 1982 | Biochem. Biophys. Res. Commun. | pmid:6809005 |
Patrignani P et al. | Selective cumulative inhibition of platelet thromboxane production by low-dose aspirin in healthy subjects. | 1982 | J. Clin. Invest. | pmid:7045161 |
Bakhle YS and Zakrzewski JT | Effects of the oestrous cycle on the metabolism of arachidonic acid in rat isolated lung. | 1982 | J. Physiol. (Lond.) | pmid:6809935 |
Watkins WD et al. | Thromboxane and pulmonary hypertension following E. coli endotoxin infusion in sheep: effect of an imidazole derivative. | 1982 | Prostaglandins | pmid:7048422 |
Hüttemeier PC et al. | Acute pulmonary hypertension and lung thromboxane release after endotoxin infusion in normal and leukopenic sheep. | 1982 | Circ. Res. | pmid:7042108 |
Kunkel SL et al. | Production of cyclooxygenase products and superoxide anion by macrophages in response to chemotactic factors. | 1982 | Prostaglandins | pmid:6300969 |
Panossian A et al. | On the mechanism of biosynthesis of leukotrienes and related compounds. | 1982 | FEBS Lett. | pmid:6297982 |
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Scherhag R et al. | Dietary administration of eicosapentaenoic and linolenic acid increases arterial blood pressure and suppresses vascular prostacyclin synthesis in the rat. | 1982 | Prostaglandins | pmid:6285420 |
Watkins WD et al. | Thromboxane and prostacyclin changes during cardiopulmonary bypass with and without pulsatile flow. | 1982 | J. Thorac. Cardiovasc. Surg. | pmid:6980332 |
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Ylikorkala O et al. | The effect of oral contraceptives on antiaggregatory prostacyclin and proaggregatory thromboxane A2 in humans. | 1982 | Am. J. Obstet. Gynecol. | pmid:7036746 |
Kelton JG et al. | Sex-related differences in the efficacy of acetylsalicylic acid (ASA) : the absorption of ASA and its effect on collagen-induced thromboxane B2 generation. | 1981 Oct 1-15 | Thromb. Res. | pmid:7330835 |
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Tsuboi T et al. | Effect of gliclazide on prostaglandin and thromboxane synthesis in guinea-pig platelets. | 1981 Jan 1-15 | Thromb. Res. | pmid:7233394 |
Singh D et al. | Evidence for the generation of hydroxyl radical during arachidonic acid metabolism by human platelets. | 1981 | Am. J. Hematol. | pmid:6274189 |
Smith EF and Lefer AM | Stabilization of cardiac lysosomal and cellular membranes in protection of ischemic myocardium due to coronary occlusion:efficacy of the nonsteroidal anti-inflammatory agent, naproxen. | 1981 | Am. Heart J. | pmid:7211667 |
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Kass MA et al. | Prostaglandin and thromboxane synthesis by microsomes of inflamed rabbit ciliary body--iris. | 1981 | Invest. Ophthalmol. Vis. Sci. | pmid:7216665 |
di Minno G et al. | Effects of any epoxymethano stable analogue of prostaglandin endoperoxides (U-46619) on human platelets. | 1981 | Thromb. Haemost. | pmid:6266066 |
Handler JS | Vasopressin-prostaglandin interactions in the regulation of epithelial cell permeability to water. | 1981 | Kidney Int. | pmid:6267350 |
Best LC et al. | Strontium ions induce production of thromboxane B2 and secretion of 5-hydroxytryptamine in washed human platelets. | 1981 | Biochem. Pharmacol. | pmid:6268118 |
Townsend ER et al. | Preservation of platelets during extracorporeal circulation in sheep. A comparison between aspirin and sulfinpyrazone. | 1981 | Circ. Res. | pmid:7249281 |
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Karmazyn M et al. | Comparative effects of acetylsalicylic acid (ASA) and sulfinpyrazone on isoproterenol-induced heart damage. | 1981 | J. Pharmacol. Exp. Ther. | pmid:6894943 |
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Laviolette M et al. | Human alveolar macrophages: a lesion in arachidonic acid metabolism in cigarette smokers. | 1981 | Am. Rev. Respir. Dis. | pmid:6794395 |
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Landgraf-Leurs MM et al. | Aggregation and thromboxane B2 formation in platelets and vascular prostacyclin production from genetically obese rats. | 1981 | Prostaglandins | pmid:6798637 |