Thromboxane b2 is a lipid of Fatty Acyls (FA) class. Thromboxane b2 is associated with abnormalities such as endothelial dysfunction, Diabetes Mellitus, Non-Insulin-Dependent, Diabetes Mellitus, Ischemia and Thrombocytosis. The involved functions are known as Platelet Activation, Excretory function, Anabolism, Inflammation and mRNA Expression. Thromboxane b2 often locates in Endothelium, Hepatic and Microsomes, Liver. The associated genes with Thromboxane b2 are PTGS2 gene, prothrombin fragment 2 and CCL14 wt Allele.
To understand associated biological information of Thromboxane b2, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
Thromboxane b2 is suspected in endothelial dysfunction, Diabetes Mellitus, Non-Insulin-Dependent, Diabetes Mellitus, Ischemia, Thrombocytosis, Acute Coronary Syndrome and other diseases in descending order of the highest number of associated sentences.
Disease | Cross reference | Weighted score | Related literature |
---|
We collected disease MeSH terms mapped to the references associated with Thromboxane b2
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
Location | Cross reference | Weighted score | Related literatures |
---|
Function | Cross reference | Weighted score | Related literatures |
---|
There are no associated biomedical information in the current reference collection.
Gene | Cross reference | Weighted score | Related literatures |
---|
There are no associated biomedical information in the current reference collection.
Authors | Title | Published | Journal | PubMed Link |
---|---|---|---|---|
Low-dose aspirin in polycythaemia vera: a pilot study. Gruppo Italiano Studio Policitemia (GISP). | 1997 | Br. J. Haematol. | pmid:9163613 | |
Klosterhalfen B et al. | The influence of heat shock protein 70 induction on hemodynamic variables in a porcine model of recurrent endotoxemia. | 1997 | Shock | pmid:9165671 |
Oguogho A et al. | Chloroquine minimizes sampling artefacts for radioimmunological determination of thromboxane B2 in plasma. | 1997 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:9175176 |
Barbieri B et al. | p-Aminobenzoic acid, but not its metabolite p-acetamidobenzoic acid, inhibits thrombin induced thromboxane formation in human platelets in a non NSAID like manner. | 1997 | Thromb. Res. | pmid:9175234 |
Vila V et al. | Fibrinopeptide A release from intraplatelet fibrinogen is related to thrombin platelet activation. | 1997 | Thromb. Res. | pmid:9175247 |
Bräutigam R et al. | Arachidonic acid of platelet phospholipids is decreased after extracorporeal removal of plasma low density lipoproteins in patients with familial hypercholesterolemia. | 1997 | Atherosclerosis | pmid:9180250 |
Murthy S et al. | Ischemia/reperfusion injury in the rat colon. | 1997 | Inflammation | pmid:9187961 |
Oosaki R et al. | Urinary leukotriene E4 and 11-dehydrothromboxane B2 in patients with aspirin-sensitive asthma. | 1997 | Allergy | pmid:9188934 |
Ali M et al. | Synthesis of prostaglandin D2 and thromboxane B2 by human platelets. | 1977 | Thromb. Res. | pmid:918907 |
Fujinishi A et al. | Effects of nisoldipine on cytosolic calcium, platelet aggregation, and coagulation/fibrinolysis in patients with coronary artery disease. | 1997 | Angiology | pmid:9194537 |
Cook ME et al. | Comparative effects of nabumetone, sulindac, and ibuprofen on renal function. | 1997 | J. Rheumatol. | pmid:9195523 |
Hato T et al. | Outside-in signaling from integrin alpha IIb beta 3 into platelets in the absence of agonist-induced signaling. | 1997 | Int. J. Hematol. | pmid:9195778 |
Carty TJ et al. | Tenidap inhibits 5-lipoxygenase product formation in vitro, but this activity is not observed in three animal models. | 1997 | Inflamm. Res. | pmid:9197987 |
Hellyer PW et al. | Effect of NG-nitro-L-arginine-methyl-ester on cardiopulmonary function and biosynthesis of cyclooxygenase products during porcine endotoxemia. | 1997 | Crit. Care Med. | pmid:9201060 |
Yan Y et al. | [Study on mechanism of eye-signs in blood stasis syndrome]. | 1996 | Zhongguo Zhong Xi Yi Jie He Za Zhi | pmid:9206243 |
Nanji AA et al. | Cholesterol supplementation prevents necrosis and inflammation but enhances fibrosis in alcoholic liver disease in the rat. | 1997 | Hepatology | pmid:9214456 |
Malini PL et al. | Thromboxane antagonism and cough induced by angiotensin-converting-enzyme inhibitor. | 1997 | Lancet | pmid:9217714 |
Ansley DM et al. | Platelet activating factor and thromboxane B2 production after cardiopulmonary bypass. | 1997 May-Jun | J Invest Surg | pmid:9219083 |
Fenner H | Differentiating among nonsteroidal antiinflammatory drugs by pharmacokinetic and pharmacodynamic profiles. | 1997 | Semin. Arthritis Rheum. | pmid:9219317 |
De la Cruz JP et al. | Effect of erythrocytes and prostacyclin production in the effect of fructose and sorbitol on platelet activation in human whole blood in vitro. | 1997 | Thromb. Res. | pmid:9219331 |
Matsumata T et al. | Urinary excretion of prostaglandins and renal function after hepatic resection. | 1997 May-Jun | Hepatogastroenterology | pmid:9222688 |
Inui Y et al. | Platelet volume and urinary prostanoid metabolites in non-insulin-dependent diabetes mellitus. | 1994 | J. Atheroscler. Thromb. | pmid:9222878 |
Hansen TN and Brockbank KG | Increased platelet aggregation due to chilling to 20 degrees C is not related to increased sensitivity to agonists. | 1997 | Transfusion | pmid:9225932 |
Calzada C et al. | Low concentrations of lipid hydroperoxides prime human platelet aggregation specifically via cyclo-oxygenase activation. | 1997 | Biochem. J. | pmid:9230133 |
Desideri N et al. | N-omega-carbethoxypentyl-4-quinolones: a new class of leukotriene biosynthesis inhibitors. | 1997 | Arch. Pharm. (Weinheim) | pmid:9230527 |
Rautanen M et al. | Experimental fat embolism induces urine 2,3-dinor-6-ketoprostaglandin F1alpha and 11-dehydrothromboxane B2 excretion in pigs. | 1997 | Crit. Care Med. | pmid:9233750 |
Davì G et al. | Diabetes mellitus, hypercholesterolemia, and hypertension but not vascular disease per se are associated with persistent platelet activation in vivo. Evidence derived from the study of peripheral arterial disease. | 1997 | Circulation | pmid:9236419 |
Johnson RD et al. | Aspirin induces increased expression of both prostaglandin H synthase-1 and prostaglandin H synthase-2 in cultured human placental trophoblast. | 1997 | Am. J. Obstet. Gynecol. | pmid:9240586 |
Szebeni J et al. | Complement activation and thromboxane secretion by liposome-encapsulated hemoglobin in rats in vivo: inhibition by soluble complement receptor type 1. | 1997 | Artif Cells Blood Substit Immobil Biotechnol | pmid:9242930 |
González E et al. | Influence of nitric oxide synthase and kinin antagonists on metabolic parameters in chronic streptozotocin-induced diabetes mellitus. | 1997 | Prostaglandins | pmid:9247972 |
Kotuliaková K et al. | Human polymorphonuclear leukocytes: effect of chloroquine on aggregation, arachidonic acid liberation and thromboxane B2 generation. | 1996 | Gen. Physiol. Biophys. | pmid:9248834 |
Brinkmann A et al. | The impact of prostanoids on pulmonary gas exchange during abdominal surgery with mesenteric traction. | 1997 | Anesth. Analg. | pmid:9249099 |
Teng CM et al. | Antiplatelet effects of some aporphine and phenanthrene alkaloids in rabbits and man. | 1997 | J. Pharm. Pharmacol. | pmid:9255715 |
van Kooten F et al. | Platelet activation and lipid peroxidation in patients with acute ischemic stroke. | 1997 | Stroke | pmid:9259748 |
Cenni E et al. | CD62, thromboxane B2, and beta-thromboglobulin: a comparison between different markers of platelet activation after contact with biomaterials. | 1997 | J. Biomed. Mater. Res. | pmid:9260099 |
Slepko N et al. | Reorientation of prostanoid production accompanies "activation" of adult microglial cells in culture. | 1997 | J. Neurosci. Res. | pmid:9260740 |
Hishinuma T et al. | Microdetermination of the thromboxane B3 gas chromatography-selected-ion monitoring using [18O]thromboxane B3 as an internal standard. | 1997 | Prostaglandins | pmid:9261859 |
Tulppala M et al. | Low-dose aspirin in prevention of miscarriage in women with unexplained or autoimmune related recurrent miscarriage: effect on prostacyclin and thromboxane A2 production. | 1997 | Hum. Reprod. | pmid:9262298 |
Nanji AA et al. | Alterations in thromboxane synthase and thromboxane A2 receptors in experimental alcoholic liver disease. | 1997 | J. Pharmacol. Exp. Ther. | pmid:9262373 |
De La Cruz JP et al. | Effects of S-adenosyl-L-methionine on platelet thromboxane and vascular prostacyclin. | 1997 | Biochem. Pharmacol. | pmid:9264331 |
Serebruany VL et al. | Could coenzyme Q10 affect hemostasis by inhibiting platelet vitronectin (CD51/CD61) receptor? | 1997 | Mol. Aspects Med. | pmid:9266521 |
Chang TS et al. | Thromboxane A2 synthase inhibition and thromboxane A2 receptor blockade by 2-[(4-cyanophenyl)amino]-3-chloro-1,4-naphthalenedione (NQ-Y15) in rat platelets. | 1997 | Biochem. Pharmacol. | pmid:9271330 |
Azevedo I et al. | Increased spontaneous release of tumour necrosis factor-alpha by alveolar macrophages from wheezy infants. | 1997 | Eur. Respir. J. | pmid:9272917 |
Ku K et al. | Influences of dietary omega-3 polyunsaturated fatty acids on the recovery of cardiac and renal functions after preservation in hyperlipidemic rats. | 1997 | Transplantation | pmid:9275102 |
Xing X and Xia S | [The injury of liver sinusoidal endothelial cells in a rat's isolated liver perfusion (ILP) model for regional chemotherapy]. | 1996 | Zhonghua Wai Ke Za Zhi | pmid:9275689 |
Lewis K et al. | Effect of neuropeptide Y on bradykinin-induced release of prostacyclin and thromboxane from guinea pig perfused lung. | 1997 | Can. J. Physiol. Pharmacol. | pmid:9276148 |
Berg J et al. | Isoenzyme-specific cyclooxygenase inhibitors: a whole cell assay system using the human erythroleukemic cell line HEL and the human monocytic cell line Mono Mac 6. | 1997 | J Pharmacol Toxicol Methods | pmid:9279772 |
Freese R and Mutanen M | Alpha-linolenic acid and marine long-chain n-3 fatty acids differ only slightly in their effects on hemostatic factors in healthy subjects. | 1997 | Am. J. Clin. Nutr. | pmid:9280178 |
Santillan-Doherty P et al. | Plasma thromboxane B2 concentrations and pulmonary vascular resistance during lung reperfusion. | 1997 Jul-Aug | J Invest Surg | pmid:9284000 |
Cipollone F et al. | Differential suppression of thromboxane biosynthesis by indobufen and aspirin in patients with unstable angina. | 1997 | Circulation | pmid:9286937 |
Trang LE et al. | Levels of prostaglandins F2 alpha and E2 and thromboxane B2 in joint fluid in rheumatoid arthritis. | 1977 | Scand. J. Rheumatol. | pmid:929121 |
Abate A et al. | Inhibition of mediator release from anaphylactic guinea pig hearts by the novel phospholipase A2 inhibitor 3-(4-octadecylbenzoyl) acrylic acid. | 1997 | Inflamm. Res. | pmid:9297549 |
Tanaka M et al. | Effects of a thromboxane synthetase inhibitor (OKY-046) in an ischemia-reperfusion model of intrauterine growth retardation in Sprague-Dawley rats. | 1997 | Biol. Neonate | pmid:9303217 |
Berlin I et al. | [Comparison between effects of morning and evening administration of effervescent calcium carbasalate (equivalent of 160 mg aspirin) on the gastroduodenal mucosa in healthy volunteers]. | 1997 | Pathol. Biol. | pmid:9309270 |
Swails WS et al. | Effect of a fish oil structured lipid-based diet on prostaglandin release from mononuclear cells in cancer patients after surgery. | 1997 Sep-Oct | JPEN J Parenter Enteral Nutr | pmid:9323688 |
Uteshev DB and Uteshev BS | [Adhesive molecules as drugs and objects of pharmacological effect in myocardial ischemia and reperfusion]. | 1997 May-Jun | Eksp Klin Farmakol | pmid:9324410 |
Moser L et al. | ACE inhibitor effects on platelet function in stages I-II hypertension. | 1997 | J. Cardiovasc. Pharmacol. | pmid:9335405 |
Matrougui K et al. | Impaired nitric oxide- and prostaglandin-mediated responses to flow in resistance arteries of hypertensive rats. | 1997 | Hypertension | pmid:9336397 |
Hashimoto Y et al. | Characteristics of protein kinase C-independent exocytosis in human platelets. | 1997 | Thromb. Res. | pmid:9336873 |
Chavali SR et al. | Decreased production of interleukin-1-beta, prostaglandin-E2 and thromboxane-B2, and elevated levels of interleukin-6 and -10 are associated with increased survival during endotoxic shock in mice consuming diets enriched with sesame seed oil supplemented with Quil-A saponin. | 1997 | Int. Arch. Allergy Immunol. | pmid:9338609 |
Zahavi M and Zahavi J | Concomitant in vitro platelet hypofunction and increased thromboxane B2 (TXB2) generation and enhanced in vivo platelet activation. A distinct syndrome in thrombosis? | 1997 | Eur. J. Haematol. | pmid:9338626 |
Supanz S et al. | Effects of the novel thromboxane (TXA2) receptor antagonist linotroban on inulin and para-aminohippuric acid clearances in the conscious male and female rat. | 1997 | Arzneimittelforschung | pmid:9342416 |
Neupert W et al. | Effects of ibuprofen enantiomers and its coenzyme A thioesters on human prostaglandin endoperoxide synthases. | 1997 | Br. J. Pharmacol. | pmid:9351505 |
Lahoz C et al. | Effects of dietary fat saturation on eicosanoid production, platelet aggregation and blood pressure. | 1997 | Eur. J. Clin. Invest. | pmid:9352251 |
Baskett A et al. | Effect of pentoxifylline, flunixin meglumine, and their combination on a model of endotoxemia in horses. | 1997 | Am. J. Vet. Res. | pmid:9361895 |
Barton MH et al. | Effects of pentoxifylline infusion on response of horses to in vivo challenge exposure with endotoxin. | 1997 | Am. J. Vet. Res. | pmid:9361896 |
Chen L et al. | Cyclooxygenase inhibition decreases nitric oxide synthase activity in human platelets. | 1997 | Am. J. Physiol. | pmid:9362253 |
Bar J et al. | The regulation of platelet aggregation in vitro by interleukin-1beta and tumor necrosis factor-alpha: changes in pregnancy and in pre-eclampsia. | 1997 | Thromb. Haemost. | pmid:9364994 |
Walker JS et al. | Nonsteroidal antiinflammatory drugs in rheumatoid arthritis and osteoarthritis: support for the concept of "responders" and "nonresponders". | 1997 | Arthritis Rheum. | pmid:9365082 |
Riendeau D et al. | Comparison of the cyclooxygenase-1 inhibitory properties of nonsteroidal anti-inflammatory drugs (NSAIDs) and selective COX-2 inhibitors, using sensitive microsomal and platelet assays. | 1997 | Can. J. Physiol. Pharmacol. | pmid:9365818 |
John H and Schlegel W | Reversed-phase high-performance liquid chromatographic method for the determination of the 11-hydroxythromboxane B2 anomers equilibrium. | 1997 | J. Chromatogr. B Biomed. Sci. Appl. | pmid:9367188 |
Capponi A et al. | Indomethacin modifies the fetal hemodynamic response induced by percutaneous umbilical blood sampling. | 1997 | Am. J. Obstet. Gynecol. | pmid:9369815 |
Siler-Khodr TM et al. | The effect of dexamethasone on CRH and prostanoid production from human term placenta. | 1997 | Prostaglandins | pmid:9373879 |
Farker K et al. | Measurements of urinary prostaglandins in young ovulatory women during the menstrual cycle and in postmenopausal women. | 1997 | Prostaglandins | pmid:9373880 |
Savla U et al. | Cyclic stretch of airway epithelium inhibits prostanoid synthesis. | 1997 | Am. J. Physiol. | pmid:9374729 |
Kobayashi T et al. | Changes in platelet calcium concentration by thromboxane A2 stimulation in patients with nephrotic syndrome of childhood. | 1997 | Nephron | pmid:9375825 |
Nygaard OP et al. | The inflammatory properties of contained and noncontained lumbar disc herniation. | 1997 | Spine | pmid:9383853 |
Xiao X et al. | Effect of captopril on renal hemodynamics and renal prostaglandins in early type II diabetic patients with normo-or microalbuminuria. | 1996 | Chin. Med. Sci. J. | pmid:9387403 |
Sang Y et al. | [Effects of tangshenkang capsule on diabetic nephropathy]. | 1996 | Zhongguo Zhong Xi Yi Jie He Za Zhi | pmid:9387731 |
Han JA and Hu WY | [Progress in the study on protective effect of saponins Panax notoginseng on ischemic brain damage]. | 1996 | Zhongguo Zhong Xi Yi Jie He Za Zhi | pmid:9387754 |
Liu Z | [Effects of acupuncture on lipid, TXB2, 6-keto-PGF, alpha in simple obese patients complicated with hyperlipidemia]. | 1996 | Zhen Ci Yan Jiu | pmid:9388312 |
Li T et al. | [Observation on TXB2 and 6-keto-PGF1 alpha in serum of patients with cor pulmonale]. | 1996 | Hua Xi Yi Ke Da Xue Xue Bao | pmid:9389073 |
Bellamy MC et al. | Changes in inflammatory mediators during orthotopic liver transplantation. | 1997 | Br J Anaesth | pmid:9389852 |
Wettstein M and Häussinger D | Cytoprotection by the osmolytes betaine and taurine in ischemia-reoxygenation injury in the perfused rat liver. | 1997 | Hepatology | pmid:9397998 |
Knowles SO and Donaldson WE | Lead disrupts eicosanoid metabolism, macrophage function, and disease resistance in birds. | 1997 Oct-Nov | Biol Trace Elem Res | pmid:9404672 |
Vezza R et al. | Antivasoconstrictor and antiaggregatory activities of picotamide unrelated to thromboxane A2 antagonism. | 1997 | Thromb. Haemost. | pmid:9408024 |
Byrne A et al. | Continued thromboxane A2 formation despite administration of a platelet glycoprotein IIb/IIIa antagonist in patients undergoing coronary angioplasty. | 1997 | Arterioscler. Thromb. Vasc. Biol. | pmid:9409315 |
Davi G et al. | In vivo formation of 8-Epi-prostaglandin F2 alpha is increased in hypercholesterolemia. | 1997 | Arterioscler. Thromb. Vasc. Biol. | pmid:9409316 |
Gerdemann R et al. | [Effect of flunixin meglumine on plasma prostanoid concentrations in horses with colic in the perioperative period]. | 1997 | DTW. Dtsch. Tierarztl. Wochenschr. | pmid:9410724 |
Davì G et al. | Enhanced thromboxane biosynthesis in patients with chronic obstructive pulmonary disease. The Chronic Obstructive Bronchitis and Haemostasis Study Group. | 1997 | Am. J. Respir. Crit. Care Med. | pmid:9412557 |
Alanko J et al. | Catechol estrogens as inhibitors of leukotriene synthesis. | 1998 | Biochem. Pharmacol. | pmid:9413936 |
Oosaki R et al. | Urinary excretion of leukotriene E4 and 11-dehydrothromboxane B2 in patients with spontaneous asthma attacks. | 1997 | Int. Arch. Allergy Immunol. | pmid:9414142 |
Moutquin JM et al. | Do prostacyclin and thromboxane contribute to the "protective effect" of pregnancies with chronic hypertension? A preliminary prospective longitudinal study. | 1997 | Am. J. Obstet. Gynecol. | pmid:9423755 |
Gresele P et al. | Platelet activation markers in patients with peripheral arterial disease--a prospective comparison of different platelet function tests. | 1997 | Thromb. Haemost. | pmid:9423790 |
Famaey JP | In vitro and in vivo pharmacological evidence of selective cyclooxygenase-2 inhibition by nimesulide: an overview. | 1997 | Inflamm. Res. | pmid:9427063 |
Akarsu ES et al. | Effect of ciliary neurotrophic factor on body temperature and cerebrospinal fluid prostanoids in the cat. | 1998 | Brain Res. Bull. | pmid:9434196 |
Qureshi MA and Gore AB | Vitamin E exposure modulates prostaglandin and thromboxane production by avian cells of the mononuclear phagocytic system. | 1997 | Immunopharmacol Immunotoxicol | pmid:9436047 |
Sheu JR et al. | Triflavin inhibits platelet-induced vasoconstriction in de-endothelialized aorta. | 1997 | Arterioscler. Thromb. Vasc. Biol. | pmid:9437193 |
Sorem KA and Siler-Khodr TM | Effect of IGF-I on placental thromboxane and prostacyclin release in severe intrauterine growth retardation. | 1997 Nov-Dec | J Matern Fetal Med | pmid:9438218 |
Kurosawa M et al. | Heterogeneity of mast cells in mastocytosis and inhibitory effect of ketotifen and ranitidine on indolent systemic mastocytosis. | 1997 | J. Allergy Clin. Immunol. | pmid:9440541 |